专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20090017057A1 STIMULATION OF AN IMMUNE RESPONSE BY CATIONIC LIPIDS 有权
标题翻译：刺激由阳离子脂肪的免疫反应
公开(公告)号：US20090017057A1
公开(公告)日：2009-01-15
申请号：US12049957
申请日：2008-03-17
申请人： Weihsu Chen , Weili Yan , Kenya Toney , Gregory Conn , Frank Bedu-Addo , Leaf Huang
发明人： Weihsu Chen , Weili Yan , Kenya Toney , Gregory Conn , Frank Bedu-Addo , Leaf Huang
IPC分类号： A61K39/00 , C07C69/602 , A61K39/12 , A61P37/02 , A61K39/02 , C07C217/46
CPC分类号： A61K31/231 , A61K31/14 , A61K31/20 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K45/06 , A61K47/646 , A61K2039/55555 , C07C219/06
摘要： The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.
摘要翻译：本发明提供了使用单独或与抗原组合的阳离子脂质来刺激免疫应答的组合物和方法。

22. 发明授权

US07361640B2 Stable lipid-comprising drug delivery complexes and methods for their production 失效
公开(公告)号：US07361640B2
公开(公告)日：2008-04-22
申请号：US10426220
申请日：2003-04-29
申请人： Leaf Huang , Xiang Gao , Frank L. Sorgi
发明人： Leaf Huang , Xiang Gao , Frank L. Sorgi
IPC分类号： A61K31/715 , A61K9/127 , C12N15/88 , C07H21/02 , C07K17/00
CPC分类号： C12N15/88 , A61K9/1272
摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

23. 发明授权

US06610321B2 Emulsion formulations for hydrophilic active agents 失效
标题翻译：亲水性活性剂的乳液制剂
公开(公告)号：US06610321B2
公开(公告)日：2003-08-26
申请号：US09214546
申请日：1999-02-17
申请人： Leaf Huang , Toshifumi Hara
发明人： Leaf Huang , Toshifumi Hara
IPC分类号： A61K9127
CPC分类号： A61K9/1275 , A61K48/00 , Y02A50/409 , Y10S514/938
摘要： This invention includes emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one hydrophilic biologically active molecule and, optionally, cholesteryl ester, and/or apoprotein; methods of preparing these emulsions; and the use of these emulsions for the delivery of hydrophilic biologically active molecules to cells.
摘要翻译：本发明包括包含水性载体和以下组分的乳液制剂：甘油三酸酯，胆固醇，磷脂，至少一种带电脂质，至少一种亲水生物活性分子和任选的胆固醇酯和/或脱蛋白; 制备这些乳液的方法; 以及使用这些乳液将亲水生物活性分子递送至细胞。

24. 发明授权

US06319516B1 Acid salts of cholesterol 失效
标题翻译：胆固醇的酸性盐
公开(公告)号：US06319516B1
公开(公告)日：2001-11-20
申请号：US09334313
申请日：1999-06-16
申请人： Leaf Huang , Richard M. Epand , Remo Bottega
发明人： Leaf Huang , Richard M. Epand , Remo Bottega
IPC分类号： A61K9127
CPC分类号： C07J41/0055 , A61K9/1272 , A61K47/54 , A61K47/554 , C07J9/00 , C12N15/64 , C12N15/88 , Y10T428/2984
摘要： A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
摘要翻译：一种稳定的水分散体，其包含阳离子脂质，其是包含胆固醇衍生的亲脂基团的分子，可被细胞酶水解并且相对抗碱基催化水解的连接体键，间隔臂和阳离子氨基，以及合适的辅助脂质。本发明还包括与水分散体混合的阳离子脂质和哺乳动物质粒DNA或其它细胞。

25. 发明授权

US06258792B1 Cationic cholesteryl derivatives containing cyclic polar groups 失效
标题翻译：含有环状极性基团的阳离子胆固醇衍生物
公开(公告)号：US06258792B1
公开(公告)日：2001-07-10
申请号：US09669031
申请日：2000-09-25
申请人： Hermant M. Deshmukh , Leaf Huang
发明人： Hermant M. Deshmukh , Leaf Huang
IPC分类号： A01N4304
CPC分类号： C07J43/00 , C07J53/00
摘要： The present invention discloses compounds which are cationic cholesteryl derivatives having a nitrogen-containing ring structure as their polar head group. These compounds are useful for delivering biologically active substances to cells and for transfecting nucleic acids into cells.
摘要翻译：本发明公开了具有含氮环结构作为其极性头基的阳离子胆固醇衍生物的化合物。这些化合物可用于将生物活性物质递送至细胞并将核酸转染入细胞。

26. 发明授权

US6120794A Emulsion and micellar formulations for the delivery of biologically active substances to cells 失效
公开(公告)号：US6120794A
公开(公告)日：2000-09-19
申请号：US534180
申请日：1995-09-26
申请人： Dexi Liu , Feng Liu , Jing-Ping Yang , Leaf Huang
发明人： Dexi Liu , Feng Liu , Jing-Ping Yang , Leaf Huang
IPC分类号： A61K9/107 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K47/18 , A61K47/24 , A61K48/00 , A61K9/127
CPC分类号： A61K9/1075 , Y10S514/938
摘要： New emulsion and micelle formulations are described as are complexes of these formulations with biologically active substances. The novel formulations are different from cationic lipid vectors such as cationic liposomes in that the complexes formed between biologically active substances and the emulsion and micellar formulations of this invention are physically stable and their transfection activity is resistant to the presence of serum. These novel formulations are disclosed to be useful in areas such as gene therapy or vaccine delivery.

27. 发明授权

US5795587A Stable lipid-comprising drug delivery complexes and methods for their production 失效
标题翻译：稳定的含脂质药物递送复合物及其生产方法
公开(公告)号：US5795587A
公开(公告)日：1998-08-18
申请号：US376701
申请日：1995-01-23
申请人： Xiang Gao , Leaf Huang
发明人： Xiang Gao , Leaf Huang
IPC分类号： A61K9/127 , A61K48/00 , C12N15/88
CPC分类号： A61K47/48315 , A61K47/48046 , A61K9/1272 , C12N15/88
摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the components of the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.
摘要翻译：描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。生产的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物的组分浓度多50至500倍。本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

28. 发明授权

US5637315A Treatment of disease states induced by oxidative stress 失效
标题翻译：治疗由氧化应激引起的疾病状态
公开(公告)号：US5637315A
公开(公告)日：1997-06-10
申请号：US349129
申请日：1994-12-02
申请人： Mark Zern , Leaf Huang , Tony Yoa
发明人： Mark Zern , Leaf Huang , Tony Yoa
IPC分类号： A61K9/127 , A61K9/133 , A61K31/05 , A61K31/19 , A61K31/355 , A61K31/375
CPC分类号： A61K31/19 , A61K31/05 , A61K31/355 , A61K31/375 , A61K9/127 , Y10S436/829
摘要： Liposome carrier systems, methods and pharmaceutical compositions that target an organ preferentially with high concentrations of at least one therapeutic agent utilize a liposome carrier having a lipid membrane and an aqueous space to deliver pharmacologically active agents, such as free radical scavengers and antioxidants, to a target organ such as the liver. At least one free radical scavenger and/or antioxidant and a liposome carrier may be provided to a liver donor prior to harvesting to preserve the liver for transplantation.
摘要翻译：优选以高浓度的至少一种治疗剂靶向器官的脂质体载体系统，方法和药物组合物利用具有脂质膜和水性空间的脂质体载体将药理活性剂（例如自由基清除剂和抗氧化剂）递送至目标器官如肝脏。可以在收获之前将至少一种自由基清除剂和/或抗氧化剂和脂质体载体提供给肝供体以保留用于移植的肝脏。

29. 发明授权

US5283185A Method for delivering nucleic acids into cells 失效
标题翻译：将核酸递送到细胞中的方法
公开(公告)号：US5283185A
公开(公告)日：1994-02-01
申请号：US751873
申请日：1991-08-28
申请人： Richard M. Epand , Remo Bottega , Leaf Huang
发明人： Richard M. Epand , Remo Bottega , Leaf Huang
IPC分类号： C12N15/09 , A61K9/127 , A61K47/48 , A61K48/00 , C07C35/42 , C07J9/00 , C07J41/00 , C12N15/63 , C12N15/64 , C12N15/88
CPC分类号： C12N15/64 , A61K47/48023 , A61K47/48123 , A61K9/1272 , C07J41/0055 , C07J9/00 , C12N15/88
摘要： A method for facilitating the transfer of nucleic acids into cells comprising preparing a mixed lipid dispersion of a cationic lipid with a co-lipid in a suitable carrier solvent. The lipid has a structure which includes a lipophilic group derived from cholesterol, a linker bond, a spacer arm including from about 1 to about 20 carbon atoms in a branched or unbranched linear alkyl chain, and a cationic amino group selected from the group consisting of primary, secondary, tertiary and quaternary amino groups. The method further comprises adding the nucleic acids to the dispersion to form a complex. The cells are then treated with the complex. There is also disclosed a novel cationic amphiphile useful for this purpose.
摘要翻译：一种促进核酸转运到细胞中的方法，包括在合适的载体溶剂中制备阳离子脂质与共脂质的混合脂质分散体。所述脂质具有包含衍生自胆固醇的亲脂基团，连接物键，在支链或非支链直链烷基链中包含约1至约20个碳原子的间隔臂的结构和选自以下的阳离子性氨基：伯，仲，叔，季氨基。该方法还包括将核酸加入到分散体中以形成复合物。然后用复合物处理细胞。还公开了一种用于此目的的新型阳离子两亲物。

30. 发明授权

US4957735A Target-sensitive immunoliposomes- preparation and characterization 失效
标题翻译：靶向敏感性免疫脂质体 - 制备和表征
公开(公告)号：US4957735A
公开(公告)日：1990-09-18
申请号：US12321
申请日：1987-02-09
申请人： Leaf Huang
发明人： Leaf Huang
IPC分类号： G01N33/532 , G01N33/58
CPC分类号： G01N33/532 , G01N33/586 , Y10S424/812 , Y10S436/829
摘要： Novel target-sensitive immunoliposomes were prepared and characterized. In this invention, target specific binding of antibody-coated liposomes was sufficient to induce bilayer destabilization, resulting in a site-specific release of liposome contents.Unilamellar liposomes were prepared by using a small quantity of palmitoyl IgG (pIgG) to stabilize the bilayer phase of the unsaturated phosphatidylethanol amine (PE) which by itself does not form stable liposomes. A mouse monoclonal IgG antibody to the glycoprotein D (gD) of Herpes Simplex Virus (HSV) and dioleoyl PE were used in one preferred embodiment.In another preferred embodiment, potentially cytotoxic antiviral drugs were entrapped in target sensitive (TS) immunoliposomes and delivered to HSV infected cells. Potency was as much as 1000 times superior to the free drug and cytotoxicity was decreased by as much as 3000 fold.
摘要翻译：制备和表征新的靶向敏感性免疫脂质体。在本发明中，抗体包被的脂质体的靶特异性结合足以诱导双层不稳定，导致脂质体含量的位点特异性释放。通过使用少量的棕榈酰IgG（pIgG）来制备单层脂质体以稳定不饱和磷脂酰乙醇胺（PE）的双相，其本身不形成稳定的脂质体。在一个优选实施方案中，使用单克隆单克隆病毒（HSV）和二油酰PE的糖蛋白D（gD）的小鼠单克隆IgG抗体。在另一个优选的实施方案中，潜在的细胞毒性抗病毒药物被包埋在靶敏感（TS）免疫脂质体中并被递送至HSV感染的细胞。效力高达游离药物的1000倍，细胞毒性降低了3000倍。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式