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21. 发明授权

US09956179B2 Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use 有权
公开(公告)号：US09956179B2
公开(公告)日：2018-05-01
申请号：US13368888
申请日：2012-02-08
申请人： Brian K. Johnson , Robert K. Prud'homme
发明人： Brian K. Johnson , Robert K. Prud'homme
IPC分类号： A61K9/14 , A61K9/51 , A01N25/04 , A01N43/70 , A61K47/34 , B01F7/22 , B01F15/00 , B01J13/00 , B01F1/00
CPC分类号： A61K9/5138 , A01N25/04 , A01N43/70 , A61K9/5146 , A61K9/5192 , A61K47/34 , B01F1/00 , B01F7/22 , B01F15/00123 , B01F15/00344 , B01F15/00357 , B01F15/00376 , B01F15/00396 , B01J13/0021 , A01N2300/00
摘要： This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.

22. 发明授权

US09943490B2 Composite flash-precipitated nanoparticles 有权
公开(公告)号：US09943490B2
公开(公告)日：2018-04-17
申请号：US12265206
申请日：2008-11-05
申请人： Robert K. Prud'homme , Marian Gindy , Ying Liu
发明人： Robert K. Prud'homme , Marian Gindy , Ying Liu
IPC分类号： B05D7/00 , A61K9/51 , A61K49/00 , A61K49/18
CPC分类号： A61K9/5153 , A61K49/0019 , A61K49/0065 , A61K49/0093 , A61K49/1857 , Y10T428/2991
摘要： The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.

23. 发明申请

US20130037977A1 Preparation of Lipid Nanoparticles 审中-公开
标题翻译：脂质纳米颗粒的制备
公开(公告)号：US20130037977A1
公开(公告)日：2013-02-14
申请号：US13639628
申请日：2011-04-07
申请人： Paul A. Burke , Marian E. Gindy , David J. Mathre , Varun Kumar , Robert K. Prud'homme
发明人： Paul A. Burke , Marian E. Gindy , David J. Mathre , Varun Kumar , Robert K. Prud'homme
IPC分类号： A61J3/07 , B82Y5/00 , B82Y40/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K9/1277
摘要： The present invention provides a process for producing lipid nanoparticles encapsulating therapeutic products, said process comprising: a) providing one or more aqueous solutions in one or more reservoirs; b) providing one or more organic solutions in one or more reservoirs, wherein one or more of the organic solutions contains a lipid and wherein one or more of the aqueous solutions and/or one or more of the organic solutions includes therapeutic products; c) mixing said one or more aqueous solutions with said one or more organic solutions in a first mixing region, wherein said first mixing region is a Multi-Inlet Vortex Mixer (MIVM), wherein said one or more aqueous solutions and said one or more organic solutions are introduced tangentially into a mixing chamber within the MIVM so as to substantially instantaneously produce a lipid nanoparticle solution containing lipid nanoparticles encapsulating therapeutic products.
摘要翻译：本发明提供了一种制备包封治疗产品的脂质纳米颗粒的方法，所述方法包括：a）在一个或多个储存器中提供一种或多种水溶液; b）在一个或多个储存器中提供一种或多种有机溶液，其中一种或多种有机溶液含有脂质，并且其中一种或多种水溶液和/或一种或多种有机溶液包括治疗产品; c）在第一混合区域中将所述一种或多种水溶液与所述一种或多种有机溶液混合，其中所述第一混合区域是多入口涡旋混合器（MIVM），其中所述一种或多种水溶液和所述一种或多种将有机溶液切向引入MIVM内的混合室中，从而基本上即时产生含有包封治疗产品的脂质纳米颗粒的脂质纳米颗粒溶液。

24. 发明申请

US20120171254A1 Process and Apparatuses for Preparing Nanoparticle Compositions with Amphiphilic Copolymers and Their Use 有权
标题翻译：用两亲共聚物制备纳米颗粒组合物及其用途的方法和装置
公开(公告)号：US20120171254A1
公开(公告)日：2012-07-05
申请号：US13368888
申请日：2012-02-08
申请人： Brian K. Johnson , Robert K. Prud'homme
发明人： Brian K. Johnson , Robert K. Prud'homme
IPC分类号： A61K9/14 , A61P39/06 , A61K31/015 , A61K47/34 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/5138 , A01N25/04 , A01N43/70 , A61K9/5146 , A61K9/5192 , A61K47/34 , B01F1/00 , B01F7/22 , B01F15/00123 , B01F15/00344 , B01F15/00357 , B01F15/00376 , B01F15/00396 , B01J13/0021 , A01N2300/00
摘要： This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.
摘要翻译：本发明公开了一种通过闪蒸沉淀制备两亲性共聚物的纳米颗粒的方法。纳米颗粒可以单独使用两亲性共聚物，也可以含有添加剂目标分子，优选为有机活性物质。在两亲共聚物纳米颗粒中包含添加剂靶分子可以改变其水溶性特征，流体动力学和/或稳定性。改变添加剂目标分子在纳米颗粒中的溶解度和稳定性可使得适合于药物给药的水不溶性化合物以及将该分子特异性地靶向患者身体的特定区域。该方法以高绝对活性含量，高产率，高生产率和高加工速率生产纳米颗粒，同时使用异常少量的两亲性共聚物。此外，所得到的颗粒根据需要显示出足够的后处理稳定性。本发明还公开了通过闪蒸沉淀生产两亲性共聚物的纳米颗粒的两种装置。

25. 发明授权

US08048950B2 Wire coating containing thermally exfoliated graphite oxide 有权
标题翻译：包含热剥离石墨氧化物的电线涂层
公开(公告)号：US08048950B2
公开(公告)日：2011-11-01
申请号：US12194007
申请日：2008-08-19
申请人： Robert K. Prud'homme , Ilhan A. Aksay , Douglas Adamson , Ahmed Abdala
发明人： Robert K. Prud'homme , Ilhan A. Aksay , Douglas Adamson , Ahmed Abdala
IPC分类号： C08K3/04
CPC分类号： H05K1/095 , B82Y30/00 , B82Y40/00 , C01B31/0423 , C01B31/043 , C01B31/0476 , C01B32/192 , C01B32/225 , C01B32/23 , C01B2204/32 , H01G4/206 , H05K3/0091 , H05K3/10 , H05K2201/0323 , Y02E60/324 , Y02E60/325 , Y02E60/328 , Y10T428/13 , Y10T428/1341 , Y10T428/1379 , Y10T428/2982
摘要： A wire coating containing a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m2/g to 2600 m2/g.
摘要翻译：包含改性氧化石墨材料的线涂层，其是表面积为约300m 2 / g至2600m 2 / g的热剥离石墨氧化物。

26. 发明申请

US20100330368A1 Composite Flash-Precipitated Nanoparticles 有权
标题翻译：复合闪烁沉淀纳米颗粒
公开(公告)号：US20100330368A1
公开(公告)日：2010-12-30
申请号：US12265206
申请日：2008-11-05
申请人： Robert K. Prud'homme , Marian Gindy , Ying Liu
发明人： Robert K. Prud'homme , Marian Gindy , Ying Liu
IPC分类号： B32B15/04
CPC分类号： A61K9/5153 , A61K49/0019 , A61K49/0065 , A61K49/0093 , A61K49/1857 , Y10T428/2991
摘要： The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.
摘要翻译：本文描述的本发明涉及包含预先形成的包封在聚合物壳内的胶体颗粒的空间稳定的胶体构造物。可控制尺寸的构造体是包含疏水性元素的纳米颗粒，具有疏水表面的带静电荷的颗粒，疏水性无机纳米结构和具有疏水域和亲水结构域的两亲共聚物。构建体通过允许预先形成的胶体剂以及在聚合物纳米颗粒的核心内的溶解的疏水性活性物质同时包封的方法制备。在各种实施方案中引入的活性物质是用于组合荧光，光学和磁共振成像应用的有机荧光染料，金属纳米结构和超顺磁性材料，以及用于治疗应用的疏水性药物。

27. 发明授权

US07771824B2 Bridged graphite oxide materials 有权
标题翻译：桥接石墨氧化物材料
公开(公告)号：US07771824B2
公开(公告)日：2010-08-10
申请号：US12204292
申请日：2008-09-04
申请人： Margarita Herrera-Alonso , Michael J. McAllister , Ilhan A. Aksay , Robert K. Prud'homme
发明人： Margarita Herrera-Alonso , Michael J. McAllister , Ilhan A. Aksay , Robert K. Prud'homme
IPC分类号： C01B31/00 , C01B31/04 , H01M4/583 , C08K3/04
CPC分类号： B82Y30/00 , B01J20/20 , C01B3/0021 , C01B3/0084 , C01B32/22 , C01B32/23 , Y02E60/325 , Y10T428/30
摘要： Bridged graphite oxide material comprising graphite sheets bridged by at least one diamine bridging group. The bridged graphite oxide material may be incorporated in polymer composites or used in adsorption media.
摘要翻译：桥接的氧化石墨材料包括由至少一个二胺桥连基团桥连的石墨片。桥接的氧化石墨材料可以掺入聚合物复合材料中或用于吸附介质中。

28. 发明授权

US06566454B2 Amphoteric stabilization of crude petroleum 失效
标题翻译：两性原油稳定化
公开(公告)号：US06566454B2
公开(公告)日：2003-05-20
申请号：US09874076
申请日：2001-06-05
申请人： Robert K. Prud'homme , Henry S. Ashbaugh
发明人： Robert K. Prud'homme , Henry S. Ashbaugh
IPC分类号： C08F29300
CPC分类号： C10L1/1955 , C08F297/02 , C08L53/00 , C10L1/1658 , C10L1/1966 , C10L1/207 , C10L1/2366 , C10L1/2368
摘要： The present invention relates to a method of using a block copolymer comprising monomeric units of 1,4-butadiene and at least one other comonomer addition products to lower the gel point of crude petroleum. The block copolymer comprises at least 10% by weight of at least one crystallizable block and at least one low crystallinity block.
摘要翻译：本发明涉及使用包含1,4-丁二烯单体单元和至少一种其它共聚单体加成产物的嵌段共聚物降低原油凝胶点的方法。嵌段共聚物包含至少10重量％的至少一个可结晶嵌段和至少一个低结晶度嵌段。

29. 发明授权

US06329741B1 Multilayer ceramic piezoelectric laminates with zinc oxide conductors 失效
标题翻译：多层陶瓷压电层压板与氧化锌导体
公开(公告)号：US06329741B1
公开(公告)日：2001-12-11
申请号：US09302758
申请日：1999-04-30
申请人： James S. Vartuli , David L. Milius , Xiaoping Li , Wei H. Shih , Wan Y. Shih , Robert K. Prud'homme , Ilhan A. Aksay
发明人： James S. Vartuli , David L. Milius , Xiaoping Li , Wei H. Shih , Wan Y. Shih , Robert K. Prud'homme , Ilhan A. Aksay
IPC分类号： H01L4108
CPC分类号： H01L41/187 , B64D15/20 , H01L41/0478 , H01L41/0926 , H01L41/0933 , H01L41/094 , H01L41/098
摘要： A modification of the traditional unimorph flextensional actuator is provided by replacing the metal shim with an electrically conducting oxide. Comprised of lead zirconate titanate and zinc oxide that is co-sintered, the laminate composite obtains large axial displacements while maintaining moderate axial loads. The varistor properties of zinc oxide dictate that the conductance increases several orders of magnitude when a critical electric field is applied. The versatility of the processing over other actuator system facilitates miniaturization, while maintaining comparable performance characteristics. Functional gradients in the material properties are created in the green body by layering thin tape cast sheets. The unique PZT-zinc oxide composite not only controls the piezoelectric gradient, but permits control of the sintering kinetics leading to the processing of either flat or highly domed structures.
摘要翻译：通过用导电氧化物代替金属垫片来提供传统的单压电致伸缩致动器的改进。由锆钛酸铅和共烧结的氧化锌组成，层压复合材料在保持适度的轴向载荷的同时获得较大的轴向位移。氧化锌的压敏电阻特性规定当施加临界电场时，电导增加数个数量级。与其他执行器系统相比，处理的多功能性有助于小型化，同时保持可比较的性能特征。材料性能的功能梯度通过分层薄带铸造板在生坯体中产生。独特的PZT-氧化锌复合材料不仅控制了压电梯度，而且可以控制烧结动力学，导致平坦或高度圆顶结构的加工。

30. 发明授权

US4532043A Method for characterizing the molecular weight and molecular weight distribution of ultra-high molecular weight water soluble polymers 失效
公开(公告)号：US4532043A
公开(公告)日：1985-07-30
申请号：US523818
申请日：1983-08-15
申请人： Robert K. Prud'homme , Frederick W. Stanley, Jr. , Martin A. Langhorst
发明人： Robert K. Prud'homme , Frederick W. Stanley, Jr. , Martin A. Langhorst
IPC分类号： G01N30/00 , G01N30/02 , G01N30/38 , G01N30/62 , G01N30/74 , G01N33/44 , B01D15/08
CPC分类号： G01N30/74 , G01N2030/001 , G01N2030/027 , G01N2030/625 , G01N30/38 , G01N33/44
摘要： The molecular weight and molecular weight distribution of diverse ultra-high molecular weight water soluble polymers is rapidly determined based on apparent size by passage of extremely dilute samples of the polymer (1-250 ppm) through a column of nonporous packing whereby separation into molecular weight (apparent size) fractions is obtained predominantly based on flow (i.e., hydrodynamic chromatography). Detection of the extremely dilute sample polymer is accomplished, e.g., by tagging the polymer with a fluorescent agent and using a flow-through fluorometer detector. The molecular weight characterization of the polymers is determined independent or less dependent of the composition of the polymer by analyzing the sample in its nonionized form.

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