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21. 发明申请

US20110144508A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE 有权
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置
公开(公告)号：US20110144508A1
公开(公告)日：2011-06-16
申请号：US12809255
申请日：2007-12-21
申请人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译：可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。

22. 发明申请

US20100292550A1 IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：可植入医疗器械
公开(公告)号：US20100292550A1
公开(公告)日：2010-11-18
申请号：US12809304
申请日：2007-12-21
申请人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström
发明人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström
IPC分类号： A61N1/365 , A61B5/1473 , A61N1/39
CPC分类号： A61B5/053 , A61B5/14546 , A61N1/36557
摘要： An analyte measuring system has an implantable medical device having a signal source arranged for generating a current signal and electrodes for applying the current signal to a surrounding tissue in a subject body. The device measures a resulting voltage signal with the electrodes and calculates an impedance signal therefrom. The system comprises a signal processor arranged for generating an estimate of a concentration of an analyte in the tissue based on a spectrum analysis of the determined impedance signal.
摘要翻译：分析物测量系统具有植入式医疗装置，其具有布置成产生电流信号的信号源和用于将电流信号施加到被检体内的周围组织的电极。该装置用电极测量得到的电压信号并从其计算阻抗信号。该系统包括信号处理器，其被布置为基于所确定的阻抗信号的频谱分析来生成组织中的分析物的浓度的估计。

23. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

24. 发明授权

US07184816B2 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US07184816B2
公开(公告)日：2007-02-27
申请号：US10864064
申请日：2004-06-09
申请人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
发明人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

25. 发明授权

US06961613B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US06961613B2
公开(公告)日：2005-11-01
申请号：US10712437
申请日：2003-11-13
申请人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
发明人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
IPC分类号： A61N1/368 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device has a control circuit that within a time cycle, delivers pacing pulses with both first and second pacing circuits with a time gap between a pacing pulse delivered by these pacing circuits. The time gap can be such that a pacing pulse delivered by the second pacing circuits falls substantially within a first time interval in which an evoked response can be expected to a pacing pulse delivered by the first pacing circuit. The control circuit performs a temporary modification of the operation of the device such that during at least one time cycle no pacing pulse is delivered by the second pacing circuit during the first time interval.
摘要翻译：可植入的双心室心脏刺激装置具有控制电路，其在一个时间周期内，通过第一起搏电路和第二起搏电路之间的时间间隔在由这些起搏电路输送的起搏脉冲之间提供起搏脉冲。时间间隙可以使得由第二起搏电路传送的起搏脉冲基本上落在第一时间间隔内，其中诱发响应可以预期到由第一起搏电路传送的起搏脉冲。控制电路对装置的操作进行暂时的修改，使得在至少一个时间周期期间，第一起搏电路在第一时间间隔期间不发出起搏脉冲。

26. 发明授权

US06447670B1 Method and apparatus for compensating for drift in potential of a reference electrode in electrochemical measurements 失效
标题翻译：用于补偿电化学测量中参考电极电位漂移的方法和装置
公开(公告)号：US06447670B1
公开(公告)日：2002-09-10
申请号：US09530295
申请日：2000-07-11
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： G01N2726
CPC分类号： G01N27/4163 , A61N1/36557 , G01N33/4925
摘要： In a method and an apparatus for measuring a concentration of at least one dissolved chemical entity in a liquid medium, employing a counter electrode, a working electrode and a reference electrode immersed in the liquid medium, at least one measurement potential is applied to the working electrode relative to the reference electrode, corresponding to a measurement voltage during at least a part of a measurement period, thereby causing the dissolved chemical entity to participate in an electrochemical reaction at the working electrode, the chemical reaction resulting in a measurement evoked current. Compensation for potential drift at the reference electrode is achieved by comparing the measurement evoked current with a predetermined value, and decreasing or increasing the measurement voltage by an incremental value, in a negative or a positive incremental step, so that the measurement current approaches a predetermined value. After each increment, a new comparison is made and the next increment is determined dependent on that most recent comparison.
摘要翻译：在液体介质中测量至少一个溶解化学物质的浓度的方法和装置中，使用浸在液体介质中的对电极，工作电极和参比电极，至少一个测量电位施加到工作电极相对于参考电极，对应于在测量周期的至少一部分期间的测量电压，从而使溶解的化学实体参与在工作电极处的电化学反应，导致测量诱发电流的化学反应。通过将测量诱发电流与预定值进行比较，以及在负增量或正增量步长中将测量电压减小或增加增量值来实现对参考电极的电位漂移的补偿，使得测量电流接近预定的值。在每个增量之后，进行新的比较，并根据最近的比较确定下一个增量。

27. 发明授权

US06188931B1 Electrode lead with temporary increased stiffness during ingrowth 失效
标题翻译：电极导线在向内生长期间具有临时增加的刚度
公开(公告)号：US06188931B1
公开(公告)日：2001-02-13
申请号：US09319403
申请日：1999-07-26
申请人： Nils Holmström , Martin Obel
发明人： Nils Holmström , Martin Obel
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： An implantable lead for an implantable active device, such as a pacemaker, has at least two electrodes, and a proximal end adapted for electrical and mechanical connection to the active device and a distal end opposite the proximal end. A ventricular electrode is carried at the distal end of the lead for sensing and/or electrical interaction with the ventricle, and an atrial electrode is carried on the lead for sensing and/or electrical interaction with the atrium, the atrial electrode being disposed between the proximal end and the ventricular electrode. The lead at its distal end has a first part with a first predetermined length, which is between 9 and 13 cm, and which exhibits a first stiffness. Adjacent to this first part is a second part, having a second predetermined length, which exceeds 15 cm, and which exhibits a second stiffness. The first stiffness of the first part provides the overall lead with a stiffness so as to force the atrial electrode in contact with the atrial wall when the lead is implanted. The second stiffness is greater then the first stiffness. The lead has a transition point between the first part and the second part, disposed at the proximal end of the second part.
摘要翻译：用于可植入有源装置（例如起搏器）的可植入导线具有至少两个电极，以及适于与主动装置电连接和机械连接的近端以及与近端相对的远端。在电极的远端承载心室电极，用于与心室的感应和/或电相互作用，并且心房电极承载在引线上，用于与心房的感应和/或电相互作用，心房电极设置在心室近端和心室电极。其远端处的引线具有第一部分，其具有第一预定长度，其在9和13cm之间，并且其具有第一刚度。与第一部分相邻的是第二部分，具有超过15cm的第二预定长度，并且具有第二刚度。第一部分的第一刚度提供了具有刚度的整体引线，以便当植入引线时迫使心房电极与心房壁接触。第二刚度大于第一刚度。引线在第一部分和第二部分之间具有设置在第二部分的近端处的转变点。

28. 发明授权

US08321016B2 Implantable medical device and a method comprising means for detecting and classifying ventricular tachyarrhythmias 有权
标题翻译：植入式医疗装置和包括用于检测和分类室性快速性心律失常的装置的方法
公开(公告)号：US08321016B2
公开(公告)日：2012-11-27
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

29. 发明授权

US08135455B2 System and method for monitoring synchrony between chambers of a heart by volume measurements and analysis 有权
标题翻译：通过体积测量和分析来监测心脏室之间的同步的系统和方法
公开(公告)号：US08135455B2
公开(公告)日：2012-03-13
申请号：US11916463
申请日：2005-06-16
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/36521 , A61B5/029 , A61B5/0295 , A61N1/3627 , A61N1/3682 , A61N1/3702
摘要： An implantable heart monitoring system includes a housing configured for implantation in a subject, at least one sensor member implanted relative to the heart of the subject to detect an electrical signal related to cardiac activity of the heart, a control circuit in the housing, and a memory accessible by the control circuit. The control circuit, from said electrical signal, derives a first value related to the volume of a first part of the heart and derives a second value related to the volume of a second part of the heart, and monitors variation of said first value over time in at least a substantial portion of a heart cycle, and monitors variation of said second value over time in said substantial portion of said heart cycle, and stores in the memory information representing the monitoring of said first and second values that represents a relationship between the first and second values in the substantial portion of the heart cycle and variation of the relationship in the substantial portion of the heart cycle.
摘要翻译：可植入心脏监测系统包括构造成用于植入对象的壳体，相对于对象的心脏植入的至少一个传感器构件，以检测与心脏的心脏活动相关的电信号，壳体中的控制电路和存储器可由控制电路访问。来自所述电信号的控制电路导出与心脏的第一部分的体积相关的第一值，并且导出与心脏的第二部分的体积相关的第二值，并且监视所述第一值随时间的变化在心脏周期的至少大部分中，并且监视所述心脏周期的所述实质部分中随时间推移的所述第二值的变化，并且存储在表示所述第一和第二值的监视的存储器信息中，所述第一和第二值表示在心脏周期的实质部分中的第一和第二值以及心脏周期的实质部分中关系的变化。

30. 发明授权

US08133187B2 Implantable medical device with heart condition detection 有权
标题翻译：具有心脏状态检测的可植入医疗器械
公开(公告)号：US08133187B2
公开(公告)日：2012-03-13
申请号：US12095216
申请日：2005-12-16
申请人： Nils Holmström , Kjell Noren
发明人： Nils Holmström , Kjell Noren
IPC分类号： A61B5/0255
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： A method for detecting a condition of a heart of a patient using an implantable medical device, including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.
摘要翻译：一种用于使用可植入医疗装置检测患者心脏状态的方法，包括以下步骤：感测指示患者心脏的心脏声音的声学信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算对应于对应于第一心音（S1）的信号的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。

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