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1. 发明授权

US06867226B2 Serotonin 5-HT3 receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3受体部分激活剂
公开(公告)号：US06867226B2
公开(公告)日：2005-03-15
申请号：US10219496
申请日：2002-08-16
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31/42 , A61K31/423 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/5513 , A61P1/00 , A61P1/08 , A61P1/12 , A61P1/14 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/30 , C07D263/58 , C07D263/60 , C07D413/04 , A61K31/50
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect.Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下发现：以下式（2）化合物为代表的新合成苯并恶唑衍生物具有强烈的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体激活作用，本发明提供了这些苯并恶唑衍生物作为5-羟色胺5-HT 3受体部分活化剂。式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代或未取代的氨基，或二 R1和R2的基团可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

2. 发明授权

US06333328B1 Serotonin 5-HT3 receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3受体部分激活剂
公开(公告)号：US06333328B1
公开(公告)日：2001-12-25
申请号：US09686759
申请日：2000-10-12
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31495
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下发现：以下式（2）化合物为代表的新合成苯并恶唑衍生物具有强烈的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体激活作用，本发明提供了这些苯并恶唑衍生物作为5-羟色胺5-HT 3受体部分激活因子。式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代或未取代的氨基，或二 R1和R2的基团可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

3. 发明授权

US6037342A Serotonin 5-HT.sub.3 receptor partial activator 失效
公开(公告)号：US6037342A
公开(公告)日：2000-03-14
申请号：US852747
申请日：1997-05-06
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31/42 , A61K31/423 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/5513 , A61P1/00 , A61P1/08 , A61P1/12 , A61P1/14 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/30 , C07D263/58 , C07D263/60 , C07D413/04 , A61N43/62 , C07D243/08 , C07D403/00
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT.sub.3 receptor partial activator which has a serotonin 5-HT.sub.3 receptor activating action, in addition to its serotonin 5-HT.sub.3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT.sub.3 receptor antagonism and serotonin 5-HT.sub.3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT.sub.3 receptor partial activators. ##STR1## In the above formula, R.sub.1 to R.sub.4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R.sub.1 and R.sub.2 may be linked together to form a ring structure, namely benzene ring; R.sub.5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.

4. 发明授权

US06552057B2 Serotonin 5-HT3 receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3受体部分激活剂
公开(公告)号：US06552057B2
公开(公告)日：2003-04-22
申请号：US09796805
申请日：2001-03-02
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K3142
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下发现：以下式（2）化合物为代表的新合成苯并恶唑衍生物具有强烈的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体激活作用，本发明提供了这些苯并恶唑衍生物作为5-羟色胺5-HT 3受体部分激活因子。式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代或未取代的氨基，或二 R1和R2的基团可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

5. 发明授权

US06297246B1 Serotonin 5-HT3, receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3，受体部分活化剂
公开(公告)号：US06297246B1
公开(公告)日：2001-10-02
申请号：US09298952
申请日：1999-04-26
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31496
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下结构式（2）所示的新合成的苯并恶唑衍生物具有强的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体活化作用，本发明提供了这些苯并恶唑衍生物作为血清素5-HT3 在上式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代的或未取代的氨基，或两个R 1和R 2可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

6. 发明授权

US08153732B2 Biaxially oriented polyphenylene sulfide film 有权
标题翻译：双轴取向聚苯硫醚薄膜
公开(公告)号：US08153732B2
公开(公告)日：2012-04-10
申请号：US13067220
申请日：2011-05-17
申请人： Takuji Higashioji , Tetsuya Machida , Masatoshi Ohkura , Yasuyuki Imanishi , Atsushi Ishio , Megumi Yamada
发明人： Takuji Higashioji , Tetsuya Machida , Masatoshi Ohkura , Yasuyuki Imanishi , Atsushi Ishio , Megumi Yamada
IPC分类号： C08L77/00 , C08L81/02 , C08L79/00
CPC分类号： B32B27/28 , B32B27/08 , B32B27/281 , B32B27/285 , B32B27/286 , B32B27/34 , B32B2270/00 , B32B2307/206 , B32B2307/518 , B32B2307/734 , C08J5/18 , C08J2381/04 , C08L81/02 , C08L2666/02
摘要： A biaxially oriented polyphenylene sulfide film contains polyphenylene sulfide and polyether imide, wherein the contents of the polyphenylene sulfide and the polyether imide are 70 to 99 parts by weight and 1 to 30 parts by weight respectively when the total amount of the polyphenylene sulfide and the polyether imide is taken as 100 parts by weight, and further contains a compound having one or more groups selected from an epoxy group, an amino group and an isocyanate group as a compatibilizing agent in an amount of 0.1 to 10 parts by weight based on 100 parts by weight of the polyphenylene sulfide and polyether imide in total, and the polyether imide forms a dispersed phase with an average particle diameter of 10 to 500 nm and the biaxially oriented polyphenylene sulfide film exhibits a tensile elongation at break of 110 to 250% in both the longitudinal direction and width direction.
摘要翻译：双轴取向聚苯硫醚膜含有聚苯硫醚和聚醚酰亚胺，其中聚苯硫醚和聚醚酰亚胺的含量分别为70〜99重量份和1〜30重量份，当聚苯硫醚和聚醚将酰亚胺作为100重量份，进一步含有相对于100重量份为0.1〜10重量份的具有一个以上选自环氧基，氨基和异氰酸酯基的基团的化合物的聚苯硫醚和聚醚酰亚胺，聚醚酰亚胺形成平均粒径为10〜500nm的分散相，双轴取向聚苯硫醚膜在拉伸断裂伸长率为110〜250％纵向和宽度方向。

7. 发明申请

US20110224384A1 Biaxially oriented polyphenylene sulfide film 有权
标题翻译：双轴取向聚苯硫醚薄膜
公开(公告)号：US20110224384A1
公开(公告)日：2011-09-15
申请号：US13067220
申请日：2011-05-17
申请人： Takuji Higashioji , Tetsuya Machida , Masatoshi Ohkura , Yasuyuki Imanishi , Atsushi Ishio , Megumi Yamada
发明人： Takuji Higashioji , Tetsuya Machida , Masatoshi Ohkura , Yasuyuki Imanishi , Atsushi Ishio , Megumi Yamada
IPC分类号： C08L81/04 , C08L63/02 , C08L79/08
CPC分类号： B32B27/28 , B32B27/08 , B32B27/281 , B32B27/285 , B32B27/286 , B32B27/34 , B32B2270/00 , B32B2307/206 , B32B2307/518 , B32B2307/734 , C08J5/18 , C08J2381/04 , C08L81/02 , C08L2666/02
摘要： A biaxially oriented polyphenylene sulfide film contains polyphenylene sulfide and polyether imide, wherein the contents of the polyphenylene sulfide and the polyether imide are 70 to 99 parts by weight and 1 to 30 parts by weight respectively when the total amount of the polyphenylene sulfide and the polyether imide is taken as 100 parts by weight, and further contains a compound having one or more groups selected from an epoxy group, an amino group and an isocyanate group as a compatibilizing agent in an amount of 0.1 to 10 parts by weight based on 100 parts by weight of the polyphenylene sulfide and polyether imide in total, and the polyether imide forms a dispersed phase with an average particle diameter of 10 to 500 nm and the biaxially oriented polyphenylene sulfide film exhibits a tensile elongation at break of 110 to 250% in both the longitudinal direction and width direction.
摘要翻译：双轴取向聚苯硫醚膜含有聚苯硫醚和聚醚酰亚胺，其中聚苯硫醚和聚醚酰亚胺的含量分别为70〜99重量份和1〜30重量份，当聚苯硫醚和聚醚将酰亚胺作为100重量份，进一步含有相对于100重量份为0.1〜10重量份的具有一个以上选自环氧基，氨基和异氰酸酯基的基团的化合物的聚苯硫醚和聚醚酰亚胺，聚醚酰亚胺形成平均粒径为10〜500nm的分散相，双轴取向聚苯硫醚膜在拉伸断裂伸长率为110〜250％纵向和宽度方向。

8. 发明申请

US20070299219A1 Biaxially Oriented Polyarylene Sulfide Film and Laminated Polyarylene Sulfide Sheets Comprising the Same 审中-公开
标题翻译：双轴取向聚亚芳基硫化物膜和层压聚亚芳基硫化物片包括它
公开(公告)号：US20070299219A1
公开(公告)日：2007-12-27
申请号：US11667384
申请日：2005-10-04
申请人： Takuji Higashioji , Tetsuya Machida , Masatoshi Ohkura , Yasuyuki Imanishi , Atsushi Ishio , Megumi Yamada
发明人： Takuji Higashioji , Tetsuya Machida , Masatoshi Ohkura , Yasuyuki Imanishi , Atsushi Ishio , Megumi Yamada
IPC分类号： C08L81/02 , C08J5/18 , C08L101/00
CPC分类号： B32B27/28 , B32B27/08 , B32B27/281 , B32B27/285 , B32B27/286 , B32B27/34 , B32B2270/00 , B32B2307/206 , B32B2307/518 , B32B2307/734 , C08J5/18 , C08J2381/04 , C08L81/02 , C08L2666/02
摘要： A biaxially oriented polyarylene sulfide film and laminated polyarylene sulfide sheets of the film contain polyarylene sulfide and other thermoplastic resin A different from the polyarylene sulfide, wherein the contents of the polyarylene sulfide and the thermoplastic resin A are 70 to 99 parts by weight and 1 to 30 parts by weight respectively when the total amount of the polyarylene sulfide and the thermoplastic resin A is taken as 100 parts by weight and the resin thermoplastic A forms a dispersed phase with an average particle diameter of 10 to 500 nm and the biaxially oriented polyarylene sulfide film exhibits a tensile elongation at break of 110 to 250% in at least one of the longitudinal direction and width direction and a tensile fracture elongation of 80 to 250% in the other direction.
摘要翻译：双轴取向聚芳硫醚膜和层压聚亚芳基硫醚片含有不同于聚芳硫醚的聚芳硫醚和其它热塑性树脂A，其中聚芳硫醚和热塑性树脂A的含量为70〜99重量份，1〜当聚芳硫醚和热塑性树脂A的总量为100重量份时，分别为30重量份，树脂热塑性A形成平均粒径为10〜500nm的分散相，双轴取向聚亚芳基硫醚在纵向方向和宽度方向中的至少一个方向上，断裂拉伸断裂伸长率为110〜250％，拉伸断裂伸长率在另一方向为80〜250％。

9. 发明授权

US06695710B2 Golf putting swing device and method of using the same 失效
标题翻译：高尔夫球摆动装置及其使用方法
公开(公告)号：US06695710B2
公开(公告)日：2004-02-24
申请号：US10207514
申请日：2002-07-29
申请人： Megumi Yamada
发明人： Megumi Yamada
IPC分类号： A63B5306
CPC分类号： A63B69/3676 , A63B69/3641 , A63B2069/3682 , A63B2071/024 , A63B2071/0694 , A63B2210/50 , A63B2225/093
摘要： The training device is comprised of two vertically mounted separated rods, which are connected by two strings. The vertically erected rods have two component structures, namely a base rod subsection and a height adjustable rod subsection. Each rod comes with a rotatable hook that can be mounted in slits to hook to the two strings. The rods are equipped with a bubble level on their top to adjust for a perpendicular mounting position. The ball is placed on the ground immediately under the lower one of two strings which serve as a sightline by which the direction of the swing of the putter is defined and to which the striking face of the putter is perpendicularly maintained.
摘要翻译：训练装置由两个垂直安装的分离的杆组成，它们通过两根绳连接。垂直竖立的杆具有两个部件结构，即基杆部分和高度可调杆部分。每个杆都带有可旋转的钩子，可以安装在狭缝中以钩住两根绳子。杆在其顶部配备有气泡高度以调整垂直安装位置。将球立即放置在两根琴弦下方的地面上，这两个琴弦用作瞄准器，通过该瞄准器定义推杆的摆动方向，并将推杆的击打面垂直保持。

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