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1. 发明授权

US08688190B2 Adherent device for sleep disordered breathing 有权
标题翻译：睡眠呼吸障碍的粘附装置
公开(公告)号：US08688190B2
公开(公告)日：2014-04-01
申请号：US13543660
申请日：2012-07-06
申请人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
发明人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
IPC分类号： A61B5/053 , A61B5/113
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.
摘要翻译：贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。该装置包括耦合到至少四个电极的阻抗电路，并且被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足。阻抗电路可以用于测量患者的水合。加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。

2. 发明申请

US20110178530A1 DIRECT DELIVERY SYSTEM FOR TRANSVASCULAR LEAD 有权
标题翻译：直升机系统
公开(公告)号：US20110178530A1
公开(公告)日：2011-07-21
申请号：US13079512
申请日：2011-04-04
申请人： Mark J. Bly
发明人： Mark J. Bly
IPC分类号： A61B19/00
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A lead delivery system for delivering a neurostimulation lead to a patient's internal jugular vein using a percutaneous stick. The system comprises a neurostimulation lead adapted to stimulate a vagus nerve from the internal jugular vein. The lead includes a proximal end, a distal end, a generally spiral shaped retaining structure interposed between the proximal and distal ends and configured to retain the lead in the internal jugular vein, an electrode coupled to the retaining structure, and a side port interposed between the retaining structure and the proximal end. The side port provides access to a lumen extending from the distal end to the side port. A guidewire is sized to fit within the side port and lumen and reduce a force exerted by the retaining structure against the internal jugular vein, thereby allowing rotation of the lead and orientation of the electrode by applying a torque to the lead. A catheter has a lumen sized to slideably receive the medical electrical lead and configured to provide access to the internal jugular vein from the percutaneous stick site. A method of delivering a medical electrical lead to a patient's internal jugular vein.
摘要翻译：用于使用经皮棒递送神经刺激导致患者颈内静脉的引导递送系统。该系统包括适于从颈内静脉刺激迷走神经的神经刺激引线。引线包括近端，远端，插入在近端和远端之间的大致螺旋形的保持结构，并且构造成将引线保持在颈内静脉内，连接到保持结构的电极和插入在保持结构和近端。侧端口提供进入从远端延伸到侧端口的内腔。导丝的尺寸设置成适合于侧端口和内腔，并且减小由保持结构抵抗颈内静脉施加的力，由此通过向引线施加扭矩来允许引线的引导和取向的旋转。导管具有尺寸适于可滑动地接收医疗电引线并且被配置为提供从经皮粘连部位进入颈内静脉的内腔。将医用电导线递送到患者的颈内静脉的方法。

3. 发明授权

US07747334B2 Left ventricular lead shapes 有权
标题翻译：左心室铅形
公开(公告)号：US07747334B2
公开(公告)日：2010-06-29
申请号：US11277326
申请日：2006-03-23
申请人： Mark J. Bly , Brian D. Soltis , Bruce A. Tockman , Avram Scheiner
发明人： Mark J. Bly , Brian D. Soltis , Bruce A. Tockman , Avram Scheiner
IPC分类号： A61N1/372
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A lead for sensing and pacing a left ventricle of the heart includes a lead body having a proximal portion and a distal portion, a lumen extending through the lead body, a conductor extending through the lead body from the proximal end to the distal end and an electrode disposed on the distal portion of the lead body and electrically coupled to the conductor. A distal tip of the lead body is continuously deflectable upon advancement and withdrawal of a stylet through the lumen at the distal portion to access a selected branch of the coronary sinus. The distal tip of the lead body may be offset before or after continuously deflecting the distal tip.
摘要翻译：用于感测和起搏心脏左心室的引线包括具有近端部分和远端部分的引线体，延伸穿过引线主体的内腔，从近端延伸穿过引线主体到远端的导体，以及电极，其设置在引线体的远端部分上并电耦合到导体。引导体的远侧末端在通过远端部分的内腔前进和取出探针时可连续偏转，以进入冠状窦的选定分支。引线体的远端可以在连续偏转远端之前或之后偏移。

4. 发明申请

US20090076345A1 Adherent Device with Multiple Physiological Sensors 审中-公开
标题翻译：具有多个生理传感器的粘附装置
公开(公告)号：US20090076345A1
公开(公告)日：2009-03-19
申请号：US12209288
申请日：2008-09-12
申请人： Yatheendhar D. Manicka , Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Scott T. Mazar , Jerry S. Wang
发明人： Yatheendhar D. Manicka , Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/00 , A61B5/0402
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a hydration signal of the patient. Electrocardiogram circuitry is coupled to at least two of the at least four electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate a signal in response to at least one of an activity or a position of the patient.
摘要翻译：用于监测患者的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的水合信号。心电图电路耦合到至少四个电极中的至少两个，以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生信号。

5. 发明申请

US20080183264A1 ELECTRODE CONFIGURATIONS FOR TRANSVASCULAR NERVE STIMULATION 审中-公开
标题翻译：用于透视神经刺激的电极配置
公开(公告)号：US20080183264A1
公开(公告)日：2008-07-31
申请号：US11668957
申请日：2007-01-30
申请人： Mark J. Bly , David J. Smith , Imad Libbus
发明人： Mark J. Bly , David J. Smith , Imad Libbus
IPC分类号： A61N1/05
CPC分类号： A61N1/057
摘要： An intravascular lead adapted to be deployed to a stimulation site within a vessel adjacent a nerve to be stimulated includes at least a first electrode adapted to deliver an electrical pulse across a vessel wall. The first electrode includes an electrically active surface having one or more surface features adapted to focus current. The first electrode is disposed on the distal portion that the electrically active surface can be directed towards the nerve to be stimulated.
摘要翻译：适于部署到邻近被刺激的神经的血管内的刺激部位的血管内线包括至少第一电极，其适于将电脉冲传送穿过血管壁。第一电极包括具有适于聚焦电流的一个或多个表面特征的电活性表面。第一电极设置在远端部分上，电活性表面可以被引导到被刺激的神经。

6. 发明申请

US20080183254A1 DUAL SPIRAL LEAD CONFIGURATIONS 有权
标题翻译：双螺旋引导配置
公开(公告)号：US20080183254A1
公开(公告)日：2008-07-31
申请号：US11668887
申请日：2007-01-30
申请人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
发明人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括分叉的远端部分，其包括形成第一螺旋的第一细长构件和形成第二螺旋的第二细长构件。螺旋可以彼此平行或串联对准。

7. 发明授权

US08591430B2 Adherent device for respiratory monitoring 有权
标题翻译：用于呼吸监测的附着装置
公开(公告)号：US08591430B2
公开(公告)日：2013-11-26
申请号：US12209268
申请日：2008-09-12
申请人： Badri Amurthur , Mark J. Bly , Imad Libbus , Yatheendhar D. Manicka
发明人： Badri Amurthur , Mark J. Bly , Imad Libbus , Yatheendhar D. Manicka
IPC分类号： A61B5/08
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： A respiratory monitoring system is provided. A measuring system is provided that includes, (i) an adherent device configured to be coupled to a patient, the adherent device including a plurality of sensors that monitor respiratory status, at least one of the sensors configured to monitor the patient's respiration, and (ii) a wireless communication device coupled to the plurality of sensors and configured to transfer patient data directly or indirectly from the plurality of sensors to a remote monitoring system. A remote monitoring system is coupled to the wireless communication device.
摘要翻译：提供呼吸监测系统。提供了一种测量系统，其包括：（i）被配置为耦合到患者的粘附装置，所述粘附装置包括监测呼吸状态的多个传感器，配置成监测患者呼吸的至少一个传感器，以及（ ii）耦合到所述多个传感器并被配置为将患者数据直接或间接地从所述多个传感器传送到远程监控系统的无线通信设备。远程监控系统耦合到无线通信设备。

8. 发明申请

US20130085347A1 ADHERENT DEVICE WITH MULTIPLE PHYSIOLOGICAL SENSORS 有权
标题翻译：具有多种生理传感器的附属装置
公开(公告)号：US20130085347A1
公开(公告)日：2013-04-04
申请号：US13598238
申请日：2012-08-29
申请人： Yatheendhar D. Manicka , Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Scott T. Mazar , Jerry S. Wang
发明人： Yatheendhar D. Manicka , Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/0408 , A61B7/00 , A61B5/046 , A61B5/0472 , A61B5/08 , A61B5/11 , A61B5/00 , A61B5/0464
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a hydration signal of the patient. Electrocardiogram circuitry is coupled to at least two of the at least four electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate a signal in response to at least one of an activity or a position of the patient.
摘要翻译：用于监测患者的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的水合信号。心电图电路耦合到至少四个电极中的至少两个，以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生信号。

9. 发明申请

US20120277549A1 ADHERENT DEVICE FOR SLEEP DISORDERED BREATHING 有权
标题翻译：用于睡眠障碍呼吸的附属装置
公开(公告)号：US20120277549A1
公开(公告)日：2012-11-01
申请号：US13543660
申请日：2012-07-06
申请人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
发明人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
IPC分类号： A61B5/0492 , A61B5/08 , A61B5/0408 , A61B5/01 , A61B5/053 , A61B5/11
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.
摘要翻译：贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。该装置包括耦合到至少四个电极并被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足的阻抗电路。阻抗电路可以用于测量患者的水合。加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。

10. 发明授权

US08182463B2 Retrograde pressure regulated infusion 有权
标题翻译：逆行压力调节输液
公开(公告)号：US08182463B2
公开(公告)日：2012-05-22
申请号：US11609143
申请日：2006-12-11
申请人： Jessica Chiu , Gregory Waimong Chan , Hongzhi Bai , Nianjiong J. Bei , Mark J. Bly , Srinivasan Sridharan , Tom Hatten
发明人： Jessica Chiu , Gregory Waimong Chan , Hongzhi Bai , Nianjiong J. Bei , Mark J. Bly , Srinivasan Sridharan , Tom Hatten
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/1002 , A61M2025/1052
摘要： A delivery catheter that includes a flexible shaft having a proximal end and a distal end, the distal end having an outer diameter less than about 13 mm; a delivery lumen having a proximal end and a distal end, the delivery lumen within the flexible shaft, the delivery lumen having at least an outlet port or at least one side hole at the distal end of the delivery lumen, the delivery lumen having a cross-sectional area at least about 5 mm2; a pressure monitoring lumen having a proximal end and a distal end, the pressure monitoring lumen within the flexible shaft; a pressure port adjacent to and connected to the distal end of the pressure monitoring lumen; a balloon inflation lumen having a proximal end and a distal end, the balloon inflation lumen within the flexible shaft; a soft tip at the distal end of the flexible shaft; a balloon at the distal end of the flexible shaft, the balloon connected to the distal end of the balloon inflation lumen, the balloon includes at least one of the following materials, polyether block amide resin, polyetheramide, polyurethane, silicone, natural latex, or synthetic latex; wherein the balloon is adapted to inflate to a diameter range of about 4 to about 15 mm.
摘要翻译：输送导管，其包括具有近端和远端的柔性轴，所述远端具有小于约13mm的外径; 输送腔，其具有近端和远端，所述输送腔在所述柔性轴内，所述输送腔至少具有出口端口或至少一个在所述输送腔的远端处的侧孔，所述输送腔具有交叉截面面积至少约5 mm2; 具有近端和远端的压力监测管腔，所述柔性轴内的所述压力监测腔; 与所述压力监视管腔的远端相邻并连接的压力口; 具有近端和远端的球囊充气腔，所述气囊膨胀腔在所述柔性轴内; 在柔性轴的远端处的软尖端; 在柔性轴的远端处的气囊，气囊连接到球囊充气腔的远端，气囊包括以下材料中的至少一种：聚醚嵌段酰胺树脂，聚醚酰胺，聚氨酯，硅氧烷，天然胶乳或合成胶乳其中所述气囊适于膨胀至约4至约15mm的直径范围。

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