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21. 发明授权

US5807709A Secreted proteins and polynucleotides encoding them 失效
公开(公告)号：US5807709A
公开(公告)日：1998-09-15
申请号：US721798
申请日：1996-09-27
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61P37/00 , A61P37/02 , C07K14/47 , C07K14/52 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/00
CPC分类号： C07K14/52 , C07K14/47 , A61K38/00
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.

22. 发明授权

US5945302A Polynucleotides encoding secreted proteins 失效
公开(公告)号：US5945302A
公开(公告)日：1999-08-31
申请号：US783395
申请日：1997-01-13
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61P3/00 , A61P3/10 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P27/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , C07K14/47 , C07K14/52 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/10
CPC分类号： C07K14/47 , C07K14/52 , A61K38/00 , Y10S530/85 , Y10S530/853
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.

23. 发明授权

US5972652A Polynucleotides encoding secreted proteins 失效
标题翻译：编码分泌蛋白的多核苷酸
公开(公告)号：US5972652A
公开(公告)日：1999-10-26
申请号：US924838
申请日：1997-09-05
申请人： Kenneth Jacobs , John M. McCoy , Lisa A. Racie , Edward R. LaVallie , David Merberg
发明人： Kenneth Jacobs , John M. McCoy , Lisa A. Racie , Edward R. LaVallie , David Merberg
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61P3/00 , A61P3/10 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P27/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , C07K14/47 , C07K14/52 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/63
CPC分类号： C07K14/47 , C07K14/52 , A61K38/00 , Y10S530/85 , Y10S530/853
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译：公开了新的多核苷酸和由此编码的蛋白质。

24. 发明授权

US06451318B1 Secreted proteins 失效
公开(公告)号：US06451318B1
公开(公告)日：2002-09-17
申请号：US09625918
申请日：2000-07-26
申请人： Kenneth Jacobs , John M. McCoy , Lisa A. Racie , Edward R. La Vallie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
发明人： Kenneth Jacobs , John M. McCoy , Lisa A. Racie , Edward R. La Vallie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： Novel proteins are disclosed.

25. 发明授权

US6084071A Human L105 polypeptides and polynucleotides encoding same 失效
标题翻译：人L105多肽和编码相同的多核苷酸
公开(公告)号：US6084071A
公开(公告)日：2000-07-04
申请号：US94287
申请日：1998-06-09
申请人： Lisa A. Racie , Kenneth Jacobs , Zhijian Lu , Edward R. LaVallie , John M. McCoy
发明人： Lisa A. Racie , Kenneth Jacobs , Zhijian Lu , Edward R. LaVallie , John M. McCoy
IPC分类号： A61K48/00 , C07K14/52 , C12N15/19 , A61K38/19
CPC分类号： C07K14/523 , A61K48/00 , Y10S930/14
摘要： A chemokine, human L105, is disclosed.
摘要翻译：公开了趋化因子人L105。

26. 发明授权

US5846770A DNA molecules encoding human chordin 失效
标题翻译：编码人类chordin的DNA分子
公开(公告)号：US5846770A
公开(公告)日：1998-12-08
申请号：US749169
申请日：1996-11-14
申请人： Edward R. LaVallie , Lisa A. Racie , Edward M. DeRobertis
发明人： Edward R. LaVallie , Lisa A. Racie , Edward M. DeRobertis
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18 , C12P21/00 , C07H21/04 , C12N1/21 , C12N15/00
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.
摘要翻译：公开了纯化的chordin蛋白质及其生产方法。还公开了编码chordin蛋白的DNA分子。蛋白质可以用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮的组织的病症和缺陷，神经，肌肉，包括心肌和其他组织和伤口，以及诸如肝，脑，肺，心脏，胰腺和肾组织的器官。蛋白质也可用于诱导抑制未分化的胚胎和干细胞的生长和/或分化。蛋白质可能与其他蛋白质，特别是蛋白质转化生长因子-β超家族的成员复合。

27. 发明授权

US07118902B2 Modified ADAMTS4 molecules and method of use thereof 失效
标题翻译：修饰的ADAMTS4分子及其使用方法
公开(公告)号：US07118902B2
公开(公告)日：2006-10-10
申请号：US10628432
申请日：2003-07-29
申请人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
发明人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
IPC分类号： C12N15/57 , C12N9/64 , C12N15/01 , C12N15/79
CPC分类号： C12N9/6489 , A61K2039/505
摘要： The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
摘要翻译：本发明涉及与相应的天然未修饰蛋白相比具有改进的稳定性的修饰的ADAMTS4蛋白。修饰的ADAMTS4蛋白可以大量表达和分离，从而进一步表征蛋白质，如晶体学和酶动力学研究。纯化的稳定蛋白质也有助于抗ADAMTS抗体的产生和ADAMTS酶抑制剂的开发。

28. 发明授权

US5986056A Chordin compositions 有权
标题翻译： Chordin组成
公开(公告)号：US5986056A
公开(公告)日：1999-11-16
申请号：US130032
申请日：1998-08-04
申请人： Edward R. LaVallie , Lisa A. Racie , Edward M. DeRobertis
发明人： Edward R. LaVallie , Lisa A. Racie , Edward M. DeRobertis
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18 , C07K14/46 , C12P21/00
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well for treatment of disorders and defects to tissue which include epidermis, nerve, muscle, including cardiac muscle, and othe tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.
摘要翻译：公开了纯化的chordin蛋白质及其生产方法。还公开了编码chordin蛋白的DNA分子。这些蛋白质可用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮，神经的组织的病症和缺陷，肌肉，包括心肌，组织和伤口，器官如肝，脑，肺，心脏，胰腺和肾组织。蛋白质也可用于诱导抑制未分化的胚胎和干细胞的生长和/或分化。蛋白质可能与其他蛋白质，特别是蛋白质转化生长因子-β超家族的成员复合。

29. 发明授权

US07026445B2 Human SDF-5 protein and compositions 失效
标题翻译：人类SDF-5蛋白和组成
公开(公告)号：US07026445B2
公开(公告)日：2006-04-11
申请号：US08949904
申请日：1997-10-15
申请人： Edward R. LaVallie , Lisa A. Racie , Gary Hattersley
发明人： Edward R. LaVallie , Lisa A. Racie , Gary Hattersley
IPC分类号： C07K1/00 , C07H21/02 , C12P27/06 , C12N1/20
CPC分类号： C07K14/52 , A61K38/00
摘要： Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
摘要翻译：公开了纯化的人SDF-5蛋白质及其生产方法。还公开了编码人SDF-5蛋白的DNA分子。蛋白质可用于调节Wnt基因与其受体的结合。在优选的实施方案中，蛋白质可用于诱导软骨细胞和/或软骨组织的形成，生长，分化，增殖和/或维持，以及用于其它组织修复，例如胰腺组织修复。

30. 发明授权

US07125701B2 Aggrecanase molecules 失效
公开(公告)号：US07125701B2
公开(公告)日：2006-10-24
申请号：US10205368
申请日：2002-07-26
申请人： Michael J. Agostino , Lisa A. Racie
发明人： Michael J. Agostino , Lisa A. Racie
IPC分类号： C12N9/48 , C12Q1/37
CPC分类号： C12N9/6421
摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

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