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21. 发明授权

US07201762B2 Vascular embolization with an expansible implant 有权
标题翻译：血管栓塞与可扩展植入物
公开(公告)号：US07201762B2
公开(公告)日：2007-04-10
申请号：US10320033
申请日：2002-12-16
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61B19/00 , A61F2/06
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译：由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。在进入血管部位时，植入物基本上扩张以填充血管部位。保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。

22. 发明授权

US6165193A Vascular embolization with an expansible implant 失效
公开(公告)号：US6165193A
公开(公告)日：2000-12-26
申请号：US110816
申请日：1998-07-06
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61B19/00 , A61B17/12 , A61F2/02 , A61L31/14 , A61L31/18
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

23. 发明授权

US09597087B2 Filamentary devices for treatment of vascular defects 有权
公开(公告)号：US09597087B2
公开(公告)日：2017-03-21
申请号：US12434465
申请日：2009-05-01
申请人： Philippe Marchand , Brian J. Cox , Robert F. Rosenbluth
发明人： Philippe Marchand , Brian J. Cox , Robert F. Rosenbluth
IPC分类号： A61F2/06 , A61B17/12 , A61M29/02 , A61B17/00 , A61M25/10
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12145 , A61B17/12177 , A61B17/1219 , A61B2017/00526 , A61B2017/00867 , A61B2017/12054 , A61B2017/12068 , A61M29/02 , A61M2025/105
摘要： Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell configured to occlude blood flow therethrough.

24. 发明申请

US20130245667A1 FILAMENTARY DEVICES AND TREATMENT OF VASCULAR DEFECTS 审中-公开
标题翻译： FILAMENTARY DEVICES AND Treatment of VASCULAR DEFECTS
公开(公告)号：US20130245667A1
公开(公告)日：2013-09-19
申请号：US13771632
申请日：2013-02-20
申请人： PHILIPPE MARCHAND , Brian J. Cox , Robert F. Rosenbluth
发明人： PHILIPPE MARCHAND , Brian J. Cox , Robert F. Rosenbluth
IPC分类号： A61M29/02
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12145 , A61B17/12177 , A61B17/1219 , A61B2017/00526 , A61B2017/00867 , A61B2017/12054 , A61B2017/12068 , A61M29/02 , A61M2025/105
摘要： Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell configured to occlude blood flow therethrough.
摘要翻译：用于治疗患者脉管系统的装置和方法，其中一些实施例被配置为用用于治疗患者的脑血管的微导管递送。一些实施例可以包括构造成阻塞血液流过其中的可渗透壳体。

25. 发明申请

US20090275974A1 FILAMENTARY DEVICES FOR TREATMENT OF VASCULAR DEFECTS 有权
标题翻译：用于治疗血管缺损的纤维装置
公开(公告)号：US20090275974A1
公开(公告)日：2009-11-05
申请号：US12434465
申请日：2009-05-01
申请人： Philippe Marchand , Brian J. Cox , Robert F. Rosenbluth
发明人： Philippe Marchand , Brian J. Cox , Robert F. Rosenbluth
IPC分类号： A61M29/04 , D04C1/00
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12145 , A61B17/12177 , A61B17/1219 , A61B2017/00526 , A61B2017/00867 , A61B2017/12054 , A61B2017/12068 , A61M29/02 , A61M2025/105
摘要： Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell configured to occlude blood flow therethrough.
摘要翻译：用于治疗患者脉管系统的装置和方法，其中一些实施例被配置为用用于治疗患者的脑血管的微导管递送。一些实施例可以包括构造成阻塞血液流过其中的可渗透壳体。

26. 发明授权

US07029487B2 Vascular embolization with an expansible implant 有权
公开(公告)号：US07029487B2
公开(公告)日：2006-04-18
申请号：US10309442
申请日：2002-12-04
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61B19/00
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

27. 发明授权

US06607538B1 Mechanism for the deployment of endovascular implants 有权
标题翻译：部署血管内植入物的机制
公开(公告)号：US06607538B1
公开(公告)日：2003-08-19
申请号：US09692248
申请日：2000-10-18
申请人： David A. Ferrera , George R. Greene, Jr. , Brian J. Cox , Robert F. Rosenbluth
发明人： David A. Ferrera , George R. Greene, Jr. , Brian J. Cox , Robert F. Rosenbluth
IPC分类号： A61F1100
CPC分类号： A61B17/1214 , A61B17/12022 , A61B17/1215 , A61B17/12163 , A61B17/1219 , A61B2017/00477 , A61B2017/00535 , A61B2017/00539 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： A mechanism for the deployment of an endovascular device having a coupling element attached to its proximal end, includes a deployment tube having a proximal end, a distal section, open distal end, and a lumen extending between the proximal and distal ends. A retention sleeve, fixed around the distal section, includes an extension extending past the distal end of the tube. The retention sleeve is fixed around the coupling element, so that the coupling element is releasably held within the extension. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly until the device is deployed within a target site. A liquid is injected through the lumen so as to push the coupling element out of the retention sleeve by fluid pressure, thereby detaching the endovascular device from the deployment tube.
摘要翻译：一种用于部署具有附接到其近端的联接元件的血管内装置的机构，包括具有近端，远端部分，开放远端以及在近端和远端之间延伸的内腔的展开管。围绕远端部分固定的保持套筒包括延伸穿过管的远端的延伸部分。保持套固定在联接元件周围，使得联接元件可释放地保持在延伸部内。在使用中，将植入物连接到其远端的展开管通过血管内直到装置部署在目标部位内。通过内腔注入液体，以便通过流体压力将联接元件推出保持套筒，从而将血管内装置与展开管分开。

28. 发明授权

US06500190B2 Vascular embolization with an expansible implant 有权
标题翻译：血管栓塞与可扩展植入物
公开(公告)号：US06500190B2
公开(公告)日：2002-12-31
申请号：US09730071
申请日：2000-12-05
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61B1900
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embodied. Preferably, the implant is formed of a hydrophobic, macro porous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolism a vascular site, the implant is compressed and passed through a micro catheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the micro catheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the micro catheter, and then to separate the implant from the retention element when the implant has been passed out of the micro catheter and into the vascular site.
摘要翻译：由可压缩泡沫材料形成的血管植入物具有压缩构造，从该构型可膨胀到基本上符合要体现的血管部位的形状和尺寸的构造。优选地，植入物由疏水的大孔多孔泡沫材料形成，其具有血管部位的缩小模型的初始构型，其可压缩成压缩构型。通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。为了栓塞血管部位，植入物被压缩并通过微导管，其微型导管已经进入血管部位。在进入血管部位时，植入物基本上扩张以填充血管部位。保持元件容纳在微导管内，并且具有可拆卸地连接到植入物的远端。使用柔性的管状展开元件将植入物和保留元件通过微导管，然后当植入物从微导管流出并进入血管部位时，将植入物与保留元件分离。

29. 发明授权

US06299619B1 Methods for embolizing a target vascular site 有权
标题翻译：栓塞目标血管部位的方法
公开(公告)号：US06299619B1
公开(公告)日：2001-10-09
申请号：US09542145
申请日：2000-04-04
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61F1100
CPC分类号： A61L31/022 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B17/12163 , A61B17/1219 , A61B2017/00004 , A61B2017/00867 , A61B2017/1205 , A61L31/145 , A61L31/18 , A61L2430/36
摘要： An embolization device includes a plurality of highly-expansible embolizing elements disposed at spaced intervals along a filamentous carrier. In a preferred embodiment, the carrier is a suitable length of very thin, highly flexible filament of nickel/titanium alloy. The embolizing elements are separated from each other on the carrier by radiopaque spacers in the form of highly flexible microcoils made of platinum or platinum/tungsten alloy. In a preferred embodiment, the embolizing elements are made of a hydrophilic, macroporous, polymeric, hydrogen foam material. The device is particularly suited for embolizing a vascular site such as an aneurysm. The embolization bodies have an initial configuration in the form of small, substantially cylindrical “micropellets” of small enough outside diameter to fit within a microcatheter. The bodies are hydrophilically expansible into an expanded configuration in which they substantially conform to and fill the vascular site while connected to the carrier. A method for embolizing a vascular site using this device includes the steps of: (a) passing a microcatheter intravascularly so that its distal end is in a vascular site; (b) providing a vascular embolization device comprising a plurality of highly expansible embolizing elements carried on a filamentous carrier and separated from each other on the carrier by microcoil spacers; (c) passing the embolization device through the microcatheter so that it emerges from the distal end of the microcatheter into the vascular site; and (d) expanding the embolizing elements in situ substantially to fill the vascular site while retaining the embolizing elements on the carrier. Preferably, the method also includes the step of deploying a vaso-occlusive device in the vascular site, or an intravascular device in a blood vessel adjacent the vascular site, before embolization device is passed through the microcatheter.
摘要翻译：栓塞装置包括沿着丝状载体以间隔设置的多个高度可膨胀的栓塞元件。在优选实施例中，载体是非常薄，高度柔性的镍/钛合金长丝的合适长度。栓塞元件在载体上通过由铂或铂/钨合金制成的高柔性微线圈形式的不透射线的间隔物相互分离。在优选的实施方案中，栓塞元件由亲水的，大孔的，聚合的氢气泡沫材料制成。该装置特别适用于栓塞血管部位如动脉瘤。栓塞体具有小的，基本上圆柱形的“微丸”的形式的初始构型，其具有足够小的外径以适合微导管。身体可亲水扩张成扩张构型，其中它们在连接到载体的同时基本上符合并填充血管部位。使用该装置栓塞血管部位的方法包括以下步骤：（a）血管内通过微导管，使其远端位于血管部位; （b）提供血管栓塞装置，其包括承载在丝状载体上的多个高度可膨胀的栓塞元件，并通过微线圈隔离物在载体上彼此分离; （c）使栓塞装置通过微导管，使其从微导管的远端出现到血管部位; 并且（d）基本上膨胀栓塞元件，基本上填充血管部位，同时将栓塞元件保持在载体上。优选地，该方法还包括在栓塞装置通过微导管之前在血管部位中部署血管闭塞装置或邻近血管部位的血管中的血管内装置的步骤。

30. 发明授权

US06238403B1 Filamentous embolic device with expansible elements 有权
标题翻译：具膨胀性元件的丝状栓塞装置
公开(公告)号：US06238403B1
公开(公告)日：2001-05-29
申请号：US09410970
申请日：1999-10-04
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： A61F1100
CPC分类号： A61L31/022 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B17/12163 , A61B17/1219 , A61B2017/00004 , A61B2017/00867 , A61B2017/1205 , A61L31/145 , A61L31/18 , A61L2430/36
摘要： An embolization device includes a plurality of highly-expansible embolizing elements disposed at spaced intervals along a filamentous carrier. In a preferred embodiment, the carrier is a suitable length of very thin, highly flexible filament of nickel/titanium alloy. The embolizing elements are separated from each other on the carrier by radiopaque spacers in the form of highly flexible microcoils made of platinum or platinum/tungsten alloy. In a preferred embodiment, the embolizing elements are made of a hydrophilic, macroporous, polymeric, hydrogel foam material. The device is particularly suited for embolizing a vascular site such as an aneurysm. The embolization bodies have an initial configuration in the form of small, substantially cylindrical “micropellets” of small enough outside diameter to fit within a microcatheter. The bodies are hydrophilically expansible into an expanded configuration in which they substantially conform to and fill the vascular site while connected to the carrier. A method for embolizing a vascular site using this device includes the steps of: (a) passing a microcatheter intravascularly so that its distal end is in a vascular site; (b) providing a vascular embolization device comprising a plurality of highly expansible embolizing elements carried on a filamentous carrier and separated from each other on the carrier by microcoil spacers; (c) passing the embolization device through the microcatheter so that it emerges from the distal end of the microcatheter into the vascular site; and (d) expanding the embolizing elements in situ substantially to fill the vascular site.
摘要翻译：栓塞装置包括沿着丝状载体以间隔间隔设置的多个高度可膨胀的栓塞元件。在优选实施例中，载体是非常薄，高度柔性的镍/钛合金长丝的合适长度。栓塞元件在载体上通过由铂或铂/钨合金制成的高柔性微线圈形式的不透射线的间隔物相互分离。在优选的实施方案中，栓塞元件由亲水的大孔聚合的水凝胶泡沫材料制成。该装置特别适用于栓塞血管部位如动脉瘤。栓塞体具有小的，基本上圆柱形的“微丸”的形式的初始构型，其具有足够小的外径以适合微导管。身体可亲水扩张成扩张构型，其中它们在连接到载体的同时基本上符合并填充血管部位。使用该装置栓塞血管部位的方法包括以下步骤：（a）血管内通过微导管，使其远端位于血管部位; （b）提供血管栓塞装置，其包括承载在丝状载体上的多个高度可膨胀的栓塞元件，并通过微线圈隔离物在载体上彼此分离; （c）使栓塞装置通过微导管，使其从微导管的远端出现到血管部位; 和（d）基本上膨胀栓塞元件以充满血管部位。

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