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1. 发明授权

US07026445B2 Human SDF-5 protein and compositions 失效
标题翻译：人类SDF-5蛋白和组成
公开(公告)号：US07026445B2
公开(公告)日：2006-04-11
申请号：US08949904
申请日：1997-10-15
申请人： Edward R. LaVallie , Lisa A. Racie , Gary Hattersley
发明人： Edward R. LaVallie , Lisa A. Racie , Gary Hattersley
IPC分类号： C07K1/00 , C07H21/02 , C12P27/06 , C12N1/20
CPC分类号： C07K14/52 , A61K38/00
摘要： Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
摘要翻译：公开了纯化的人SDF-5蛋白质及其生产方法。还公开了编码人SDF-5蛋白的DNA分子。蛋白质可用于调节Wnt基因与其受体的结合。在优选的实施方案中，蛋白质可用于诱导软骨细胞和/或软骨组织的形成，生长，分化，增殖和/或维持，以及用于其它组织修复，例如胰腺组织修复。

2. 发明授权

US08933130B2 Treatment of vasomotor symptoms with selective estrogen receptor modulators 有权
标题翻译：用选择性雌激素受体调节剂治疗血管舒缩症状
公开(公告)号：US08933130B2
公开(公告)日：2015-01-13
申请号：US12308640
申请日：2007-06-22
申请人： C. Richard Lyttle , Bart Henderson , Gary Hattersley
发明人： C. Richard Lyttle , Bart Henderson , Gary Hattersley
IPC分类号： A61K31/136 , A61K31/135
CPC分类号： A61K31/136
摘要： The present invention is directed toward methods for treating vasomotor symptoms, (e.g., hot flashes and night sweats) in a patient in need thereof comprising administering a SERM as described herein.
摘要翻译：本发明涉及在有需要的患者中治疗血管舒缩症状（例如潮热和盗汗）的方法，其包括施用本文所述的SERM。

3. 发明申请

US20130006217A1 METHOD OF DRUG DELIVERY FOR PTH, PTHrP AND RELATED PEPTIDES 审中-公开
标题翻译： PTH，PTHrP和相关肽的药物递送方法
公开(公告)号：US20130006217A1
公开(公告)日：2013-01-03
申请号：US13452412
申请日：2012-04-20
申请人： Gary Hattersley , Kris J. Hansen , Amy S. Determan , Ying Zhang
发明人： Gary Hattersley , Kris J. Hansen , Amy S. Determan , Ying Zhang
IPC分类号： A61M5/00
摘要： The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
摘要翻译：本发明提供了与皮内递送PTHrP和PTHrP类似物，特别是[Glu22,25，Leu23,28,31，Aib29，Lys26,30] hPTHrP（1-34）NH2有关的组合物，装置，方法和方法。

4. 发明授权

US5846931A Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide and methods of inducing cartilage by administration of same 失效
标题翻译：包含骨形态发生蛋白和截短的甲状旁腺激素相关肽的组合物和通过其给药来诱导软骨的方法
公开(公告)号：US5846931A
公开(公告)日：1998-12-08
申请号：US926942
申请日：1997-09-10
申请人： Gary Hattersley , Vicki A. Rosen
发明人： Gary Hattersley , Vicki A. Rosen
IPC分类号： A61K38/00 , A61K31/00 , A61K38/22 , A61K38/29 , A61P19/00 , A61P19/02 , A61P19/04 , C07K14/495 , A61K38/17 , C07K14/51 , C07K14/635
CPC分类号： A61K38/29
摘要： Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor-.beta. (TGF-.beta.) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
摘要翻译：公开了具有软骨细胞和软骨组织诱导活性的蛋白质的组合物，以及使用这些组合物的方法。组合物包含与甲状旁腺激素相关多肽（PTHrP）或等同的PTH样多肽组合的蛋白质的转化生长因子-β（TGF-β）超家族中的一种或多种蛋白质，特别是骨形态发生蛋白（BMP）。组合物和方法可用于治疗骨关节炎，软骨缺损和相关组织修复。

5. 发明授权

US5700774A Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same 失效
标题翻译：包含骨形态发生蛋白和截短的甲状旁腺激素相关肽的组合物，以及通过其施用诱导软骨的方法
公开(公告)号：US5700774A
公开(公告)日：1997-12-23
申请号：US622101
申请日：1996-03-26
申请人： Gary Hattersley , Vicki A. Rosen
发明人： Gary Hattersley , Vicki A. Rosen
IPC分类号： A61K38/00 , A61K31/00 , A61K38/22 , A61K38/29 , A61P19/00 , A61P19/02 , A61P19/04 , A61K38/18
CPC分类号： A61K38/29
摘要： Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor-.beta. (TGF-.beta.) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
摘要翻译：公开了具有软骨细胞和软骨组织诱导活性的蛋白质的组合物，以及使用这些组合物的方法。组合物包含与甲状旁腺激素相关多肽（PTHrP）或等同的PTH样多肽组合的蛋白质的转化生长因子-β（TGF-β）超家族中的一种或多种蛋白质，特别是骨形态发生蛋白（BMP）。组合物和方法可用于治疗骨关节炎，软骨缺损和相关组织修复。

6. 发明申请

US20110124617A1 Combination Therapy for BreastCancer Comprising an Antiestrogenic Agent 审中-公开
标题翻译：包含抗雌激素剂的乳腺癌组合疗法
公开(公告)号：US20110124617A1
公开(公告)日：2011-05-26
申请号：US12991791
申请日：2009-05-07
申请人： C. Richard Lyttle , Gary Hattersley , Louis O'Dea
发明人： C. Richard Lyttle , Gary Hattersley , Louis O'Dea
IPC分类号： A61K31/5685 , A61K31/138 , A61K31/4196 , A61P5/24 , A61P25/22
CPC分类号： A61K45/06 , A61K31/137 , A61K31/138 , A61K31/4196 , A61K31/5685 , A61K2300/00
摘要： This invention relates to combination therapies for the treatment of breast cancer comprising administering to a subject in need thereof a compound of Formula I or a pharmaceutically acceptable salt thereof and an anti-estrogenic agent (e.g., an aromatase inhibitor, a SERM that is not the SERM of Formula I, a GNRH agonist, a GNRH antagonist, or an estrogen receptor downregulator) and to compositions (e.g., pharmaceutical compositions) comprising a compound of Formula I or a pharmaceutically acceptable salt thereof and an anti-estrogenic agent. This invention also relates to a method of treating the side effects (e.g., vasomotor disturbances, osteoporosis and musculoskeletal complaints) associated with anti-estrogen therapy in a subject treated with one or more anti-estrogenic agents (e.g., an aromatase inhibitor, a SERM that is not the SERM of Formula I, a GNRH agonist, a GNRH antagonist or an estrogen receptor downregulator). The method comprises administering to the subject an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及用于治疗乳腺癌的组合疗法，包括向有需要的受试者施用式I化合物或其药学上可接受的盐和抗雌激素药（例如芳香酶抑制剂，不是式I的SERM，GNRH激动剂，GNRH拮抗剂或雌激素受体下调体）以及包含式I化合物或其药学上可接受的盐和抗雌激素剂的组合物（例如药物组合物）。本发明还涉及一种治疗与一种或多种抗雌激素剂（例如，芳香酶抑制剂，SERM）治疗的受试者中与抗雌激素治疗相关的副作用（例如血管舒缩障碍，骨质疏松症和肌肉骨骼症）不是式I的SERM，GNRH激动剂，GNRH拮抗剂或雌激素受体下调体）。该方法包括向受试者施用有效量的式I化合物或其药学上可接受的盐。

7. 发明申请

US20100105733A1 Treatment of vasomotor symptoms with selective estrogen receptor modulators 有权
标题翻译：用选择性雌激素受体调节剂治疗血管舒缩症状
公开(公告)号：US20100105733A1
公开(公告)日：2010-04-29
申请号：US12308640
申请日：2007-06-22
申请人： C. Richard Lyttle , Bart Henderson , Gary Hattersley
发明人： C. Richard Lyttle , Bart Henderson , Gary Hattersley
IPC分类号： A61K31/137 , A61K31/445 , A61P9/00
CPC分类号： A61K31/136
摘要： The present invention is directed toward methods for treating vasomotor symptoms, (e.g., hot flashes and night sweats) in a patient in need thereof comprising administering a SERM as described herein.
摘要翻译：本发明涉及在有需要的患者中治疗血管舒缩症状（例如潮热和盗汗）的方法，包括施用如本文所述的SERM。

8. 发明申请

US20060111562A1 Human SDF-5 protein and compositions 审中-公开
公开(公告)号：US20060111562A1
公开(公告)日：2006-05-25
申请号：US11304999
申请日：2005-12-16
申请人： Edward LaVallie , Lisa Racie , Gary Hattersley
发明人： Edward LaVallie , Lisa Racie , Gary Hattersley
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/52 , A61K38/00
摘要： Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.

9. 发明授权

US5902785A Cartilage induction by bone morphogenetic proteins 失效
标题翻译：骨形态发生蛋白软骨诱导
公开(公告)号：US5902785A
公开(公告)日：1999-05-11
申请号：US646193
申请日：1996-05-07
申请人： Gary Hattersley , Neil M. Wolfman , Elisabeth A. Morris , Vicki A. Rosen
发明人： Gary Hattersley , Neil M. Wolfman , Elisabeth A. Morris , Vicki A. Rosen
IPC分类号： A61K38/00 , A61K38/18 , A61L27/22 , C07K14/51 , A61K38/16
CPC分类号： A61L27/227 , A61K38/1875 , C07K14/51
摘要： Compositions of proteins with cartilaginous tissue inducing and maintenance activity are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
摘要翻译：公开了具有软骨组织诱导和维持活性的蛋白质组合物。组合物可用于治疗骨关节炎，软骨缺损和相关组织修复。

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