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1. 发明授权

US07296678B2 Packaging for the transport of sterile objects or objects to be sterilised 有权
标题翻译：用于运输无菌物品或灭菌物品的包装
公开(公告)号：US07296678B2
公开(公告)日：2007-11-20
申请号：US10511577
申请日：2003-05-06
申请人： Claire Raynal-Olive , Jean-Pierre Grimard
发明人： Claire Raynal-Olive , Jean-Pierre Grimard
IPC分类号： A61B17/06 , A61L2/20 , B65B55/02
CPC分类号： B65D81/20 , A61L2/208 , A61L2/26 , A61L2202/182 , A61M5/001 , A61M5/002 , B65B31/028 , B65B55/10
摘要： A packaging having a box, and a cover sheet made of a material that is not permeable to decontamination gas. The cover sheet has a window closed by a piece of selectively impervious material. A flexible piece of a material that is not permeable to a decontamination gas is fixed to the cover sheet by at least one of its edges and has a free part which is able to move between a diffusion position and a non-diffusion position.
摘要翻译：具有盒子的包装和由不能去污净化气体的材料制成的覆盖片。覆盖片具有由一片选择性渗透材料封闭的窗口。不能透过净化气体的材料的柔性片通过其边缘中的至少一个固定到覆盖片，并且具有能够在扩散位置和非扩散位置之间移动的自由部分。

2. 发明授权

US07100768B2 Package for products to be sterilized with a high-temperature sterilizing fluid 有权
标题翻译：用高温灭菌液灭菌的产品包装
公开(公告)号：US07100768B2
公开(公告)日：2006-09-05
申请号：US10485930
申请日：2001-11-16
申请人： Jean-Pierre Grimard , Jean-Claude Thibault
发明人： Jean-Pierre Grimard , Jean-Claude Thibault
IPC分类号： A61B17/06
CPC分类号： A61L2/183 , A61L2/26 , A61L2202/181 , A61L2202/24 , A61M5/008
摘要： The invention concerns a plastic package, having a content capable of being sterilised at high temperature, said package comprising at least a fluid communication member (16) between the inside and the outside of said package consisting of at least a frame circumscribing an opening and an inner seal (18) closing the opening, and whereof the peripheral edge (18a, 22a) continuously linked to said frame, said inner seal including, a selectively sealing material sheet whereof the cutoff threshold from outside inwards, stops contaminating particles and allows through the thermal sterilising fluid, said selectively sealing material being deformable in the plane of said sheet at said high temperature. The invention is characterised in that it comprises means compensating the planar deformation of the selectively sealing material sheet, when said inner seal (18) is in contact with the thermal sterilising fluid, said compensating means being designed to release at least part of the load in the direction opening the fluid communication member (16) applied on the frame as a result of said deformation.
摘要翻译：本发明涉及一种塑料包装，其具有能够在高温下灭菌的内容物，所述包装至少包括在所述包装的内部和外部之间的流体连通构件（16），该流体连通构件至少包括围绕开口的框架和封闭开口的内密封件（18），以及与所述框架连续连接的周边边缘（18a，22a），所述内密封件包括选择性密封材料片，其中从外侧进入的截止阈值停止污染颗粒，并允许通过热灭菌流体，所述选择性密封材料可在所述高温下在所述片材的平面中变形。本发明的特征在于，当所述内部密封件（18）与热灭菌流体接触时，其包括补偿选择性密封材料片材的平面变形的装置，所述补偿装置设计成将至少部分负载释放作为所述变形的结果，打开施加在框架上的流体连通构件（16）的方向。

3. 发明授权

US07044125B2 Drug delivery system including holder and drug container 有权
标题翻译：药物输送系统，包括持有人和药物容器
公开(公告)号：US07044125B2
公开(公告)日：2006-05-16
申请号：US10632603
申请日：2003-08-01
申请人： Lionel Vedrine , Hubert Jansen , Jean Pierre Grimard , Michel Guillory
发明人： Lionel Vedrine , Hubert Jansen , Jean Pierre Grimard , Michel Guillory
IPC分类号： A61M11/00 , A61M5/315
CPC分类号： B05B11/02 , A61M5/31591 , A61M11/06 , A61M15/0025 , A61M15/0065 , A61M15/08 , A61M2005/208 , A61M2205/073 , A61M2210/0618
摘要： A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system. A plurality of slots are provided on the holder that permit multiple equal doses of the substance to be administered to each nostril of the patient.
摘要翻译：用于施用预先剂量的药物，疫苗等物质的药物递送系统。药物输送系统包括保持器和保持在保持器中的诸如注射器的预填充药物容器。药物容器包括用于容纳物质的桶，位于桶内的可移动止动件，以及具有开口的钝端，桶内的物质可以通过该开口排出。保持器包括远端部分和近端部分，每个远端部分和近端部分被构造成容纳药物容器，远侧部分能够组装到近端部分，该近端部分在激活输送系统期间用作柱塞杆。在保持器上设置多个槽，其允许向患者的每个鼻孔施用多个相等剂量的物质。

4. 发明申请

US20050226763A1 Packaging for sterile objects or objects to be sterilized 有权
标题翻译：无菌物品或灭菌物品的包装
公开(公告)号：US20050226763A1
公开(公告)日：2005-10-13
申请号：US10511579
申请日：2003-04-18
申请人： Claire Raynal-Olive , Jean-Pierre Grimard
发明人： Claire Raynal-Olive , Jean-Pierre Grimard
IPC分类号： B65B55/02 , A61L2/20 , A61L2/26 , A61M5/00 , B65D81/24
CPC分类号： A61L2/208 , A61L2/26 , A61L2202/182 , A61M5/001 , A61M5/002
摘要： This package (1) comprises a box (3) intended to accommodate objects (2) which are sterile and a covering sheet (4) made of a selectively leaktight material, fastened to the box (3) so as to seal the latter in a leaktight manner. This package (1) comprises one layer (6) of a material forming a screen which is at least partial with respect to a decontamination gas and/or able to absorb a decontamination gas, this layer (6) having a shape and dimensions such that it can be placed in the box (3) along the covering sheet (4) and that it lies above the objects (2) and at least a plate or a grill (20) provided with projections (21), shaped in order, in a diffusion position, to allow unrestricted diffusion of the sterilization gas over the objects (2), and, in a nondiffisuion position, to restrict or prevent diffusion of the decontamination gas over these same objects (2).
摘要翻译：该包装（1）包括用于容纳无菌的物品（2）的盒子（3）和由选择性的密封材料制成的覆盖片材（4），固定到盒子（3）上，以将其密封在盒子密封的方式。该包装（1）包括形成筛网的至少部分相对于净化气体和/或能够吸收净化气体的一层材料（6），该层（6）的形状和尺寸使得它可以沿着覆盖片（4）放置在盒（3）中，并且它位于物体（2）上方，并且至少设置有设置有突起（21）的板或格栅（20）扩散位置，以允许灭菌气体在物体（2）上的不受限制的扩散，以及在非扩散位置，以限制或防止净化气体在这些相同物体上的扩散（2）。

5. 发明授权

US06638440B1 Method and installation for surface marking of a substrate 有权
标题翻译：衬底表面标记的方法和安装
公开(公告)号：US06638440B1
公开(公告)日：2003-10-28
申请号：US09857062
申请日：2001-08-02
申请人： Jean-Pierre Grimard
发明人： Jean-Pierre Grimard
IPC分类号： B44C122
CPC分类号： B65D23/14 , B41J2/442 , B41J3/4073 , B41J11/0015 , B41M5/24 , B41M7/0081 , B44C1/228 , B44C1/26 , C03C23/0025
摘要： A method for surface marking a solid substrate (1), according to which, during an exposures sequence, said substrate is exposed to coherent monochromatic light (2) in order to strip said substrate over an indented surface (3), wherein the exposure conditions, including duration, are set in order to restrict said indented surface to simple abrasion designed for the bonding of a printing medium, and the exposure sequence is followed by a sequence of projecting in discrete form, during which particles (6) of said printing medium, the deposition of which subsequently defines a printing element (4), are projected in targeted fashion into the indented surface (3, 31). A device for marking a surface of a substrate is also provided.
摘要翻译：一种用于表面标记固体基底（1）的方法，根据该方法，在曝光序列期间，将所述基底暴露于相干单色光（2），以便在凹凸表面（3）上剥离所述基底，其中曝光条件设置包括持续时间，以便将所述缩进表面限制为用于结合打印介质的简单磨损，并且曝光顺序之后是以离散形式突出的序列，期间所述打印介质的颗粒（6），其沉积随后限定印刷元件（4）以目标方式投影到凹入表面（3,31）中。还提供了用于标记基板表面的装置。

6. 发明授权

US06553722B1 Device for connecting doors between two chambers isolated from the external medium 有权
标题翻译：在与外部介质隔离的两个室之间连接门的装置
公开(公告)号：US06553722B1
公开(公告)日：2003-04-29
申请号：US09857059
申请日：2002-01-29
申请人： Jean-Yves Porret , Jean-Pierre Grimard , Claude Imbert
发明人： Jean-Yves Porret , Jean-Pierre Grimard , Claude Imbert
IPC分类号： E06B300
CPC分类号： B01L1/02 , G21F7/005 , G21F7/047
摘要： This connecting device applies to a sealed connection device in which, firstly, each chamber, respectively a stationary chamber “A” and a transportable chamber “B” has at least one access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing elements (12, 14), one (2) of the two doors being articulated to its flange (4), and secondly, the two doors (2, 3) have an element to lock their respective flanges (4, 5) and complementary connecting elements which allow them to be connected thereby forming, through contact of sealing elements (12, 16), an internal space “C” isolating their faces (17, 18) opposite each other from the external medium. The elements of connecting the two doors (2, 3) together comprise a network of ducts (30, 34, 35) formed at least in one of the doors and emerging, at one of its ends, from the external face (18) of the said door in the said sealed internal space “C”, the said network being connected, at its other end, to a source (30) of vacuum.
摘要翻译：该连接装置适用于密封连接装置，其中，首先，每个室，分别为固定室“A”和可运输室“B”具有至少一个进入开口，其具有与凸缘（2）配合的门（2,3）（4，5），插入密封元件（12,14），两个门中的一个（2）铰接到其凸缘（4），其次，两个门（2,3）具有锁定元件它们各自的凸缘（4,5）和互补的连接元件允许它们通过密封元件（12,16）的接触形成，从而形成隔离其彼此相对的面（17,18）的内部空间“C” 外部介质。将两个门（2,3）连接在一起的元件包括形成在至少一个门中的管道网（30,34,35），并且在其一个端部处从其外表面（18）所述门在所述密封的内部空间“C”中，所述网络在其另一端连接到真空源（30）。

7. 发明授权

US5819964A Lyophilization closure assembly for a medicament container for use during a lyophilization process 失效
标题翻译：用于在冻干过程中使用的药物容器的冻干闭合组件
公开(公告)号：US5819964A
公开(公告)日：1998-10-13
申请号：US825836
申请日：1997-04-04
申请人： Jean Pierre Grimard
发明人： Jean Pierre Grimard
IPC分类号： B65D51/16 , A61J1/05 , B65D51/00 , B65D51/18 , B65D51/24 , B65D41/58
CPC分类号： B65D51/002 , B65D51/241
摘要： A lyophilization closure assembly for a container or vial is disclosed. The lyophilization closure assembly is self-supporting with the container and may be employed with the container during a lyophilization process, eliminating the need for a separate crimping operation outside of the sterile environment in which lyophilization is conducted. The lyophilization closure assembly includes a body with a skirt disposed around the rim of the container. The skirt features one or more deflectable abutments and one or more deflectable latches positionable about the rim of the container, and defines one or more vapor passages. An elastomeric closure is retained within the body for sealing the open top of the medicament container. The elastomeric closure features a plug for sealing the open top of the container and a top surface facing away from the open top of the container. The body defines an opening over the elastomeric closure that delimits an access area on the top surface of the closure. A membrane is removably secured over the access area of the elastomeric closure and hermetically encloses the access area.
摘要翻译：公开了一种用于容器或小瓶的冻干封闭组件。冻干封闭组件与容器自支撑并且可以在冷冻干燥过程中与容器一起使用，从而不需要进行冷冻干燥的无菌环境之外的单独卷曲操作。冻干闭合组件包括具有设置在容器的边缘周围的裙部的主体。裙部具有一个或多个可偏转的邻接部以及可围绕容器的边缘定位的一个或多个可偏转的闩锁，并且限定一个或多个蒸气通道。弹性体封闭件保持在主体内，用于密封药物容器的开口顶部。弹性体闭合件具有用于密封容器的敞开顶部的塞子和背离容器开口顶部的顶表面。主体限定弹性封闭件上的开口，其限定封闭件顶表面上的通路区域。膜可移除地固定在弹性体封闭件的进入区域上并且密封地包围进入区域。

8. 发明授权

US08460241B2 Needle protection assembly with locking element 有权
标题翻译：带锁定元件的针保护组件
公开(公告)号：US08460241B2
公开(公告)日：2013-06-11
申请号：US12937672
申请日：2009-04-14
申请人： Jean-Pierre Grimard
发明人： Jean-Pierre Grimard
IPC分类号： A61M5/00 , A61M5/32 , A61M5/178 , A61M5/31
CPC分类号： A61M5/326 , A61M5/3272 , A61M2005/3247
摘要： The application relates to a needle protection assembly (1) comprising a support (2), a needle shield (8), urging means (10) located between said support (2) and said needle shield (8), tending to displace said needle shield (8) distally over said needle (3), wherein the assembly comprises one abutment (5) provided on said support (2), receiving a locking element (10a), a part of said urging means being laterally movable with respect to said support (2) and forming part of said locking element (10a).
摘要翻译：本申请涉及一种针保护组件（1），其包括支撑件（2），针护罩（8），位于所述支撑件（2）和所述针护罩（8）之间的推动装置（10），倾向于使所述针所述组件包括设置在所述支撑件（2）上的一个支座（5），接收锁定元件（10a），所述推动装置的一部分可相对于所述支撑件（2）侧向移动，支撑件（2）并形成所述锁定元件（10a）的一部分。

9. 发明授权

US06969375B2 Sealed connection device for medical use of the luer lock type and syringe incorporating such a device 有权
标题翻译：用于鲁尔锁式医疗用途的密封连接装置和结合这种装置的注射器
公开(公告)号：US06969375B2
公开(公告)日：2005-11-29
申请号：US10296429
申请日：2001-05-23
申请人： Jean-Claude Thibault , Hubert Jansen , Jean-Pierre Grimard
发明人： Jean-Claude Thibault , Hubert Jansen , Jean-Pierre Grimard
IPC分类号： A61M5/32 , A61M5/34 , A61M5/31
CPC分类号： A61M5/344 , A61M5/3202 , A61M5/346
摘要： Luer lock type connection device for medical use having a nozzle in which an axial internal passage is formed. The nozzle includes a bearing connection surface and a proximal annular retention zone. The connection device also has a flange forming an axial open seat having a wall that includes a distal part with internal screw thread, and a transverse proximal part in which a central proximal retention opening is formed, and whose diameter is matched to that of the proximal annular zone of the nozzle. The proximal annular retention zone of the nozzle and/or the central proximal retention opening of the flange include a circular band or cord covered or treated with a roughening agent.
摘要翻译：用于医疗用途的鲁尔锁式连接装置具有其中形成有轴向内部通道的喷嘴。喷嘴包括轴承连接表面和近端环形保持区域。连接装置还具有形成轴向开口座的凸缘，其具有包括具有内螺纹的远侧部分的壁和横向近端部分，其中形成有中心近端保持开口，并且其直径与近端喷嘴的环形区域。喷嘴的近端环形保持区域和/或凸缘的中心近侧保持开口包括用粗糙剂覆盖或处理的圆形带或绳索。

10. 发明申请

US20050103666A1 Package for products to be sterlised with a high-temperature sterilising fluid 有权
标题翻译：用高温灭菌液灭菌的产品包装
公开(公告)号：US20050103666A1
公开(公告)日：2005-05-19
申请号：US10485930
申请日：2001-11-16
申请人： Jean-Pierre Grimard , Jean-Claude Thibault
发明人： Jean-Pierre Grimard , Jean-Claude Thibault
IPC分类号： B65D77/26 , A61J1/14 , A61L2/26 , B65D53/04 , B65D81/20 , A61L15/00
CPC分类号： A61L2/183 , A61L2/26 , A61L2202/181 , A61L2202/24 , A61M5/008
摘要： The invention concerns a plastic package, having a content capable of being sterilised at high temperature, said package comprising at least a fluid communication member (16) between the inside and the outside of said package consisting of at least a frame circumscribing an opening and an inner seal (18) closing the opening, and whereof the peripheral edge (18a, 22a) is continuously linked to said frame, said inner seal including, a selectively sealing material sheet whereof the cutoff threshold from outside inwards, stops contaminating particles and allows through the thermal sterilising fluid, said selectively sealing material being deformable in the plane of said sheet at said high temperature. The invention is characterised in that it comprises means compensating the planar deformation of the selectively sealing material sheet, when said inner seal (18) is in contact with the thermal sterilising fluid, said compensating means being designed to release at least part of the load in the direction opening the fluid communication member (16) applied on the frame as a result of said deformation.
摘要翻译：本发明涉及一种塑料包装，其具有能够在高温下灭菌的内容物，所述包装至少包括在所述包装的内部和外部之间的流体连通构件（16），该流体连通构件至少包括围绕开口的框架和封闭开口的内部密封件（18），并且周边边缘（18a，22a）连续地连接到所述框架，所述内部密封件包括选择性地密封材料片，其中从外侧进入的截止阈值停止污染颗粒，允许通过热灭菌流体，所述选择性密封材料可在所述高温下在所述片材的平面中变形。本发明的特征在于，当所述内部密封件（18）与热灭菌流体接触时，其包括补偿选择性密封材料片材的平面变形的装置，所述补偿装置设计成将至少部分负载释放作为所述变形的结果，打开施加在框架上的流体连通构件（16）的方向。

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