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21. 发明授权

US06998228B2 Method and apparatus for solid state molecular analysis 失效
公开(公告)号：US06998228B2
公开(公告)日：2006-02-14
申请号：US10179102
申请日：2002-06-25
申请人： Eric Henderson , Curtis Mosher , Michael P. Lynch
发明人： Eric Henderson , Curtis Mosher , Michael P. Lynch
IPC分类号： C12Q1/68
CPC分类号： G01N33/543 , C12Q1/6834 , C12Q1/6837 , Y10S977/853 , Y10S977/858 , C12Q2565/601 , C12Q2565/501
摘要： The invention is a method for the formation and analysis of novel miniature deposition domains. These deposition domains are placed on a surface to form a molecular array. The molecular array is scanned with an AFM to analyze molecular recognition events and the effect of introduced agents on defined molecular interactions. This approach can be carried out in a high throughput format, allowing rapid screening of thousands of molecular species in a solid state array. The procedures described here have the added benefit of allowing the measurement of changes in molecular binding events resulting from changes in the analysis environment or introduction of additional effector molecules to the assay system. The processes described herein are extremely useful in the search for compounds such as new drugs for treatment of undesirable physiological conditions. The method and apparatus of the present invention does not require the labeling of the deposition material or the target sample and may also be used to deposit large size molecules without harming the same.

22. 发明申请

US20050239193A1 Device and method of use for detection and characterization of microorganisms and microparticles 审中-公开
标题翻译：用于微生物和微粒的检测和表征的装置和方法
公开(公告)号：US20050239193A1
公开(公告)日：2005-10-27
申请号：US10977551
申请日：2004-10-29
申请人： Eric Henderson , Saju Nettikadan , Curtis Mosher , James Johnson
发明人： Eric Henderson , Saju Nettikadan , Curtis Mosher , James Johnson
IPC分类号： C12M1/26 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/70 , G01N33/48 , G01N33/50 , G01N33/68 , G01Q30/04 , G01Q60/00 , G06F19/00
CPC分类号： G01N33/56983 , C12M41/36 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N33/552 , G01N33/6854 , G01Q70/18 , C12Q2565/518 , C12Q2527/127 , C12Q2521/107
摘要： The present invention includes a method and apparatus for the detection of a microorganism or microparticle.
摘要翻译：本发明包括用于检测微生物或微粒的方法和装置。

23. 发明授权

US6146899A Height referencing biochemical cassette 失效
标题翻译：高度参考生化胶带
公开(公告)号：US6146899A
公开(公告)日：2000-11-14
申请号：US258559
申请日：1999-02-26
申请人： Marc D. Porter , Vivian W. Jones , Curtis L. Mosher , Eric Henderson
发明人： Marc D. Porter , Vivian W. Jones , Curtis L. Mosher , Eric Henderson
IPC分类号： C40B40/06 , C40B40/10 , G01N33/543 , C12Q1/68 , G01N33/00
CPC分类号： B82Y30/00 , G01N33/54373 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , Y10T436/143333
摘要： A height referencing biochemical cassette comprising of a surface suitable to act as a coupling agent, a height referencing indicator, and molecules bonded to the surface. This cassette is a capable of use to test for bonding to these molecules through measuring the height difference between the indicator and the surface. This invention provides an efficient means to quickly and easily test for bonding of molecules to other molecules.
摘要翻译：包括生物化学盒的高度，其包括适合作为偶联剂的表面，高度参考指示剂和结合到表面的分子。该盒能够用于通过测量指示器和表面之间的高度差来测试与这些分子的结合。本发明提供了快速且容易地测试分子与其它分子结合的有效手段。

24. 发明申请

US20100154086A1 NOVEL ENHANCED PROCESSES FOR MOLECULAR SCREENING AND CHARACTERIZATION 审中-公开
标题翻译：用于分子筛选和表征的新型增强方法
公开(公告)号：US20100154086A1
公开(公告)日：2010-06-17
申请号：US11776511
申请日：2007-07-11
申请人： Eric Henderson , Curtis Mosher
发明人： Eric Henderson , Curtis Mosher
IPC分类号： G01Q60/24
CPC分类号： G01Q60/42
摘要： A general high-throughput screening (HTS) process using an atomic force microscope (AFM) to detect and measure molecular recognition events. The AFM is used to measure changes in molecular complex height, friction, shape, elasticity or any other relevant parameters that report a molecular recognition event. In addition, the force involved in molecular recognition and bonding is directly measured using the technique of force spectroscopy. In one embodiment, a flow chamber is used to introduce molecules and assay their effect on a molecular interaction occurring between molecules on the AFM probe and a surface. In some cases the surface may be an introduced microparticle. In a second embodiment, the sample is a solid phase array of molecules that is interrogated by a functionalized AFM probe, and the effects of introduced agents at each molecular address in the array is measured by force spectroscopy.
摘要翻译：使用原子力显微镜（AFM）检测和测量分子识别事件的通用高通量筛选（HTS）过程。 AFM用于测量分子复合物高度，摩擦，形状，弹性或报告分子识别事件的任何其他相关参数的变化。此外，使用力光谱技术直接测量参与分子识别和结合的力。在一个实施方案中，流动室用于引入分子并测定它们对在AFM探针和表面上的分子之间发生的分子相互作用的影响。在一些情况下，表面可以是引入的微粒。在第二个实施方案中，样品是由功能化的AFM探针询问的分子的固相阵列，并且通过力谱测量在阵列中的每个分子地址处引入的试剂的影响。

25. 发明授权

US07060448B2 Evaluating binding affinities by force stratification and force panning 失效
公开(公告)号：US07060448B2
公开(公告)日：2006-06-13
申请号：US10958092
申请日：2004-10-04
申请人： Eric Henderson , Curtis Mosher
发明人： Eric Henderson , Curtis Mosher
IPC分类号： G01N33/53
CPC分类号： C07K16/065 , Y10S436/807
摘要： The present invention is a method for selectively removing objects from a surface utilizing a probe. The probe is scanned over the surface utilizing a greater and greater relative amount of force so that a certain number of the objects are removed from the surface. The force required to remove the objects from the surface can be calculated utilizing Hook's law and the spring constant of the probe. After removal of the objects that have a relatively weaker binding affinity with the surface, the remaining objects can be harvested, characterized, and subjected to further study.

26. 发明授权

US07008769B2 Nanoscale molecular arrayer 失效
公开(公告)号：US07008769B2
公开(公告)日：2006-03-07
申请号：US09929865
申请日：2001-08-14
申请人： Eric Henderson , Curtis Mosher
发明人： Eric Henderson , Curtis Mosher
IPC分类号： C12Q1/68 , C12M1/36 , G01N15/06
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00698 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01L3/0244 , B82B3/00 , C40B40/06 , C40B50/14 , Y10S977/924
摘要： The present invention is a dedicated apparatus for the formation of array that includes one or more deposition domains comprised of one or more deposition materials. The present invention may include an X, Y controller, an X, Y translation stage, a loading substrate, a deposition substrate, a Z controller, and a deposition probe. A computer controls all of the relative positions of each of the components. Furthermore, the present invention utilizes a humidity control system to create a capillary bridge between the probe and the substrate for transferring the deposition material between the loading substrate, the deposition probe, and the deposition substrate.

27. 发明申请

US20050251700A1 Dynamic voltage scaling system 有权
标题翻译：动态电压缩放系统
公开(公告)号：US20050251700A1
公开(公告)日：2005-11-10
申请号：US10840635
申请日：2004-05-05
申请人： Eric Henderson , Michael Drop , Tauseef Kazi
发明人： Eric Henderson , Michael Drop , Tauseef Kazi
IPC分类号： G06F1/32 , H04L7/00
CPC分类号： G06F1/3296 , G06F1/3203 , Y02D10/172
摘要： Methods and apparatus for implementing a Dynamic Voltage Scaling (DVS) system are presented herein. In one embodiment, an embedded delay checker (EDC) cell is used to measure the actual activity and delay of a critical path within a microprocessor core, which is the basis for dynamically altering the voltage to the core. In another embodiment, a slaved ring oscillator (SRO) cell is placed adjacent to the microprocessor core and is used along with EDC cells to provide redundancy to a DVS system.
摘要翻译：本文介绍了实现动态电压调节（DVS）系统的方法和设备。在一个实施例中，使用嵌入式延迟检查器（EDC）单元来测量微处理器内核内的关键路径的实际活动和延迟，这是动态地改变对核心的电压的基础。在另一个实施例中，从属环形振荡器（SRO）单元放置在与微处理器核心相邻的位置处，并与EDC单元一起使用以向DVS系统提供冗余。

28. 发明申请

US20050059091A1 Evaluating binding affinities by force stratification and force panning 失效
标题翻译：通过强制分层和强制平移来评估约束力
公开(公告)号：US20050059091A1
公开(公告)日：2005-03-17
申请号：US10958092
申请日：2004-10-04
申请人： Eric Henderson , Curtis Mosher
发明人： Eric Henderson , Curtis Mosher
IPC分类号： G01N33/53 , G01Q60/00 , C07K16/06 , G01N33/566 , G01Q80/00 , C12M1/34
CPC分类号： C07K16/065 , Y10S436/807
摘要： The present invention is a method for selectively removing objects from a surface utilizing a probe. The probe is scanned over the surface utilizing a greater and greater relative amount of force so that a certain number of the objects are removed from the surface. The force required to remove the objects from the surface can be calculated utilizing Hook's law and the spring constant of the probe. After removal of the objects that have a relatively weaker binding affinity with the surface, the remaining objects can be harvested, characterized, and subjected to further study.
摘要翻译：本发明是利用探针从表面选择性地去除物体的方法。使用更大和更大的相对的力量将探头扫描在表面上，使得一定数量的物体从表面移除。可以使用钩定律和探头的弹簧常数来计算从表面去除物体所需的力。在去除与表面具有相对较弱的结合亲和力的物体之后，可以收集，表征和进一步研究剩余的物体。

29. 发明授权

US06651107B1 Reduced hardware network adapter and communication 有权
标题翻译：减少硬件网络适配器和通讯方式
公开(公告)号：US06651107B1
公开(公告)日：2003-11-18
申请号：US09401005
申请日：1999-09-21
申请人： Michael R. Conley , Eric Henderson
发明人： Michael R. Conley , Eric Henderson
IPC分类号： G06F1516
CPC分类号： H04L12/413 , G06F13/385 , H04L12/40013 , H04L12/40032 , H04L49/90 , H04L49/9073 , Y02D10/14 , Y02D10/151
摘要： The present invention provides a network interface adapter for connecting a client computer to a computer network that includes a reduced hardware media access controller (MAC) coupled through a physical interface (PHY) to the network physical link. A significant portion of the MAC functionality is implemented as software within the processor of the host client computer. The hardware portion of the preferred MAC implementation provides memory for buffering communications between the PHY and the client computer. The preferred hardware aspects of a MAC in accordance with the present invention also includes a register interface for register-driven communications between the hardware portion of the MAC and the software portions of the MAC implemented within the client computer. By implementing most of the MAC functionality in software within the host computer, the preferred MAC provides lower cost, lower power consumption, and generally greater flexibility.
摘要翻译：本发明提供了一种用于将客户计算机连接到计算机网络的网络接口适配器，计算机网络包括通过物理接口（PHY）耦合到网络物理链路的简化硬件媒体访问控制器（MAC）。 MAC功能的重要部分被实现为主机客户端计算机的处理器内的软件。优选MAC实现的硬件部分提供用于缓冲PHY和客户端计算机之间的通信的存储器。根据本发明的MAC的优选硬件方面还包括用于MAC的硬件部分和在客户端计算机中实施的MAC的软件部分之间的寄存器驱动通信的寄存器接口。通过在主计算机内的软件中实现大多数MAC功能，优选的MAC提供了较低的成本，更低的功耗和更大的灵活性。

30. 发明授权

US5863642A Water resistant and vapor phase corrosion inhibitor composite material 失效
标题翻译：防水和气相腐蚀抑制剂复合材料
公开(公告)号：US5863642A
公开(公告)日：1999-01-26
申请号：US686539
申请日：1996-07-26
申请人： Eric Henderson , Lorence J. Reed , Kevin D. Jagielski
发明人： Eric Henderson , Lorence J. Reed , Kevin D. Jagielski
IPC分类号： B32B27/18 , B32B7/02 , B32B5/08 , B32B27/32
CPC分类号： B32B27/18 , Y10T428/24992 , Y10T442/169 , Y10T442/2025 , Y10T442/3886
摘要： A water resistant and vapour phase corrosion inhibitor composite material for wrapping around metallic items for protection and to reduce corrosion during storage and transportation. The composite material comprises a high strength, tear resistant, flexible scrim, a low density layer impregnated with a solid form vapour phase corrosion inhibitor, and a barrier layer to reduce the transmission of water, water vapour, oxygen and other environmental gases through the composite material. The barrier layer also reduces the atmospheric loss of gaseous vapour phase corrosion inhibitor from around the wrapped item. Each layer is formed from a polyolefin material to create a multi-layered polyolefin composite material that is easily recyclable.
摘要翻译：用于环绕金属物品的防水和气相腐蚀抑制剂复合材料，用于保护和减少储存和运输过程中的腐蚀。复合材料包括高强度，抗撕裂，柔韧的稀松布，浸渍有固体形式的气相腐蚀抑制剂的低密度层，以及阻挡层，以通过复合材料减少水，水蒸汽，氧气和其它环境气体的透过性材料。阻隔层还可以减少包裹物品周围的气态气相腐蚀抑制剂的大气损失。每个层由聚烯烃材料形成，以产生易于回收的多层聚烯烃复合材料。

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