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21. 发明申请

US20090292194A1 Chiropractic Care Management Systems and Methods 审中-公开
标题翻译：按摩护理管理系统和方法
公开(公告)号：US20090292194A1
公开(公告)日：2009-11-26
申请号：US12468493
申请日：2009-05-19
申请人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
发明人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
IPC分类号： A61B5/04 , A61B5/11
CPC分类号： A61B5/02438 , A61B5/0002 , A61B5/02405 , A61B5/0245 , A61B5/0488 , A61B5/1116 , A61B5/1118 , A61B5/6823 , A61B5/6833 , A61B2560/0412 , A61B2560/045 , A61B2562/0219 , A61B2562/043 , A61B2562/166
摘要： An adherent device may be placed on a patient's chest for monitoring heart rate variability for chiropractic care. The device may comprise an adherent patch configured to adhere to the patient continuously for an extended period, for example an extended period of one week, and the HRV can be determined for the extended period. Two or more electrodes may be used to measure a cardiac signal and determine the HRV. The device may comprise accelerometers to measure at least one of posture, flexion/extension or lateral movement of the patient. The device may be placed on the patient and used in the clinic, and the patient may be sent home from the clinic with the adherent device. The device may wirelessly transmit heart rate data to an external device, such as a handheld monitor, that the chiropractor may consult during treatment.
摘要翻译：可以将粘附装置放置在患者胸部上，用于监测脊椎按摩护理的心率变异性。该装置可以包括附着贴片，其被配置为持续持续延长的时间段，例如延长的一周的周期，并且可以在延长的时间段内确定HRV。可以使用两个或更多个电极来测量心脏信号并确定HRV。该装置可以包括加速计以测量患者的姿势，屈曲/伸展或横向运动中的至少一个。该装置可以放置在患者身上并在诊所中使用，并且患者可以从附属设备从诊所送回家中。该设备可以将心率数据无线地传输到治疗期间脊医可以咨询的外部设备，例如手持式监视器。

22. 发明申请

US20080183264A1 ELECTRODE CONFIGURATIONS FOR TRANSVASCULAR NERVE STIMULATION 审中-公开
标题翻译：用于透视神经刺激的电极配置
公开(公告)号：US20080183264A1
公开(公告)日：2008-07-31
申请号：US11668957
申请日：2007-01-30
申请人： Mark J. Bly , David J. Smith , Imad Libbus
发明人： Mark J. Bly , David J. Smith , Imad Libbus
IPC分类号： A61N1/05
CPC分类号： A61N1/057
摘要： An intravascular lead adapted to be deployed to a stimulation site within a vessel adjacent a nerve to be stimulated includes at least a first electrode adapted to deliver an electrical pulse across a vessel wall. The first electrode includes an electrically active surface having one or more surface features adapted to focus current. The first electrode is disposed on the distal portion that the electrically active surface can be directed towards the nerve to be stimulated.
摘要翻译：适于部署到邻近被刺激的神经的血管内的刺激部位的血管内线包括至少第一电极，其适于将电脉冲传送穿过血管壁。第一电极包括具有适于聚焦电流的一个或多个表面特征的电活性表面。第一电极设置在远端部分上，电活性表面可以被引导到被刺激的神经。

23. 发明授权

US08897868B2 Medical device automatic start-up upon contact to patient tissue 有权
标题翻译：医疗设备在与患者组织接触时自动启动
公开(公告)号：US08897868B2
公开(公告)日：2014-11-25
申请号：US12209276
申请日：2008-09-12
申请人： Scott T. Mazar , Mark J. Bly , Arthur Lai
发明人： Scott T. Mazar , Mark J. Bly , Arthur Lai
IPC分类号： A61B5/05 , A61N1/365 , A61B5/0402 , A61B5/04 , A61B18/18 , A61N1/37 , A61B5/0408
CPC分类号： A61B5/6843 , A61B5/0402 , A61B5/04085 , A61B5/053 , A61B5/0531 , A61B5/6832 , A61B5/6885 , A61B2560/0209 , A61B2560/0214 , A61N1/36125 , A61N1/36139 , A61N1/36521 , A61N1/3702 , A61N1/378 , A61N2001/083
摘要： Methods and devices for monitoring and/or treating patients comprise a switch to automatically start-up the device when the device contacts tissue. By automatically starting up the device, the device may be installed without the clinician and/or user turning on the device, such that the device can be easy to use. In many embodiments, the device comprises startup circuitry with very low current and/or power consumption, for example less than 100 pA. The startup circuitry can detect tissue contact and turn on circuitry that is used to monitor or treat the patient.
摘要翻译：用于监测和/或治疗患者的方法和装置包括当装置接触组织时自动启动装置的开关。通过自动启动设备，可以在没有临床医生和/或用户打开设备的情况下安装设备，使得设备易于使用。在许多实施例中，该装置包括具有非常低的电流和/或功率消耗的启动电路，例如小于100pA。启动电路可以检测组织接触并打开用于监测或治疗患者的电路。

24. 发明申请

US20090076336A1 Medical Device Automatic Start-up Upon Contact to Patient Tissue 有权
标题翻译：医疗器械接触患者组织时自动启动
公开(公告)号：US20090076336A1
公开(公告)日：2009-03-19
申请号：US12209276
申请日：2008-09-12
申请人： Scott T. Mazar , Mark J. Bly
发明人： Scott T. Mazar , Mark J. Bly
IPC分类号： A61B5/00
CPC分类号： A61B5/6843 , A61B5/0402 , A61B5/04085 , A61B5/053 , A61B5/0531 , A61B5/6832 , A61B5/6885 , A61B2560/0209 , A61B2560/0214 , A61N1/36125 , A61N1/36139 , A61N1/36521 , A61N1/3702 , A61N1/378 , A61N2001/083
摘要： Methods and devices for monitoring and/or treating patients comprise a switch to automatically start-up the device when the device contacts tissue. By automatically starting up the device, the device may be installed without the clinician and/or user turning on the device, such that the device can be easy to use. In many embodiments, the device comprises startup circuitry with very low current and/or power consumption, for example less than 100 pA. The startup circuitry can detect tissue contact and turn on circuitry that is used to monitor or treat the patient.
摘要翻译：用于监测和/或治疗患者的方法和装置包括当装置接触组织时自动启动装置的开关。通过自动启动设备，可以在没有临床医生和/或用户打开设备的情况下安装设备，使得设备易于使用。在许多实施例中，该装置包括具有非常低的电流和/或功率消耗的启动电路，例如小于100pA。启动电路可以检测组织接触并打开用于监测或治疗患者的电路。

25. 发明申请

US20110178530A1 DIRECT DELIVERY SYSTEM FOR TRANSVASCULAR LEAD 有权
标题翻译：直升机系统
公开(公告)号：US20110178530A1
公开(公告)日：2011-07-21
申请号：US13079512
申请日：2011-04-04
申请人： Mark J. Bly
发明人： Mark J. Bly
IPC分类号： A61B19/00
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A lead delivery system for delivering a neurostimulation lead to a patient's internal jugular vein using a percutaneous stick. The system comprises a neurostimulation lead adapted to stimulate a vagus nerve from the internal jugular vein. The lead includes a proximal end, a distal end, a generally spiral shaped retaining structure interposed between the proximal and distal ends and configured to retain the lead in the internal jugular vein, an electrode coupled to the retaining structure, and a side port interposed between the retaining structure and the proximal end. The side port provides access to a lumen extending from the distal end to the side port. A guidewire is sized to fit within the side port and lumen and reduce a force exerted by the retaining structure against the internal jugular vein, thereby allowing rotation of the lead and orientation of the electrode by applying a torque to the lead. A catheter has a lumen sized to slideably receive the medical electrical lead and configured to provide access to the internal jugular vein from the percutaneous stick site. A method of delivering a medical electrical lead to a patient's internal jugular vein.
摘要翻译：用于使用经皮棒递送神经刺激导致患者颈内静脉的引导递送系统。该系统包括适于从颈内静脉刺激迷走神经的神经刺激引线。引线包括近端，远端，插入在近端和远端之间的大致螺旋形的保持结构，并且构造成将引线保持在颈内静脉内，连接到保持结构的电极和插入在保持结构和近端。侧端口提供进入从远端延伸到侧端口的内腔。导丝的尺寸设置成适合于侧端口和内腔，并且减小由保持结构抵抗颈内静脉施加的力，由此通过向引线施加扭矩来允许引线的引导和取向的旋转。导管具有尺寸适于可滑动地接收医疗电引线并且被配置为提供从经皮粘连部位进入颈内静脉的内腔。将医用电导线递送到患者的颈内静脉的方法。

26. 发明授权

US07747334B2 Left ventricular lead shapes 有权
标题翻译：左心室铅形
公开(公告)号：US07747334B2
公开(公告)日：2010-06-29
申请号：US11277326
申请日：2006-03-23
申请人： Mark J. Bly , Brian D. Soltis , Bruce A. Tockman , Avram Scheiner
发明人： Mark J. Bly , Brian D. Soltis , Bruce A. Tockman , Avram Scheiner
IPC分类号： A61N1/372
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A lead for sensing and pacing a left ventricle of the heart includes a lead body having a proximal portion and a distal portion, a lumen extending through the lead body, a conductor extending through the lead body from the proximal end to the distal end and an electrode disposed on the distal portion of the lead body and electrically coupled to the conductor. A distal tip of the lead body is continuously deflectable upon advancement and withdrawal of a stylet through the lumen at the distal portion to access a selected branch of the coronary sinus. The distal tip of the lead body may be offset before or after continuously deflecting the distal tip.
摘要翻译：用于感测和起搏心脏左心室的引线包括具有近端部分和远端部分的引线体，延伸穿过引线主体的内腔，从近端延伸穿过引线主体到远端的导体，以及电极，其设置在引线体的远端部分上并电耦合到导体。引导体的远侧末端在通过远端部分的内腔前进和取出探针时可连续偏转，以进入冠状窦的选定分支。引线体的远端可以在连续偏转远端之前或之后偏移。

27. 发明申请

US20080183254A1 DUAL SPIRAL LEAD CONFIGURATIONS 有权
标题翻译：双螺旋引导配置
公开(公告)号：US20080183254A1
公开(公告)日：2008-07-31
申请号：US11668887
申请日：2007-01-30
申请人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
发明人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括分叉的远端部分，其包括形成第一螺旋的第一细长构件和形成第二螺旋的第二细长构件。螺旋可以彼此平行或串联对准。

28. 发明授权

US08182463B2 Retrograde pressure regulated infusion 有权
标题翻译：逆行压力调节输液
公开(公告)号：US08182463B2
公开(公告)日：2012-05-22
申请号：US11609143
申请日：2006-12-11
申请人： Jessica Chiu , Gregory Waimong Chan , Hongzhi Bai , Nianjiong J. Bei , Mark J. Bly , Srinivasan Sridharan , Tom Hatten
发明人： Jessica Chiu , Gregory Waimong Chan , Hongzhi Bai , Nianjiong J. Bei , Mark J. Bly , Srinivasan Sridharan , Tom Hatten
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： A delivery catheter that includes a flexible shaft having a proximal end and a distal end, the distal end having an outer diameter less than about 13 mm; a delivery lumen having a proximal end and a distal end, the delivery lumen within the flexible shaft, the delivery lumen having at least an outlet port or at least one side hole at the distal end of the delivery lumen, the delivery lumen having a cross-sectional area at least about 5 mm2; a pressure monitoring lumen having a proximal end and a distal end, the pressure monitoring lumen within the flexible shaft; a pressure port adjacent to and connected to the distal end of the pressure monitoring lumen; a balloon inflation lumen having a proximal end and a distal end, the balloon inflation lumen within the flexible shaft; a soft tip at the distal end of the flexible shaft; a balloon at the distal end of the flexible shaft, the balloon connected to the distal end of the balloon inflation lumen, the balloon includes at least one of the following materials, polyether block amide resin, polyetheramide, polyurethane, silicone, natural latex, or synthetic latex; wherein the balloon is adapted to inflate to a diameter range of about 4 to about 15 mm.
摘要翻译：输送导管，其包括具有近端和远端的柔性轴，所述远端具有小于约13mm的外径; 输送腔，其具有近端和远端，所述输送腔在所述柔性轴内，所述输送腔至少具有出口端口或至少一个在所述输送腔的远端处的侧孔，所述输送腔具有交叉截面面积至少约5 mm2; 具有近端和远端的压力监测管腔，所述柔性轴内的所述压力监测腔; 与所述压力监视管腔的远端相邻并连接的压力口; 具有近端和远端的球囊充气腔，所述气囊膨胀腔在所述柔性轴内; 在柔性轴的远端处的软尖端; 在柔性轴的远端处的气囊，气囊连接到球囊充气腔的远端，气囊包括以下材料中的至少一种：聚醚嵌段酰胺树脂，聚醚酰胺，聚氨酯，硅氧烷，天然胶乳或合成胶乳其中所述气囊适于膨胀至约4至约15mm的直径范围。

29. 发明申请

US20100191310A1 Communication-Anchor Loop For Injectable Device 审中-公开
标题翻译：通信锚点注入装置
公开(公告)号：US20100191310A1
公开(公告)日：2010-07-29
申请号：US12509678
申请日：2009-07-27
申请人： Mark J. Bly
发明人： Mark J. Bly
IPC分类号： A61N1/08
CPC分类号： A61B5/0031 , A61B5/6846 , A61B5/6882 , A61B17/3468 , A61B2560/063
摘要： An injectable electronics device has a housing sized to fit within an injection tool lumen with one or more electrical components position within the housing, and a self-expanding loop antenna coupled to at least one electrical component within the housing. The self-expanding loop antenna is expandable from a first compressed shape to a second expanded shape.
摘要翻译：可注射电子设备具有壳体，其尺寸设置成在壳体内具有一个或多个电气部件位置的装配在注射工具内腔内，以及联接到壳体内的至少一个电气部件的自扩张环形天线。自膨胀环形天线可从第一压缩形状扩展成第二扩展形状。

30. 发明申请

US20080183187A1 DIRECT DELIVERY SYSTEM FOR TRANSVASCULAR LEAD 审中-公开
标题翻译：直升机系统
公开(公告)号：US20080183187A1
公开(公告)日：2008-07-31
申请号：US11669047
申请日：2007-01-30
申请人： Mark J. Bly
发明人： Mark J. Bly
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A lead delivery system for delivering a neurostimulation lead to a patient's internal jugular vein using a percutaneous stick. The system comprises a neurostimulation lead adapted to stimulate a vagus nerve from the internal jugular vein. The lead includes a proximal end, a distal end, a generally spiral shaped retaining structure interposed between the proximal and distal ends and configured to retain the lead in the internal jugular vein, an electrode coupled to the retaining structure, and a side port interposed between the retaining structure and the proximal end. The side port provides access to a lumen extending from the distal end to the side port. A guidewire is sized to fit within the side port and lumen and reduce a force exerted by the retaining structure against the internal jugular vein, thereby allowing rotation of the lead and orientation of the electrode by applying a torque to the lead. A catheter has a lumen sized to slideably receive the medical electrical lead and configured to provide access to the internal jugular vein from the percutaneous stick site. A method of delivering a medical electrical lead to a patient's internal jugular vein.
摘要翻译：用于使用经皮棒递送神经刺激导致患者颈内静脉的引导递送系统。该系统包括适于从颈内静脉刺激迷走神经的神经刺激引线。引线包括近端，远端，插入在近端和远端之间的大致螺旋形的保持结构，并且构造成将引线保持在颈内静脉内，连接到保持结构的电极和插入在保持结构和近端。侧端口提供进入从远端延伸到侧端口的内腔。导丝的尺寸设置成适合于侧端口和内腔，并且减小由保持结构抵抗颈内静脉施加的力，由此通过向引线施加扭矩来允许引线的引导和取向的旋转。导管具有尺寸适于可滑动地接收医疗电引线并且被配置为提供从经皮粘连部位进入颈内静脉的内腔。将医用电导线递送到患者的颈内静脉的方法。

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