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21. 发明授权

US09175295B2 Modified transposon vector and its use 有权
标题翻译：改性转座子载体及其用途
公开(公告)号：US09175295B2
公开(公告)日：2015-11-03
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： C12N15/79 , C12N5/10 , C12N15/85
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

22. 发明申请

US20110183911A1 METHOD FOR IMPROVING NEUROTRANSMISSION FAILURE USING A NOVEL AGENT 审中-公开
标题翻译：使用新型药剂改善神经递质失败的方法
公开(公告)号：US20110183911A1
公开(公告)日：2011-07-28
申请号：US13012545
申请日：2011-01-24
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/17 , C07K14/435 , A61P25/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

23. 发明申请

US20100291122A1 METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 有权
标题翻译：用于增强与肽的免疫应答的方法
公开(公告)号：US20100291122A1
公开(公告)日：2010-11-18
申请号：US12596741
申请日：2008-04-18
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K39/00 , C07K14/435 , A61K38/17 , A61P25/28 , A61P37/04
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白诱导增强的免疫应答的肽。淀粉样蛋白肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白肽或其部分诱导增强的免疫应答。可能具有相同作用的DNA疫苗，其包含编码淀粉样蛋白的基因; 肽或其部分，其通过加入或插入半胱氨酸诱导增强的免疫应答。

24. 发明申请

US20100281551A1 MODIFIED TRANSPOSON VECTOR AND ITS USE 有权
标题翻译：改进的传输矢量及其使用
公开(公告)号：US20100281551A1
公开(公告)日：2010-11-04
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： A01K67/033 , C12N15/79 , C12P21/00 , C12N5/10
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

25. 发明申请

US20100272271A1 SPEAKER SYSTEM 有权
标题翻译：扬声器系统
公开(公告)号：US20100272271A1
公开(公告)日：2010-10-28
申请号：US12373631
申请日：2007-05-28
申请人： Takahiro Hayakawa , Noboru Katta , Junichi Matsuda , Kenichi Noguchi
发明人： Takahiro Hayakawa , Noboru Katta , Junichi Matsuda , Kenichi Noguchi
IPC分类号： H04R1/00
CPC分类号： H04R1/323 , B60R11/0217 , B60R2011/0092 , H04R3/12 , H04R2499/13
摘要： A loudspeaker system capable of simultaneously providing listeners with a listening environment not giving them a feeling of strangeness. The loudspeaker system (100) comprises drive motors (111 to 113, 121 to 123) for so driving at least first R-channel loudspeaker (101) that the current first listening position is substantially included in the perpendicularly bisecting plane of a line joining the intersecting point of the first R-channel speaker (101) and its directivity axis and the intersecting point of the second R-channel loudspeaker (120) and its directivity axis and so driving at least fourth L-channel loudspeaker (104) that the current second listening point is substantially included in the perpendicularly bisecting plane of the line joining the intersecting point of a third L-channel loudspeaker (103) and its directivity axis and the intersecting point of a fourth L-channel loudspeaker (104) and its directivity axis. The loudspeaker system (100) further comprises their motor driver section (130).
摘要翻译：一种扬声器系统，能够同时向聆听者提供听觉环境，而不会给听众带来陌生感。扬声器系统（100）包括用于驱动至少第一R声道扬声器（101）的驱动电动机（111至113,121至123），使得当前第一收听位置基本上包括在连接到该第一R声道扬声器的线的垂直二等分平面中所述第一R声道扬声器（101）的指向性轴与所述第二R声道扬声器（120）的相交点及其方向轴之间的相交点，从而驱动至少第四L声道扬声器（104）第二收听点基本上包括在连接第三L声道扬声器（103）的交点与其方向轴和第四L声道扬声器（104）的相交点及其方向轴之间的线的垂直二等分平面中。扬声器系统（100）还包括其电动机驱动器部分（130）。

26. 发明授权

US07663776B2 Document processing apparatus and method 失效
标题翻译：文件处理装置和方法
公开(公告)号：US07663776B2
公开(公告)日：2010-02-16
申请号：US11210733
申请日：2005-08-25
申请人： Masashi Namiki , Yasunori Kawanishi , Shinya Yamaguchi , Junichi Matsuda , Shoichi Nakagami
发明人： Masashi Namiki , Yasunori Kawanishi , Shinya Yamaguchi , Junichi Matsuda , Shoichi Nakagami
IPC分类号： G06K15/00 , G06K9/18 , G06F17/00
CPC分类号： G06F17/241 , G06F17/242
摘要： The object of the present invention is to provide a document processing apparatus capable of extracting written-in notes on a paper document and printing a document only of written-in notes or a document with a part of written-in notes by a writer left behind, and setting a limit on printing on each written-in note. The above object is achieved by apparatus for processing a document by providing a paper document to print with information for identifying an electronic document as the origin of printing, comprising: written-in notes extracting means for extracting a difference (written-in notes) between the paper document and an electronic document and storing written-notes as image information; text conversion means for converting extracted written-in notes into text as character information, and storing the text; and means for generating a print document by laying out image information of written-in notes and written-in information in text form.
摘要翻译：本发明的目的是提供一种文件处理装置，其能够提取纸质文件上的书写笔记，并且仅将写入笔记的文档或具有留下的作者的一部分书写笔记的文件打印，并在每个写入笔记上设置打印限制。上述目的是通过提供一种通过提供用于识别作为打印原点的电子文档的信息打印的纸质文档的装置来实现的，包括：写入纸币提取装置，用于提取打印纸纸质文件和电子文件，并将书面记录作为图像信息存储; 文本转换装置，用于将提取的书写笔记转换为文本作为字符信息，并存储文本; 以及通过以文本形式布置写入笔记和写入信息的图像信息来生成打印文档的装置。

27. 发明申请

US20090042585A1 TERMINAL POSITIONING METHOD, TERMINAL POSITIONING SYSTEM, POSITIONING SERVER, AND PROGRAM 审中-公开
标题翻译：终端定位方法，终端定位系统，定位服务器和程序
公开(公告)号：US20090042585A1
公开(公告)日：2009-02-12
申请号：US12293248
申请日：2007-03-16
申请人： Junichi Matsuda
发明人： Junichi Matsuda
IPC分类号： H04W4/02
CPC分类号： G01S5/0009 , G01S5/021 , G01S5/0263
摘要： [Subject] The present invention is directed to realize failure detection without directly detecting a failed positioning system.[Solving Means] A terminal positioning system includes positioning systems 101 and 102 and a failure detector 104. When a failure occurs in one of the positioning systems 101 and 102, by monitoring a use state of the other positioning system, the failure in one of the positioning systems is detected. Priorities of positioning process on the positioning systems 101 and 102 may be determined so that the priority of positioning process on one of the positioning systems is higher than that on the other positioning system. The one of the positioning systems can perform positioning at higher precision than the other positioning system.
摘要翻译：发明内容本发明旨在实现故障检测而不直接检测故障定位系统。终端定位系统包括定位系统101和102以及故障检测器104.当定位系统101和102中的一个发生故障时，通过监视另一个定位系统的使用状态，检测定位系统。可以确定定位系统101和102上的定位过程的优先级，使得定位处理在一个定位系统上的优先级高于另一个定位系统上的定位处理的优先级。定位系统之一可以以比其他定位系统更高的精度执行定位。

28. 发明申请

US20070293431A1 METHOD FOR IMPROVING NEUROTRANSMISSION FAILURE USING A NOVEL AGENT 审中-公开
标题翻译：使用新型药剂改善神经递质失败的方法
公开(公告)号：US20070293431A1
公开(公告)日：2007-12-20
申请号：US11782510
申请日：2007-07-24
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/16 , A61K38/00 , A61P25/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

29. 发明申请

US20070177161A1 Positioning system, positioning method, and program thereof 有权
标题翻译：定位系统，定位方法及程序
公开(公告)号：US20070177161A1
公开(公告)日：2007-08-02
申请号：US10591370
申请日：2005-03-03
申请人： Kenichi Ishii , Junichi Matsuda
发明人： Kenichi Ishii , Junichi Matsuda
IPC分类号： G01B11/14
CPC分类号： H05B37/029 , G01S1/70 , G01S5/0009 , G01S5/16
摘要： A positioning system includes an illumination device, a terminal, and a positioning server. The illumination device transmits identification information. The terminal transmits the identification information received from the illumination device, to the positioning server. The positioning server uses the identification information received from the terminal, thereby searching an illumination installation position database registered in advance so as to identify the terminal position. This eliminates power supply for positioning infrastructure and facilitates attachment to a ceiling, thereby realizing the positioning infrastructure at a low cost.
摘要翻译：定位系统包括照明装置，终端和定位服务器。照明装置发送识别信息。终端将从照明装置接收的识别信息发送到定位服务器。定位服务器使用从终端接收的识别信息，从而搜索预先登记的照明安装位置数据库，以识别终端位置。这消除了用于定位基础设施的电源，并且便于附接到天花板，从而以低成本实现定位基础设施。

30. 发明申请

US20060211609A1 Novel agent for improving neurotransmission failure 审中-公开
标题翻译：改善神经传导衰竭的新药
公开(公告)号：US20060211609A1
公开(公告)日：2006-09-21
申请号：US10536963
申请日：2003-11-28
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/17 , A61K38/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

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