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1. 发明授权

US06998228B2 Method and apparatus for solid state molecular analysis 失效
公开(公告)号：US06998228B2
公开(公告)日：2006-02-14
申请号：US10179102
申请日：2002-06-25
申请人： Eric Henderson , Curtis Mosher , Michael P. Lynch
发明人： Eric Henderson , Curtis Mosher , Michael P. Lynch
IPC分类号： C12Q1/68
CPC分类号： G01N33/543 , C12Q1/6834 , C12Q1/6837 , Y10S977/853 , Y10S977/858 , C12Q2565/601 , C12Q2565/501
摘要： The invention is a method for the formation and analysis of novel miniature deposition domains. These deposition domains are placed on a surface to form a molecular array. The molecular array is scanned with an AFM to analyze molecular recognition events and the effect of introduced agents on defined molecular interactions. This approach can be carried out in a high throughput format, allowing rapid screening of thousands of molecular species in a solid state array. The procedures described here have the added benefit of allowing the measurement of changes in molecular binding events resulting from changes in the analysis environment or introduction of additional effector molecules to the assay system. The processes described herein are extremely useful in the search for compounds such as new drugs for treatment of undesirable physiological conditions. The method and apparatus of the present invention does not require the labeling of the deposition material or the target sample and may also be used to deposit large size molecules without harming the same.

2. 发明授权

US4620865A Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides 失效
标题翻译：除草和杀藻剂1,5-二取代-1H-吡唑-4-甲酰胺
公开(公告)号：US4620865A
公开(公告)日：1986-11-04
申请号：US833309
申请日：1986-02-24
申请人： James R. Beck , Michael P. Lynch
发明人： James R. Beck , Michael P. Lynch
IPC分类号： A01N43/56 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/22 , C07D231/38 , C07D401/04
CPC分类号： C07D231/38 , A01N43/56 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/22 , C07D401/04
摘要： 1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.
摘要翻译： 1,5-二取代-1H-吡唑-4-甲酰胺衍生物，可用作除草剂和水生杀藻剂。

3. 发明授权

US07339282B2 Topographically indexed support substrates 失效
标题翻译：地形索引支撑基板
公开(公告)号：US07339282B2
公开(公告)日：2008-03-04
申请号：US11328783
申请日：2006-01-10
申请人： Juntao Xu , Curtis Mosher , Michael P. Lynch
发明人： Juntao Xu , Curtis Mosher , Michael P. Lynch
IPC分类号： G03F9/00 , G03F7/20 , H01L23/544 , H01L21/76 , H01L21/70
CPC分类号： H01L23/544 , B01J2219/00527 , B01J2219/00536 , B01J2219/00542 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01L3/5085 , B01L9/50 , B01L2300/0819 , B82Y30/00 , H01L2924/0002 , H01L2924/09701 , H01L2924/00
摘要： The present invention provides an indexed support substrate. The support substrate comprises at least one set of indexing features that are distinguishable from one another and from the surrounding substrate. The support substrate also comprises a set of useful domains. The indexing features are positioned on the substrate in such a way as to correspond to the useful domains in an identifying fashion.
摘要翻译：本发明提供了一种索引支撑衬底。所述支撑基底包括至少一组彼此可区分并与周围基底相分离的分度特征。支撑衬底还包括一组有用的结构域。索引特征以这样的方式定位在基板上，以便以识别方式对应于有用的域。

4. 发明授权

US06391901B1 Thrombin inhibitors 失效
标题翻译：凝血酶抑制剂
公开(公告)号：US06391901B1
公开(公告)日：2002-05-21
申请号：US09423148
申请日：2000-01-21
申请人： Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Alan D Palkowitz , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
发明人： Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Alan D Palkowitz , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Minsheng Zhang
IPC分类号： A61K314025
CPC分类号： C07D333/58 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D333/56 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of defined compounds of formula I as thrombin inhibitors.
摘要翻译：本申请涉及本文定义的式I（及其药学上可接受的盐）的新型化合物，其制备方法和中间体，包含式I的新化合物的药物制剂，以及定义的式I化合物作为凝血酶抑制剂的用途。

5. 发明申请

US20100096371A1 SYSTEM AND METHOD FOR SURFACE CLEANING USING A LASER INDUCED SHOCK WAVE ARRAY 审中-公开
标题翻译：使用激光诱发的冲击波阵列进行表面清洁的系统和方法
公开(公告)号：US20100096371A1
公开(公告)日：2010-04-22
申请号：US12582226
申请日：2009-10-20
申请人： Robert R. Bousquet , Chad Y. Sheng , Michael P. Lynch , Robert A. Rashford
发明人： Robert R. Bousquet , Chad Y. Sheng , Michael P. Lynch , Robert A. Rashford
IPC分类号： B23K26/36
CPC分类号： B23K26/0846 , B23K26/0676 , B23K26/356
摘要： A contamination removal system for continuous cleaning of contamination from an exposed contaminated surface of a substrate by creating and moving a laser induced shock wave array across the contaminated surface includes a laser beam source and laser beam delivery assembly receiving a beam generated at the laser beam source and directing the beam for the generation of a shock wave array. The beam delivery assembly includes mirrors and beam splitters which split the laser beam into many laser beams. The contamination removal system also includes a control assembly composed of an analog or digital controller and a motion controller linked to the operating components of the present system and ensuring proper operation thereof. A substrate motion control/holder assembly supports the substrate adjacent the beam delivery assembly. The substrate motion control/holder assembly is linked to the motion controller of the control assembly for complete and comprehensive operation, wherein the substrate motion control/holder assembly continually translates the substrate in a highly controlled manner to ensure the creation of the shock wave array along the exposed contaminated surface of the substrate in a systematic manner such that the contaminates are moved off of the exposed contaminated surface of the substrate resulting in a clean surface for subsequent use and fabrication.
摘要翻译：用于通过在受污染的表面上产生和移动激光诱发的冲击波阵列来连续清洁来自基底的暴露的污染表面的污染的污染物去除系统包括激光束源和激光束传送组件，其接收在激光束源处产生的光束并引导光束产生冲击波阵列。光束传送组件包括将激光束分成许多激光束的反射镜和分束器。污染物去除系统还包括由模拟或数字控制器和连接到本系统的操作部件的运动控制器组成的控制组件，并确保其正确的操作。衬底运动控制/保持器组件支撑邻近束传送组件的衬底。衬底运动控制/保持器组件连接到控制组件的运动控制器以用于完整和全面的操作，其中衬底运动控制/保持器组件以高度受控的方式连续地平移衬底，以确保沿冲击波阵列的形成以系统方式暴露的基底的污染表面，使得污染物从衬底的暴露的污染表面移开，形成干净的表面，用于随后的使用和制造。

6. 发明授权

US5153316A Intermediates for herbicidal phenylimidazolones 失效
标题翻译：用于除草苯并咪唑酮的中间体
公开(公告)号：US5153316A
公开(公告)日：1992-10-06
申请号：US710223
申请日：1991-06-04
申请人： Gary D. Crouse , Michael P. Lynch , Jeffery D. Webster , John P. Wright
发明人： Gary D. Crouse , Michael P. Lynch , Jeffery D. Webster , John P. Wright
IPC分类号： A01N43/50 , A01N43/54 , C07D207/26 , C07D207/263 , C07D211/76 , C07D223/10 , C07D233/32 , C07D233/90 , C07D239/54 , C07D239/557 , C07D471/04 , C07D487/04
CPC分类号： C07D207/27 , A01N43/50 , A01N43/54 , C07D211/76 , C07D223/10 , C07D233/32 , C07D239/557 , C07D471/04 , C07D487/04
摘要： The present invention relates to novel phenylimidazolone compounds of the formula ##STR1## wherein A is a bond or C.dbd.T;R is --H, Alk, halo-Alk, cyano-Alk, or phenyl;R.sup.1 is --H, Alk, halogen, halo-Alk, --CN; or when A is a bond, R and R.sup.1 may together form a saturated, partially saturated, or unsaturated three to seven member carbon ring, and the ring may be substituted at any position independently with one or more Alk, --O--Alk, --CN, halogen, --OH, or .dbd.O groups;T is O or S;U is --H;V is --OH, or U and V may together form a bond;W is halogen or --CN, and when W is halogen, R.sup.1 is --CN;X is --H or halogen;Y is --H, halogen, --CN, Alk, --CF.sub.3, or --OCF.sub.3 ;Z is --H, halogen, --OH, Alk, aryloxy, C.sub.1-6 acyl, --NH.sub.2, --NO.sub.2, --NR.sup.2 SO.sub.2 R.sup.2, --N(SO.sub.2 R.sup.2).sub.2, --NR.sup.2 COR.sup.2, or B; or Y and Z may together form a saturated, partially saturated, or unsaturated three to seven member carbon ring, wherein each carbon may be independently replaced with N, O, or S, and the ring may be substituted at any position independently with one or more Alk, --O--Alk, .dbd.O, --SO.sub.2 R.sup.2, or C.sub.1-6 acyl groups;Alk is a straight, branched, or cyclic saturated or unsaturated C.sub.1-6 hydrocarbon group;B is --O--Alk, wherein each carbon may be independently replaced with one or more O or S groups, and optionally substituted with one or more halogen or C.sub.1-6 acyl groups; orthe agriculturally acceptable salts, amides, and esters thereof.The compounds are useful as herbicides.
摘要翻译：本发明涉及新的式（I）所示的苯基咪唑酮化合物，其中A是一个键或C = T; R是-H，Alk，卤代-Alk，氰基-Alk或苯基; R1是-H，Alk，卤素，卤素-Alk，-CN; 或当A为键时，R和R 1可以一起形成饱和的，部分饱和的或不饱和的三至七元碳环，并且该环可以在任何位置独立地被一个或多个Alk，-O-Alk， CN，卤素，-OH或= O基团; T为O或S; U是-H V是-OH，或U和V可以一起形成键; W为卤素或-CN，当W为卤素时，R 1为-CN; X是-H或卤素; Y是-H，卤素，-CN，Alk，-CF 3或-OCF 3; Z是-H，卤素，-OH，Alk，芳氧基，C1-6酰基，-NH2，-NO2，-NR2SO2R2，-N（SO2R2）2，-NR2COR2或B; 或Y和Z可以一起形成饱和的，部分饱和的或不饱和的三至七个碳环，其中每个碳可以独立地被N，O或S代替，并且该环可以在任何位置独立地被一个或多个 -O-Alk，= O，-SO2R2或C1-6酰基; Alk是直链，支链或环状的饱和或不饱和C 1-6烃基; B是-O-Alk，其中每个碳可以独立地被一个或多个O或S基团取代，并且任选被一个或多个卤素或C 1-6酰基取代; 或其农业上可接受的盐，酰胺和酯。该化合物可用作除草剂。

7. 发明授权

US07690325B2 Method and apparatus for depositing material onto a surface 失效
标题翻译：用于将材料沉积到表面上的方法和设备
公开(公告)号：US07690325B2
公开(公告)日：2010-04-06
申请号：US11120042
申请日：2005-04-29
申请人： Eric R. Henderson , Juntao Xu , Michael P. Lynch , Curtis L. Mosher , Janice Lillian Huff , Saju Rappai Nettikadan
发明人： Eric R. Henderson , Juntao Xu , Michael P. Lynch , Curtis L. Mosher , Janice Lillian Huff , Saju Rappai Nettikadan
IPC分类号： B05C5/00 , B05B7/06 , B05C3/00
CPC分类号： B01L3/0244 , B01J2219/00387 , B01J2219/00659 , B01L3/0248 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0838 , B01L2300/10 , B01L2400/02 , B01L2400/0406
摘要： Some embodiments of the present invention provide an apparatus and method in which material is deposited upon a surface from an elongated beam having an aperture defined therein through which the material is moved by passive adsorption. The elongated beam can be substantially planar along substantially its entire length, can be oriented at an acute angle with respect to the surface during deposition processes, and can have a length no greater than about 2 mm. In some embodiments, the aperture can be elongated, can extend from a material reservoir to a location short of the terminal end of the elongated beam or through the terminal end of the elongated beam, and can have a portion extending through the thickness of the elongated beam.
摘要翻译：本发明的一些实施例提供了一种装置和方法，其中材料从具有限定在其中的孔的细长梁沉积在表面上，通过该孔通过被动吸附来移动材料。细长梁基本上可以在其整个长度上基本上是平面的，在沉积过程中可以相对于表面以锐角定向，并且可以具有不大于约2mm的长度。在一些实施例中，孔可以是细长的，可以从材料储存器延伸到短于细长梁的终端的位置或者通过细长梁的终端，并且可以具有延伸穿过细长梁的厚度的部分光束。

8. 发明授权

US06716578B1 Method for solid state genome analysis 失效
标题翻译：固态基因组分析方法
公开(公告)号：US06716578B1
公开(公告)日：2004-04-06
申请号：US09519271
申请日：2000-03-07
申请人： Eric Henderson , Michael P. Lynch
发明人： Eric Henderson , Michael P. Lynch
IPC分类号： C12Q168
CPC分类号： C12Q1/6841 , Y10S977/854 , C12Q2565/601
摘要： The invention is a solid state process for analyzing genomes by visualizing sequence specific markers (e.g., proteins that bind a defined DNA sequence elements) by scanning probe microscopy. The method includes linear display of the nucleic acid on a solid surface, image acquisition by the scanning probe microscope, and digital data analysis. The acts of the method result in a bar code type display of each fragment of the DNA sample. These bar codes are then used to place the fragments in the order they appear on the original DNA sample.
摘要翻译：本发明是通过扫描探针显微镜观察序列特异性标记（例如，结合确定的DNA序列元件的蛋白质）来分析基因组的固态方法。该方法包括在固体表面上线性显示核酸，通过扫描探针显微镜进行图像采集和数字数据分析。该方法的行为导致DNA样品的每个片段的条形码类型显示。然后使用这些条形码按其在原始DNA样品上显示的顺序放置片段。

9. 发明授权

US06573369B2 Method and apparatus for solid state molecular analysis 失效
标题翻译：固态分子分析方法和装置
公开(公告)号：US06573369B2
公开(公告)日：2003-06-03
申请号：US09574519
申请日：2000-05-18
申请人： Eric Henderson , Curtis Mosher , Michael P. Lynch
发明人： Eric Henderson , Curtis Mosher , Michael P. Lynch
IPC分类号： C07H2102
CPC分类号： G01N33/543 , C12Q1/6834 , C12Q1/6837 , Y10S977/853 , Y10S977/858 , C12Q2565/601 , C12Q2565/501
摘要： The invention is a method for the formation and analysis of novel miniature deposition domains. These deposition domains are placed on a surface to form a molecular array. The molecular array is scanned with an AFM to analyze molecular recognition events and the effect of introduced agents on defined molecular interactions. This approach can be carried out in a high throughput format, allowing rapid screening of thousands of molecular species in a solid state array. The procedures described here have the added benefit of allowing the measurement of changes in molecular binding events resulting from changes in the analysis environment or introduction of additional effector molecules to the assay system. The processes described herein are extremely useful in the search for compounds such as new drugs for treatment of undesirable physiological conditions. The method and apparatus of the present invention does not require the labeling of the deposition material or the target sample and may also be used to deposit large size molecules without harming the same.
摘要翻译：本发明是形成和分析新型微型沉积区域的方法。将这些沉积区域放置在表面上以形成分子阵列。用AFM扫描分子阵列以分析分子识别事件以及引入的试剂对定义的分子相互作用的影响。该方法可以以高通量格式进行，允许在固态阵列中快速筛选成千上万个分子物质。这里描述的程序具有允许测量由分析环境的变化引起的分子结合事件的变化或将附加效应分子引入测定系统的附加益处。本文所述的方法在寻找用于治疗不良生理条件的新药物等化合物方面非常有用。本发明的方法和装置不需要对沉积材料或目标样品进行标记，也可以用于沉积大尺寸分子而不伤害它们。

10. 发明授权

US06541499B1 Antithrombotic agents 失效
标题翻译：抗血栓药
公开(公告)号：US06541499B1
公开(公告)日：2003-04-01
申请号：US09423147
申请日：2000-01-21
申请人： Jolie A Bastian , Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Valentine J Klimkowski , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Jeffrey T Mullaney , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Jennifer M Tinsley , Michael R Wiley , Minsheng Zhang
发明人： Jolie A Bastian , Nickolay Y Chirgadze , Michael L Denney , Matthew J Fisher , Robert J Foglesong , Richard W Harper , Mary G Johnson , Valentine J Klimkowski , Ho-Shen Lin , Michael P Lynch , Jefferson R McCowan , Shawn C Miller , Jeffrey T Mullaney , Michael E Richett , Daniel J Sall , Gerald F Smith , Kumiko Takeuchi , Jennifer M Tinsley , Michael R Wiley , Minsheng Zhang
IPC分类号： A61K314196
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
摘要： The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译：本发明涉及式（I）的新化合物及其药学上可接受的盐，如本文所定义，其制备方法和中间体，包含新型式（I）化合物的药物制剂，以及式（I）化合物 I）作为凝血酶抑制剂。

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