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    • 25. 发明申请
    • Use of human prostate cell lines in cancer treatment
    • 人类前列腺细胞系在癌症治疗中的应用
    • US20050249756A1
    • 2005-11-10
    • US11178415
    • 2005-07-12
    • Angus DalgleishPeter SmithAndrew SuttonAnthony Walker
    • Angus DalgleishPeter SmithAndrew SuttonAnthony Walker
    • A61K9/08A61K35/48A61K38/00A61K39/00A61K39/02A61K39/04A61K39/05A61K39/08A61K39/10A61K39/39A61K47/10A61K47/20A61K47/42A61P13/08A61P35/00A61P37/04C12N5/08
    • A61K39/0011A61K2039/5152
    • The invention here relates to a product comprised of a cell line or lines intended for use as an allogeneic immunotherapy agent for the treatment of cancer in mammals and humans. All of the studies of cell-based cancer vaccines to date have one feature in common, namely the intention to use cells that contain at least some TSAs and/or TAAs that are shared with the antigens present in patients' tumour. In each case, tumour cells are utilised as the starting point on the premise that only rumour cells will contain TSAs or TAAs of relevance, and the tissue origins of the cells are matched to the tumour site in patients. A primary aspect of the invention is the use of immortalised normal, non-malignant cells as the basis of an allogeneic cell cancer vaccine. Normal cells do not possess TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines. For prostate cancer, for example, a vaccine may be based on one or a combination of different immortalised normal cell lines derived from the prostate. The cell lines are lethally irradiated utilising gamma irradiation at 50-300 Gy to ensure that they are replication incompetent prior to use in the mammal or human.
    • 本发明涉及由用于治疗哺乳动物和人类癌症的同种异体免疫治疗剂的细胞系或细胞系的产品。 迄今为止,基于细胞的癌症疫苗的所有研究具有共同的特征,即意图使用含有至少一些与存在于患者肿瘤中的抗原共享的TSA和/或TAA的细胞。 在每种情况下,肿瘤细胞以起始点为前提,只有谣言细胞将含有相关性的TSA或TAAs,并且细胞的组织起源与患者的肿瘤部位相匹配。 本发明的主要方面是使用永生化的正常非恶性细胞作为同种异体细胞癌疫苗的基础。 正常细胞不具有TSA或相关浓度的TAA,因此令人惊讶的是,正常细胞作为抗癌疫苗是有效的。 对于前列腺癌,例如,疫苗可以基于来源于前列腺的不同永生化正常细胞系的一种或组合。 使用50-300Gy的γ照射来致死细胞系,以确保它们在使用哺乳动物或人之前是无法复制的。
    • 27. 发明授权
    • Bridge deck panel installation system and method
    • 桥面板安装系统及方法
    • US5802652A
    • 1998-09-08
    • US669170
    • 1996-06-24
    • Peter Smith
    • Peter Smith
    • E01D19/12E01D21/00
    • E01D19/125E01D2101/268
    • A system and method for the installation of prefabricated composite structural members is disclosed. The system utilizes deck panels which have a plurality of structural member pairs attached to the underside such that a series of channels are formed. Bored through each deck panel is a plurality of access holes that project through the panel and into one of said channels. Thus, installers can access underlying bridge girders from the surface of the deck panels thereby allowing for top-side installation. The system also provides a top-side vertically adjusting device for raising or lowering the deck panels to allow for the top-side installation of shimming devices.
    • 公开了一种用于安装预制复合结构构件的系统和方法。 该系统使用具有多个结构构件对的甲板面板,所述结构构件对连接到下侧,使得形成一系列通道。 穿过每个甲板面板的钻孔是穿过面板突出并进入所述通道之一的多个进入孔。 因此,安装人员可以从甲板面板的表面接入底层桥梁,从而允许顶部安装。 该系统还提供了用于升高或降低甲板板的顶部垂直调节装置,以允许顶部安装匀场装置。
    • 28. 发明授权
    • Apparatus and method for receiving and processing a bet
    • 用于接收和处理下注的装置和方法
    • US5464971A
    • 1995-11-07
    • US108705
    • 1994-01-31
    • Peter H. SutcliffePeter Smith
    • Peter H. SutcliffePeter Smith
    • G06Q50/00G07B1/02G07G5/00G06F15/30
    • G06Q50/34G07B1/02G07F17/3288G07G5/00
    • In a betting shop terminal, a betting slip is inserted into a slot, and pressed against a glass plate by means of a hinged plate. A CCD camera generates an electrical image of the betting slip, and stores it in a memory. A thermal printer generates a hard copy of the image of the betting slip, from the stored electrical image signal, together with additional information, to form a receipt for the customer. The additional information comprises a unique serial number, the amount of the stake, and optionally the time of the bet. This information is stored also in the memory, together with the electrical image. The bet can be fully entered at a later time, subsequent to the transaction, by a settler, using the terminal or an alternative terminal. Winning bets are automatically calculated from the entered information and race information received from a remote station. A plurality of such terminals intercommunicate to process shared data. A remote station can receive data relating to bets taken etc., from the terminal over a communication link.
    • PCT No.PCT / GB92 / 00449 Sec。 371日期1994年1月31日 102(e)日期1994年1月31日PCT 1991年3月12日PCT公布。 第WO92 / 16914号公报 日期为1992年10月1日。在博彩店终端中,将投注单插入槽中,并通过铰链板压在玻璃板上。 CCD相机产生投注单的电子图像,并将其存储在存储器中。 热敏打印机从存储的电子图像信号与附加信息一起产生投注单的图像的硬拷贝,以形成客户的收据。 附加信息包括唯一的序列号,权益的数量,以及可选的下注时间。 该信息也与电子图像一起存储在存储器中。 投注可以在交易之后的下一个时间,由定居者使用终端或替代终端完全输入。 从输入的信息和从远程站接收的比赛信息自动计算获胜投注。 多个这样的终端相互通信以处理共享数据。 远程站可以通过通信链路从终端接收与等待的赌注有关的数据。
    • 29. 发明授权
    • Singly fueled multiple thrusters simultaneously energized by a common
power supply
    • 单一燃料的多个推进器同时由公共电源供电
    • US5339623A
    • 1994-08-23
    • US993769
    • 1992-12-22
    • Peter Smith
    • Peter Smith
    • B64G1/00B64G1/26B64G1/40F03H1/00F02K1/00
    • F03H1/0018B64G1/26B64G1/406B64G1/007
    • A spacecraft has, in addition to redundant thrusters T3, T4 prime thrusters T1 or T2 arranged to be operated one at a time which are supplied with propellant 1 via valves V1 and V2. The thrusters are of the kind in which energy is transferred to the propellant by employing electrodes which create a current flow path through the propellant gas. A single power supply PSU1 provides power to several electrically-powered thrusters. It is connected such that when actuated all the thrusters to which it is connected become charged. However, only the thruster which receives propellant is able to carry current as the propellant forms part of the current carrying circuit, and this thruster therefore draws power. This technique allows the use of a single power supply for several thrusters while eliminating or minimizing the necessity to switch power from one thruster to another.
    • 除了冗余的推进器T3,T4之外,还有一个主动推进器T1或T2,它们被布置成一次一个地被操作,一个通过阀V1和V2被供给推进剂1。 推进器是通过使用产生通过推进剂气体的电流流动的电极将能量转移到推进剂的那种。 单个电源PSU1为几个电动推进器提供电力。 它被连接成使得当其被连接的所有推进器被致动时被充电。 然而,只有接收推进剂的推进器才能够承载电流,因为推进剂形成了载流电路的一部分,因此该推进器就会吸引电力。 这种技术允许为几个推进器使用单个电源,同时消除或最小化从一个推进器切换到另一个推进器的必要性。
    • 30. 发明授权
    • Reactive dyes
    • 活性染料
    • US5019134A
    • 1991-05-28
    • US391291
    • 1989-08-08
    • Denis R. A. RidyardPeter Smith
    • Denis R. A. RidyardPeter Smith
    • C09B19/00C09B62/002C09B62/04C09B62/503D06P1/38
    • C09B62/0025
    • Triphenodioxazine reactive dyes containing at least one fiber-reactive group, the dye, in the free acid form, having the formula: ##STR1## wherein each of T.sup.1 and T.sup.2, independently, represents H, Cl, Br, F, SO.sub.3 H or an optionally substituted alkyl or aryl radical;each of A.sup.1 and A.sup.2 represents alkyl, alkoxy, Cl, Br, COOH, SO.sub.3 H or optionally substituted sulphamoyl;n has a value of 0, 1 or 2;m has a value of 1 or 2;R.sup.1 represents H or a group of the formula: ##STR2## wherein Z represents a fiber-reactive group;each of R.sup.2 and R.sup.3, independently, represents H or an optionally substituted hydrocarbon radical;B represents an optionally substituted divalent hydrocarbon radical; andD represents a group of the formula ##STR3## wherein R.sup.4 represents H, an optionally substituted hydrocarbon radical free from fiber-reactive residues or an acyl radical;R.sup.5 represents H or an optionally substituted hydrocarbon radical;R.sup.6 represents H or an optionally substituted hydrocarbon radical free from fiber-reactive residues;Q represents O or S; anda has a value of 0 or 1,with the proviso that when D is NH.sub.2, B is an arylene radical.