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21. 发明授权

US08765359B2 Method of fabricating patterned functional substrates 有权
标题翻译：制作图案化功能基板的方法
公开(公告)号：US08765359B2
公开(公告)日：2014-07-01
申请号：US13489099
申请日：2012-06-05
申请人： Andres Fernandez , Shaunak Roy , Jay Shafto , Norman L. Burns , Claudia Richter , Pierre F. Indermuhle
发明人： Andres Fernandez , Shaunak Roy , Jay Shafto , Norman L. Burns , Claudia Richter , Pierre F. Indermuhle
IPC分类号： G03F7/26
CPC分类号： G03F7/20 , B05D1/60 , G03F7/405
摘要： Methods of preparing organosilane-functionalized regions on a substrate surface and more specifically fabricating patterned functionalized substrates suitable to be optically read, the methods generally comprising employing a vapor deposition process of an organosilane gas onto a lithographically patterned silicon surface followed by removal of the patterning media in a bath of organic solvents and ultrasonic excitation. The inventive methods provide optimized surface density of functional species while avoiding deleterious effects that can occur when lithographically patterned substrates are exposed to various gaseous species during the functionalization process.
摘要翻译：在衬底表面上制备有机硅烷官能化区域的方法，更具体地制备适于光学读取的图案化官能化衬底的方法，所述方法通常包括将有机硅烷气体的气相沉积工艺应用于光刻图案化的硅表面，随后除去图案形成介质在有机溶剂和超声波激发浴中。本发明的方法提供功能物质的优化的表面密度，同时避免当在功能化过程中将光刻图案化的基底暴露于各种气态物质时可能发生的有害影响。

22. 发明申请

US20120122721A1 METHOD FOR NUCLEIC ACID DETECTION USING VOLTAGE ENHANCEMENT 有权
标题翻译：使用电压增强的核酸检测方法
公开(公告)号：US20120122721A1
公开(公告)日：2012-05-17
申请号：US13337968
申请日：2011-12-27
申请人： Andres Fernandez , Bryan Staker , Radoje Drmanac
发明人： Andres Fernandez , Bryan Staker , Radoje Drmanac
IPC分类号： C40B30/04
CPC分类号： C12Q1/6832 , C12Q1/6825 , C12Q2523/307 , C12Q2565/501 , C12Q2565/607
摘要： Methods are provided for carrying out nucleic acid analysis, including sequence identification, employing voltage and/or controlled electric charge to enhance operation. A device comprises substrates for nucleic acid analysis, a first electrically conductive layer, a first electrically insulative layer of dielectric material on the first conductive layer, a second electrically conductive layer disposed upon the first insulative layer in a pattern to define discrete attachment sites for macromolecules on the first insulative layer, the second conductive layer provided with means for resisting affinity for the macromolecules to impede their attachment to sites on the second conductive layer, and terminals for the first and second conductive layers for applying a voltage pattern between the first and the second conductive layers to control affinity between the macromolecules and the discrete attachment sites.
摘要翻译：提供用于进行核酸分析的方法，包括序列鉴定，采用电压和/或受控电荷以增强操作。一种器件包括用于核酸分析的衬底，第一导电层，第一导电层上的介电材料的第一电绝缘层，第二导电层，以图案形式设置在第一绝缘层上，以限定大分子的离散附着位点在第一绝缘层上，第二导电层设置有用于抵抗大分子阻挡其附着于第二导电层上的部位的亲和力的装置，以及用于在第一和第二绝缘层之间施加电压图案的第一和第二导电层的端子第二导电层以控制大分子和离散附着位点之间的亲和力。

23. 发明申请

US20110269644A1 STRUCTURES FOR ENHANCED DETECTION OF FLUORESCENCE 有权
标题翻译：用于增强荧光检测的结构
公开(公告)号：US20110269644A1
公开(公告)日：2011-11-03
申请号：US13181289
申请日：2011-07-12
申请人： Andres Fernandez
发明人： Andres Fernandez
IPC分类号： C40B30/10 , C40B60/14 , C40B50/14 , B05D5/06 , B05D5/12
CPC分类号： G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： Substrates are provided for use in the detection, identification and analysis of biologic or chemical samples that are labeled with a fluorescent label, in which the plane of maximum fluorescence is displaced from a reflective substrate surface so that the intensity maximum of the standing wave interference pattern of incident and reflected probe radiation is enhanced. The format of the substrates includes substantially planar surfaces as well as substrates with introduced variations to the substrate surface, e.g., depressions, wells, pedestals and the like, disposed in arrays or other similar structures such that one or more fluorophore-comprising objects can be attached thereto.
摘要翻译：提供了用于检测，识别和分析用荧光标记标记的生物或化学样品的底物，其中最大荧光平面从反射衬底表面移位，使得驻波干涉图的强度最大值的事件和反射探针辐射得到增强。衬底的形式包括基本平坦的表面以及具有引入到衬底表面的变化的衬底，例如设置在阵列或其它类似结构中的凹陷，阱，基座等，使得一个或多个含荧光体的物体可以是附在其上。

24. 发明申请

US20090270273A1 ARRAY STRUCTURES FOR NUCLEIC ACID DETECTION 审中-公开
标题翻译：核酸检测的阵列结构
公开(公告)号：US20090270273A1
公开(公告)日：2009-10-29
申请号：US12427255
申请日：2009-04-21
申请人： Norman Burns , Andres Fernandez , Karen Shannon
发明人： Norman Burns , Andres Fernandez , Karen Shannon
IPC分类号： C40B30/04 , C40B40/08 , C40B50/14
CPC分类号： C12Q1/6837 , B01J2219/00364 , B01J2219/00432 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , C12Q1/6874 , C12Q2565/513 , C12Q2533/107 , C12Q2525/191 , C12Q2525/179
摘要： Devices formed as optically readable substrates are provided having a high feature density (e.g., attachment or deposition sites) in arrays comprising macromolecules, specifically amplicons, and devices and methods are provided for analysis of target nucleic acids having an undetermined sequence. High density arrayed nucleic acids are provided which are amenable to individual or multiple nucleotide interrogation, and which are particularly useful to determine the nucleotide sequence of a complex target nucleic acid sequence
摘要翻译：提供了形成为光学可读基底的装置，其具有包括大分子，特别是扩增子的阵列中的高特征密度（例如，附着或沉积位点），并且提供了用于分析具有未确定序列的靶核酸的装置和方法。提供了高密度排列的核酸，其可适于单个或多重核苷酸询问，并且其特别可用于确定复合靶核酸序列的核苷酸序列

25. 发明申请

US20090117006A1 STRUCTURES FOR ENHANCED DETECTION OF FLUORESCENCE 有权
标题翻译：用于增强荧光检测的结构
公开(公告)号：US20090117006A1
公开(公告)日：2009-05-07
申请号：US12261447
申请日：2008-10-30
申请人： Andres Fernandez
发明人： Andres Fernandez
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： Substrates are provided for use in the detection, identification and analysis of biologic or chemical samples that are labeled with a fluorescent label, in which the plane of maximum fluorescence is displaced from a reflective substrate surface so that the intensity maximum of the standing wave interference pattern of incident and reflected probe radiation is enhanced. The format of the substrates includes substantially planar surfaces as well as substrates with introduced variations to the substrate surface, e.g., depressions, wells, pedestals and the like, disposed in arrays or other similar structures such that one or more fluorophore-comprising objects can be attached thereto.
摘要翻译：提供了用于检测，识别和分析用荧光标记标记的生物或化学样品的底物，其中最大荧光平面从反射衬底表面移位，使得驻波干涉图的强度最大值的事件和反射探针辐射得到增强。衬底的形式包括基本平坦的表面以及具有引入到衬底表面的变化的衬底，例如设置在阵列或其它类似结构中的凹陷，阱，基座等，使得一个或多个含荧光体的物体可以是附在其上。

26. 发明授权

US06791742B2 MEMS structure with raised electrodes 有权
公开(公告)号：US06791742B2
公开(公告)日：2004-09-14
申请号：US10700734
申请日：2003-11-03
申请人： Bryan P. Staker , Lawrence P. Muray , Andres Fernandez
发明人： Bryan P. Staker , Lawrence P. Muray , Andres Fernandez
IPC分类号： G02B2600
CPC分类号： G02B26/0841 , B81B3/0086 , B81B2201/042
摘要： In an electrostatically controlled deflection apparatus, such as a MEMS array having cavities formed around electrodes and which is mounted directly on a dielectric or controllably resistive substrate in which are embedded electrostatic actuation electrodes disposed in alignment with the individual MEMS elements, a mechanism is provided to mitigate the effects of uncontrolled dielectric surface potentials between the MEMS elements and the electrostatic actuation electrodes, the mechanism being raised electrodes relative to the dielectric or controllably resistive surface of the substrate. The aspect ratio of the gaps between elements (element height to element separation ratio) is at least 0.1 and preferably at least 0.5 and preferably between 0.75 and 2.0 with a typical choice of about 1.0, assuming a surface fill factor of 50% or greater. Higher aspect ratios at these fill factors are believed not to provide more than marginal improvement.

27. 发明授权

US06717325B2 Method and apparatus for actuation of a two-axis MEMS device using three actuation elements 有权
标题翻译：使用三个致动元件致动两轴MEMS装置的方法和装置
公开(公告)号：US06717325B2
公开(公告)日：2004-04-06
申请号：US10093318
申请日：2002-03-06
申请人： Andres Fernandez , William C. Dickson
发明人： Andres Fernandez , William C. Dickson
IPC分类号： H02N100
CPC分类号： G02B26/0833
摘要： Apparatus and methods are provided for driving a two-axis MEMS mirror using three non-contact actuation elements or electrodes. A differential bi-directional mirror control uses unipolar drive voltages biased at a suitable value. Transformation functions map two-axis tip-tilt commands to three actuation drive signals for selected electrode orientations and sizes.
摘要翻译：提供了用于使用三个非接触致动元件或电极驱动双轴MEMS镜的装置和方法。差分双向镜控制使用以适当值偏置的单极驱动电压。转换功能将两轴尖端倾斜命令映射到三个驱动驱动信号，以选择电极方向和尺寸。

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