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21. 发明申请

US20090054436A1 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS 有权
标题翻译：单克隆杂合物作为激酶抑制剂
公开(公告)号：US20090054436A1
公开(公告)日：2009-02-26
申请号：US12253491
申请日：2008-10-17
申请人： Robert M. Borzilleri , Lyndon A.M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
发明人： Robert M. Borzilleri , Lyndon A.M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
IPC分类号： A61K31/4412 , C07D211/74 , C07D239/34 , A61K31/513 , A61P43/00 , A61K31/5377 , C07D239/47 , C07D413/12
CPC分类号： C07D213/82 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/89 , C07D239/34 , C07D239/42 , C07D239/47 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
摘要翻译：本发明涉及具有下式的化合物及其用于治疗癌症的方法。

22. 发明授权

US07420098B2 Dual zone aromatic alkylation process 有权
标题翻译：双区芳烃烷基化工艺
公开(公告)号：US07420098B2
公开(公告)日：2008-09-02
申请号：US11622937
申请日：2007-01-12
申请人： Robert J. Schmidt
发明人： Robert J. Schmidt
IPC分类号： C07C2/66
CPC分类号： C07C2/66 , B01J29/70 , B01J29/7007 , B01J35/0006 , B01J37/0009 , B01J2229/42 , C07C2529/70 , Y02P20/52 , C07C15/085
摘要： A process for the catalytic alkylation of an aromatic substrate with an alkylating agent is disclosed that comprises contacting the aromatic substrate and the alkylating agent in sequential alkylation zones to obtain an alkylaromatic. The first catalyst comprises UZM-8 zeolite and the second catalyst comprises beta zeolite. The process is particularly well suited for the alkylation of benzene with propylene to produce cumene.
摘要翻译：公开了一种用烷基化剂催化烷基化芳族底物的方法，其包括使芳族底物和烷基化剂在顺序的烷基化区中接触以获得烷基芳族化合物。第一种催化剂包括UZM-8沸石，第二种催化剂包括β沸石。该方法特别适用于苯与丙烯的烷基化以产生枯烯。

23. 发明授权

US07268267B2 Alkylation process using UZM-8 zeolite 失效
标题翻译：使用UZM-8沸石的烷基化方法
公开(公告)号：US07268267B2
公开(公告)日：2007-09-11
申请号：US11170420
申请日：2005-06-29
申请人： Deng-Yang Jan , James A. Johnson , Robert J. Schmidt , Guy B. Woodle
发明人： Deng-Yang Jan , James A. Johnson , Robert J. Schmidt , Guy B. Woodle
IPC分类号： C07C2/66
CPC分类号： C07C2/66 , B01J29/06 , B01J29/70 , B01J29/7007 , B01J2229/42 , C07C6/126 , C07C2521/04 , C07C2529/70 , Y02P20/52 , Y02P20/584 , C07C15/073 , C07C15/085
摘要： A process for the alkylation of aromatics with olefins using a solid catalyst bed containing UZM-8 zeolite is disclosed. A polyalkylated aromatic is passed to the catalyst bed to reduce the concentration of the olefin at alkylation conditions. A portion of the effluent recovered from the catalyst bed may be recycled to the catalyst bed. Such operation can decrease the catalyst deactivation rate and the formation of diphenylalkanes. The process disclosed herein is applicable to processes for the production of a wide variety of commercially important alkylated aromatics, including ethylbenzene and cumene.
摘要翻译：公开了使用含有UZM-8沸石的固体催化剂床用烯烃烷基化芳族化合物的方法。将多烷基化芳族化合物通入催化剂床，以在烷基化条件下降低烯烃的浓度。从催化剂床回收的一部分流出物可以再循环到催化剂床。这种操作可以降低催化剂失活速率和二苯基烷烃的形成。本文公开的方法适用于生产各种商业上重要的烷基化芳族化合物（包括乙苯和枯烯）的方法。

24. 发明授权

US07141701B1 Decomposition of cumene hydroperoxide 有权
标题翻译：氢过氧化枯烯的分解
公开(公告)号：US07141701B1
公开(公告)日：2006-11-28
申请号：US11207951
申请日：2005-08-19
申请人： Robert J. Schmidt , Russell C. Schulz , Patrick J. Bullen , Constante P. Tagamolila , Steven P. Lankton , Gary A. Peterson , Michael E. Fettis
发明人： Robert J. Schmidt , Russell C. Schulz , Patrick J. Bullen , Constante P. Tagamolila , Steven P. Lankton , Gary A. Peterson , Michael E. Fettis
IPC分类号： C07C45/00 , C07C37/08 , C07C15/40
CPC分类号： C07C37/08 , C07C1/20 , C07C45/53 , C07C2527/054 , C07C15/44 , C07C49/08 , C07C39/04
摘要： A process for decomposing a cumene oxidation product mixture containing cumene hydroperoxide (CHP) and dimethylphenolcarbinol (DMPC) to produce phenol and acetone.
摘要翻译：一种用于分解含有氢过氧化枯烯（CHP）和二甲基苯酚甲醇（DMPC）的枯烯氧化产物混合物以产生苯酚和丙酮的方法。

25. 发明授权

US06894201B1 Process and apparatus for the removal of nitrogen compounds from a fluid stream 失效
标题翻译：用于从流体流中除去氮化合物的方法和装置
公开(公告)号：US06894201B1
公开(公告)日：2005-05-17
申请号：US10741470
申请日：2003-12-19
申请人： Robert J. Schmidt , Andrew S. Zarchy
发明人： Robert J. Schmidt , Andrew S. Zarchy
IPC分类号： C07C2/66 , C07C7/13
CPC分类号： C07C7/13 , C07C2/66 , Y02P20/52 , C07C15/02 , C07C15/04
摘要： Disclosed is a process and apparatus for removing nitrogen compounds from an alkylation substrate such as benzene. A conventional adsorbent bed can be used to adsorb basic organic nitrogen compounds and a hot adsorbent bed of acidic molecular sieve can adsorb the weakly basic nitrogen compounds such as nitrites. Water facilitates the adsorption of the weakly basic nitrogen compounds. Running an alkylation substrate stream from a fractionation column of elevated temperature and suitable water concentration to the hot adsorbent bed may be advantageous.
摘要翻译：公开了一种从烷基化底物如苯中除去氮化合物的方法和装置。常规的吸附剂床可用于吸附碱性有机氮化合物，酸性分子筛的热吸附床可以吸附弱碱性氮化合物如亚硝酸盐。水促进弱碱性氮化合物的吸附。从高温和合适的水浓度的分馏塔中经历烷基化底物流到热吸附床可能是有利的。

26. 发明授权

US06809102B2 Cyano-substituted dihydropyrimidine compounds and their use to treat diseases 有权
标题翻译：氰基取代的二氢嘧啶化合物及其用于治疗疾病的用途
公开(公告)号：US06809102B2
公开(公告)日：2004-10-26
申请号：US10104257
申请日：2002-03-22
申请人： Spencer David Kimball , Louis J. Lombardo , David B. Rawlins , Hai-Yun Xiao , Robert J. Schmidt , David K. Williams
发明人： Spencer David Kimball , Louis J. Lombardo , David B. Rawlins , Hai-Yun Xiao , Robert J. Schmidt , David K. Williams
IPC分类号： A61K31513
CPC分类号： C07D239/22 , C07D211/90 , C07D401/10 , C07D403/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物诱导有丝分裂停滞，从而使其成为抗癌剂。式I化合物还可用于治疗可通过诱导有丝分裂停止治疗的其它疾病。

27. 发明授权

US5565617A Process for purifying an alkylate stream 失效
标题翻译：纯化烷基化物流的方法
公开(公告)号：US5565617A
公开(公告)日：1996-10-15
申请号：US445619
申请日：1995-05-22
申请人： Robert J. Schmidt , Paul A. Sechrist , Paul T. Barger , Christopher D. Gosling
发明人： Robert J. Schmidt , Paul A. Sechrist , Paul T. Barger , Christopher D. Gosling
IPC分类号： C07C7/00 , C07C9/16
CPC分类号： C07C9/16 , C07C7/005
摘要： A process for purifying an alkylate feedstream is disclosed. The feedstream contains hydrogen, hydrogen chloride, C.sub.2 -C.sub.7+ alkanes, C.sub.2 -C.sub.6 alkenes and C.sub.2 -C.sub.6 alkyl halides. The process involves flowing the alkylate through a series of separation zones and a reaction zone to provide a halide free alkylate stream.
摘要翻译：公开了一种纯化烷基化物进料流的方法。进料流含有氢，氯化氢，C 2 -C 7 +烷烃，C 2 -C 6烯烃和C 2 -C 6烷基卤化物。该方法包括使烷基化物流过一系列分离区和反应区，以提供无卤化物的烷基化物流。

28. 发明授权

US5498810A Selective isoparaffin synthesis from naphtha 失效
标题翻译：石脑油选择性异链烷烃合成
公开(公告)号：US5498810A
公开(公告)日：1996-03-12
申请号：US293530
申请日：1994-08-19
申请人： Paula L. Bogdan , R. Joe Lawson , J. W. Adriaan Sachtler , Robert J. Schmidt
发明人： Paula L. Bogdan , R. Joe Lawson , J. W. Adriaan Sachtler , Robert J. Schmidt
IPC分类号： C10G59/02 , C10G65/08 , C10G69/08 , C07C6/00
CPC分类号： C10G65/08 , C10G59/02 , C10G69/08 , Y10S585/94
摘要： A process combination is disclosed to selectively upgrade naphtha to obtain products suitable for further upgrading to reformulated fuels. A naphtha feedstock is hydrogenated to saturate aromatics, followed by selective isoparaffin synthesis to yield light and heavy naphtha and isobutane; isobutane and isopentane in the product are obtained in superequilibrium concentrations. The heavy naphtha may be processed by reforming, light naphtha may be isomerized, and isobutane may be upgraded by dehydrogenation, etherification and/or alkylation to yield gasoline components from the process combination suitable for production of reformulated gasoline.
摘要翻译：公开了一种方法组合以选择性地升级石脑油以获得适于进一步升级至重整燃料的产品。将石脑油原料氢化以使芳烃饱和，随后进行选择性异链烷烃合成以产生轻质和重质石脑油和异丁烷; 产物中的异丁烷和异戊烷以超平衡浓度获得。重石脑油可以通过重整进行处理，轻质石脑油可以被异构化，并且可以通过脱氢，醚化和/或烷基化来提高异丁烷，以从适于生产重整汽油的方法组合产生汽油组分。

29. 发明授权

US5026951A Process for paraffin isomerization with liquid phase adsorptive product separation 失效
标题翻译：用液相吸附产物分离石蜡异构化方法
公开(公告)号：US5026951A
公开(公告)日：1991-06-25
申请号：US462262
申请日：1990-01-09
申请人： Robert J. Schmidt , Lynn H. Rice , Srikantiah Raghuram
发明人： Robert J. Schmidt , Lynn H. Rice , Srikantiah Raghuram
IPC分类号： C07C5/27 , C07C9/00
CPC分类号： C07C9/00 , C07C5/2791
摘要： A combination isomerization and liquid phase adsorptive separation process is given increased efficiency and cost effectiveness by the elimination of a column for the separation of desorbent material from selectively retained components. By decreasing the ratio of normal paraffin desorbent to the selective pore volume circulation rate, the extract column can be eliminated without providing other means for the rejection or recovery of desorbent material. This reduction in the ratio of normal paraffin desorbent to selective pore volume circulation rate has been found not to decrease the recovery from the adsorption section. The elimination of the column provides a substantial decrease in the cost of the equipment to operate a combination isomerization zone and liquid phase adsorption section. In an alternate arrangement, the extract column is replaced with a deisohexanizer column. The deisohexanizer column can be used to produce a C.sub.5 -C.sub.6 product stream having research octane numbers of 93 or greater.
摘要翻译：组合异构化和液相吸附分离方法通过消除用于将解吸剂材料与选择性保留的组分分离的柱来提高效率和成本效益。通过降低正常石蜡脱附剂与选择孔体积循环速率的比例，可以消除萃取柱而不提供用于排除或回收解吸材料的其它方法。发现正常石蜡脱附剂与选择性孔体积循环速率之比的这种降低不会降低吸附段的回收率。柱的消除大大降低了操作组合异构化区和液相吸附段的设备的成本。在替代布置中，萃取柱用脱乙酸酯柱代替。脱甲基塔可用于生产具有研究辛烷值为93或更高的C5-C6产物流。

30. 发明授权

US4901828A Method and apparatus for controlling displacement of a piston in a shock absorber 失效
标题翻译：用于控制减震器中活塞位移的方法和装置
公开(公告)号：US4901828A
公开(公告)日：1990-02-20
申请号：US361720
申请日：1989-05-31
申请人： Robert J. Schmidt , Jerome J. Zawada, Jr.
发明人： Robert J. Schmidt , Jerome J. Zawada, Jr.
IPC分类号： F16F9/48 , F16F9/49
CPC分类号： F16F9/49 , F16F9/48 , Y10T16/276
摘要： A shock absorber for damping the movement of the body of an automobile is provided. The shock absorber comprises a pressure cylinder forming a working chamber operable to store damping fluid. The shock absorber further comprises a reciprocating piston disposed in the working chamber operable to divide the working chamber into first and second portions. An axially extending piston rod is disposed within the working chamber and is connected to the piston. Finally, the shock absorber includes an annular collar and a split ring for controlling the displacement of the piston.
摘要翻译：提供了用于阻尼汽车车身运动的减震器。减震器包括形成可操作以存储阻尼流体的工作室的压力缸。所述减震器还包括设置在所述工作室中的往复式活塞，可操作以将所述工作室分成第一和第二部分。轴向延伸的活塞杆设置在工作室内并与活塞连接。最后，减震器包括用于控制活塞位移的环形套环和开口环。

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