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    • 21. 发明申请
    • SLIDABLE ROOM ASSEMBLY AND METHOD OF INSTALLATION
    • 可滑动的房间组装和安装方法
    • US20060186683A1
    • 2006-08-24
    • US11381378
    • 2006-05-03
    • Bernard GarceauJames Young
    • Bernard GarceauJames Young
    • B60P3/34
    • B60P3/34
    • A slidable room assembly comprises a vehicle body having an opening formed in an exterior wall, and a reciprocable slideout unit or compartment disposed in the opening and slidable between a retracted position and an extended position. Sliding movement of the slideout unit is controlled by means of a drive mechanism that includes two sets of cabling. The drive mechanism includes a frame installed about the opening in the vehicle body. The frame includes a header, a sill and two pre-assembled jambs. The pre-assembled jambs have a plurality of pulleys with a plurality of cables pre-installed inside the jambs around the pulleys. One end of the cables, attached to the slidable room, is pre-strung through a cable extension hole. The other end of the cables extends out an end of the jamb.
    • 一种可滑动的房间组件包括具有形成在外壁中的开口的车体和设置在该开口中并可在缩回位置和伸出位置之间滑动的可往复运动的插入单元或隔间。 通过包括两组电缆的驱动机构来控制插座单元的滑动运动。 驱动机构包括安装在车身上的开口周围的框架。 框架包括一个标题,一个底框和两个预先组装的边框。 预组装的侧柱具有多个滑轮,其中预先安装在滑轮周围的侧壁内的多根电缆。 连接到可滑动的房间的电缆的一端通过电缆延伸孔预先穿过。 电缆的另一端延伸到侧柱的末端。
    • 22. 发明申请
    • Methods of preventing and treating RSV infections and related conditions
    • 预防和治疗RSV感染和相关病症的方法
    • US20060115485A1
    • 2006-06-01
    • US11263230
    • 2005-10-31
    • Genevieve LosonskyEdward ConnorJames YoungHerren WuWilliam Dall'Acqua
    • Genevieve LosonskyEdward ConnorJames YoungHerren WuWilliam Dall'Acqua
    • A61K39/42
    • C07K16/1027A61K2039/505A61K2039/543C07K2317/21C07K2317/24C07K2317/52C07K2317/55C07K2317/565C07K2317/567C07K2317/72C07K2317/92C07K2317/94
    • The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (kon) of at least 2×105 M−1s−1 and a dissociation rate (koff) of less than 5×10−4 s−1.
    • 本发明提供了用于预防,治疗和/或改善呼吸道合胞病毒(RSV)感染(例如急性RSV疾病或RSV上呼吸道感染(URI))和/或下呼吸道感染(LRI)的方法, ),中耳炎(优选来源于,由RSV感染引起或与RSV感染相关联,例如RSV URI和/或LRI),和/或与其相关的症状或呼吸病症(例如,哮喘,喘鸣和/或 反应性气道疾病(RAD)),包括向所述人施用有效量的一种或多种以高亲和力和/或高亲合力免疫特异性结合一种或多种RSV抗原的抗体。 在一些实施方案中,一种或多种抗体包含修饰的IgG恒定结构域或其FcRn结合片段,导致更长的体内血清半衰期。 在具体实施方案中,本发明的方法包括施用有效量的一种或多种经免疫特异性结合一种或多种RSV抗原的修饰的抗体,其具有至少2×10 6的结合速率(kNI) 小于5×10-6的解离速率(k >) 4 -1
    • 23. 发明申请
    • Intermediate and assembly assistance components for fluid driven tools and tools incorporating the same
    • 用于流体驱动工具和结合其的工具的中间和组装辅助部件
    • US20060040599A1
    • 2006-02-23
    • US10923378
    • 2004-08-20
    • James YoungDouglas PylesMichael YouhouseBrian Roache
    • James YoungDouglas PylesMichael YouhouseBrian Roache
    • B24B27/08
    • B25F5/00
    • A flow guide configured for insertion in a cavity defined between an outer housing and a nested inner motor housing of a fluid driven tool and a tool incorporating the same. The flow guide has a longitudinal axis and includes at least two longitudinal portions disposed parallel to the longitudinal axis and defining longitudinal channel therebetween. At least one substantially circumferential rib portion connects the at least two longitudinal portions at points defining a plane substantially transverse to the longitudinal axis. A portion of the at least one rib portion located in the longitudinal channel has a thickness less than a width of the cavity surrounding the rib to define a circumferential recess that permits fluid communication in the longitudinal channel across the at least one rib. Also provided is a fluid driven tool having an outer housing and an inner motor housing nested in the outer housing and defining a cavity therebetween. The cavity has a first end with a first exhaust passageway and a second end with a second exhaust passageway. The inner motor housing has a motor chamber with at least one inlet port for a fluid driven motor and a fluid inlet, and an inlet manifold disposed in the cavity. The inlet manifold has a recessed portion with a surrounding seal configured to engage the inner motor housing and connect the fluid inlet to the at least one inlet port of the inner motor housing. Also provided is a fluid driven tool having an outer housing and an inner motor housing nested in the outer housing. An inner surface of the outer housing and an outer surface of the inner motor housing have portions that mate upon nesting the inner motor housing in the outer housing and provide reinforced areas for clamping regions of the outer housing located over the reinforced areas.
    • 流动引导件,其构造成用于插入限定在流体驱动工具的外部壳体和嵌套式内部马达壳体之间的空腔中,以及结合其的工具。 流动引导件具有纵向轴线并且包括平行于纵向轴线设置的至少两个纵向部分并且在其之间限定纵向通道。 至少一个基本上周向的肋部分在限定基本上横向于纵向轴线的平面的点处连接至少两个纵向部分。 位于纵向通道中的至少一个肋部分的一部分具有小于围绕肋的空腔的宽度的厚度,以限定允许在纵向通道中跨越至少一个肋的流体连通的周向凹部。 还提供了一种流体驱动工具,其具有嵌套在外壳体中并且在其间限定空腔的外壳体和内电动机壳体。 空腔具有带有第一排气通道的第一端和具有第二排气通道的第二端。 内部马达壳体具有马达室,其具有用于流体驱动马达和流体入口的至少一个入口端口和设置在空腔中的入口歧管。 入口歧管具有凹入部分,其具有围绕密封件的构造以接合内部马达壳体并且将流体入口连接到内部马达壳体的至少一个入口端口。 还提供了一种流体驱动工具,其具有嵌套在外壳体中的外壳体和内电动机壳体。 外壳体的内表面和内电动机壳体的外表面具有将内电机壳体嵌套在外壳体中的部分,并且提供加强区域,用于夹紧位于加强区域上方的外壳体的区域。
    • 24. 发明申请
    • Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
    • 给予/给予抗RSV抗体进行预防和治疗的方法
    • US20050147616A1
    • 2005-07-07
    • US10962285
    • 2004-10-08
    • James YoungScott KoenigLeslie JohnsonWilliam HuseJeffrey WatkinsHerren Wu
    • James YoungScott KoenigLeslie JohnsonWilliam HuseJeffrey WatkinsHerren Wu
    • C07K16/10C12P21/08A61K39/42C07H21/04C07K16/08C12N5/06C12Q1/70
    • C07K16/1027A61K2039/505C07K2317/24C07K2317/56C07K2317/565
    • The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection
    • 本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段,以及包含所述抗体和抗体片段的组合物。 本发明包括预防人类呼吸道合胞病毒(RSV)感染的方法,包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段,其中一定的血清滴度为 所述抗体或抗体片段在所述人受试者中实现。 本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法,包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段,其中一定 所述抗体或抗体片段的血清滴度在所述人受试者中实现。 本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物,以及使用所述组合物检测或诊断RSV感染的方法
    • 25. 发明申请
    • System for remotely controlling client recording and storage behavior
    • 用于远程控制客户端记录和存储行为的系统
    • US20050050577A1
    • 2005-03-03
    • US10339700
    • 2003-01-08
    • Paul WestbrookHoward LookJames YoungStephen LacyTimothy Davison
    • Paul WestbrookHoward LookJames YoungStephen LacyTimothy Davison
    • H04N5/76H04N7/025H04N7/16H04N7/173
    • H04N21/6543H04N5/76H04N5/765H04N5/782H04N5/91H04N7/025H04N7/162H04N21/2181H04N21/2407H04N21/4147H04N21/4331H04N21/4334H04N21/4335H04N21/44222H04N21/4516H04N21/4532H04N21/458H04N21/4622H04N21/466H04N21/4667H04N21/47214H04N21/4755H04N21/8586
    • A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The invention accepts as input a prioritized list of program viewing preferences which is compared with a database of program guide objects that indicate when programs of interest are actually broadcast. A schedule of time versus available storage space is generated that is optimal for the viewer's explicit or derived preferred content. The viewer may request that certain content be captured, which results in the highest possible priority for those content. The invention provides objects called a capture requests that are sent by the service to client systems. Capture requests reflect local storage management decisions about how the client system storage is partitioned. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests.
    • 用于远程控制客户端记录和存储行为的系统在客户端系统存储设备上调度多媒体内容的记录,存储和删除。 本发明接受作为输入的节目观看偏好的优先列表,其与指示感兴趣的节目实际上被广播的节目指南对象的数据库进行比较。 生成时间与可用存储空间的时间表,对于观看者的显式或派生的优选内容是最佳的。 观众可以请求捕获某些内容,这导致那些内容的最高可能的优先级。 本发明提供了被称为由服务发送给客户端系统的捕获请求的对象。 捕获请求反映了关于客户端系统存储分区的本地存储管理决策。 捕获请求还允许服务以与观众请求某些内容被记录但是比观看者可以请求更强大的相同的方式确定由客户端系统记录的内容。 拍摄请求的记录请求可以抢占查看器请求或以与查看器请求相同或较低的优先级输入。 捕获请求可以调整记录请求的所有方面并影响捕获请求本身。 客户端系统的操作功能也由服务使用捕获请求来操纵。
    • 26. 发明授权
    • Process of forming microporous fibers and filaments
    • 形成微孔纤维和细丝的方法
    • US5230843A
    • 1993-07-27
    • US718445
    • 1991-06-20
    • Robert E. HowardJames Young
    • Robert E. HowardJames Young
    • D01D5/247D01F6/04H01M2/16
    • D01D5/247D01F6/04H01M2/1653
    • Fibers and filaments of an ultra-high-molecular-weight polyolefin that have a void volume greater than about 20% and are wettable. Wettability is imparted to the fibers and filaments by incorporating a filler into the composition that is hygroscopic, has a particle size less than about 10 microns in diameter and a surface area greater than about 30 square meters per gram. The preferred fillers are those that contain surface silanol groups. The fibers and filaments are formed by the process of preparing a mixture of an ultra-high-molecular-weight polyolefin, filler and plasticizer, metering the mixture to an extruder, heating and kneading the blend in the extruder, conveying the extrudate to a fiber or filament forming type die, expressing the extrudate through the die openings to form fibers or filaments, and extracting at least a portion of the extractable plasticizer to provide the desired porosity. The fibers and filaments may be formed into nonwoven webs directly by the melt blown or spun bonded process or by airlaying or wetlaying techniques. Such webs are particularly useful as a battery separator. The filaments may also be woven into fabric.
    • 超高分子量聚烯烃的纤维和长丝具有大于约20%的空隙体积并且是可润湿的。 通过在吸湿性组合物中加入填料,具有直径小于约10微米的粒径和大于约30平方米每克的表面积,赋予纤维和长丝润湿性。 优选的填料是含有表面硅烷醇基团的填料。 纤维和长丝通过制备超高分子量聚烯烃,填料和增塑剂的混合物的方法形成,将混合物计量到挤出机中,在挤出机中加热和捏合共混物,将挤出物输送到纤维 或长丝成型型模具,通过模具开口表达挤出物以形成纤维或长丝,并提取至少一部分可提取的增塑剂以提供所需的孔隙率。 纤维和长丝可以通过熔喷或纺粘方法直接形成非织造纤维网,或者通过气流铺设或湿法技术形成。 这种网是特别有用的电池隔膜。 长丝也可以织成织物。
    • 27. 发明授权
    • Microporous filaments and fibers, and articles made therefrom
    • 微孔纤维和纤维,以及由其制成的制品
    • US5126219A
    • 1992-06-30
    • US718444
    • 1991-06-20
    • Robert E. HowardJames Young
    • Robert E. HowardJames Young
    • D01D5/247D01F6/04H01M2/16
    • H01M2/1653D01D5/247D01F6/04Y10T428/25Y10T428/259Y10T442/3976
    • Fibers and filaments of an ultra-high-molecular-weight polyolefin that have a void volume greater than about 20% and are wettble. Wettability is imparted to the fibers and filaments by incorporating a filler into the composition that is hygroscopic, has a particle size less than about 10 microns in diameter and a surface area greater than about 30 square meters per gram. The preferred fillers are those that contain surface silanol groups. The fibers and filaments are formed by the process of preparing a mixture of an ultra-high-molecular-weight polyolefin, filler and plasticizer, metering the mixture to an extruder, heating and kneading the blend in the extruder, conveying the extrudate to a fiber or filament forming type die, expressing the extrudate through the die openings to form fibers or filaments, and extracting at least a portion of the extractable plasticizer to provide the desired porosity. The fibers and filaments may be formed into nonwoven webs directly by the melt blown or spun bonded process or by airlaying or wetlaying techniques. Such webs are particularly useful as a battery separator. The filaments may also be woven into fabric.
    • 超高分子量聚烯烃的纤维和长丝具有大于约20%的空隙体积并且是湿润的。 通过在吸湿性组合物中加入填料,具有直径小于约10微米的粒径和大于约30平方米每克的表面积,赋予纤维和长丝润湿性。 优选的填料是含有表面硅烷醇基团的填料。 纤维和长丝通过制备超高分子量聚烯烃,填料和增塑剂的混合物的方法形成,将混合物计量到挤出机中,在挤出机中加热和捏合共混物,将挤出物输送到纤维 或长丝成型型模具,通过模具开口表达挤出物以形成纤维或长丝,并提取至少一部分可提取的增塑剂以提供所需的孔隙率。 纤维和长丝可以通过熔喷或纺粘方法直接形成非织造纤维网,或通过气流成型或湿法技术形成。 这种网是特别有用的电池隔膜。 长丝也可以织成织物。