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21. 发明授权

US09345835B2 Cartridge stopper for an intradermal delivery system 有权
标题翻译：用于皮内递送系统的塞子塞子
公开(公告)号：US09345835B2
公开(公告)日：2016-05-24
申请号：US12737453
申请日：2009-07-17
申请人： Ying Xu , Robert Banik , Lionel Vedrine
发明人： Ying Xu , Robert Banik , Lionel Vedrine
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24
CPC分类号： A61M5/31511 , A61M5/24 , A61M5/2466 , A61M5/31515 , A61M5/31551 , A61M5/31573 , A61M5/31585 , A61M2005/2407
摘要： A device for delivering a medicament intradermally includes a cartridge (112) having a first end (110) and a second end (114) and defining a volume (111) therebetween. The volume (111) is adapted to contain the medicament. A driving member (121) has a first end (126) and a second end (128). The first end (126) of the driving member (121) is disposed in the cartridge (112) and the second end (128) of the driving member (121) is disposed outside the cartridge (112). A stopper (115) is slidably disposed in the cartridge volume (111). The driving member (121) is releasably disposed in the stopper (115) such that when the driving member (121) is retracted from the cartridge (112) the stopper (115) is disengaged from the driving member (121) and remains in the cartridge volume (111).
摘要翻译：用于皮内递送药物的装置包括具有第一端（110）和第二端（114）并且在其间限定体积（111）的药筒（112）。体积（111）适于容纳药物。驱动构件（121）具有第一端（126）和第二端（128）。驱动构件（121）的第一端（126）设置在盒（112）中，并且驱动构件（121）的第二端（128）设置在盒（112）的外部。止动器（115）可滑动地设置在盒体积（111）中。驱动构件（121）可释放地设置在止动件（115）中，使得当驱动构件（121）从盒（112）缩回时，止动件（115）与驱动构件（121）脱离并保持在盒体积（111）。

22. 发明授权

US09174010B2 Sprayer, in particular for medical use 有权
标题翻译：喷雾器，特别适用于医疗用途
公开(公告)号：US09174010B2
公开(公告)日：2015-11-03
申请号：US12867920
申请日：2009-02-02
申请人： Lionel Vedrine
发明人： Lionel Vedrine
IPC分类号： B05B11/00 , A61M11/00 , A61M15/00 , B65D41/34
CPC分类号： A61M11/00 , A61M11/007 , A61M15/0025 , B05B11/0027 , B65D41/3409 , Y10T29/49945
摘要： A sprayer includes a container of product to be sprayed, provided with a delivery opening for this product, and a spraying assembly. The spraying assembly is in fluid communication with the delivery opening and is securable onto the container by insertion about a mounting axis. The spraying assembly includes a sprayer body delimiting a proximal area conformed so as to be securable to the container, and includes a distal wall, transverse to the mounting axis, in which a spraying aperture is arranged, and a cap intended to be mounted on the sprayer body. The cap includes a wall transverse to the mounting axis, which is sufficiently rigid so as to bear, without substantial damaging, a force from 50 to 100 N necessary to secure the sprayer body to the container and thus to enable the transmission to the sprayer body of this force.
摘要翻译：喷雾器包括一个待喷射的产品的容器，该容器设置有用于该产品的输送开口和一个喷涂组件。喷射组件与输送口流体连通，并通过围绕安装轴线的插入而固定在容器上。喷涂组件包括一个喷涂器主体，其限定适合于容器的近侧区域，并且包括横向于安装轴线的远侧壁，其中布置有喷射孔，以及盖子，其将安装在喷雾器体。盖子包括横向于安装轴线的壁，其具有足够的刚性，从而承受50到100N的力而不会将喷雾器本体固定在容器上，从而能够传递到喷雾器体的力量

23. 发明授权

US08469923B2 Cartridge for powder and liquid drug 有权
标题翻译：粉末和液体药物的药筒
公开(公告)号：US08469923B2
公开(公告)日：2013-06-25
申请号：US12679508
申请日：2008-09-29
申请人： Lionel Vedrine , Roger W. Groskopf , Matthew Sweeney , Dnyanesh A. Talpade , Min Wei , Ruane Jeter
发明人： Lionel Vedrine , Roger W. Groskopf , Matthew Sweeney , Dnyanesh A. Talpade , Min Wei , Ruane Jeter
IPC分类号： A61M37/00
CPC分类号： A61M5/284 , A61M5/2448 , A61M5/288 , A61M5/3134 , A61M5/31513 , A61M5/345 , A61M5/347 , A61M5/348 , A61M2005/3104 , A61M2005/31516 , B65B3/003
摘要： A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle. The insert extends into the retainer and forms a liquid-tight seal across the opening. Advantageously, with the subject invention, a reconstitution assembly may be provided which has a sufficiently large distal opening during assembly which allows a dry component to be introduced into the device in a dry state.
摘要翻译：本文提供了用于保持和混合医疗产品的药筒或注射器，其包括具有圆柱形壁的管状体，其具有第一和第二相对端。该壁包括内表面和外表面，其中内表面至少沿着药物混合区域具有大致恒定的横截面。第一止动件可滑动地设置在第一和第二端之间的壁内，第一止动件限定与内表面的液密密封。第二止动件可滑动地设置在第一止挡件和第一端之间的壁内，第二止动件限定与内表面的液密密封。柔性插入件设置在第二端处或附近，插入件与壁形成液密密封，插入件可被医用针或其它穿刺器械刺穿。刚性保持器固定到其上具有开口的壁上，用于提供通过医用针穿刺插入物的通路。插入件延伸到保持器中并且跨越开口形成液密密封。有利地，对于本发明，可以提供在组装期间具有足够大的远端开口的重构组件，其允许在干燥状态下将干燥部件引入装置。

24. 发明申请

US20110201999A1 NEEDLE MOUNTING FEATURE FOR ENSURING PROPER RECONSTITUTION SEQUENCE 有权
标题翻译：用于确保适当重新配置顺序的针脚安装功能
公开(公告)号：US20110201999A1
公开(公告)日：2011-08-18
申请号：US13119200
申请日：2009-09-18
申请人： Richard A. Cronenberg , Asif Fayyaz , Atul Patel , Matthew D. Sweeney , Lionel Vedrine
发明人： Richard A. Cronenberg , Asif Fayyaz , Atul Patel , Matthew D. Sweeney , Lionel Vedrine
IPC分类号： A61M5/31 , A61M5/34
CPC分类号： A61M5/2448 , A61M5/2066 , A61M5/3129 , A61M5/3134 , A61M5/3243 , A61M5/344 , A61M5/347 , A61M2005/2407 , A61M2005/2496 , A61M2005/3104
摘要： A medical injector is provided herein having a body and a needle mounting surface movable relative to the body, the needle mounting surface having features for mounting a needle thereto. In an initial state, the needle mounting surface is disposed within the body with no needle mounted thereto. With relative movement between the body and the needle mounting surface, the needle mounting surface is urged out of the body. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered.
摘要翻译：本发明提供了一种具有可相对于身体移动的主体和针安装表面的医疗注射器，针安装表面具有用于将针安装到其上的特征。在初始状态下，针安装表面设置在主体内，没有针安装在其上。通过主体和针安装表面之间的相对移动，针安装表面被推出身体。有利地，提供了一种医疗注射器，其确保在制备装置时的适当顺序，特别是关于在制备要施用的药物之后允许将医用针安装到装置的步骤。

25. 发明申请

US20110054390A1 Extended Use Medical Device 有权
标题翻译：延长使用医疗器械
公开(公告)号：US20110054390A1
公开(公告)日：2011-03-03
申请号：US12585061
申请日：2009-09-02
申请人： Gary Searle , Keith N. Knapp , Roman Tunkel , Peter Skutnik , Lionel Vedrine
发明人： Gary Searle , Keith N. Knapp , Roman Tunkel , Peter Skutnik , Lionel Vedrine
IPC分类号： A61M5/168 , A61M5/142
CPC分类号： A61M5/158 , A61M5/1413 , A61M5/14212 , A61M5/14224 , A61M5/14248 , A61M5/16886 , A61M5/1723 , A61M5/3134 , A61M5/385 , A61M5/46 , A61M2005/14208 , A61M2005/14268 , A61M2005/1585 , A61M2005/16872 , A61M2205/16 , A61M2205/702 , A61M2209/045 , A61M2230/005 , A61M2230/201
摘要： Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device. Another embodiment comprises a partially reusable and partially disposable medical device implementing the above features.
摘要翻译：提供了一种扩展使用的独立的，可穿戴的医疗设备。该装置优选地配置有输注展开机构，用于将输注针可变地插入和缩回到不同的深度，或者将输注针从输注部位完全缩回，然后在整个输注期间在预定时间段之后重新插入输注针循环，以延长输注部位的生存能力。另一个实施例包括双针展开机构，其也可以可变地插入和缩回输注针。优选地设置流量传感器，用于检测通过输注套管的流动的停止并且发出针部署机构以尝试在不同深度输注或部署第二输注针。优选地，可重新填充的储存器组件用于通过扩展使用该装置来供应药物。另一实施例包括实现上述特征的部分可再利用和部分一次性医疗装置。

26. 发明申请

US20060151629A1 Spray device and method 有权
公开(公告)号：US20060151629A1
公开(公告)日：2006-07-13
申请号：US11347902
申请日：2006-02-06
申请人： Lionel Vedrine , Laurent Barrelle
发明人： Lionel Vedrine , Laurent Barrelle
IPC分类号： A62C11/00
CPC分类号： A61M15/0028 , A61M5/284 , A61M11/06 , B05B11/0083 , B05B11/02
摘要： A spray device including a barrel having a bypass and at least two spaced stoppers defining a first and second chambers and a spray nozzle. Movement of the first stopper drives the second stopper to the bypass and the fluid in the first chamber into the second chamber, mixing the fluid and substance. Continued movement of the first and second stoppers drives the mixture through the spray nozzle. The spray device may include a third stopper having a body in the tubular barrel which is moved toward the spray nozzle. The movement of the third stopper provides space for the mixture and prevents unpressurized fluid from flowing through the spray nozzle. The third stopper includes an axial stalk. The stalk may be deformable or the stalk may be separate from the body and the spray nozzle includes a longitudinal internal passage which provides communication with the spray port.

27. 发明授权

US07044125B2 Drug delivery system including holder and drug container 有权
标题翻译：药物输送系统，包括持有人和药物容器
公开(公告)号：US07044125B2
公开(公告)日：2006-05-16
申请号：US10632603
申请日：2003-08-01
申请人： Lionel Vedrine , Hubert Jansen , Jean Pierre Grimard , Michel Guillory
发明人： Lionel Vedrine , Hubert Jansen , Jean Pierre Grimard , Michel Guillory
IPC分类号： A61M11/00 , A61M5/315
CPC分类号： B05B11/02 , A61M5/31591 , A61M11/06 , A61M15/0025 , A61M15/0065 , A61M15/08 , A61M2005/208 , A61M2205/073 , A61M2210/0618
摘要： A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system. A plurality of slots are provided on the holder that permit multiple equal doses of the substance to be administered to each nostril of the patient.
摘要翻译：用于施用预先剂量的药物，疫苗等物质的药物递送系统。药物输送系统包括保持器和保持在保持器中的诸如注射器的预填充药物容器。药物容器包括用于容纳物质的桶，位于桶内的可移动止动件，以及具有开口的钝端，桶内的物质可以通过该开口排出。保持器包括远端部分和近端部分，每个远端部分和近端部分被构造成容纳药物容器，远侧部分能够组装到近端部分，该近端部分在激活输送系统期间用作柱塞杆。在保持器上设置多个槽，其允许向患者的每个鼻孔施用多个相等剂量的物质。

28. 外观设计

USD447559S1 Drug container holder 失效
公开(公告)号：USD447559S1
公开(公告)日：2001-09-04
申请号：US29121338
申请日：2000-04-05
申请人： Hubert Jansen , Lionel Vedrine , Eric Denis , Samuel Bernier , Emmanuel Delarue
设计人： Hubert Jansen , Lionel Vedrine , Eric Denis , Samuel Bernier , Emmanuel Delarue

29. 发明申请

US20120302966A1 Monodose Nasal Drug Delivery System 有权
标题翻译： Monodose鼻给药系统
公开(公告)号：US20120302966A1
公开(公告)日：2012-11-29
申请号：US13517496
申请日：2010-12-23
申请人： Lionel Vedrine
发明人： Lionel Vedrine
IPC分类号： A61M11/00
CPC分类号： A61M11/007 , A61M5/282 , A61M15/08 , B05B11/02
摘要： A delivery device for delivery of a medicament to a user including a container defining a reservoir storing the medicament, a body in which the container is received, a spray nozzle arranged on one of the body and the container for receiving medicament expelled from the container, and a pusher actuatable for pushing the medicament from the container reservoir through the nozzle, said pusher being movable from a rest position to a fully activated position relative to said body in response to an actuating force. The assembly is particularly applicable to nasal syringes where it is desirable to deliver the medicament in the form of a spray.
摘要翻译：一种用于将药物输送给使用者的输送装置，包括限定储存药剂的容器的容器，容纳容器的容器，布置在主体和容器中的一个上的喷嘴，用于接收从容器中排出的药物，以及推动器，其可致动以将药物从容器储存器推动通过喷嘴，所述推动器可响应于致动力而从静止位置相对于所述主体移动到完全启动位置。该组件特别适用于需要以喷雾形式输送药物的鼻注射器。

30. 发明授权

US08262641B2 Filling system and method for syringes with short needles 有权
标题翻译：注射器用短针的灌装系统和方法
公开(公告)号：US08262641B2
公开(公告)日：2012-09-11
申请号：US12537497
申请日：2009-08-07
申请人： Lionel Vedrine , Paul G. Alchas , Christopher N. Cindrich
发明人： Lionel Vedrine , Paul G. Alchas , Christopher N. Cindrich
IPC分类号： A61M5/32 , A61B19/00
CPC分类号： A61J1/2096 , A61J1/1406 , A61J1/201 , A61J1/2055 , A61M5/1782 , A61M2039/042
摘要： A filling system for syringes utilizing short needles to be filled from a vial having a thick septum is described. The system may be useful in any situation where the septum or vial stopper of a medication container is thicker than the usable length of the needle on the delivery device. Preferably, the syringe is filled just prior to use. The short needle includes an optional limiter which only permits a certain predetermined length of the needle cannula to protrude beyond the limiter a distance which limits penetration of the needle tip into both the skin and a vial stopper. The system and adapter may be useful for needles having a protrusion distance from approximately 0.5 mm to 3 mm, or any needle with a protrusion length shorter that the thickness of a septum to be accessed. Furthermore, a device is provided with shielding capabilities to shield the needle of the device.
摘要翻译：描述了从具有厚的隔膜的小瓶中填充使用短针的注射器的填充系统。在药物容器的隔膜或药瓶塞子比输送装置上的针的可用长度更厚的任何情况下，该系统可能是有用的。优选地，注射器在使用之前被填充。短针包括可选的限制器，其仅允许针套管的某个预定长度突出超过限制器一定距离，该距离限制针尖进入皮肤和药瓶塞子的穿透距离。系统和适配器对于具有大约0.5mm至3mm的突出距离的针或具有比要访问的隔膜的厚度更短的突出长度的针可能是有用的。此外，设备具有屏蔽能力以屏蔽设备的针。

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