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21. 发明授权

US06488701B1 Stent-graft assembly with thin-walled graft component and method of manufacture 失效
标题翻译：具有薄壁移植物组件的支架移植物组件及其制造方法
公开(公告)号：US06488701B1
公开(公告)日：2002-12-03
申请号：US09053145
申请日：1998-03-31
申请人： John E. Nolting , Michael S. Williams , Matthew J. Birdsall , Robert D. Lashinski , Samuel L. Shull
发明人： John E. Nolting , Michael S. Williams , Matthew J. Birdsall , Robert D. Lashinski , Samuel L. Shull
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/90 , A61F2/91 , A61F2002/072 , A61F2250/0023 , A61F2250/0039 , B29C53/38 , B29C53/60 , B29L2023/007
摘要： A stent-graft assembly having a thin-walled membrane and method of preparing the same are disclosed. In a first embodiment, the assembly comprises a stent, a coating and a porous membrane, wherein the membrane is less than 0.040 inch thick or less. Portions of the coating extend into the pores of the thin membrane to sealingly engage the membrane to achieve secure adhesion. In a second embodiment the coating and thin membrane bond to form a homogenous structure. In an alternative embodiment, the assembly comprises an inner and outer thin membrane bound to one another through the interstices of the support member and a coating at the proximal and distal regions. In any of the foregoing embodiments, the proximal and distal regions of the stent-graft assembly may comprise an additional coating, whereby layers of material are sealed, thereby minimizing thrombogenic potential of free ends of the assembly.
摘要翻译：公开了一种具有薄壁膜的支架移植组件及其制备方法。在第一实施例中，组件包括支架，涂层和多孔膜，其中所述膜小于0.040英寸或更小。涂层的一部分延伸到薄膜的孔中以密封地接合膜以实现牢固的粘附。在第二实施方案中，涂层和薄膜键合以形成均匀结构。在替代实施例中，组件包括通过支撑构件的间隙和在近侧区域和远侧区域处的涂层彼此结合的内部和外部薄膜。在任何前述实施例中，支架 - 移植物组件的近端和远端区域可以包括另外的涂层，由此密封材料层，从而最小化组件自由端的血栓形成潜力。

22. 发明授权

US6129738A Method and apparatus for treating stenoses at bifurcated regions 失效
标题翻译：用于治疗分叉区狭窄的方法和装置
公开(公告)号：US6129738A
公开(公告)日：2000-10-10
申请号：US100416
申请日：1998-06-20
申请人： Randall T. Lashinski , Philip J. Haarstad , Matthew J. Birdsall
发明人： Randall T. Lashinski , Philip J. Haarstad , Matthew J. Birdsall
IPC分类号： A61F2/06 , A61F2/86 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61F2/954 , A61F2/958 , A61F2/86 , A61F2002/065 , A61M2025/1045 , A61M2025/1093
摘要： A method and apparatus for treating stenoses at bifurcated regions of body lumens is disclosed. A balloon catheter system is disclosed comprising two balloon catheters, or a balloon catheter having a bifurcated distal end, with a linking guide wire lumen at the distal end of one balloon catheter, or one branch of the bifurcated catheter, for linking the two balloons or branches such that the device can be tracked to a treatment site. Once at the treatment site, the balloon catheters or branches of the bifurcated distal end can be unlinked and separately positioned within the branches of the bifurcated body lumen. The apparatus can also serve as a delivery system for multiple prostheses or a bifurcated endoluminal prosthesis.
摘要翻译：公开了一种用于在体腔的分叉区域处理狭窄的方法和装置。公开了一种气囊导管系统，其包括两个球囊导管或具有分叉远端的球囊导管，其中一个球囊导管的远端处的连接导丝管腔或分叉导管的一个分支用于连接两个气囊或分支，使得设备可以跟踪到治疗部位。一旦在治疗部位，分叉的远端的气囊导管或分支可以被取消连接并且分开地定位在分叉的体腔的分支内。该装置还可以用作多个假体或分叉的腔内假体的递送系统。

23. 发明授权

US6071296A Stent for improved transluminal deployment 失效
标题翻译：支架用于改善腔内部署
公开(公告)号：US6071296A
公开(公告)日：2000-06-06
申请号：US852307
申请日：1997-05-07
申请人： Robert D. Lashinski , Matthew J. Birdsall
发明人： Robert D. Lashinski , Matthew J. Birdsall
IPC分类号： A61F2/86 , A61F2/90 , A61M29/00
CPC分类号： A61F2/90 , A61F2/91 , A61F2/915 , A61F2/86 , A61F2002/8486 , A61F2002/91558
摘要： A stent and method for manufacturing a stent comprising an expandable, generally tubular body portion in which one or both ends of the stent are provided with a generally rounded, smooth radiused portion that forms a bulbous protrusion out of the plane of the circumference of the stent. The design of the stent increases the profile of the end of the stent and decreases the risk of injury or vessel dissection during stent deployment.
摘要翻译：一种用于制造支架的支架和方法，其包括可扩张的，大致管状的主体部分，其中所述支架的一端或两端设置有大致圆形且平滑的圆形部分，所述部分在所述支架的圆周平面外形成球状突起。支架的设计增加了支架末端的轮廓，并降低了支架展开期间损伤或血管夹层的风险。

24. 发明授权

US07740655B2 Reinforced surgical conduit for implantation of a stented valve therein 有权
标题翻译：用于在其中植入支架瓣膜的加强手术导管
公开(公告)号：US07740655B2
公开(公告)日：2010-06-22
申请号：US11278932
申请日：2006-04-06
申请人： Matthew J. Birdsall
发明人： Matthew J. Birdsall
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/06 , A61F2/2433 , A61F2/2475 , A61F2/90 , A61F2230/0054 , A61F2250/006
摘要： A pulmonary valve replacement system having a vascular conduit and a prosthetic valve device including a valve operably connected to a support structure. The prosthetic valve device is positioned within the vascular conduit. A conduit support includes a substantially circular cross-section. The conduit support is positioned adjacent to and reinforces the vascular conduit. In one embodiment, the pulmonary valve replacement system includes a catheter and an inflatable member operably attached to the catheter. The prosthetic valve device is disposed on the inflatable member. The invention provides a method for replacing a pulmonary valve including providing a vascular conduit positioned at a treatment site. The vascular conduit includes a conduit support positioned adjacent the vascular conduit. A prosthetic valve device is deployed within the vascular conduit via catheter. The prosthetic valve device includes a valve operably connected to a support structure. The vascular conduit is supported with the conduit support.
摘要翻译：一种具有血管导管和包括可操作地连接到支撑结构的瓣膜的假体瓣膜装置的肺动脉瓣膜置换系统。假体瓣膜装置位于血管内。管道支撑件包括基本圆形的横截面。导管支撑件邻近并加强血管导管。在一个实施例中，肺动脉瓣膜置换系统包括导管和可操作地附接到导管的可充气构件。假体阀装置设置在可膨胀构件上。本发明提供一种替换肺动脉瓣的方法，包括提供位于治疗部位的血管导管。血管导管包括邻近血管导管定位的导管支架。假体瓣膜装置通过导管部署在血管导管内。假体阀装置包括可操作地连接到支撑结构的阀。血管导管用导管支撑支撑。

25. 发明申请

US20090196899A1 Controlled Alloy Stent 审中-公开
标题翻译：受控合金支架
公开(公告)号：US20090196899A1
公开(公告)日：2009-08-06
申请号：US12023268
申请日：2008-01-31
申请人： Matthew J. Birdsall , Jeffrey W. Allen , Darrel Untereker
发明人： Matthew J. Birdsall , Jeffrey W. Allen , Darrel Untereker
IPC分类号： A61F2/84 , A61F2/82 , A61F2/06
CPC分类号： B22F3/1121 , A61F2/82 , A61F2250/0023 , A61F2250/0067 , A61L31/022 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B22F3/1146 , B22F2999/00 , B22F1/0007
摘要： A method of manufacturing a stent includes determining a porosity characteristic and combining at least two predetermined alloy constituents based on the porosity characteristic. The method further determines a solidification profile based on the porosity characteristic and combined alloy constituents and solidifies the combined alloy constituents based on the solidification profile. In addition, the method includes forming a stent framework from the solidified alloy constituents, removing at least a portion of at least one of the alloy constituents, and forming pores within the stent framework based on the removal and consistent with the porosity characteristic.
摘要翻译：制造支架的方法包括确定孔隙率特性，并且基于孔隙率特性组合至少两个预定的合金成分。该方法还基于孔隙率特性和组合的合金成分进一步确定凝固曲线，并基于固化曲线固化组合的合金成分。此外，该方法包括从固化的合金成分形成支架框架，去除合金成分中的至少一种的至少一部分，并且基于去除并与孔隙特性一致，在支架框架内形成孔。

26. 发明申请

US20090024199A1 Controlled Porosity Stent 有权
标题翻译：可控孔隙支架
公开(公告)号：US20090024199A1
公开(公告)日：2009-01-22
申请号：US11778430
申请日：2007-07-16
申请人： Matthew J. Birdsall , Jeffrey W. Allen
发明人： Matthew J. Birdsall , Jeffrey W. Allen
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , Y10T29/49885 , Y10T29/49995 , Y10T29/49996
摘要： A method of manufacturing a stent includes forming a stent blank including a predetermined alloy composition, the alloy composition including at least base element and at least one sacrificial element and forming a stent framework from the stent blank. The method further includes removing at least a portion of the sacrificial element and forming at least one pore based on the removal. A method of manufacturing a vascular treatment system includes forming a stent blank including a predetermined alloy composition including at least one base element and at least one sacrificial element. The method further includes forming a stent framework and removing at least a portion of the sacrificial element. The method also includes forming at least one pore based on the removal, bending the stent framework to a delivery shape, and attaching the bent stent framework including the formed pores to a catheter.
摘要翻译：制造支架的方法包括形成包括预定合金组成的支架坯料，所述合金组合物至少包括基体元件和至少一个牺牲元件，并从支架坯件形成支架框架。该方法还包括去除牺牲元件的至少一部分并基于去除形成至少一个孔。一种制造血管治疗系统的方法包括形成包括至少一个基底元件和至少一个牺牲元件的预定合金组合物的支架坯料。该方法还包括形成支架框架并去除牺牲元件的至少一部分。该方法还包括基于去除形成至少一个孔，将支架框架弯曲成输送形状，以及将包括形成的孔的弯曲支架框架附接到导管。

27. 发明授权

US07208172B2 Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices 失效
标题翻译：金属复合涂层，用于从可植入装置的表面输送治疗剂
公开(公告)号：US07208172B2
公开(公告)日：2007-04-24
申请号：US10701262
申请日：2003-11-03
申请人： Matthew J. Birdsall , Richard L. Klein , Nathan Maier
发明人： Matthew J. Birdsall , Richard L. Klein , Nathan Maier
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.
摘要翻译：公开了一种用于可植入医疗装置的金属复合涂层及其形成方法。该复合涂层包括形成在该装置的表面上的至少一个金属或金属粘结层，随后是连接层上的一个或多个附加层的化学电化学包层。一种或多种治疗或生物活性剂与至少一种无电化学电化学包层共沉积。

28. 发明授权

US07018400B2 Endolumenal prothesis and method of use in bifurcation regions of body lumens 失效
公开(公告)号：US07018400B2
公开(公告)日：2006-03-28
申请号：US10369352
申请日：2003-02-17
申请人： Robert D. Lashinski , Matthew J. Birdsall , Dennis L. Brooks , Philip J. Haarstad , James C. Peacock, III , Antonio Colombo
发明人： Robert D. Lashinski , Matthew J. Birdsall , Dennis L. Brooks , Philip J. Haarstad , James C. Peacock, III , Antonio Colombo
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/91541 , A61F2002/91558 , A61F2250/0039
摘要： An endolumenal medical device assembly is provided for use in a bifurcation region of a body lumen. An expandable prosthesis, preferably an endolumenal support device such as a stent, is included in the assembly and is adjustable from a radially collapsed condition to a radially expanded condition. The expandable prosthesis further includes a prosthesis passageway and a side port through which the prosthesis passageway communicates externally of the prosthesis. A dilator or an access device is engaged within the prosthesis passageway and also through the side port while the expandable prosthesis is in the radially collapsed condition. By coupling a guidewire to an access device engaged within the side port and positioning the guidewire therein, the expandable prosthesis may be positioned in the bifurcation region such that its distal end portion is in a first branch lumen extending from the bifurcation, its proximal end portion is in a common proximal lumen of the bifurcation region, and the side port is aligned with an entrance zone to a second branch lumen extending from the bifurcation. When the expandable prosthesis is positioned at the bifurcation region in this orientation, the access device maintains percutaneous translumenal access to the second branch lumen through the prosthesis passageway and the side port while the expandable prosthesis is adjusted from the radially collapsed condition to the radially expanded condition. In addition, a dilator when engaged within the side port is adapted to expand the bore formed by the side port from an initial inner diameter to a larger expanded inner diameter. A second, lateral expandable prosthesis can also be coupled to the first expandable prosthesis at a location adjacent to the side port such that the dilator or access device extending through the side port is engaged within a lateral prosthesis lumen, extending through the lateral expandable prosthesis.

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