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21. 发明授权

US07921854B2 Endovenous laser treatment for varicose veins 有权
标题翻译：静脉曲张静脉激光治疗
公开(公告)号：US07921854B2
公开(公告)日：2011-04-12
申请号：US11562944
申请日：2006-11-22
申请人： David R. Hennings , Mitchel P. Goldman , Robert A. Weiss , Eric B. Taylor , Don Johnson
发明人： David R. Hennings , Mitchel P. Goldman , Robert A. Weiss , Eric B. Taylor , Don Johnson
IPC分类号： A61B19/00
CPC分类号： A61B18/24 , A61B2017/00084 , A61B2018/00005 , A61B2018/00196 , A61B2018/2261 , A61B2090/036 , A61F7/10 , A61F2007/101
摘要： Improved devices and methods for removing blood from a blood vessel in preparation for endovenous laser ablation are described. The improved methods include one or more of: placing the patient in the Trendelenburg position, applying external compression around the vein, massaging the vein, cooling the vein externally, encouraging spasming of the vein, and removing blood with a suction device.
摘要翻译：描述了改进的用于从血管中移除血液的装置和方法，以准备静止的激光烧蚀。改进的方法包括以下一个或多个：将患者置于Trendelenburg位置，在静脉周围施加外部压迫，按摩静脉，从外部冷却静脉，鼓励静脉静脉和用抽吸装置去除血液。

22. 发明申请

US20100042085A1 Endovenous Closure of Varicose Veins with Mid Infrared Laser 有权
标题翻译：用中红外激光静脉闭合静脉曲张
公开(公告)号：US20100042085A1
公开(公告)日：2010-02-18
申请号：US12604815
申请日：2009-10-23
申请人： David R. Hennings , Mitchel P. Goldman , Robert A. Weiss , Eric B. Taylor , Don Johnson
发明人： David R. Hennings , Mitchel P. Goldman , Robert A. Weiss , Eric B. Taylor , Don Johnson
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B2017/00084 , A61B2018/00005 , A61B2018/00196 , A61B2018/2261 , A61B2090/036
摘要： This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 1.8 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308. A motorized pull-back device 104 is used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.
摘要翻译：本发明是一种用于治疗静脉曲张200或更大隐静脉202的改进方法和装置。该方法包括以1.2至1.8μm范围内的红外激光辐射以从容器200或202内部的方式使用，血管壁704的内皮细胞被破坏，血管壁704中的胶原纤维被加热到它们永久收缩的位置，血管200或202被封闭并最终吸收。该装置包括通过光纤导管300传送的激光器102，其可以具有磨砂或漫射光纤尖端308.使用电动拉回装置104，并且热传感器600可用于帮助控制维持适当的处理温度。

23. 发明申请

US20080249519A1 METHOD AND APPARATUS FOR APPLYING ENERGY TO BIOLOGICAL TISSUE INCLUDING THE USE OF TUMESCENT TISSUE COMPRESSION 审中-公开
公开(公告)号：US20080249519A1
公开(公告)日：2008-10-09
申请号：US12140219
申请日：2008-06-16
申请人： Mitchel P. Goldman , Robert A. Weiss , Arthur W. Zikorus , James G. Chandler
发明人： Mitchel P. Goldman , Robert A. Weiss , Arthur W. Zikorus , James G. Chandler
IPC分类号： A61B18/04 , A61M29/02
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2017/22038 , A61B2017/22051 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1475 , A61B2090/3782 , A61B2218/002
摘要： An electrode catheter is introduced into a hollow anatomical structure, such as a vein, and is positioned at a treatment site within the structure. Tumescent fluid is injected into the tissue surrounding the treatment site to produce tumescence of the surrounding tissue which then compresses the vein. The solution may include an anesthetic, and may further include a vasoconstrictive drug that shrinks blood vessels. The tumescent swelling in the surrounding tissue causes the hollow anatomical structure to become compressed, thereby exsanguinating the treatment site. Energy is applied by an electrode catheter in apposition with the vein wall to create a heating effect. The heating effect causes the hollow anatomical structure to become molded and durably assume the compressed dimensions caused by the tumescent technique. The electrode catheter can be moved within the structure so as to apply energy to a large section of the hollow anatomic structure. In a further aspect, the location of the electrodes is determined by impedance monitoring. Also, temperature sensors at the treatment site are averaged to determine the site temperature.

24. 发明授权

US07396355B2 Method and apparatus for applying energy to biological tissue including the use of tumescent tissue compression 有权
标题翻译：用于向生物组织施加能量的方法和装置，包括使用肿胀组织压缩
公开(公告)号：US07396355B2
公开(公告)日：2008-07-08
申请号：US10872646
申请日：2004-06-21
申请人： Mitchel P. Goldman , Robert A. Weiss , Arthur W. Zikorus , James G. Chandler
发明人： Mitchel P. Goldman , Robert A. Weiss , Arthur W. Zikorus , James G. Chandler
IPC分类号： A61B18/18
CPC分类号： G02F1/134363 , A61B18/1492 , A61B2017/22038 , A61B2017/22051 , A61B2017/22067 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00488 , A61B2018/00589 , A61B2018/00898 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2090/3782 , A61B2218/002 , G02F1/136213 , G02F1/136259 , G02F2201/12
摘要： An electrode catheter is introduced into a hollow anatomical structure, such as a vein, and is positioned at a treatment site within the structure. Tumescent fluid is injected into the tissue surrounding the treatment site to produce tumescence of the surrounding tissue which then compresses the vein. The solution may include an anesthetic, and may further include a vasoconstrictive drug that shrinks blood vessels. The tumescent swelling in the surrounding tissue causes the hollow anatomical structure to become compressed, thereby exsanguinating the treatment site. Energy is applied by an electrode catheter in apposition with the vein wall to create a heating effect. The heating effect causes the hollow anatomical structure to become molded and durably assume the compressed dimensions caused by the tumescent technique. The electrode catheter can be moved within the structure so as to apply energy to a large section of the hollow anatomic structure. In a further aspect, the location of the electrodes is determined by impedance monitoring. Also, temperature sensors at the treatment site are averaged to determine the site temperature.
摘要翻译：将电极导管引入到诸如静脉的中空解剖结构中，并且位于结构内的治疗部位。将肿胀流体注射到处理部位周围的组织中，以产生周围组织的肿胀，然后压缩静脉。溶液可以包括麻醉剂，并且还可以包括收缩血管的血管收缩药物。周围组织的肿胀肿胀导致中空的解剖结构变得压缩，从而使治疗部位脱垂。能量通过电极导管与静脉壁一起施加以产生加热效果。加热效果使得中空的解剖结构变得模制并且持久地承受由肿胀技术引起的压缩尺寸。电极导管可以在结构内移动，以将能量施加到中空解剖结构的大部分。在另一方面，通过阻抗监测确定电极的位置。此外，将处理部位的温度传感器平均以确定现场温度。

25. 发明授权

US07396300B2 Adhesion process 有权
标题翻译：粘附过程
公开(公告)号：US07396300B2
公开(公告)日：2008-07-08
申请号：US10603241
申请日：2003-06-24
申请人： Michael J. Tzivanis , William M. Risen, Jr. , Robert A. Weiss , Thomas J. Kennedy, III , David M. Melanson
发明人： Michael J. Tzivanis , William M. Risen, Jr. , Robert A. Weiss , Thomas J. Kennedy, III , David M. Melanson
IPC分类号： A63B37/06 , A63B37/08
CPC分类号： B29C66/712 , A63B37/0003 , A63B37/0039 , A63B37/0075 , A63B37/0076 , A63B45/00 , B29C65/02 , B29C66/02245 , B29C66/026 , B29C66/034 , B29C66/71 , B29C66/73161 , B29K2075/00 , B29K2077/00 , B29K2096/005 , B29L2009/00 , B29L2031/54 , B29L2031/545 , B29K2071/00 , B29K2067/003 , B29K2023/00
摘要： Disclosed is a process to increase adhesion between two adjacent layers. The process comprises roughening the surface of one layer followed by chlorination of the roughened surface and joining of the layers, or treating the surface of one layer with a silicone-based adhesion promoter and joining the layers. In one preferred embodiment the process comprises roughening the surface of one layer, followed by chlorination of the roughened surface, joining of the layers and post-treatment of the molded layers at an elevated temperature for a predetermined time.
摘要翻译：公开了增加两个相邻层之间的粘合力的方法。该方法包括使一层的表面粗糙化，随后粗化表面的氯化和层的连接，或用硅氧烷基粘合促进剂处理一层的表面并连接这些层。在一个优选实施方案中，该方法包括使一层的表面粗糙化，随后将粗糙化表面进行氯化，层的接合和在高温下将模塑层后处理预定时间。

26. 发明授权

US06214260B1 Conductive elastomeric foams by in-situ vapor phase polymerization of pyrroles 失效
标题翻译：导电弹性泡沫通过原位气相聚合的吡咯
公开(公告)号：US06214260B1
公开(公告)日：2001-04-10
申请号：US09626952
申请日：2000-07-27
申请人： Michael D. Bessette , Robert A. Weiss , Poh Poh Gan , Can Erkey , Yueping Fu
发明人： Michael D. Bessette , Robert A. Weiss , Poh Poh Gan , Can Erkey , Yueping Fu
IPC分类号： H01B106
CPC分类号： C08J9/42 , C08J2203/08 , C08J2323/02 , C08J2327/06 , C08J2375/04 , C08J2439/00 , H01B1/127 , H01B1/128
摘要： A conductive elastomeric foam composite is presented, comprising an elastomer foam and polypyrrole, thiophene, or aniline and derivatives thereof. The foam is manufactured by first diffusing an oxidant into the dense polymer phase of a solvent-swollen foam and then diffusing pyrrole or pyrrole derivative vapor or solution into the dried foam, resulting in an in situ chemical oxidative polymerization of pyrrole at the oxidant site. Only about 5 wt % of conductive polymer is required for observing an insulator to conductor transition. The conductivity of the composite foam can be effectively controlled between 10−7 and 10−1 S/cm by varying either the amount of oxidant used and/or the copolymer composition.
摘要翻译：提出了一种导电弹性体泡沫复合材料，其包括弹性体泡沫体和聚吡咯，噻吩或苯胺及其衍生物。通过首先将氧化剂扩散到溶剂溶胀泡沫的致密聚合物相中，然后将吡咯或吡咯衍生物蒸气或溶液扩散到干燥的泡沫中，从而在氧化剂位置进行吡咯的原位化学氧化聚合来制造泡沫体。只有约5重量％的导电聚合物才能观察绝缘体到导体的转变。通过改变所使用的氧化剂的量和/或共聚物组成，复合泡沫体的电导率可以有效地控制在10-7和10-1S / cm之间。

27. 发明授权

US4901719A Electrosurgical conductive gas stream equipment 失效
标题翻译：电外科导电气流设备
公开(公告)号：US4901719A
公开(公告)日：1990-02-20
申请号：US224485
申请日：1988-07-26
申请人： Robert P. Trenconsky , Carol Bertrand , Robert A. Weiss
发明人： Robert P. Trenconsky , Carol Bertrand , Robert A. Weiss
IPC分类号： A61B17/32 , A61B18/00 , A61B18/14
CPC分类号： A61B18/042 , A61B17/3203 , A61B18/14 , A61B18/1233 , A61B2018/00761 , A61B2018/00886 , A61B2018/1213
摘要： An electrosurgical unit for conducting a predetermined ionizable gas in a jet stream to the tissue at a predetermined flow rate sufficient to clear natural fluids from the tissue and to substantially expose the tissue stroma and for exposing the gas to an electrical radio frequency energy to ionize the gas in conductive pathways in the gas jet stream. The unit includes a nozzle which is releasably connected to a handle for easy manipulation by a surgeon with the nozzle including means for supporting an electrode in an optimal position for initiation of the ionization of the gas. Also, a connecting system is disclosed for connecting the hose on which the handle is mounted to a gas delivery apparatus and supply or electrical energy which permits the hose to rotate while maintaining a positive hermetic seal to prevent the hose from kinking during use by a surgeon.
摘要翻译：一种电外科单元，用于以预定的流速将喷射流中的预定可电离气体以预定的流速传导到组织中，该流速足以从组织中清除天然流体并基本上暴露组织基质，并将气体暴露于电射频能量以电离气体在气体射流中的导电通路中。该单元包括可释放地连接到手柄的喷嘴，以便外科医生易于操作，喷嘴包括用于将电极支撑在用于引发气体电离的最佳位置的装置。此外，公开了一种用于将其上安装有手柄的软管连接到气体输送装置的连接系统以及允许软管旋转同时保持正气密密封以防止软管在外科医生使用期间扭结的供应或电能。

28. 发明授权

US4768969A Electrical connector 失效
标题翻译：电连接器
公开(公告)号：US4768969A
公开(公告)日：1988-09-06
申请号：US60116
申请日：1987-06-09
申请人： Ronald W. Bauer , Robert A. Weiss
发明人： Ronald W. Bauer , Robert A. Weiss
IPC分类号： A61B18/16 , H01R11/22 , H01R12/77 , H01R9/07
CPC分类号： A61B18/16 , H01R11/22 , H01R12/777 , Y10S439/909
摘要： An electrical connector achieves improvements in connecting a patient plate to an electrosurgical generator. The connector is preferably of the lever operated type, and electrical contacts are connected on the lever and connected within a passageway internally in a housing of the connector. A tongue portion of the patient plate is inserted in the passageway. Upon closure of the lever, the contacts on the lever extend into the passageway above the lower contacts to mechanically contact and retain the tongue portion between the contacts and to electrically contact the tongue portion by which to conduct current to the patient plate. A recess is formed in the lower marginal area of the passageway and a retaining structure on the lever member extends into the passageway to deform the tongue portion into the indention. The electrical contacts are spacially separated and electrically interconnected to provide an upper and lower electrical contact point for the tongue conductor which is electrically insulated from another spacially separated upper and lower electrical contact point.
摘要翻译：电连接器实现将患者板连接到电外科发生器上的改进。连接器优选地是杠杆操作型，并且电触头连接在杠杆上并且连接在连接器壳体内部的通道内。患者板的舌部插入通道中。在杠杆闭合时，杠杆上的触点延伸到下接触件上方的通道中，以将触头部分机械地接触并保持在触头之间，并且电接触舌部，以将电流传导到患者平板。在通道的下边缘区域中形成凹部，并且杆构件上的保持结构延伸到通道中，以将舌部变形成凹陷。电触点被空间分离并且电互连，以提供用于舌导体的上和下电接触点，其与另一空间分离的上下电接触点电绝缘。

29. 发明申请

US20150183988A1 Strain-Promoted Crosslinking of PEG-based Hydrogels via Copper-Free Cycloaddition 审中-公开
标题翻译：通过无铜环加成的PEG基水凝胶的应变促进交联
公开(公告)号：US20150183988A1
公开(公告)日：2015-07-02
申请号：US14418507
申请日：2013-07-31
申请人： Matthew Becker , Robert A. Weiss
发明人： Matthew Becker , Robert A. Weiss
IPC分类号： C08L71/00 , C08L89/00
CPC分类号： C08L71/00 , A61K9/06 , A61K47/34 , C08G65/325 , C08G65/33389 , C08L71/02 , C08L89/00 , C08L2205/02
摘要： The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems. These novel hydrogels do not require a catalyst to cross link, thus avoiding the biocompatibility problems common to many catalysts. Nor is the crosslinking process affected by the presence of catalysts or other substances, which have interfered with crosslinking in known strain induced hydrogels. Because of their crosslinking reaction kinetics, these novel hydrogels can encapsulate and transport highly sensitive cells and other biological additives and have no known toxic byproducts.
摘要翻译：本发明涉及一种共价交联的水凝胶，其包含8-元环炔官能化聚亚烷基二醇和多臂甘油异戊酸三叠氮化物的应变促进反应产物及其制备方法。因为前体材料可以在不引起交联的情况下被操纵，只要未达到应变阈值，这些水凝胶允许机械控制何时发生交联（并且在何处发生），并且比以前的应变活化或温度激活的系统更容易使用。这些新颖的水凝胶不需要催化剂交联，从而避免许多催化剂常见的生物相容性问题。交联过程也不受催化剂或其他物质的存在的影响，这些物质干扰已知应变诱导的水凝胶中的交联。由于它们的交联反应动力学，这些新颖的水凝胶可以包封和输送高敏感性细胞和其他生物添加剂，并且没有已知的有毒副产物。

30. 发明申请

US20080275380A1 SONIC ENDOVENOUS CATHETER 有权
标题翻译： SONIC内置导管
公开(公告)号：US20080275380A1
公开(公告)日：2008-11-06
申请号：US11928624
申请日：2007-10-30
申请人： David R. Hennings , David J. Fullmer , Craig Lindsay , Eric B. Taylor , Robert A. Weiss
发明人： David R. Hennings , David J. Fullmer , Craig Lindsay , Eric B. Taylor , Robert A. Weiss
IPC分类号： A61M25/00
CPC分类号： A61B8/0841 , A61B8/0833 , A61B8/12 , A61B8/488 , A61B18/245 , A61B2090/378 , A61B2090/3929 , A61H23/00 , A61M25/01 , A61M2025/0166
摘要： A device and method to improve the ultrasound visibility of a catheter placed inside the body is described. The catheter is sonically vibrated by an external driver device that transmits the acoustic vibration down the catheter and inside the body. An ultrasound transducer is used to pick up the ultrasound vibrations directly or detects the sonic vibrations using a Doppler mode ultrasound machine.
摘要翻译：描述了改善置于体内的导管的超声可见性的装置和方法。导管通过外部驱动装置进行声波振动，该外部驱动装置将声波振动向下传导至导管和体内。使用超声波换能器直接拾取超声波振动，或使用多普勒超声波机器检测声音振动。

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