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21. 发明申请

US20090099621A1 RESPIRATORY STIMULATION FOR TREATING PERIODIC BREATHING 有权
标题翻译：呼吸刺激治疗周期性呼吸
公开(公告)号：US20090099621A1
公开(公告)日：2009-04-16
申请号：US12249842
申请日：2008-10-10
申请人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
发明人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/0816 , A61N1/3601
摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.
摘要翻译：描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

22. 发明授权

US08551010B2 Respiration monitoring for heart failure using implantable device 失效
标题翻译：使用可植入装置进行心力衰竭呼吸监测
公开(公告)号：US08551010B2
公开(公告)日：2013-10-08
申请号：US13553098
申请日：2012-07-19
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

23. 发明申请

US20100298733A1 Method and System for Heart Failure Status Evaluation Based on a Disordered Breathing Index 有权
标题翻译：基于无序呼吸指数的心力衰竭状态评估方法与系统
公开(公告)号：US20100298733A1
公开(公告)日：2010-11-25
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

24. 发明授权

US08226570B2 Respiration monitoring for heart failure using implantable device 有权
标题翻译：使用可植入装置进行心力衰竭呼吸监测
公开(公告)号：US08226570B2
公开(公告)日：2012-07-24
申请号：US11463076
申请日：2006-08-08
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

25. 发明授权

US08428711B2 Respiratory stimulation for treating periodic breathing 有权
标题翻译：呼吸刺激治疗周期性呼吸
公开(公告)号：US08428711B2
公开(公告)日：2013-04-23
申请号：US12249842
申请日：2008-10-10
申请人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
发明人： Zheng Lin , Kenneth C. Beck , Jonathan Kwok , Kent Lee , Yachuan Pu , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61B5/0816 , A61N1/3601
摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.
摘要翻译：描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

26. 发明申请

US20080039730A1 RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 有权
标题翻译：使用可移植设备进行心脏衰竭的呼吸监测
公开(公告)号：US20080039730A1
公开(公告)日：2008-02-14
申请号：US11463076
申请日：2006-08-08
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

27. 发明申请

US20070129643A1 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US20070129643A1
公开(公告)日：2007-06-07
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

28. 发明申请

US20080319513A1 NEURAL STIMULATION WITH RESPIRATORY RHYTHM MANAGEMENT 有权
标题翻译：神经刺激与呼吸环境管理
公开(公告)号：US20080319513A1
公开(公告)日：2008-12-25
申请号：US11767901
申请日：2007-06-25
申请人： Yachuan Pu , Anthony V. Caparso , Gerrard M. Carlson , Joseph M. Pastore
发明人： Yachuan Pu , Anthony V. Caparso , Gerrard M. Carlson , Joseph M. Pastore
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0816 , A61B5/4035 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.
摘要翻译：系统实施例包括至少一个呼吸传感器，神经刺激治疗传递模块和控制器。呼吸传感器适用于监测患者的呼吸。神经刺激治疗递送模块适于产生用于刺激患者的自主神经靶标用于慢性神经刺激治疗的神经刺激信号。控制器适于接收来自指示患者呼吸的至少一个呼吸传感器的呼吸信号，并且适于使用使用呼吸信号导出的呼吸变异性测量来控制神经刺激治疗递送模块。

29. 发明授权

US08630704B2 Neural stimulation with respiratory rhythm management 有权
公开(公告)号：US08630704B2
公开(公告)日：2014-01-14
申请号：US11767901
申请日：2007-06-25
申请人： Yachuan Pu , Anthony V. Caparso , Gerrard M. Carlson , Joseph M. Pastore
发明人： Yachuan Pu , Anthony V. Caparso , Gerrard M. Carlson , Joseph M. Pastore
IPC分类号： A61N1/08
CPC分类号： A61N1/36139 , A61B5/0816 , A61B5/4035 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.

30. 发明授权

US08696589B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US08696589B2
公开(公告)日：2014-04-15
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
发明人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

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