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21. 发明授权

US08062309B2 Defect occlusion apparatus, system, and method 失效
标题翻译：缺陷闭塞装置，系统和方法
公开(公告)号：US08062309B2
公开(公告)日：2011-11-22
申请号：US11207249
申请日：2005-08-19
申请人： David J. Sogard , Leonard B. Richardson , Kent D. Harrison , Diane M. Sheahen
发明人： David J. Sogard , Leonard B. Richardson , Kent D. Harrison , Diane M. Sheahen
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/3478 , A61B34/20 , A61B2017/00004 , A61B2017/00243 , A61B2017/00575 , A61B2017/00588 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867 , A61B2017/0404 , A61B2017/0443 , A61B2017/06171 , A61B2017/0647 , A61B2017/3488
摘要： Methods, apparatus, and systems for occluding a multiplicity of parallel membranes, such as found in a patent foramen ovale (PFO). Methods, apparatus, and systems include the use of a positioning device that can be seated on the limbus of the septum secundum (SS). The positioning device includes a piercing member that can pierce the SS and septum primum (SP). The positioning device also includes a fastening member that can engage the SS and SP to fasten the tissues and occlude a PFO.
摘要翻译：闭塞多个平行膜的方法，装置和系统，例如在卵孔专利（PFO）中发现的。方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘上的定位装置。定位装置包括能够穿透SS和隔膜（SP）的穿刺构件。定位装置还包括紧固构件，其能够接合SS和SP以紧固组织并闭塞PFO。

22. 发明授权

US08430059B2 Precision pen height control for micro-scale direct writing technology 有权
标题翻译：精密笔高度控制微尺度直写技术
公开(公告)号：US08430059B2
公开(公告)日：2013-04-30
申请号：US12137235
申请日：2008-06-11
申请人： Timothy J. Mickley , Frank Genovese , James Feng , Leonard B. Richardson
发明人： Timothy J. Mickley , Frank Genovese , James Feng , Leonard B. Richardson
IPC分类号： B05C11/00 , G01D15/16
CPC分类号： G05B19/25 , G05B2219/37131 , G05B2219/45238 , H05K3/1241 , H05K2203/0126 , H05K2203/163
摘要： An apparatus for precision pen height control which includes a dispensing member, a fluid dispensing system, a vertical position sensing system, and a vertical position controller. The fluid dispensing system is in fluid communication with an opening in the dispensing member via a tubular member. A vertical position sensing system, which includes a diffraction grating and a sensor, is engaged to the tubular member. The sensor is positioned adjacent the diffraction grating. The diffraction grating is engaged to a vertical support, which is engaged to the tubular member. The sensor produces a vertical position signal based upon the position of the vertical support. The vertical position controller is engaged to the vertical position sensing system, and receives a control signal generated from the vertical position signal. The vertical position controller produces and applies vertical forces to the vertical support in response to the control signal.
摘要翻译：一种用于精密笔高度控制的装置，包括分配构件，流体分配系统，垂直位置感测系统和垂直位置控制器。流体分配系统经由管状构件与分配构件中的开口流体连通。包括衍射光栅和传感器的垂直位置传感系统与管状部件接合。传感器位于衍射光栅附近。衍射光栅接合到垂直支撑件，该支撑件与管状构件接合。传感器基于垂直支撑件的位置产生垂直位置信号。垂直位置控制器接合到垂直位置感测系统，并且接收从垂直位置信号产生的控制信号。垂直位置控制器响应于控制信号产生并向垂直支撑件施加垂直力。

23. 发明授权

US08375553B2 Locking element for vascular closure device 失效
标题翻译：用于血管闭合装置的锁定元件
公开(公告)号：US08375553B2
公开(公告)日：2013-02-19
申请号：US12841901
申请日：2010-07-22
申请人： Michael Pikus , Leonard B. Richardson , Joe Groff , James G. Hansen
发明人： Michael Pikus , Leonard B. Richardson , Joe Groff , James G. Hansen
IPC分类号： B21D39/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00526 , A61B2017/00615 , A61B2017/00623 , A61B2017/00654 , A61B2017/00659 , A61B2017/0454 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , Y10T29/53709 , Y10T29/53996
摘要： In one illustrative example, a device for sealing an opening in a vessel wall and/or tissue tract may include an anchor, a filament, a plug, and a knot. The anchor may be configured to be disposed adjacent to an interior surface of the vessel wall adjacent the opening in the vessel wall. The filament may have a distal end coupled to the anchor and may be configured to extend proximally through the vessel opening and/or tissue tract. The plug may be disposed about at least a portion of the filament member. The knot may be disposed about the filament proximal of the plug and may be configured to move over the filament and secure the plug relative to the anchor. The knot may be independent of the filament member.
摘要翻译：在一个说明性示例中，用于密封容器壁和/或组织管道中的开口的装置可以包括锚固件，细丝，塞子和结。锚固件可以被配置成邻近容器壁中与容器壁中的开口相邻的内表面。细丝可以具有联接到锚固件的远端并且可以构造成向近侧延伸穿过血管开口和/或组织道。插塞可以围绕着长丝构件的至少一部分设置。结可以围绕插塞的灯丝周围设置，并且可以被配置为在灯丝上方移动并且相对于锚固件固定插头。结可以独立于细丝构件。

24. 发明授权

US07837619B2 Transeptal apparatus, system, and method 有权
标题翻译：过境设备，系统和方法
公开(公告)号：US07837619B2
公开(公告)日：2010-11-23
申请号：US11207317
申请日：2005-08-19
申请人： David J. Sogard , Leonard B. Richardson , Kent D. Harrison , Diane M. Sheahen
发明人： David J. Sogard , Leonard B. Richardson , Kent D. Harrison , Diane M. Sheahen
IPC分类号： A61B1/00 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/3478 , A61B2017/00243 , A61B2017/00575 , A61B2017/3488
摘要： Methods, apparatus, and systems for locating a patent foramen ovale (PFO) with a positioning device that can be configured to occlude the PFO. Methods, apparatus, and systems include the use of a positioning device that can be seated on the limbus of a septum secundum (SS). The positioning device includes a piercing member that can pierce the SS and a septum primum.
摘要翻译：用于定位具有定位装置的专利孔卵孔（PFO）的方法，装置和系统，所述定位装置可被配置为闭塞PFO。方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘上的定位装置。该定位装置包括能刺穿SS和穿孔的刺穿构件。

25. 发明申请

US20090312878A1 Precision Pen Height Control for Micro-Scale Direct Writing Technology 有权
标题翻译：微型直写技术的精密笔高度控制
公开(公告)号：US20090312878A1
公开(公告)日：2009-12-17
申请号：US12137235
申请日：2008-06-11
申请人： Timothy J. Mickley , Frank Genovese , James Feng , Leonard B. Richardson
发明人： Timothy J. Mickley , Frank Genovese , James Feng , Leonard B. Richardson
IPC分类号： G05D7/00
CPC分类号： G05B19/25 , G05B2219/37131 , G05B2219/45238 , H05K3/1241 , H05K2203/0126 , H05K2203/163
摘要： An apparatus for precision pen height control which includes a dispensing member, a fluid dispensing system, a vertical position sensing system, and a vertical position controller The fluid dispensing system is in fluid communication with an opening in the dispensing member via a tubular member. A vertical position sensing system, which includes a diffraction grating and a sensor, is engaged to the tubular member. The sensor is positioned adjacent the diffraction grating The diffraction grating is engaged to a vertical support, which is engaged to the tubular member. The sensor produces a vertical position signal based upon the position of the vertical support The vertical position controller is engaged to the vertical position sensing system, and receives a control signal generated from the vertical position signal. The vertical position controller produces and applies vertical forces to the vertical support in response to the control signal.
摘要翻译：一种用于精密笔高度控制的装置，其包括分配构件，流体分配系统，垂直位置感测系统和垂直位置控制器。流体分配系统经由管状构件与分配构件中的开口流体连通。包括衍射光栅和传感器的垂直位置传感系统与管状部件接合。传感器定位在衍射光栅附近。衍射光栅与垂直支撑件接合，垂直支撑件与管状构件接合。传感器基于垂直支撑件的位置产生垂直位置信号。垂直位置控制器接合到垂直位置感测系统，并且接收从垂直位置信号产生的控制信号。垂直位置控制器响应于控制信号产生并向垂直支撑件施加垂直力。

26. 发明授权

US06999807B2 pH measuring balloon 有权
标题翻译： pH测量气球
公开(公告)号：US06999807B2
公开(公告)日：2006-02-14
申请号：US10349674
申请日：2003-01-23
申请人： Scott R. Smith , Jaydeep Y. Kokate , Leonard B. Richardson , Eric M. Dobrava
发明人： Scott R. Smith , Jaydeep Y. Kokate , Leonard B. Richardson , Eric M. Dobrava
IPC分类号： A61B5/00
CPC分类号： A61B5/14539 , A61B5/1459
摘要： The present invention relates to devices and methods for measuring the pH of blood in the vicinity of a vulnerable plaque. A balloon including an opto-electric device may be positioned proximate a vulnerable plaque. The balloon can be inflated to partially occlude blood flow enabling interaction between lipid laden blood and pH-sensitive material either within the balloon or on the wall(s) of the balloon. The selected pH-sensitive material is one whose optical properties change as a function of the pH of blood in the vasculature. An opto-electric device may be used for measuring the optical property and/or the change in the optical characteristics of the pH-sensitive compound.
摘要翻译：本发明涉及用于测量易损斑块附近血液pH值的装置和方法。包括光电装置的气囊可以位于易损斑块附近。气囊可以被充气以部分阻塞血液流动，从而能够在球囊内或气球的壁上与脂质负载血液和pH敏感材料之间的相互作用。选择的pH敏感材料是其光学性质随脉管系统中血液pH值变化的物质。可以使用光电装置来测量pH敏感化合物的光学特性和/或光学特性的变化。

27. 发明授权

US09358365B2 Precision electrode movement control for renal nerve ablation 有权
标题翻译：精神电极移动控制肾神经消融
公开(公告)号：US09358365B2
公开(公告)日：2016-06-07
申请号：US13194920
申请日：2011-07-30
申请人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/14 , A61M25/01 , A61B18/18 , A61B18/20 , A61B19/00 , A61B18/00 , A61M25/00
CPC分类号： A61B18/1492 , A61B18/1815 , A61B18/20 , A61B90/39 , A61B2018/00011 , A61B2018/00434 , A61B2018/00577 , A61B2018/00589 , A61B2018/00791 , A61B2018/00875 , A61M25/0054 , A61M25/0113 , A61M25/0127 , A61M25/0138 , A61M25/0147
摘要： A catheter is configured to access a renal artery. A lumen of the catheter's shaft is dimensioned to receive a flexible actuation member which extends between the shaft's proximal and distal ends. The actuation member is moveable within the lumen and subject to elastic deformation, friction, and/or whip along its length. A flexible support member is coupled to a distal end of the actuation member and extendible beyond a distal tip of the shaft. An RF ablation electrode at a distal end of the support member is configured to ablated perivascular renal nerve tissue. A position converter at the distal end of the shaft is configured to convert movement of the actuation member into one or both of controlled rotational and axial movement of the support member and electrode to one of a multiplicity of stable circumferential positions substantially free of elastic deformation, friction, and/or whip impacting actuation member movement.
摘要翻译：导管配置成进入肾动脉。导管轴的内腔的尺寸被设计成容纳在轴的近端和远端之间延伸的柔性致动构件。致动构件可在内腔内移动并且沿其长度受到弹性变形，摩擦和/或鞭状。柔性支撑构件联接到致动构件的远端并且可延伸超过轴的远侧末端。在支撑构件的远端处的RF消融电极被配置为消融血管周围肾神经组织。在轴的远端处的位置转换器被配置为将致动构件的运动转换成支撑构件和电极的受控旋转和轴向运动到基本上没有弹性变形的多个稳定的圆周位置中的一个或两个，摩擦和/或搅动撞击致动构件运动。

28. 发明授权

US09301843B2 Venous valve apparatus, system, and method 有权
标题翻译：静脉瓣装置，系统及方法
公开(公告)号：US09301843B2
公开(公告)日：2016-04-05
申请号：US12943238
申请日：2010-11-10
申请人： Leonard B. Richardson , Jason P. Hill
发明人： Leonard B. Richardson , Jason P. Hill
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , Y10S623/91
摘要： A venous valve apparatus, system and method for valve replacement. The valve includes a valve frame, a valve leaflet joined to the valve frame, and a support frame. The valve leaflet includes surfaces defining a reversibly sealable opening for unidirectional flow of a liquid. The support frame meets the valve frame on an axis, where the valve frame and the support frame extend from the axis in an opposing direction. The system further includes a catheter, where the valve can be reversibly joined to the catheter at a location between a proximal end and a distal end of the catheter. The system can be used to deploy the valve from the catheter at a predetermined location.
摘要翻译：一种用于瓣膜置换的静脉瓣装置，系统和方法。阀包括阀架，连接到阀框架的阀叶片和支撑框架。阀瓣包括限定用于液体的单向流动的可逆密封开口的表面。支撑框架在一个轴线上与阀框架相遇，其中阀门框架和支撑框架从相对方向的轴线延伸。该系统还包括导管，其中阀可以在导管的近端和远端之间的位置处可逆地连接到导管。该系统可用于在预定位置从导管部署阀。

29. 发明授权

US08128681B2 Venous valve apparatus, system, and method 有权
标题翻译：静脉瓣装置，系统及方法
公开(公告)号：US08128681B2
公开(公告)日：2012-03-06
申请号：US10741992
申请日：2003-12-19
申请人： Susan M. Shoemaker , Leonard B. Richardson , Paul F. Chouinard , Jason P. Hill
发明人： Susan M. Shoemaker , Leonard B. Richardson , Paul F. Chouinard , Jason P. Hill
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/06 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2230/0013 , Y10T137/0491
摘要： A venous valve with a tubular frame that includes an outer surface and an inner surface opposite the outer surface and defining a lumen, and a cover over at least the outer surface of the tubular frame, where the cover includes surfaces defining a reversibly sealable opening for unidirectional flow of a liquid through the lumen. A system with the venous valve and a catheter including a proximal end and a distal end, the venous valve located between the proximal end and distal end of the catheter. A method including forming the venous valve and reversibly joining the venous valve and a catheter. A method including positioning at least part of the catheter including the venous valve at a predetermined location and deploying the venous valve from the catheter at the predetermined location.
摘要翻译：一种具有管状框架的静脉瓣，其包括外表面和与所述外表面相对并且限定内腔的内表面，以及至少所述管状框架的外表面上的盖，其中所述盖包括限定可逆密封开口的表面，液体通过管腔的单向流动。具有静脉瓣和包括近端和远端的导管的系统，所述静脉瓣位于导管的近端和远端之间。一种包括形成静脉瓣并可逆地连接静脉瓣和导管的方法。一种方法，包括将包括静脉瓣的导管的至少一部分定位在预定位置并且在预定位置从导管展开静脉瓣。

30. 发明授权

US07854761B2 Methods for venous valve replacement with a catheter 有权
标题翻译：用导管静脉瓣置换的方法
公开(公告)号：US07854761B2
公开(公告)日：2010-12-21
申请号：US10741995
申请日：2003-12-19
申请人： Leonard B. Richardson , Jason P. Hill
发明人： Leonard B. Richardson , Jason P. Hill
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , Y10S623/91
摘要： A venous valve apparatus, system and method for valve replacement. The valve includes a valve frame, a valve leaflet joined to the valve frame, and a support frame. The valve leaflet includes surfaces defining a reversibly sealable opening for unidirectional flow of a liquid. The support frame meets the valve frame on an axis, where the valve frame and the support frame extend from the axis in an opposing direction. The system further includes a catheter, where the valve can be reversibly joined to the catheter at a location between a proximal end and a distal end of the catheter. The system can be used to deploy the valve from the catheter at a predetermined location.
摘要翻译：一种用于瓣膜置换的静脉瓣装置，系统和方法。阀包括阀架，连接到阀框架的阀叶片和支撑框架。阀瓣包括限定用于液体的单向流动的可逆密封开口的表面。支撑框架在一个轴线上与阀框架相遇，其中阀门框架和支撑框架从相对方向的轴线延伸。该系统还包括导管，其中阀可以在导管的近端和远端之间的位置处可逆地连接到导管。该系统可用于在预定位置从导管部署阀。

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