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21. 发明授权

US6005100A Trehalose composition for prolonging product shelf life 失效
标题翻译：海藻糖组合物延长产品保质期
公开(公告)号：US6005100A
公开(公告)日：1999-12-21
申请号：US874736
申请日：1997-06-13
申请人： Takahiko Mandai , Takashi Shibuya , Toshiyuki Sugimoto , Toshio Miyake
发明人： Takahiko Mandai , Takashi Shibuya , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23C9/123 , A23L3/3427 , A23L3/3562 , A23L3/42 , A23L15/00 , A61K8/60 , A61Q5/00 , A61Q7/00 , A61Q19/00 , B01J20/22 , C07H1/00
CPC分类号： B01J20/22 , A23C9/1232 , A23L15/20 , A23L3/3427 , A23L3/3562 , A23L3/42 , A61K8/60 , A61Q19/00 , A61Q11/00 , A61Q5/00 , A61Q7/00
摘要： Disclosed are a novel desiccant containing a non-reducing anhydrous trehalose as an effective ingredient; a dehydration of hydrous matters, e.g. food products, pharmaceuticals and cosmetics, therewith; and dehydrated products obtained by the dehydration. Such hydrous matters are dehydrated without causing alteration or deterioration by incorporating anhydrous trehalose into the hydrous matters to convert the anhydrous trehalose into hydrous crystalline trehalose. The anhydrous trehalose are anhydrous crystalline trehalose and hydrous amorphous trehalose.
摘要翻译：公开了含有非还原性无水海藻糖作为有效成分的新型干燥剂; 水合物的脱水，例如食品，药品和化妆品; 脱水得到的脱水产物。这些含水物质通过将无水海藻糖掺入含水物质中而不引起改变或劣化，将无水海藻糖转化成含水结晶海藻糖而脱水。无水海藻糖是无水结晶海藻糖和含水无定形海藻糖。

22. 发明授权

US5922580A Non-reducing saccharide-forming enzyme, its preparation and uses 失效
公开(公告)号：US5922580A
公开(公告)日：1999-07-13
申请号：US941553
申请日：1997-09-30
申请人： Kazuhiko Maruta , Michio Kubota , Toshiyuki Sugimoto , Toshio Miyake
发明人： Kazuhiko Maruta , Michio Kubota , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23L1/236 , A21D2/18 , A23C9/13 , A23C9/152 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/48 , A23G4/00 , A23G4/10 , A23J3/16 , A23L1/09 , A23L1/31 , A23L1/314 , A23L1/32 , A23L2/60 , A61K8/00 , A61K8/60 , A61K8/66 , A61K8/73 , A61K9/36 , A61K31/00 , A61K31/02 , A61K38/21 , A61K47/26 , A61Q11/00 , A61Q17/04 , A61Q19/00 , C07H20060101 , C07H1/00 , C07H1/06 , C07H3/00 , C07H3/04 , C07H3/06 , C07K7/00 , C08B37/00 , C12N1/20 , C12N9/24 , C12N9/26 , C12N9/90 , C12P19/00 , C12P19/12 , C12P19/14 , C12P19/24 , C12R1/41 , C13K20060101 , C13K13/00 , C07H3/02
CPC分类号： C13K13/00 , A23G3/343 , A23G3/346 , A23G3/42 , A23G4/10 , A23L13/428 , A23L15/20 , A23L27/33 , A61K8/60 , A61K8/66 , A61Q11/00 , A61Q19/00 , C07H1/00 , C07H3/04 , C12N9/90 , C12P19/12 , A23G2200/06 , A61Q17/04 , A61Q19/02 , A61Q7/00
摘要： Disclosed are novel non-reducing saccharide-forming enzyme, and its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Rhizobium sp. M-11 (FERM BP 4130) and Arthrobacter sp. Q36 (FERM BP-4316), and capable of forming non-reducing saccharides having a trehalose structure when allowed to act on reducing partial starch hydrolysates. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals.

23. 发明授权

US5885969A Enzyme-treated hesperidin, process for producing the same and method of using enzyme-treated hesperidin 失效
标题翻译：酶处理的橙皮苷，其制备方法和使用酶处理的橙皮苷的方法
公开(公告)号：US5885969A
公开(公告)日：1999-03-23
申请号：US881056
申请日：1997-06-24
申请人： Toshio Miyake , Takashi Yumoto
发明人： Toshio Miyake , Takashi Yumoto
IPC分类号： A23L2/02 , A23B7/154 , A23L1/272 , A23L1/275 , A23L2/44 , A23L2/58 , A23L2/70 , A23L3/3544 , C07H17/07 , C09B67/00 , C12P19/14 , C12P19/60 , A61K31/70
CPC分类号： C12P19/605 , A23B7/154 , A23L2/44 , A23L2/58 , A23L3/3544 , A23L5/41 , C07H17/07
摘要： An enzyme-treated hesperidin, comprising alpha-glucosyl hesperidin, hesperidin and beta-monoglucosyl hesperetin, wherein the content of hesperidin is 0.1 part or less by weight; and that of beta-monoglucosyl hesperetin, 0.1 to 0.5 part by weight, on the basis of 1 part by weight of alpha-glucosyl hesperidin. The present invention also provides a process to produce enzyme-treated hesperidin, which comprises subjecting a solution containing alpha-glucosyl hesperidin and intact hesperidin to alpha-L-rhamnosidase to convert the intact hesperidin into beta-monoglucosyl hesperetin. The enzyme-treated hesperidin, which is excellent in water solubility and is free from crystal precipitation (clouding) even if stored for a prolonged period of time, can be produced from a material containing alpha-glucosylhesperidin and hesperidin by conducting the above simple treatment of material. The present invention further provides a method of using the enzyme-treated hesperidin. The enzyme-treated hesperidin can be used in the prevention of clouding of a canned tangerine and prevention of fading of natural coloring matter.
摘要翻译：一种酶处理的橙皮苷，其包含α-葡糖基橙皮苷，橙皮苷和β-单葡萄糖基橙皮素，其中橙皮苷的含量为0.1重量份或更少; 基于1重量份的α-葡萄糖基橙皮苷的β-葡萄糖基橙皮素0.1〜0.5重量份。本发明还提供了一种生产酶处理的橙皮苷的方法，其包括将含有α-葡糖基橙皮苷和完整的橙皮苷的溶液经受α-L-鼠李糖苷酶将完整的橙皮苷转化成β-单葡糖基橙皮素。通过进行上述简单的处理，可以通过含有α-葡萄糖苷基和橙皮苷的材料来生产即使长时间贮存也具有优异的水溶性并且没有晶体沉淀（混浊）的酶处理橙皮苷材料。本发明还提供了使用酶处理的橙皮苷的方法。酶处理的橙皮苷可用于防止罐装橘子的混浊和防止天然色素的褪色。

24. 发明授权

US5883243A Non-reducing saccharides, their preparations and uses 失效
标题翻译：非还原糖，其制备和用途
公开(公告)号：US5883243A
公开(公告)日：1999-03-16
申请号：US797248
申请日：1997-02-07
申请人： Tomoyuki Nishimoto , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
发明人： Tomoyuki Nishimoto , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： C07H3/06 , C12P19/04 , C07H1/00 , C12P19/00
CPC分类号： C07H3/06 , C12P19/04
摘要： .alpha.-Isomaltosyl .alpha.-isomaltoside represented by O-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-.alpha.-D-glucopyranosyl O-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-.alpha.-D-glucopyranoside is a novel non-reducing saccharide which promotes the growth of bifid bacteria, has an anti-caries activity, and promotes the mineral absorption. Similarly as the non-reducing saccharide, .alpha.-isomaltosyl .alpha.-glucoside and .alpha.-isomaltotriosyl .alpha.-glucoside can be also used to prevent caries and promote the growth of bifid bacteria and the mineral absorption. These saccharides can be used alone or in combination in a variety of foods, cosmetics and pharmaceuticals.
摘要翻译：由α-α-D-吡喃葡萄糖基 - （1-> 6）-β-D-吡喃葡萄糖基O-α-D-吡喃葡萄糖基 - （1-> 6）-β-D-吡喃葡萄糖苷代表的α-异麦角糖型α-异麦芽糖苷是促进双歧杆菌生长的新型非还原性糖类具有抗龋齿活性，促进矿物质吸收。类似地，作为非还原性糖，α-异麦芽糖基α-葡萄糖苷和α-异麦芽糖基α-葡糖苷也可用于预防龋齿并促进双歧杆菌的生长和矿物质吸收。这些糖类可以单独使用，也可以组合使用于各种食品，化妆品，药品等。

25. 发明授权

US5876975A Trehalose phosphorylase its preparation and uses 失效
标题翻译：海藻糖磷酸酶的制备及用途
公开(公告)号：US5876975A
公开(公告)日：1999-03-02
申请号：US103509
申请日：1998-06-24
申请人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K38/00 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C12P19/44 , C07K1/00 , C12P21/06
CPC分类号： C12N9/1051 , C12P19/18 , A61K38/00
摘要： A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with .beta.-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.
摘要翻译：一种热稳定的海藻糖磷酸化酶，其可从Thermoanaerobium属的微生物获得，并且在无机磷酸存在下水解海藻糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸。海藻糖磷酸化酶也可以通过重组DNA技术制备。当酶在其他糖类存在下与β-D-葡萄糖-1-磷酸作为糖供体接触时，通常已知但几乎不可获得的包括葡糖基-D-半乳糖苷的葡糖基转移的糖可以是以工业规模生产，成本相对较低。

26. 发明授权

US5780620A Non-reducing oligosaccharides and their production and use 失效
标题翻译：非还原寡糖及其生产和使用
公开(公告)号：US5780620A
公开(公告)日：1998-07-14
申请号：US762940
申请日：1996-12-10
申请人： Takahiko Mandai , Takashi Shibuya , Toshiyuki Sugimoto , Toshio Miyake
发明人： Takahiko Mandai , Takashi Shibuya , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23L1/236 , A23C9/00 , A23C9/13 , A23C9/156 , A23C9/20 , A23G1/00 , A23G1/40 , A23G3/00 , A23G3/34 , A23G3/42 , A23G4/00 , A23G4/10 , A23L1/054 , A23L1/064 , A23L1/09 , A23L1/187 , A23L1/39 , A23L2/00 , A23L2/39 , A23L2/52 , A23L2/60 , A61K8/60 , A61K8/63 , A61K8/73 , A61K9/00 , A61K9/20 , A61K31/70 , A61K31/702 , A61K31/715 , A61K47/36 , A61P3/00 , A61P3/02 , A61Q7/00 , A61Q11/00 , A61Q19/00 , C07H3/06 , C08B37/00 , C12P19/14 , C12P19/18 , C13K13/00 , C07H1/00
CPC分类号： C12P19/18 , A23C9/1307 , A23C9/156 , A23C9/203 , A23G1/40 , A23G3/346 , A23G3/42 , A23G4/10 , A23L2/39 , A23L2/52 , A23L2/60 , A23L21/12 , A23L23/00 , A23L27/33 , A23L27/36 , A23L29/35 , A23L9/10 , A61K8/60 , A61Q19/00 , C07H3/06 , C12P19/14 , C12Y204/01019 , C12Y302/0102 , C12Y302/02001 , A23G2200/06 , A61Q11/00 , A61Q17/04 , A61Q19/02 , A61Q7/00
摘要： Novel non-reducing oligosaccharide having a structure represented by the formula of alpha-D-oligoglucosyl alpha-D-oligoglucoside is obtained by exposing either an aqueous solution which contains trehalose and an alpha-glucosyl saccharide or an aqueous solution which contains a non-reducing saccharide bearing a trehalose structure at its end to a saccharide-transferring enzyme. The oligosaccharide has a reduced sweetness, superior stability, appropriate viscosity and less or no susceptibility to crystallization or superior solubility when in crystalline form. These features make the oligosaccharide very useful in various compositions including foods, beverages, cosmetics, pharmaceuticals and shaped bodies.
摘要翻译：通过将含有海藻糖和α-葡糖基糖的水溶液或含有非还原性糖的糖水溶液暴露于具有由下式表示的结构的新型非还原性寡糖的α-脱氧葡糖苷在其末端具有糖转移酶的海藻糖结构的糖类。低聚糖具有降低的甜度，优异的稳定性，适当的粘度，较少或不结晶的易感性或在结晶形式时具有优异的溶解性。这些特征使寡糖在各种组合物中非常有用，包括食品，饮料，化妆品，药物和成型体。

27. 发明授权

US5714368A Thermostable non-reducing saccharide-forming enzyme its production and uses 失效
标题翻译：热稳定性非还原性糖形成酶其生产和用途
公开(公告)号：US5714368A
公开(公告)日：1998-02-03
申请号：US466434
申请日：1995-06-06
申请人： Tetsuya Nakada , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
发明人： Tetsuya Nakada , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23L7/10 , A23L27/00 , C12N9/24 , C12P19/14 , C12N9/26 , C12N9/10 , C12N9/14
CPC分类号： C12P19/14 , C12N9/2428 , C12Y302/01003
摘要： Disclosed are novel thermostable non-reducing saccharides-forming enzyme, its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Sulfolobus acidocaldarius (ATCC 33909 and ATCC 49426) and Sulfolobus solfataricus (ATCC 35091 and ATCC 35092), and capable of forming non-reducing saccharides having a trehalose structure as an end unit when allowed to act on reducing partial starch hydrolysates at a temperature of over 55.degree. C. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals.
摘要翻译：公开了新型热稳定性非还原性糖形成酶，其制备和用途。该酶可以从微生物的培养物获得，例如硫酸亚硫酸杆菌（ATCC 33909和ATCC 49426）和溶血糠鱼（Sulfolobus solfataricus）（ATCC 35091和ATCC 35092），并且能够形成具有海藻糖结构的非还原性糖作为终端单元在超过55℃的温度下还原部分淀粉水解产物起作用。当允许作用于非还原糖时，葡糖淀粉酶和α-葡糖苷酶容易产生海藻糖。这些非还原性糖和海藻糖广泛用于食品，化妆品和药物。

28. 发明授权

US5610047A Non-reducing saccharide-forming enzyme, its preparation and uses 失效
标题翻译：非还原性糖形成酶，其制备及用途
公开(公告)号：US5610047A
公开(公告)日：1997-03-11
申请号：US412865
申请日：1995-03-29
申请人： Kazuhiko Maruta , Michio Kubota , Toshiyuki Sugimoto , Toshio Miyake
发明人： Kazuhiko Maruta , Michio Kubota , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23L1/236 , A21D2/18 , A23C9/13 , A23C9/152 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/48 , A23G4/00 , A23G4/10 , A23J3/16 , A23L1/09 , A23L1/31 , A23L1/314 , A23L1/32 , A23L2/60 , A61K8/00 , A61K8/60 , A61K8/66 , A61K8/73 , A61K9/36 , A61K31/00 , A61K31/02 , A61K38/21 , A61K47/26 , A61Q11/00 , A61Q17/04 , A61Q19/00 , C07H20060101 , C07H1/00 , C07H1/06 , C07H3/00 , C07H3/04 , C07H3/06 , C07K7/00 , C08B37/00 , C12N1/20 , C12N9/24 , C12N9/26 , C12N9/90 , C12P19/00 , C12P19/12 , C12P19/14 , C12P19/24 , C12R1/41 , C13K20060101 , C13K13/00 , C12N9/10 , C12N9/14
CPC分类号： C13K13/00 , A23G3/343 , A23G3/346 , A23G3/42 , A23G4/10 , A23L13/428 , A23L15/20 , A23L27/33 , A61K8/60 , A61K8/66 , A61Q11/00 , A61Q19/00 , C07H1/00 , C07H3/04 , C12N9/90 , C12P19/12 , A23G2200/06 , A61Q17/04 , A61Q19/02 , A61Q7/00
摘要： Disclosed are novel non-reducing saccharide-forming enzyme, and its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Rhizobium sp. M-11 (FERM BP 4130) and Arthrobacter sp. Q36 (FERM BP-4316), and capable of forming non-reducing saccharides having a trehalose structure when allowed to act on reducing partial starch hydrolysates. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals.
摘要翻译：公开了新型非还原性糖形成酶及其制备和用途。该酶可从诸如根瘤菌属的微生物培养物获得。 M-11（FERM BP 4130）和节杆菌属 Q36（FERM BP-4316），并能够形成具有海藻糖结构的非还原性糖类，当其作用于还原部分淀粉水解产物时。葡糖淀粉酶和α-葡萄糖苷酶当允许作用于非还原糖时容易产生海藻糖。这些非还原性糖和海藻糖广泛用于食品，化妆品和药物。

29. 发明授权

US5529779A Purified propolis-extract, and its preparation and uses 失效
标题翻译：纯化蜂胶提取物及其制备和用途
公开(公告)号：US5529779A
公开(公告)日：1996-06-25
申请号：US243548
申请日：1994-05-16
申请人： Shoich Hamada , Satoshi Iritani , Toshio Miyake
发明人： Shoich Hamada , Satoshi Iritani , Toshio Miyake
IPC分类号： A23C9/12 , A23G1/00 , A23G1/30 , A23G3/00 , A23G3/34 , A23G3/48 , A23G4/00 , A23L1/076 , A23L1/30 , A23L2/38 , A24B15/10 , A61K8/00 , A61K8/96 , A61K8/98 , A61K35/64 , A61K36/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , B01D11/02 , B01D15/00 , A61K35/78
CPC分类号： A61K36/00 , A61K35/644 , A61K8/988 , A61Q19/00 , A61Q11/00 , A61Q17/04 , A61Q19/02
摘要： Disclosed is a novel purified propolis-extract which contains the effective components of propolis in a readily absorbable- and utilizable-form in vivo, as well as having an absorbance ratio (A.sub.310 /A.sub.660) of higher than 4,000, having a relatively-high quality and a satisfactory handleability, color, flavor, taste and antiseptic activity, and being substantially free of resins, waxes and dark colored impurities. The purified propolis-extract is prepared by a process comprising decreasing a readily water-soluble organic solvent in its aqueous high-concentration solution containing a crude propolis-extract to a prescribed concentration to form an upper-layer liquid containing the effective components of propolis and a lower-layer liquid containing a viscous sediment, and separating and recoverying the upper-layer liquid.
摘要翻译：公开了一种新颖的纯化蜂胶提取物，其在体内含有易吸收和可利用的形式的蜂胶的有效成分，并且具有高于4000的吸光度比（A310 / A660），具有相对高的质量并且具有令人满意的可操作性，颜色，风味，味道和防腐活性，并且基本上不含树脂，蜡和深色杂质。纯化的蜂胶提取物通过包括将含有粗蜂胶 - 提取物的含水高浓度溶液中容易溶于水的有机溶剂降低至规定浓度以形成含有蜂胶有效成分的上层液体的方法制备，含有粘性沉淀物的下层液体，以及分离和回收上层液体。

30. 发明授权

US5494667A Topically applied hair restorer containing pine extract 失效
标题翻译：含松果体的局部应用毛发修复剂
公开(公告)号：US5494667A
公开(公告)日：1996-02-27
申请号：US255897
申请日：1994-06-07
申请人： Yukio Uchida , Satoshi Iritani , Toshio Miyake
发明人： Yukio Uchida , Satoshi Iritani , Toshio Miyake
IPC分类号： A61K8/67 , A61K8/97 , A61K36/00 , A61K36/736 , A61Q7/00 , A61K35/78
CPC分类号： A61Q7/00 , A61K8/676 , A61K8/97 , A61Q5/006
摘要： A pine extract combined with a bamboo extract and/or a Japanese apricot extract effectively promotes the growth and regeneration of hair for human and animals. Administration of these compounds leads to no substantial side effects. The topically applied hair restorer containing these compounds is also effective in the prevention of alopecias, as well as in the protection of falling out of hair, dandruff, and itching of the scalp. These properties render these compounds useful in hair restorers for human and animals.
摘要翻译：与竹提取物和/或日本杏提取物组合的松树提取物有效地促进人和动物的头发的生长和再生。这些化合物的施用导致没有实质的副作用。包含这些化合物的局部应用的头发恢复剂在预防脱发以及保护脱发，头皮屑和头皮瘙痒方面也是有效的。这些性质使这些化合物可用于人和动物的毛发修复。

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