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    • 26. 再颁专利
    • Benzoic acid derivatives and process for preparing the same
    • 苯甲酸衍生物及其制备方法
    • USRE36477E
    • 1999-12-28
    • US104559
    • 1998-06-25
    • Koichi Shudo
    • Koichi Shudo
    • C07F7/08C07F7/30C07F7/10C07F7/18
    • C07F7/30C07F7/0818
    • Benzoic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or lower-alkyl, R.sub.2 and R.sub.4 represent hydrogen, trimethylsilyl, or trimethylgermyl, R.sub.3 represents hydrogen, lower-alkyl, trimethylsilyl, or trimethylgermyl, R.sub.5 represents hydrogen, lower-alkyl, acetyl, or hydroxy, at least one of R.sub.2 and R.sub.3 being trimethylsilyl or trinethylgermyl, and R.sub.6 means hydroxy, lower-alkoxy, or a group of the formula --NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 mean hydrogen or lower-alkyl, and X represents a group of the formula --CONH--, --NHCO--, --COO--, --OCO--, --COCH.dbd.CH--, --COCH.dbd.C(OH), or --CH.dbd.CH--, which exhibit excellent effect as differentiation-inducing agents for neoplastic cells, especially leukemia cells, or a therapeutic agent for psoriasis or immune and inflammatory diseases, and a process for the preparation thereof, are disclosed.
    • 由式(I)表示的苯甲酸衍生物:其中R1表示氢或低级烷基,R2和R4表示氢,三甲基甲硅烷基或三甲基锗烷基,R3表示氢,低级烷基,三甲基甲硅烷基或三甲基锗烷基,R5表示氢, 烷基,乙酰基或羟基,R 2和R 3中的至少一个为三甲基甲硅烷基或三乙基锗烷基,R 6表示羟基,低级烷氧基或式-NR 7 R 8基团,其中R 7和R 8表示氢或低级烷基,X 代表式为-CONH-,-NHCO-,-COO-,-OCO-,-COCH = CH-,-COCH = C(OH)或-CH = CH-的基团, 公开了用于肿瘤细胞,特别是白血病细胞的诱导剂或牛皮癣或免疫和炎性疾病的治疗剂及其制备方法。