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21. 发明授权

US06469505B1 Method and apparatus to reduce perturbation field effects in MR images by restricting the region of interest 失效
标题翻译：通过限制感兴趣区域来减少MR图像的扰动场效应的方法和装置
公开(公告)号：US06469505B1
公开(公告)日：2002-10-22
申请号：US09540687
申请日：2000-03-31
申请人： Joseph K. Maier , Xiaohong Zhou , Steven J. Huff
发明人： Joseph K. Maier , Xiaohong Zhou , Steven J. Huff
IPC分类号： G01V300
CPC分类号： G01R33/56563 , G01R33/5604 , G01R33/56518
摘要： A method and apparatus for correcting ghost artifacts that are related to orthogonal perturbation magnetic fields is disclosed. The technique includes acquiring MR data and an MR reference scan, each in the presence of orthogonal perturbation magnetic fields. However, the region of interest for the MR reference scan is limited to a relatively narrow band within the imaging subject. Preferably, the narrow band is selected in the vicinity of the magnet iso-center and parallel to the readout direction. Alternatively, the narrow band can also be selected in the limited region where the orthogonal perturbation fields are either minimal or constant along the phase encoding direction, and parallel to the readout direction. The selection of the relatively narrow band is accomplished by either spatially saturating surrounding regions, or using a two-dimensional spatially selective RF pulse. Phase correction values can then be calculated from a more accurately defined slope and intercept of the phase of the MR reference scan and used to correct the MR data. A reconstructed MR image using this technique has reduced ghost artifacts otherwise caused by the adverse effects of the orthogonal perturbation fields in the phase correction process.
摘要翻译：公开了一种用于校正与正交扰动磁场相关的重影伪影的方法和装置。该技术包括获取MR数据和MR参考扫描，每个在存在正交扰动磁场的情况下。然而，用于MR参考扫描的感兴趣区域被限制在成像对象内的相对较窄的频带。优选地，在磁体等中心附近并且平行于读出方向选择窄带。或者，也可以在有限区域选择窄带，其中正交扰动场沿相位编码方向为最小或恒定，并且平行于读出方向。通过空间饱和的周围区域或使用二维空间选择性RF脉冲来实现相对窄带的选择。然后可以从更准确地定义的MR参考扫描的相位的斜率和截距来计算相位校正值，并用于校正MR数据。使用该技术的重构MR图像减少了由相位校正处理中的正交扰动场的不利影响引起的鬼影。

22. 发明授权

US6114852A Method employing point source to determine motion induced errors in MR imaging 失效
标题翻译：方法采用点源确定MR成像中的运动诱导误差
公开(公告)号：US6114852A
公开(公告)日：2000-09-05
申请号：US236195
申请日：1999-01-23
申请人： Xiaohong Zhou , Graeme C. McKinnon
发明人： Xiaohong Zhou , Graeme C. McKinnon
IPC分类号： G01R33/567 , G01V3/00
CPC分类号： G01R33/56509 , G01R33/5673
摘要： A method is provided for determining errors in MR imaging which result from translational motion of an object. In accordance with the method, an MR point source is rigidly joined to the object in selected spatial relationship, and for movement in unison therewith. An MR system is operated to acquire an overall k-space signal which represents an image of the object and of the point source collectively, the overall k-space signal being contaminated by phase errors which result from the motion. A k-space data set which represents an image of the point source alone, and which remains contaminated by the phase errors, is filtered or separated out from the overall k-space signal. The MR system is operated in selected association with the point source to acquire a reference k-space data set, which represents an image of the point source alone but which is unaffected by the phase errors resulting from the motion. The reference k-space data set is then selectively compared with the filtered k-space data set, to determine the phase errors. Alternatively, the reference k-space data set can be replaced by a plurality of k-space alignment lines in parallel relationship to the phase-encoding axis.
摘要翻译：提供了一种用于确定由对象的平移运动产生的MR成像中的误差的方法。根据该方法，MR点源以选定的空间关系刚性地连接到对象，并与其一起移动。操作MR系统用于获取表示对象和点源的图像的总体k空间信号，整体k空间信号被由运动产生的相位误差污染。仅表示点源的图像并且被相位误差污染的k空间数据集被从整个k空间信号中滤波或分离出来。 MR系统与点源选择关联地操作以获取参考k空间数据集，其表示单独的点源的图像，但不受运动导致的相位误差的影响。然后，将参考k空间数据集与经滤波的k空间数据集进行选择性比较，以确定相位误差。或者，参考k空间数据集可以由与相位编码轴平行的多个k空间对准线代替。

23. 发明授权

US5864233A Method to reduce eddy current effects in diffusion-weighted echo planar imaging 失效
标题翻译：减少扩散加权回波平面成像中涡流效应的方法
公开(公告)号：US5864233A
公开(公告)日：1999-01-26
申请号：US803808
申请日：1997-02-22
申请人： Xiaohong Zhou , Joseph K. Maier , Hammond Glenn Reynolds
发明人： Xiaohong Zhou , Joseph K. Maier , Hammond Glenn Reynolds
IPC分类号： G01N27/90 , G01R33/563 , G01R33/565 , G01V3/00
CPC分类号： G01R33/56341 , G01R33/56518
摘要： An eddy current correction method is provided for use in an MR system disposed to generate difflusion-weighted echo planar images by employing a bipolar diffusion-weighting gradient as well as the nominal components in an echo planar imaging pulse sequence. The correction method comprises the steps of deriving eddy current parameters (i.e., amplitude and time constant) associated with each eddy-current-induced magnetic field component caused by the diffusion-weighting gradient, and generating a set of correction terms, each of the correction terms being a function of the parameters. The method includes the further steps of modifyg a set of ideal echo planar imaging gradients and the receiver phase and frequency to respectively offset the eddy current induced magnetic field gradient and the spatially independent B.sub.0 -magnetic field. The modification occurs in two stages. Prior to data acquisition, errors are exactly corrected by altering the pre-phasing and the slice-refocusing gradient areas as well as the initial receiver phase. During data acquisition, the eddy current induced errors are approximately compensated for by adding offset gradients and dynamically changing the receiver phase and frequency using either a piece-wise-constant approximation or a constant approximation. Using either method, artifacts in diffusion-weighted echo planar images can be significantly reduced.
摘要翻译：提供涡流校正方法用于MR系统，其被布置为通过采用双极扩散加权梯度以及回波平面成像脉冲序列中的标称分量来产生散射加权回波平面图像。校正方法包括以下步骤：导出与由扩散加权梯度引起的每个涡流感应磁场分量相关联的涡流参数（即振幅和时间常数），以及产生一组校正项，每个校正术语是参数的函数。该方法包括以下步骤：修改一组理想的回波平面成像梯度，以及接收器相位和频率以分别偏移涡流感应磁场梯度和空间上独立的B0磁场。修改发生在两个阶段。在数据采集之前，通过改变预定相和切片重新聚焦梯度区域以及初始接收器相位来精确地校正误差。在数据采集过程中，通过增加偏移梯度和使用分段常数近似或恒定近似来动态地改变接收器相位和频率，近似补偿涡流感应误差。使用任一种方法，扩散加权回波平面图像中的伪影可以显着减少。

24. 发明授权

US5672969A Reduction of Nyquist ghost artifacts in oblique echo planar imaging 失效
标题翻译：在倾斜回波平面成像中减少奈奎斯特幻影
公开(公告)号：US5672969A
公开(公告)日：1997-09-30
申请号：US637879
申请日：1996-04-25
申请人： Xiaohong Zhou , Joseph K. Maier , Frederick H. Epstein
发明人： Xiaohong Zhou , Joseph K. Maier , Frederick H. Epstein
IPC分类号： G01R33/54 , A61B5/055 , G01R33/561 , G01R33/565 , G01R33/20
CPC分类号： G01R33/56572 , G01R33/5616
摘要： In a magnetic resonance imaging (MRI) system, a method is provided for reducing oblique Nyquist ghost artifact in an image produced by an oblique EPI scan. Prior to commencing the EPI scan, referencing pre-scans are conducted to generate pre-scan echo trains respectively corresponding to the physical gradient axes. Distortion compensating parameters are derived from the pre-scan echo trains for reducing Nyquist ghost by alternatively modifying the data acquisitions stage of the oblique EPI scan, or the post-data acquisition image processing stage thereof. In one mode of operation, the pre-scan echo trains are generated while a subject is in the MRI system. In another mode of operation, pre-scan echo trains are generated while no subject is present in the MR system, so that the distortion compensating parameters represent characteristics of the MR system only, and thus may be used for EPI scans of different protocols. For such mode of operation the distortion compensating parameters may be computed as a function of readout gradient pulse spacing.
摘要翻译：在磁共振成像（MRI）系统中，提供了一种用于减少由倾斜EPI扫描产生的图像中的倾斜奈奎斯特幻影伪像的方法。在开始EPI扫描之前，进行参考预扫描以产生分别对应于物理梯度轴的预扫描回波列。通过交替地修改倾斜EPI扫描的数据采集阶段或其后数据采集图像处理阶段，从预扫描回波列导出失真补偿参数，以减少奈奎斯特重影。在一种操作模式中，当受检者在MRI系统中时，产生预扫描回波列。在另一种操作模式中，在MR系统中不存在主体的情况下产生预扫描回波串，使得失真补偿参数仅表示MR系统的特性，因此可用于不同协议的EPI扫描。对于这种操作模式，失真补偿参数可以作为读出梯度脉冲间隔的函数来计算。

25. 发明授权

US08774918B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US08774918B2
公开(公告)日：2014-07-08
申请号：US12362838
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/3621 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3706 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

26. 发明授权

US08703200B2 Inhibition of neovascularization by cerium oxide nanoparticles 有权
标题翻译：通过氧化铈纳米颗粒抑制新生血管形成
公开(公告)号：US08703200B2
公开(公告)日：2014-04-22
申请号：US12429650
申请日：2009-04-24
申请人： James F. McGinnis , Xiaohong Zhou , Lily L. Wong , Sudipta Seal
发明人： James F. McGinnis , Xiaohong Zhou , Lily L. Wong , Sudipta Seal
IPC分类号： A61K9/14 , A01N59/16 , A61K33/24
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

27. 发明授权

US08688210B2 Implantable medical device crosstalk evaluation and mitigation 有权
标题翻译：植入式医疗器械串扰评估和缓解
公开(公告)号：US08688210B2
公开(公告)日：2014-04-01
申请号：US12362859
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/0424 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7217 , A61B2560/0271 , A61N1/36185 , A61N1/3622 , A61N1/365 , A61N1/3686 , A61N1/37247 , A61N1/37288 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

28. 发明授权

US08417334B2 Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions 有权
公开(公告)号：US08417334B2
公开(公告)日：2013-04-09
申请号：US10039307
申请日：2001-10-26
申请人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
发明人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.

29. 发明申请

US20120185008A1 VAGAL STIMULATION 有权
公开(公告)号：US20120185008A1
公开(公告)日：2012-07-19
申请号：US13353824
申请日：2012-01-19
申请人： Xiaohong Zhou , Robert Stadler , Richard Cornelussen , Lillian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
发明人： Xiaohong Zhou , Robert Stadler , Richard Cornelussen , Lillian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

30. 发明申请

US20120109240A1 AUTOMATIC ADJUSTMENT OF ARRHYTHMIA DETECTION PARAMETERS 审中-公开
标题翻译：自动调整ARRHYTHMIA检测参数
公开(公告)号：US20120109240A1
公开(公告)日：2012-05-03
申请号：US12915877
申请日：2010-10-29
申请人： Xiaohong Zhou , Robert Stadler , Bruce D. Gunderson , Walter H. Olson
发明人： Xiaohong Zhou , Robert Stadler , Bruce D. Gunderson , Walter H. Olson
IPC分类号： A61N1/39 , A61N1/365
CPC分类号： A61N1/3706 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61N1/3621
摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).
摘要翻译：用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

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