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21. 发明申请

US20100249927A1 MEDICAL DEVICES WITH GALVANIC PARTICULATES 审中-公开
标题翻译：具有气雾颗粒的医疗装置
公开(公告)号：US20100249927A1
公开(公告)日：2010-09-30
申请号：US12731848
申请日：2010-03-25
申请人： Chunlin Yang , Ying Sun , Frank R. Cichocki, JR. , Saumen N. Bar , James E. Hauschild , Uri Herzberg , Yufu Li , Xintian Ming , Wei Kong
发明人： Chunlin Yang , Ying Sun , Frank R. Cichocki, JR. , Saumen N. Bar , James E. Hauschild , Uri Herzberg , Yufu Li , Xintian Ming , Wei Kong
IPC分类号： A61F2/02 , H01B1/22 , B32B5/16 , B05D3/00
CPC分类号： A61L27/306 , A61L27/52 , A61L27/54 , A61L29/106 , A61L29/14 , A61L29/16 , A61L31/088 , A61L31/145 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/606 , A61L2300/622 , A61L2420/04 , Y10T428/256
摘要： Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting.
摘要翻译：公开了具有电偶颗粒的可植入医疗装置。颗粒可以涂覆在医疗装置的表面的至少一部分上。此外，电化学颗粒可以包含在用于制造抗微生物医疗装置的材料中，或者可以嵌入医疗装置的表面中。本发明还提供了新的涂布方法和加工方法。该装置可具有促进抗微生物，消炎和组织再生的有利特征和作用。

22. 发明申请

US20090068246A1 COLLAGEN-RELATED PEPTIDES AND USES THEREOF 有权
标题翻译：胶原相关肽及其用途
公开(公告)号：US20090068246A1
公开(公告)日：2009-03-12
申请号：US12179778
申请日：2008-07-25
申请人： William A. Kinney , Mabel Alamino Cejas , Bruce E. Maryanoff , Thomas Matalenas , Chunlin Yang
发明人： William A. Kinney , Mabel Alamino Cejas , Bruce E. Maryanoff , Thomas Matalenas , Chunlin Yang
IPC分类号： A61K38/39 , A61L27/60 , G01N33/566 , A61P7/04
CPC分类号： C07K14/78 , A61K38/39 , G01N33/86 , G01N2800/224
摘要： The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.
摘要翻译：本发明涉及具有能够非共价自组装的N-和C-末端具有疏水性氨基酸基团的胶原相关多肽（CRP），其能够形成胶原模拟三重螺旋和原纤维，并且其合成，使用方法和的组合物。

23. 发明申请

US20060287676A1 Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use 审中-公开
标题翻译：术中将治疗剂涂覆在缝合线上的方法，复合缝合线和使用方法
公开(公告)号：US20060287676A1
公开(公告)日：2006-12-21
申请号：US11315905
申请日：2005-12-22
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61L17/00
CPC分类号： A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent, methods of repairing soft tissue defects with coated sutures and composite sutures coated with therapeutic agents.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括使缝合线与包含治疗剂的装置接触，用涂覆的缝合线修复软组织缺陷的方法以及用治疗剂涂覆的复合缝合线。

24. 发明申请

US20060287675A1 Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use 审中-公开
标题翻译：术中将治疗剂涂覆在缝线复合缝合线上的方法及使用方法
公开(公告)号：US20060287675A1
公开(公告)日：2006-12-21
申请号：US11315793
申请日：2005-12-22
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61L17/00
CPC分类号： A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent, methods of repairing soft tissue defects with coated sutures and composite sutures coated with therapeutic agents.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括使缝合线与包含治疗剂的装置接触，用涂覆的缝合线修复软组织缺陷的方法以及用治疗剂涂覆的复合缝合线。

25. 发明申请

US20060286289A1 Method of intraoperative coating therapeutic agents onto sutures 审中-公开
标题翻译：术中将治疗剂涂在缝合线上的方法
公开(公告)号：US20060286289A1
公开(公告)日：2006-12-21
申请号：US11153285
申请日：2005-06-15
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Deyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Deyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61F13/02
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括将缝合线接触含有治疗剂的装置。

26. 发明申请

US20060222680A1 Method of preparing crosslinked collagen microspheres 审中-公开
标题翻译：制备交联胶原微球的方法
公开(公告)号：US20060222680A1
公开(公告)日：2006-10-05
申请号：US11095802
申请日：2005-03-31
申请人： Chunlin Yang , Mark Timmer
发明人： Chunlin Yang , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： B01J13/14
摘要： The present invention is drawn to methods of preparing crosslinked collagen microspheres and microparticles, where a solution of soluble collagen in an aqueous acidic medium is combined with an emulsifying agent to form a first mixture of the soluble collagen solution and the emulsifying agent, the first mixture then is combined with a hydrophobic liquid under conditions effective to form water-in-oil emulsion of the hydrophobic liquid and the first mixture, the water-in-oil emulsion then is added to a buffered alcohol solution under conditions effective to form a dispersion of a continuous liquid phase and a dispersed solid phase of collagen fibers reconstituted from the soluble collagen solution, the liquid phase then is removed from the dispersion to provide collagen microspheres, the collagen microspheres then are crosslinked to form crosslinked collagen microspheres, and the crosslinked collagen microspheres then are optionally dried to form crosslinked collagen microparticles.
摘要翻译：本发明涉及制备交联胶原微球和微粒的方法，其中可溶性胶原在酸性介质中的溶液与乳化剂结合形成可溶性胶原溶液和乳化剂的第一混合物，第一混合物然后在有效形成疏水性液体和第一混合物的油包水乳液的条件下与疏水性液体混合，然后在有效形成分散体的条件下将油包水乳液加入缓冲的醇溶液中从可溶性胶原溶液中重新构成胶原纤维的连续液相和分散固相，然后从分散体中除去液相，提供胶原微球，然后将胶原微球交联形成交联胶原微球，并将交联的胶原微球然后任选地干燥以形成交联的胶原微粒。

27. 发明申请

US20130309222A1 AFFINITY PEPTIDES TOWARD INFLIXIMAB 有权
公开(公告)号：US20130309222A1
公开(公告)日：2013-11-21
申请号：US13474056
申请日：2012-05-17
申请人： Daphne Ann Salick Ryan , John Kehoe , John Wheeler , Chunlin Yang , Abla Creasey
发明人： Daphne Ann Salick Ryan , John Kehoe , John Wheeler , Chunlin Yang , Abla Creasey
IPC分类号： C07K7/08 , A61K39/395 , C07K7/06
CPC分类号： A61K47/42 , A61K39/3955 , A61K2039/505 , C07K7/08 , C07K14/525 , C07K16/241 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： We have disclosed affinity peptides toward infliximab. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for infliximab.
摘要翻译：我们已经向英夫利昔单抗公开了亲和肽。更具体地，我们已经公开了一种亲和力生物基质，其中亲和肽共价连接到生物相容的可生物降解的聚合物上。亲和力生物基质可用于制备英夫利昔单抗的控制释放装置。

28. 发明申请

US20120318843A1 TISSUE STAPLER HAVING A THICKNESS COMPENSATOR INCORPORATING AN OXYGEN GENERATING AGENT 有权
标题翻译：装有氧气发生剂的厚度补偿器的组织包装机
公开(公告)号：US20120318843A1
公开(公告)日：2012-12-20
申请号：US13531623
申请日：2012-06-25
申请人： CORTNEY E. HENDERSON , Taylor W. Aronhalt , Chunlin Yang , Charles J. Scheib , Venkataramanan Mandakolathur Vasudevan , Andrew C. Yoo , Frederick E. Shelton, IV
发明人： CORTNEY E. HENDERSON , Taylor W. Aronhalt , Chunlin Yang , Charles J. Scheib , Venkataramanan Mandakolathur Vasudevan , Andrew C. Yoo , Frederick E. Shelton, IV
IPC分类号： A61B17/068
CPC分类号： A61B17/0643 , A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/105 , A61B17/1155 , A61B17/2909 , A61B17/295 , A61B50/30 , A61B90/92 , A61B2017/00004 , A61B2017/003 , A61B2017/00314 , A61B2017/00327 , A61B2017/00473 , A61B2017/00477 , A61B2017/00495 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/0641 , A61B2017/07214 , A61B2017/07221 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/0725 , A61B2017/07257 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2902 , A61B2017/2908 , A61B2017/291 , A61B2017/2919 , A61B2017/292 , A61B2017/2923 , A61B2017/2927 , A61B2017/2931 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , A61B2050/3008 , A61B2050/314 , A61B2090/037
摘要： A staple cartridge assembly for use with a surgical stapler. The assembly has a cartridge body having a support portion with a plurality of staple cavities with openings. There is also a plurality of staples, wherein at least a portion of each the staple is removably stored within a the staple cavity. Each the staple is movable between an unfired position and a fired position, and is deformable between an unfired configuration and a fired configuration. The assembly also includes a compressible tissue thickness compensator configured to be captured within the staples. The compressible tissue thickness compensator at least partially covers the staple cavity openings. The compressed tissue thickness compensator is configured to assume different compressed heights within different the staples. The compressible tissue thickness compensator comprising a lyophilized foam having an oxygen generating agent embedded therein.
摘要翻译：用于外科缝合器的钉仓组件。该组件具有一个带有主体的盒体，该主体具有多个具有开口的缝合腔的支撑部分。还有多个钉，其中每个钉的至少一部分可移除地存储在钉腔内。每个订书钉可以在未燃位置和点火位置之间移动，并且可在未烧制配置和烧制配置之间变形。组件还包括构造成捕获在钉内的可压缩组织厚度补偿器。可压缩组织厚度补偿器至少部分地覆盖钉腔开口。压缩的组织厚度补偿器构造成在不同的钉内具有不同的压缩高度。可压缩组织厚度补偿器包括其中嵌入有氧发生剂的冻干泡沫。

29. 发明申请

US20120241500A1 TISSUE THICKNESS COMPENSATOR COMPRISING FIBERS TO PRODUCE A RESILIENT LOAD 有权
标题翻译：组织厚度补偿器，包括纤维以产生耐久性负载
公开(公告)号：US20120241500A1
公开(公告)日：2012-09-27
申请号：US13433144
申请日：2012-03-28
申请人： Mark D. Timmer , Joseph H. Contiliano , Taylor W. Aronhalt , Chunlin Yang , Charles J. Scheib , Katherine J. Schmid , Frederick E. Shelton, IV
发明人： Mark D. Timmer , Joseph H. Contiliano , Taylor W. Aronhalt , Chunlin Yang , Charles J. Scheib , Katherine J. Schmid , Frederick E. Shelton, IV
IPC分类号： A61B17/068
CPC分类号： A61B17/07207 , A61B17/00491 , A61B17/0643 , A61B17/0644 , A61B17/072 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00477 , A61B2017/00495 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/0725 , A61B2017/07257 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , F04C2270/0421
摘要： A nonwoven compensator for an end effector of a surgical instrument can comprise a plurality of spring fibers dispersed throughout the nonwoven compensator. The nonwoven compensator can be positioned in the end effector such as adjacent to a deck surface of a fastener cartridge that is positioned in the end effector. When a fastener from the fastener cartridge is moved from an initial position to a fired position, the fastener can be configured to engage the nonwoven compensator. The fastener can compress a portion of the nonwoven compensator in a staple entrapment area defined by the fired staple. The spring fibers in the nonwoven compensator can comprise a resilient material and can be deformed when the fastener compresses a portion of the nonwoven compensator. Further, the nonwoven compensator can comprise non-spring fibers, a haemostatic material, and/or a homogenous absorbable polymer matrix.
摘要翻译：用于外科器械的端部执行器的非织造补偿器可以包括分散在整个非织造补偿器中的多个弹簧纤维。非织造补偿器可以定位在端部执行器中，例如邻近定位在末端执行器中的紧固件卡盘的甲板表面。当来自紧固件卡盘的紧固件从初始位置移动到打火位置时，紧固件可构造成接合非织造补偿器。紧固件可以在由烧制的订书钉限定的钉夹持区域中压缩非织造补偿器的一部分。非织造补偿器中的弹簧纤维可以包括弹性材料，并且当紧固件压缩非织造补偿器的一部分时可以变形。此外，非织造补偿器可以包括非弹簧纤维，止血材料和/或均匀的可吸收聚合物基质。

30. 发明授权

US08076294B2 Collagen-related peptides and uses thereof 有权
标题翻译：胶原相关肽及其用途
公开(公告)号：US08076294B2
公开(公告)日：2011-12-13
申请号：US12179778
申请日：2008-07-25
申请人： William A. Kinney , Mabel Alarnino Cejas , Bruce E. Maryanoff , Thomas Matalenas , Chunlin Yang
发明人： William A. Kinney , Mabel Alarnino Cejas , Bruce E. Maryanoff , Thomas Matalenas , Chunlin Yang
IPC分类号： A61K38/39 , C07K14/78
CPC分类号： C07K14/78 , A61K38/39 , G01N33/86 , G01N2800/224
摘要： The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.
摘要翻译：本发明涉及具有能够非共价自组装的N-和C-末端具有疏水性氨基酸基团的胶原相关多肽（CRP），其能够形成胶原模拟三重螺旋和原纤维，并且其合成，使用方法和的组合物。

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