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21. 发明授权

US06383289B2 Apparatus for liquid carbon dioxide systems 失效
标题翻译：液体二氧化碳系统装置
公开(公告)号：US06383289B2
公开(公告)日：2002-05-07
申请号：US09794294
申请日：2001-02-27
申请人： Joseph M. DeSimone , Ruben G. Carbonell
发明人： Joseph M. DeSimone , Ruben G. Carbonell
IPC分类号： B05D312
CPC分类号： H01L21/6715 , B05C11/08 , B05D1/005 , B08B7/0021
摘要： Spin coating apparatuses for applying liquid to substrates include pressure vessels having enclosed chambers therein, holders for rotating substrates positioned in the enclosed chambers, liquid dispensers positioned in the enclosed chambers for depositing a carbon dioxide liquid on the substrates, and pressure reservoirs in fluid communication with the liquid dispensers for storing a carbon dioxide liquid.
摘要翻译：用于将液体涂敷于基材的旋转涂布装置包括其中具有封闭室的压力容器，用于旋转位于封闭室内的基板的保持器，位于封闭室内的液体分配器，用于在基板上沉积二氧化碳液体;以及压力容器，用于储存二氧化碳液体的液体分配器。

22. 发明授权

US06211422B1 Enzyme catalysis in carbon dioxide fluids 失效
标题翻译：二氧化碳液体中的酶催化
公开(公告)号：US06211422B1
公开(公告)日：2001-04-03
申请号：US09352249
申请日：1999-07-13
申请人： Joseph M. DeSimone , Ruben G. Carbonell , Stephanie A. Crette , Jonathan L. Kendall
发明人： Joseph M. DeSimone , Ruben G. Carbonell , Stephanie A. Crette , Jonathan L. Kendall
IPC分类号： C12P100
CPC分类号： C12P41/001 , C12P1/00 , Y02P20/544
摘要： A method for the enzymatic production of a desired product in a liquid or supercritical carbon dioxide fluid. The method comprises: (a) providing a reaction mixture comprising at least one reaction substrate and a crosslinked enzyme crystal catalyst in a liquid or supercritical carbon dioxide fluid; and (b) reacting said substrate with said crosslinked enzyme crystal catalyst in said carbon dioxide fluid to produce said product. The reacting step is typically followed by the step of (c) separating the product from said reaction mixture. The crosslinked enzyme crystal catalyst preferably comprises an enzyme crystal crosslinked with a multifunctional crosslinking agent, said crosslinked enzyme crystal having resistance to exogeneous proteolysis, such that the crosslinked enzyme crystal retains at least about 80 percent of its initial activity after incubation for three hours in the presence of a concentration of Pronase™ protease that causes the soluble uncrosslinked form of the enzyme that is crystallized to form said enzyme crystal that is crosslinked to lose at least about 80 percent of its initial activity under the same conditions. Reaction mixtures useful for carrying out the foregoing method and product mixtures produced by the foregoing method are also disclosed.
摘要翻译：在液体或超临界二氧化碳流体中酶促生产所需产物的方法。该方法包括：（a）在液体或超临界二氧化碳流体中提供包含至少一个反应底物和交联的酶晶体催化剂的反应混合物; 和（b）使所述底物与所述交联的酶晶体催化剂在所述二氧化碳流体中反应以产生所述产物。反应步骤通常是（c）从所述反应混合物中分离产物的步骤。交联酶晶体催化剂优选包含与多官能交联剂交联的酶晶体，所述交联酶晶体具有对外源性蛋白水解的抗性，使得交联的酶晶体在孵育3小时后保留其初始活性的至少约80％存在一种浓度的Pronase TM蛋白酶，其引起可溶性的未交联形式的酶，其被结晶以形成所述交联的酶晶体，以在相同条件下损失其初始活性的至少约80％。还公开了可用于实施上述方法的反应混合物和通过前述方法制备的产物混合物。

23. 发明授权

US06191256B1 Recombinant factor VIII binding peptides 有权
标题翻译：重组因子VIII结合肽
公开(公告)号：US06191256B1
公开(公告)日：2001-02-20
申请号：US09196934
申请日：1998-11-20
申请人： Li Ang Chen , Joseph A. Buettner , Ruben G. Carbonell
发明人： Li Ang Chen , Joseph A. Buettner , Ruben G. Carbonell
IPC分类号： C07K500
CPC分类号： C07K7/06 , C07K5/1019 , C07K14/755
摘要： Peptides that have domains that bind to recombinant factor VIII (rFVIII) are disclosed. A method of rFVIII binding assay using the peptides deduced from a combinatorial library in a filtration plate process is described. A method of using peptides having these available binding domains in an affinity chromatography process to purify factor VIII is also taught.
摘要翻译：公开了具有结合重组因子VIII（rFVIII）的结构域的肽。描述了使用在过滤板方法中从组合文库推导的肽的rFVIII结合测定法。还教导了在亲和层析方法中使用具有这些可用结合结构域的肽以纯化因子VIII的方法。

24. 发明授权

US5985836A Alpha-1 proteinase inhibitor binding peptides 失效
标题翻译： α-1蛋白酶抑制剂结合肽
公开(公告)号：US5985836A
公开(公告)日：1999-11-16
申请号：US127574
申请日：1998-07-31
申请人： Patrick D. Bastek , John M. Lang , George A. Baumbach , Ruben G. Carbonell
发明人： Patrick D. Bastek , John M. Lang , George A. Baumbach , Ruben G. Carbonell
IPC分类号： C07K7/06 , A61K38/00 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06
摘要： Peptides which bind to alpha-1 Proteinase inhibitor (AlPI) are disclosed. The peptides have an available AlPI binding domain which may be any of the following preferred sequences: Val Ile Trp Leu Val Arg, Ile Ile Trp Leu Tyr Lys, Arg Tyr Arg Ile Phe Ile, Arg Ala Phe Trp Tyr Ile, Arg Phe Ile Tyr Tyr Thr, Tyr Lys Phe Arg Phe Trp, Leu Ile Val His Arg Trp, Pro Tyr Trp Ile Val Arg, Ala Arg Trp Tyr Ile His, Gln Tyr His Phe Trp Tyr, Arg Leu Trp Arg Tyr Gly, Val Ile Tyr Leu Val Arg, Val Ile Phe Leu Val Arg, Lys Ile Phe Leu Val Arg, Arg Ile Phe Leu Val Arg, His Ile Phe Leu Val Arg, Arg Val Leu Phe Ile Val, or Arg Val Leu Phe Ile His (SEQ ID NOS: 1-8, 10, 11, 15, 36, 37, 45, 46, 47, 61, and 62 respectively). A method of using peptides having these available binding domains in an affinity chromatography process to purify AlPI is described.
摘要翻译：公开了结合α-1蛋白酶抑制剂（AlPI）的肽。肽具有可用的AlPI结合结构域，其可以是以下优选的序列：Val Ile Trp Leu Val Arg，Ile Ile Trp Leu Tyr Lys，Arg Tyr Arg Ile Phe Ile，Arg Ala Phe Trp Tyr Ile，Arg Phe Ile Tyr Tyr Thr，Tyr Lys Phe Arg Phe Trp，Leu Ile Val His Arg Trp，Pro Tyr Trp Ile Val Arg，Ala Arg Trp Tyr Ile His，Gln Tyr His Phe Trp Tyr，Arg Leu Trp Arg Tyr Gly，Val Ile Tyr Leu Val Arg，Val Ile Phe Leu Val Arg，Lys Ile Phe Leu Val Arg，Arg Ile Phe Leu Val Arg，His Ile Phe Leu Val Arg，Arg Val Leu Phe Ile Val或Arg Val Leu Phe Ile His（SEQ ID NOS：1 分别为-8,10,11,15,36,37,45,46,47,61和62）。描述了在亲和层析方法中使用具有这些可用结合域的肽纯化AlPI的方法。

25. 发明授权

US4913902A Purification by affinity binding to liposomes 失效
标题翻译：通过亲和性结合脂质体进行纯化
公开(公告)号：US4913902A
公开(公告)日：1990-04-03
申请号：US119351
申请日：1987-11-10
申请人： Peter K. Kilpatrick , Ruben G. Carbonell , Johnny D. Powers
发明人： Peter K. Kilpatrick , Ruben G. Carbonell , Johnny D. Powers
IPC分类号： C12N9/00 , A61K39/44 , C07K1/16 , C07K1/22 , C07K14/575 , C07K14/705 , C07K16/00
CPC分类号： C07K1/22 , Y10S436/829
摘要： A method of extracting a compound specifically bound by a ligand from a crude solution containing the compound is disclosed. The method comprises providing a multiplicity of liposomes having the ligand bound to the surface thereof, and mixing the liposomes with the crude solution so that the ligand binds to the compound to be extracted. The liposomes are then separated from the crude solution and the compound to be extracted recovered from the liposomes.
摘要翻译：公开了从含有该化合物的粗溶液中提取由配体特异结合的化合物的方法。该方法包括提供多种脂质体，其具有与其表面结合的配体，并将脂质体与粗溶液混合，使得配体与要提取的化合物结合。然后将脂质体与粗溶液分离，并从脂质体中回收待提取的化合物。

26. 发明授权

US09091006B2 Conformal coating of polymer fibers on nonwoven substrates 有权
标题翻译：聚合物纤维在非织造基材上的共形涂层
公开(公告)号：US09091006B2
公开(公告)日：2015-07-28
申请号：US12994403
申请日：2009-06-10
申请人： Yong Zheng , Samana Roy Chowdhury , Patrick Vasconcelos Gurgel , Haiyan Liu , Ruben G. Carbonell
发明人： Yong Zheng , Samana Roy Chowdhury , Patrick Vasconcelos Gurgel , Haiyan Liu , Ruben G. Carbonell
IPC分类号： D04H1/56 , D04H1/64 , D06M10/00 , D06M10/02 , D06M14/22 , D06M14/26 , D06M14/28
CPC分类号： D04H1/56 , D04H1/565 , D04H1/587 , D04H1/64 , D04H1/641 , D06M10/001 , D06M10/025 , D06M14/22 , D06M14/26 , D06M14/28 , D06M14/32 , D06M14/34 , Y10T442/20 , Y10T442/277 , Y10T442/2861 , Y10T442/2877 , Y10T442/2885 , Y10T442/2893 , Y10T442/2902 , Y10T442/291 , Y10T442/2918 , Y10T442/60 , Y10T442/659
摘要： The present invention describes a novel process for the conformal coating of polymer fibers of nonwoven substrates. This process is based on modification of polymer fiber surfaces by controlling the degree of etching and oxidation to improve adhesion of initiators to the surface and to facilitate subsequent conformal polymer grafting. The modified fiber surfaces render new functionalities to the surface, such as increased hydrophilicity, attached ligands or changed surface energy. The invention includes the modified polymer fibers produced by the process described herein.
摘要翻译：本发明描述了一种用于非织造衬底的聚合物纤维的保形涂层的新方法。该方法基于通过控制蚀刻和氧化程度来改进聚合物纤维表面，以改善引发剂对表面的粘合性并有利于随后的共形聚合物接枝。改性的纤维表面赋予表面新的功能，例如增加的亲水性，附着的配体或改变的表面能。本发明包括通过本文所述方法生产的改性聚合物纤维。

27. 发明申请

US20120264671A1 METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS 审中-公开
标题翻译：使用环境友好的溶剂从基材中除去残留物和物质的方法和组合物
公开(公告)号：US20120264671A1
公开(公告)日：2012-10-18
申请号：US13527146
申请日：2012-06-19
申请人： Ruben G. Carbonell , Peter Kilpatrick , Nael Zaki
发明人： Ruben G. Carbonell , Peter Kilpatrick , Nael Zaki
IPC分类号： C11D3/20
CPC分类号： C11D11/0076 , B01D11/0288 , C10G1/04 , C10G21/003 , C10G21/08 , C10G21/16 , C10G29/22 , C10G2300/206 , C10G2300/301 , C10G2300/44 , C11D7/266 , C11D7/5022
摘要： Environmentally friendly solvents used to dissolve or remove residues and/or substances from substrates wherein the residue and/or substance is contacted with a Generally Recognized As Safe solvent to dissolve the residue and/or substance in the solvent followed by the extraction of the residue and/or substance from the solvent such as by contact with carbon dioxide.
摘要翻译：用于溶解或去除底物残留物和/或物质的环境友好的溶剂，其中残余物和/或物质与一般认可的安全溶剂接触以将残余物和/或物质溶解在溶剂中，然后萃取残余物， /或溶剂中的物质，例如与二氧化碳接触。

28. 发明授权

US08201445B2 Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents 有权
标题翻译：使用环保溶剂从底物中除去残留物和物质的方法和组合物
公开(公告)号：US08201445B2
公开(公告)日：2012-06-19
申请号：US13221059
申请日：2011-08-30
申请人： Ruben G. Carbonell , Peter Kilpatrick , Nael Zaki
发明人： Ruben G. Carbonell , Peter Kilpatrick , Nael Zaki
IPC分类号： G01G9/00
CPC分类号： C11D11/0076 , B01D11/0288 , C10G1/04 , C10G21/003 , C10G21/08 , C10G21/16 , C10G29/22 , C10G2300/206 , C10G2300/301 , C10G2300/44 , C11D7/266 , C11D7/5022
摘要： Environmentally friendly solvents used to dissolve or remove residues and/or substances from substrates wherein the residue and/or substance is contacted with a Generally Recognized As Safe solvent to dissolve the residue and/or substance in the solvent followed by the extraction of the residue and/or substance from the solvent such as by contact with carbon dioxide.
摘要翻译：用于溶解或去除底物残留物和/或物质的环境友好的溶剂，其中残余物和/或物质与一般认可的安全溶剂接触以将残余物和/或物质溶解在溶剂中，然后萃取残余物， /或溶剂中的物质，例如与二氧化碳接触。

29. 发明授权

US08163563B2 Devices and methods for removing target agents from a sample 有权
标题翻译：从样品中去除目标试剂的设备和方法
公开(公告)号：US08163563B2
公开(公告)日：2012-04-24
申请号：US11148335
申请日：2005-06-09
申请人： Ruben G. Carbonell
发明人： Ruben G. Carbonell
IPC分类号： G01N21/77
CPC分类号： B01L3/5023 , B01D15/00 , B01D15/08 , B01J20/28026 , B01J20/28028 , B01J20/28033 , B01J20/28057 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/286 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3234 , B01J20/3236 , B01J20/3238 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01L2300/0848 , G01N1/40 , G01N1/405 , G01N1/4077
摘要： The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.
摘要翻译：本发明提供了用于从样品中除去目标试剂的装置，测试试剂盒和方法。该装置含有一个或多个孔径大于10μm的多孔基质和浸渍在其中的多个颗粒。目标代理附加设备并从样品中移除。

30. 发明申请

US20100288028A1 Methods and Compositions for Removing Residues and Substances from Substrates Using Environmentally Friendly Solvents 有权
标题翻译：使用环保溶剂除去底物残留物和物质的方法和组合
公开(公告)号：US20100288028A1
公开(公告)日：2010-11-18
申请号：US12844080
申请日：2010-07-27
申请人： Ruben G. Carbonell , Peter Kilpatrick , Nael Zaki
发明人： Ruben G. Carbonell , Peter Kilpatrick , Nael Zaki
IPC分类号： G01N1/00
CPC分类号： C11D11/0076 , B01D11/0288 , C10G1/04 , C10G21/003 , C10G21/08 , C10G21/16 , C10G29/22 , C10G2300/206 , C10G2300/301 , C10G2300/44 , C11D7/266 , C11D7/5022
摘要： Environmentally friendly solvents used to dissolve or remove residues and/or substances from substrates wherein the residue and/or substance is contacted with a Generally Recognized As Safe solvent to dissolve the residue and/or substance in the solvent followed by the extraction of the residue and/or substance from the solvent such as by contact with carbon dioxide.
摘要翻译：用于溶解或去除底物残留物和/或物质的环境友好的溶剂，其中残余物和/或物质与一般认可的安全溶剂接触以将残余物和/或物质溶解在溶剂中，然后萃取残余物， /或溶剂中的物质，例如与二氧化碳接触。

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