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21. 发明授权

US06825003B2 Cyclic lipopeptide acylase 失效
标题翻译：循环脂肽酰基转移酶
公开(公告)号：US06825003B2
公开(公告)日：2004-11-30
申请号：US10050150
申请日：2002-01-18
申请人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
发明人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
IPC分类号： C12N120
CPC分类号： C12P21/02 , A61K38/00 , C07K7/56 , C12N9/80
摘要： The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl]
摘要翻译：本发明提供一种环状脂肽酰基转移酶，其可以有效地使酰基侧链环化脂肽化合物脱酰化，特别是FR901379由下列通式[I]表示的物质或其类似物，以及环肽化合物的制备方法包括使用所述酰基转移酶[其中R 1是酰基; R 2是羟基或酰氧基; R 3是氢或羟基; R 4是氢或羟基; R 5是氢或羟基磺酰氧基和R 6是氢或氨基甲酰基]

22. 发明授权

US06576135B1 Method for separating lactone-containing high-molecular weight compounds 有权
公开(公告)号：US06576135B1
公开(公告)日：2003-06-10
申请号：US10069964
申请日：2002-03-08
申请人： Tomoji Higaki , Takashi Yoshiyasu , Norihiro Hashimoto , Keiji Honda , Hiroshi Hatanaka , Michio Yamashita
发明人： Tomoji Higaki , Takashi Yoshiyasu , Norihiro Hashimoto , Keiji Honda , Hiroshi Hatanaka , Michio Yamashita
IPC分类号： B01D1508
CPC分类号： C07D498/18
摘要： A method for separating a lactone-containing high-molecular weight compound comprising subjecting a mixture of a lactone-containing high-molecular weight compound having, as its side-chain, at least one of a lower alkenyl group and a lower alkoxy group and its analogous compound(s) to either one or both steps in any order of a step (A) for adsorbing the mixture to a nonionic adsorption resin and eluting with an aqueous solvent containing silver ions, and a step (B) for adsorbing the mixture to a basic active alumina and eluting with an organic solvent to separate each of the compounds.

23. 发明授权

US06492513B1 Method for separating analogous organic compounds 有权
标题翻译：分离类似有机化合物的方法
公开(公告)号：US06492513B1
公开(公告)日：2002-12-10
申请号：US09926611
申请日：2001-11-26
申请人： Yutaka Nishihara , Keiji Honda , Koji Mukai , Norihiro Hashimoto , Hiroshi Hatanaka , Michio Yamashita
发明人： Yutaka Nishihara , Keiji Honda , Koji Mukai , Norihiro Hashimoto , Hiroshi Hatanaka , Michio Yamashita
IPC分类号： C07D49816
CPC分类号： C07D498/18 , B01D15/185 , B01D2215/023 , B01J39/05 , B01J39/20 , B01J39/26
摘要： The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.
摘要翻译：本发明涉及一种通过使用磺酸基从具有烯基作为侧链的含内酯的高分子量化合物分离具有烷基作为侧链的含内酯的高分子量化合物的方法含有银离子预处理的阳离子交换树脂。

24. 发明授权

US06423530B1 Process for preparing FR900482 and compounds analogous thereto 失效
标题翻译：制备FR900482及其类似物的方法
公开(公告)号：US06423530B1
公开(公告)日：2002-07-23
申请号：US09705898
申请日：2000-11-06
申请人： Masaru Tsuboi , Shiho Shimizu , Michio Yamashita , Yasuhisa Tsurumi , Seiji Hashimoto
发明人： Masaru Tsuboi , Shiho Shimizu , Michio Yamashita , Yasuhisa Tsurumi , Seiji Hashimoto
IPC分类号： C12N114
CPC分类号： C12P17/188 , Y10S435/929
摘要： A process for producing a compound of the general formula (I): (wherein R1 represents hydrogen, a lower alkanoyl group or a lower alkyl group; R2 and R3 each represents hydrogen or a lower alkanoyl group) characterized in that a compound of the general formula (II): (wherein R1, R2 and R3 are respectively as defined above) is reacted with a culture of a strain of microorganism belonging to the genus Fusarium or its cells harvested by filtering the broth.
摘要翻译：一种制备通式（I）的化合物的方法（其中R 1表示氢，低级烷酰基或低级烷基; R 2和R 3各自表示氢或低级烷酰基），其特征在于通式式（II）:(其中R1，R2和R3分别如上定义）与属于镰刀菌属的微生物菌株或通过过滤肉汤收获的细胞的培养物反应。

25. 发明授权

US06372474B1 Cyclic lipopeptide acylase 失效
标题翻译：循环脂肽酰基转移酶
公开(公告)号：US06372474B1
公开(公告)日：2002-04-16
申请号：US09659335
申请日：2000-09-12
申请人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
发明人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
IPC分类号： C12N950
CPC分类号： C12P21/02 , A61K38/00 , C07K7/56 , C12N9/80
摘要： The present invention provides a cyclic lipopeptide acrylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl]
摘要翻译：本发明提供一种环状脂肽丙烯酸酯，其可以有效地脱酰基环状脂肽化合物的酰基侧链，特别是由以下通式[I]表示的FR901379物质或其类似物，以及环肽化合物的制备方法包括使用所述酰基转移酶[其中R1是酰基; R2是羟基或酰氧基; R3是氢或羟基; R4是氢或羟基; R5是氢或羟基磺酰氧基; 和R6是氢或氨基甲酰基]

26. 发明授权

US06207434B1 Process for the deacylation of cyclic lipopeptides 有权
标题翻译：环状脂肽脱酰的方法
公开(公告)号：US06207434B1
公开(公告)日：2001-03-27
申请号：US09142045
申请日：1998-09-03
申请人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
发明人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
IPC分类号： C12N914
CPC分类号： C12R1/465 , C07K7/56 , C12N9/80
摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.
摘要翻译：提供了能够使环状脂肽化合物的酰基侧链脱酰化的环状脂肽酰基酶。物质FR901379或其具有通式[I]的类似物，其有效性以及包含使用酰基转移酶的环肽化合物的制备方法。

27. 发明授权

US5446022A WF11243 substance 失效
标题翻译： WF11243物质
公开(公告)号：US5446022A
公开(公告)日：1995-08-29
申请号：US140074
申请日：1993-11-04
申请人： Akihiko Fujie , Shigehiro Takase , Michio Yamashita , Tomoko Sato , Seiji Hashimoto , Masakuni Okuhara
发明人： Akihiko Fujie , Shigehiro Takase , Michio Yamashita , Tomoko Sato , Seiji Hashimoto , Masakuni Okuhara
IPC分类号： A61K38/00 , C07K7/08 , C12P21/04 , C07K11/02 , A61K38/12 , C12N1/14 , C12P21/02
CPC分类号： C07K7/08 , A61K38/00 , Y10S435/911
摘要： The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.
摘要翻译： PCT No.PCT / JP92 / 00586 Sec。 371日期：1993年11月4日 102（e）日期1993年11月4日PCT提交1992年5月8日PCT公布。 WO92 / 19648 PCT出版物本发明涉及具有以下推定结构的新型多肽：t杀真菌剂和原生动物作用。

28. 发明授权

US4768363A Method of levelling two-layered clad metal sheet 失效
标题翻译：两层复合金属板的整平方法
公开(公告)号：US4768363A
公开(公告)日：1988-09-06
申请号：US887033
申请日：1986-07-02
申请人： Michio Yamashita , Hiroshi Yoshida , Toru Sasaki , Hideo Abe , Tsuneo Nagamine , Norio Takashima , Hideki Watanabe , Shuji Watanabe
发明人： Michio Yamashita , Hiroshi Yoshida , Toru Sasaki , Hideo Abe , Tsuneo Nagamine , Norio Takashima , Hideki Watanabe , Shuji Watanabe
IPC分类号： B21B1/38 , B21B37/44 , B21D1/02 , C21D1/00 , B21D37/16 , B21D3/02
CPC分类号： B21D1/02 , B21B37/44 , C21D1/00 , B21B2001/383
摘要： A method for preventing the camber of a two-layered clad metal sheet having a base layer and a covering layer of different metals which exhibit different amounts of thermal contraction. The method comprises developing a temperature difference .DELTA. T expressed by the following formula between the base layer and the covering layer during a hot levelling, by providing a greater cooling effect before or during levelling to the layer which exhibits the greater thermal contraction than to the layer which exhibits the smaller thermal contraction:.DELTA.T=f (.DELTA..alpha., .alpha., a, To)where,.DELTA..alpha.: the difference in thermal expansion coefficient between both metalsa: the clad ratio (ratio of covering layer thickness to total sheet thickness)To: hot leveller inlet temperature (.degree.C.).alpha.: mean thermal expansion coefficient of both metals.Since the layer which exhibits a greater thermal contraction is forcibly cooled before or during a hot levelling adequately and by a required amount, the clad metal sheet does not exhibit any substantial camber after cooled down to the room temperature.
摘要翻译： PCT No.PCT / JP85 / 00658 Sec。 371日期：1986年7月2日 102（e）日期1986年7月2日PCT提交1985年11月28日PCT公布。公开号WO86 / 03435 日期：1986年6月19日。一种防止具有不同金属的基底层和覆盖层的两层复合金属片的弯度的方法，其具有不同的热收缩量。该方法包括在热平整过程中在基底层和覆盖层之间通过下列公式表示的温差DELTA T，通过在与层之间呈现更大的热收缩的层的平整之前或期间提供更大的冷却效果其表现出较小的热收缩：DELTA T = f（DELTAα，α，a，To）其中，ΔTAα：两种金属之间的热膨胀系数之差a：包层比（覆盖层厚度与总板厚的比率）To：热矫平机入口温度（℃）α：两种金属的平均热膨胀系数。由于表现出较大的热收缩的层在热调平之前或期间被充分地强度冷却并且所需的量，所以在冷却至室温后，复合金属板不会显示任何实质的弧度。

29. 发明授权

US4743555A Biologically pure culture of Streptomyces sandaensis No. 6897 失效
标题翻译： Streptomyces sandaensis No.6897的生物纯培养
公开(公告)号：US4743555A
公开(公告)日：1988-05-10
申请号：US913478
申请日：1986-09-30
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/04 , C07D498/18 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55 , Y10S435/886
摘要： A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.

30. 发明授权

US07858219B2 Locking mechanism of battery pack 有权
标题翻译：电池组的锁定机构
公开(公告)号：US07858219B2
公开(公告)日：2010-12-28
申请号：US12160219
申请日：2007-01-11
申请人： Kigen Agehara , Michio Yamashita
发明人： Kigen Agehara , Michio Yamashita
IPC分类号： H01M2/10 , B23B51/00 , B23B21/00 , B23Q5/04
CPC分类号： H01M2/1022 , B25F5/02 , H01M2/1055
摘要： A locking mechanism of a battery pack A is provided with a hook 14 which can be locked to a mounting part B of an object equipment such as an electric tool in a state slid with respect to the mounting part, and operation parts 16 for releasing the lock which are linked to the hook 14, on a case which contains a battery. The hook 14 is urged to move upward by an elastic body in a direction of being locked to the mounting part B.The operation parts 16 are arranged in both side parts of the case within such a range that they can be grasped with a single hand from both sides of a backward end in the sliding direction of the case. When the operation parts 16 are operated from the both sides, the lock between the hook 14 and the mounting part B is released against the urge by the elastic body.
摘要翻译：电池组A的锁定机构设置有钩14，该钩14可以相对于安装部滑动的状态被锁定到诸如电动工具的物体设备的安装部分B，以及用于释放锁定在与包含电池的壳体上连接的钩14上。钩14被弹性体沿着与安装部分B锁定的方向向上移动。操作部16布置在壳体的两侧部分中，可以用单手抓住从壳体的滑动方向的后端的两侧。当从两侧操作操作部件16时，钩14和安装部件B之间的锁定被克服弹性体的冲击而释放。

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