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21. 发明授权

US5633724A Evanescent scanning of biochemical array 失效
标题翻译：生化阵列扫描扫描
公开(公告)号：US5633724A
公开(公告)日：1997-05-27
申请号：US520456
申请日：1995-08-29
申请人： David A. King , Jens-Peter Seher
发明人： David A. King , Jens-Peter Seher
IPC分类号： G01N21/55 , G01B9/02 , G01N21/41
CPC分类号： G01N21/648 , G01N21/552 , G01N21/7746
摘要： An apparatus for detecting a target substance in a pixel array is provided. The apparatus has a light source to emit a light suitable for exciting the target substance in the array, a total internal reflection (TIR) member, and a light detector. The TIR member has a TIR surface on which the array is located. The light from the light source passes into the TIR member and is reflected by the TIR surface. The array is within an evanescent field region at the TIR surface. The light detector is adapted to detect light emitted from the array as a result of evanescent excitation of the target substance.
摘要翻译：提供了一种用于检测像素阵列中的目标物质的装置。该装置具有用于发射适合于激发阵列中的目标物质的光源，全内反射（TIR）部件和光检测器。 TIR构件具有阵列所在的TIR表面。来自光源的光通过TIR构件并被TIR表面反射。阵列位于TIR表面的消逝场区域内。光检测器适于检测由于靶物质的ev逝激发而从阵列发射的光。

22. 发明授权

US5504653A Heat sinking assembly for electrical components 失效
标题翻译：电气元件散热组件
公开(公告)号：US5504653A
公开(公告)日：1996-04-02
申请号：US343070
申请日：1994-11-21
申请人： William S. Murphy , David A. King
发明人： William S. Murphy , David A. King
IPC分类号： H01L23/40 , H05K7/20
CPC分类号： H01L23/4093 , H01L2924/0002
摘要： A heat sinking assembly for dissipating thermal energy from heat generating electrical components wherein the heat sinking assembly includes a component support member and a housing which surrounds and clamps the electrical components to the heat sink wherein the components are not heat sunk until the first half of the housing assembly is attached to the circuit board or to the second half of the housing assembly. The clamping force for the electrical components may also be varied for optimum heat transfer.
摘要翻译：一种散热组件，其用于从发热电气部件散热热能，其中所述散热组件包括部件支撑部件和壳体，所述部件支撑部件和壳体围绕并夹持所述电气部件到所述散热器，其中，所述部件不被加热，直到所述散热组件的前半部分壳体组件附接到电路板或壳体组件的第二半部。用于电气部件的夹紧力也可以变化以获得最佳的热传递。

23. 发明授权

US5432610A Diode-pumped power build-up cavity for chemical sensing 失效
标题翻译：用于化学传感的二极管泵浦功率积聚腔
公开(公告)号：US5432610A
公开(公告)日：1995-07-11
申请号：US228317
申请日：1994-04-15
申请人： David A. King , William F. Carlsen , Damien F. Gray , Richard J. Pittaro
发明人： David A. King , William F. Carlsen , Damien F. Gray , Richard J. Pittaro
IPC分类号： G01N21/01 , G01N21/65 , H01S3/082 , H01S5/14 , G01N21/00 , H01S3/098
CPC分类号： G01N21/65 , H01S5/14 , H01S3/082 , H01S5/141
摘要： A semiconductor laser power build-up system includes a semi-conductor laser. An optical resonance cavity is defined between at least two reflective elements and has an intracavity light beam along an intracavity beam path. A return light beam, which is a portion of the intracavity light beam, is transmitted through one of the reflective elements and is coincident with but oppositely directed relative to the incident beam. The laser is wholly optically locked to the cavity and the intracavity beam passes substantially without loss within the cavity. In a preferred application, a sample is placed in the cavity and a detector is provided to sense chemicals in the sample by, for example, detecting Raman-scattered light. A wavelength-determining element such as a grating or an etalon is preferably in the incident beam path between the laser and the cavity. The reflective elements can have very low transmission losses, an emission facet of the laser can have very low reflectivity, and feedback into the laser may be strong, for example, above 3%. When the laser is a diode laser, the invention provides for driving the diode laser with a current that is less than its bare-diode threshold current.
摘要翻译：半导体激光发电系统包括半导体激光器。在至少两个反射元件之间限定光学谐振腔，并且具有沿着腔内光束路径的腔内光束。作为腔内光束的一部分的返回光束通过反射元件中的一个透射并且相对于入射光束重合而相反地定向。激光器完全光学地锁定到空腔，并且腔内光束在腔内基本上没有损失。在优选的应用中，将样品放置在空腔中，并且提供检测器以通过例如检测拉曼散射光来感测样品中的化学物质。诸如光栅或标准具的波长确定元件优选地在激光器和空腔之间的入射光束路径中。反射元件可以具有非常低的传输损耗，激光器的发射小面可以具有非常低的反射率，并且反射到激光器中可能是强的，例如高于3％。当激光器是二极管激光器时，本发明提供了驱动二极管激光器的电流小于其二极管二极管阈值电流。

24. 发明授权

US07847923B2 Differentiation of flow cytometry pulses and applications 有权
标题翻译：流式细胞术脉冲和应用的分化
公开(公告)号：US07847923B2
公开(公告)日：2010-12-07
申请号：US11862680
申请日：2007-09-27
申请人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
IPC分类号： G01P3/36
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译：一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数在测量窗口上。

25. 发明申请

US20100121257A1 CAPACITIVE FLUID LEVEL SENSING 有权
标题翻译：电容式液位感测
公开(公告)号：US20100121257A1
公开(公告)日：2010-05-13
申请号：US12267214
申请日：2008-11-07
申请人： David A. King
发明人： David A. King
IPC分类号： A61F9/007 , A61M31/00
CPC分类号： A61M31/00 , A61F9/00745 , A61M1/0005 , A61M1/0007 , A61M1/0031 , A61M1/0058 , A61M2205/123 , A61M2205/3317 , A61M2205/3382 , A61M2205/3386 , A61M2205/3389 , G01F23/265 , G01F23/266 , G01F23/268 , Y10T137/7306
摘要： A capacitive fluid level sensing arrangement for use in a medical device is provided. The arrangement includes at least one pair of conductive plates configured to increase and decrease the amount of electric charge stored in relation to the level of fluid within a fluid maintaining device, such as a reservoir. The conductive plates are electrically connected to a medical device and are configured to measure the charge stored between the plates and thus sense the fluid level. The electric circuit may communicate the measurement to an instrument host arrangement for operating a pump configured to remove fluid from the reservoir and move the fluid to a collector when the level exceeds a preset upper level amount. The instrument host arrangement may stop operating the pump when the fluid level is reduced to a preset lower level amount.
摘要翻译：提供了一种用于医疗装置的电容式液面检测装置。该装置包括至少一对导电板，其被配置为增加和减少相对于流体维持装置（例如储存器）内的流体水平而存储的电荷量。导电板电连接到医疗装置，并且被配置成测量存储在板之间的电荷，从而感测流体水平。电路可以将测量值传送到仪器主机装置，用于操作构造成从储存器移除流体的泵，并且当液位超过预设的上限量时将流体移动到收集器。当液位降低到预设的较低水平量时，仪器主机装置可以停止操作泵。

26. 发明授权

US07666149B2 Cassette of lancet cartridges for sampling blood 有权
标题翻译：用于取样血液的柳叶刀墨盒盒
公开(公告)号：US07666149B2
公开(公告)日：2010-02-23
申请号：US10282927
申请日：2002-10-28
申请人： Tad Decatur Simons , Michael Greenstein , Dominique M. Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique M. Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/00 , B65D81/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/15113 , A61B5/15153 , A61B5/15159 , A61B5/15165 , A61B5/15174 , A61B2562/0295 , Y10S436/808
摘要： A cassette containing cartridges for sampling blood from a patient. The cassette includes a container for storing a plurality of cartridges and at least one cartridge in the container. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case for lancing the skin of the patient to yield blood. The container has a compartment that contains at least one cartridge. A cartridge from the compartment can be loaded onto a glucometer that drives the lancet in the cartridge to lance the skin of a patient.
摘要翻译：包含用于从患者取血的药筒的药盒。盒式磁带包括用于存储多个盒的容器和容器中的至少一个盒。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动柳叶刀将尖端延伸到药筒壳体外部，以便撕裂患者的皮肤以产生血液。容器具有包含至少一个盒的隔间。来自隔室的药筒可以被装载到驱动药筒中的刺血针的血糖仪上以刺穿患者的皮肤。

27. 发明授权

US07541152B2 Integrated light source for diagnostic arrays 有权
标题翻译：用于诊断阵列的集成光源
公开(公告)号：US07541152B2
公开(公告)日：2009-06-02
申请号：US10328422
申请日：2002-12-24
申请人： David A. King , Richard J. Pittaro
发明人： David A. King , Richard J. Pittaro
IPC分类号： G01N33/53
CPC分类号： G01N21/6428 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N33/582
摘要： The present invention relates to methods of detecting analytes in a molecular array. More specifically, the invention relates to compositions and methods of illuminating or irradiating analytes bound to a feature on an array.
摘要翻译：本发明涉及检测分子阵列中分析物的方法。更具体地，本发明涉及照射或照射与阵列上的特征结合的分析物的组合物和方法。

28. 发明授权

US06742039B1 System and method for connecting to a device on a protected network 有权
标题翻译：用于连接到受保护网络上的设备的系统和方法
公开(公告)号：US06742039B1
公开(公告)日：2004-05-25
申请号：US09466812
申请日：1999-12-20
申请人： Eric B. Remer , David A. King , David L. Remer
发明人： Eric B. Remer , David A. King , David L. Remer
IPC分类号： G06F1516
CPC分类号： H04L63/02 , Y10S707/99939
摘要： A novel system and method for connecting to an entity behind a firewall or proxy enhances network security and eliminates the costs and risks associated with modifying the firewall or proxy. The invention uses a trusted arbitrator as an intermediary between (1) a local area network protected by an access control mechanism such as a firewall or proxy and (2) external entities seeking to connect with an entity within the network. Requests from external entities are routed to the trusted arbitrator, which communicates with a connection entity located behind the firewall or proxy.
摘要翻译：用于连接到防火墙或代理后面的实体的新型系统和方法增强了网络安全性，并消除了与修改防火墙或代理相关联的成本和风险。本发明使用信任仲裁器作为（1）由诸如防火墙或代理等访问控制机制保护的局域网和（2）寻求与网络内的实体连接的外部实体的中介。来自外部实体的请求被路由到可信仲裁器，该仲裁器与位于防火墙或代理之后的连接实体进行通信。

29. 发明授权

US06222860B1 Laser system tolerating disturbances using multiple modes 有权
标题翻译：激光系统允许使用多种模式的干扰
公开(公告)号：US06222860B1
公开(公告)日：2001-04-24
申请号：US09227105
申请日：1999-01-07
申请人： Richard J. Pittaro , David A. King , Martin Wunderling , Jens-Peter Seher
发明人： Richard J. Pittaro , David A. King , Martin Wunderling , Jens-Peter Seher
IPC分类号： H01S3131
CPC分类号： G01N21/65 , G01N21/39 , H01S3/08022 , H01S3/082 , H01S3/09415 , H01S3/105
摘要： A laser system includes a gain medium for providing and amplifying a laser beam within an optical resonator. According to the invention, the laser system actively provides a plurality of different optical modes for stabilizing the laser beam, preferably by forcing the laser beam to jump between different optical modes more frequent than environmental disturbances occur. Providing the plurality of different optical modes can be achieved e.g. by varying the phase of the laser beam and/or by varying the optical length of the optical resonator. The laser system can be employed in a gas monitoring system, e.g. for monitoring a respiration and/or anaesthetic gas, for providing a Raman spectrum of the gas to be monitored.
摘要翻译：激光系统包括用于在光学谐振器内提供和放大激光束的增益介质。根据本发明，激光系统主动地提供多种不同的光学模式来稳定激光束，优选地通过迫使激光束比不同环境干扰更频繁地在不同的光学模式之间跳跃。提供多种不同的光学模式可以被实现。通过改变激光束的相位和/或通过改变光学谐振器的光学长度来实现。激光系统可以用于气体监测系统，例如，用于监测呼吸和/或麻醉气体，以提供待监测气体的拉曼光谱。

30. 发明授权

US6036924A Cassette of lancet cartridges for sampling blood 失效
标题翻译：用于取样血液的柳叶刀墨盒盒
公开(公告)号：US6036924A
公开(公告)日：2000-03-14
申请号：US985299
申请日：1997-12-04
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/15 , A61B17/32
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/15113 , A61B5/15153 , A61B5/15174 , A61B2562/0295 , A61B5/15159 , A61B5/15165 , Y10S436/808
摘要： A cassette containing cartridges for sampling blood from a patient. The cassette includes a container for storing a plurality of cartridges and at least one cartridge in the container. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case for lancing the skin of the patient to yield blood. The container has a compartment that contains at least one cartridge. A cartridge from the compartment can be loaded onto a glucometer that drives the lancet in the cartridge to lance the skin of a patient.
摘要翻译：包含用于从患者取血的药筒的药盒。盒式磁带包括用于存储多个盒的容器和容器中的至少一个盒。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动柳叶刀将尖端延伸到药筒壳体外部，以便撕裂患者的皮肤以产生血液。容器具有包含至少一个盒的隔间。来自隔室的药筒可以被装载到驱动药筒中的刺血针的血糖仪上以刺激患者的皮肤。

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