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1. 发明授权

US6114852A Method employing point source to determine motion induced errors in MR imaging 失效
标题翻译：方法采用点源确定MR成像中的运动诱导误差
公开(公告)号：US6114852A
公开(公告)日：2000-09-05
申请号：US236195
申请日：1999-01-23
申请人： Xiaohong Zhou , Graeme C. McKinnon
发明人： Xiaohong Zhou , Graeme C. McKinnon
IPC分类号： G01R33/567 , G01V3/00
CPC分类号： G01R33/56509 , G01R33/5673
摘要： A method is provided for determining errors in MR imaging which result from translational motion of an object. In accordance with the method, an MR point source is rigidly joined to the object in selected spatial relationship, and for movement in unison therewith. An MR system is operated to acquire an overall k-space signal which represents an image of the object and of the point source collectively, the overall k-space signal being contaminated by phase errors which result from the motion. A k-space data set which represents an image of the point source alone, and which remains contaminated by the phase errors, is filtered or separated out from the overall k-space signal. The MR system is operated in selected association with the point source to acquire a reference k-space data set, which represents an image of the point source alone but which is unaffected by the phase errors resulting from the motion. The reference k-space data set is then selectively compared with the filtered k-space data set, to determine the phase errors. Alternatively, the reference k-space data set can be replaced by a plurality of k-space alignment lines in parallel relationship to the phase-encoding axis.
摘要翻译：提供了一种用于确定由对象的平移运动产生的MR成像中的误差的方法。根据该方法，MR点源以选定的空间关系刚性地连接到对象，并与其一起移动。操作MR系统用于获取表示对象和点源的图像的总体k空间信号，整体k空间信号被由运动产生的相位误差污染。仅表示点源的图像并且被相位误差污染的k空间数据集被从整个k空间信号中滤波或分离出来。 MR系统与点源选择关联地操作以获取参考k空间数据集，其表示单独的点源的图像，但不受运动导致的相位误差的影响。然后，将参考k空间数据集与经滤波的k空间数据集进行选择性比较，以确定相位误差。或者，参考k空间数据集可以由与相位编码轴平行的多个k空间对准线代替。

2. 发明授权

US6070095A Method for reducing translational motion artifacts in MR imaging 失效
标题翻译：减少MR成像中的平移运动伪影的方法
公开(公告)号：US6070095A
公开(公告)日：2000-05-30
申请号：US089205
申请日：1998-06-02
申请人： Graeme C. McKinnon , Xiaohong Zhou
发明人： Graeme C. McKinnon , Xiaohong Zhou
IPC分类号： G01R33/565 , A61B5/055
CPC分类号： G01R33/56509
摘要： A method is provided for correcting for effects of translational motion or movement of an object in MR imaging. In accordance with the method, an MR point source is joined to the object for translational movement in unison therewith, the point source being maintained in selectively spaced-apart relationship with the object. The method further comprises acquiring a set of k-space data representing images of the object and point source collectively, and deriving a function representing the square of the magnitude of the k-space data set. An inverse Fourier transform operation is applied to the derived function to generate a correlation function with a number of correlation components, a specified one of the correlation components comprising the cross-correlation of the object and the point source. All of the correlation components are then discarded, except for the specified correlation component, which provides an adjusted MR image representing the object from which effects of the translational motion have been substantially eliminated.
摘要翻译：提供了一种用于校正MR成像中的物体的平移运动或运动的影响的方法。根据该方法，MR点源被连接到对象以与其一致地进行平移运动，点源保持与对象的选择性间隔关系。该方法进一步包括：一组获取表示该对象和点源的图像的一组k空间数据，以及导出表示该k空间数据集的大小的平方的函数。对衍生函数应用逆傅里叶变换操作以产生具有多个相关分量的相关函数，所述相关分量包括对象和点源的互相关的相关分量中的指定的一个。除了指定的相关分量之外，所有相关分量被丢弃，该相关分量提供了表示已经基本上消除了平移运动的影响的对象的经调整的MR图像。

3. 发明授权

US6043656A Method for compensating an MRI system for residual magnetization 有权
标题翻译：用于补偿MRI系统的残余磁化的方法
公开(公告)号：US6043656A
公开(公告)日：2000-03-28
申请号：US197858
申请日：1998-11-23
申请人： Jingfei Ma , Xiaohong Zhou , Graeme C. McKinnon
发明人： Jingfei Ma , Xiaohong Zhou , Graeme C. McKinnon
IPC分类号： A61B5/055 , G01R33/48 , G01R33/565 , G01V3/00
CPC分类号： G01R33/56518
摘要： An MRI system includes a gradient compensation system which appends magnetization reset gradient waveforms to imaging gradient waveforms produced during a scan. The magnetization compensation gradients maintain the residual magnetization in the MRI system at a constant level which reduces image artifacts.
摘要翻译： MRI系统包括梯度补偿系统，其将磁化复位梯度波形附加到在扫描期间产生的成像梯度波形。磁化补偿梯度将MRI系统中的剩余磁化强度保持在恒定水平，从而降低图像伪影。

4. 发明授权

US09775987B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US09775987B2
公开(公告)日：2017-10-03
申请号：US12362792
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36 , A61N1/37 , A61N1/372 , A61N1/39 , A61N1/362 , A61N1/365 , A61N1/08
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/3621 , A61N1/36521 , A61N1/37 , A61N1/37247 , A61N1/37282 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

5. 发明授权

US09192769B2 Shunt-current reduction techniques for an implantable therapy system 有权
标题翻译：用于植入式治疗系统的分流电流还原技术
公开(公告)号：US09192769B2
公开(公告)日：2015-11-24
申请号：US12551331
申请日：2009-08-31
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
IPC分类号： A61N1/08 , A61N1/37 , A61N1/36 , A61N1/372
CPC分类号： A61N1/3718 , A61N1/08 , A61N1/086 , A61N1/36114 , A61N1/37288
摘要： Techniques for minimizing interference between the first and second medical devices or between the different therapy modules of a common medical device are described herein. In some examples, a medical device may include shunt-current mitigation circuitry and/or at least one clamping structure that helps minimize or even eliminate shunt-current that feeds into a first therapy module of the medical device via one or more electrodes electrically connected to the first therapy module. The shunt-current may be generated by the delivery of electrical stimulation by a second therapy module. The second therapy module may be enclosed in a common housing with the first therapy module or may be separate, e.g., a part of a separate medical device.
摘要翻译：本文描述了用于最小化第一和第二医疗装置之间或在普通医疗装置的不同治疗模块之间的干扰的技术。在一些示例中，医疗装置可以包括分流电流缓解电路和/或至少一个夹持结构，其有助于最小化或甚至消除通过电连接到医疗装置的一个或多个电极馈入医疗装置的第一治疗模块的分流电流第一疗法模块。分流电流可以通过第二治疗模块的电刺激递送来产生。第二治疗模块可以用第一治疗模块封闭在共同的壳体中，或者可以是分离的，例如单独的医疗装置的一部分。

6. 发明授权

US08725259B2 Vagal stimulation 有权
公开(公告)号：US08725259B2
公开(公告)日：2014-05-13
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

7. 发明申请

US20130060150A1 METHOD AND APPARATUS FOR MONITORING CARDIAC AND RESPIRATORY CONDITIONS USING ACOUSTIC SOUNDS 审中-公开
标题翻译：使用声音监测心脏和呼吸系统状况的方法和装置
公开(公告)号：US20130060150A1
公开(公告)日：2013-03-07
申请号：US13456357
申请日：2012-04-26
申请人： Zhendong Song , Xiaohong Zhou
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61B5/0205 , A61B7/00 , A61B5/08
CPC分类号： A61B7/003 , A61B5/02 , A61B5/0205 , A61B5/0826 , A61B7/00 , A61N1/3627 , A61N1/36514
摘要： A medical device system and associated method discriminating conditions that includes a plurality of sensors, a sensing module coupled to the plurality of sensors and configured to acquire signals from the plurality of sensors, and a processor coupled to the sensing module and configured to determine a change in a respiratory related sounds in response to a signal from a sensor of the plurality of sensors, select one or more sensors of the plurality of sensors associated with the determined change, determine a respiratory signature in response to signals from the selected one or more sensors, and determine the respiratory condition in response to the determined respiratory signature.
摘要翻译：一种医疗设备系统和相关联的方法来区分包括多个传感器的条件，耦合到多个传感器并被配置为从多个传感器获取信号的感测模块以及耦合到感测模块并被配置为确定变化的处理器在响应于来自多个传感器的传感器的信号的呼吸相关声音中，选择与所确定的变化相关联的多个传感器中的一个或多个传感器，响应于来自所选择的一个或多个传感器的信号来确定呼吸特征并且响应于所确定的呼吸标志来确定呼吸状况。

8. 发明申请

US20130060149A1 METHOD AND APPARATUS FOR MONITORING CARDIAC AND RESPIRATORY CONDITIONS USING ACOUSTIC SOUNDS 审中-公开
标题翻译：使用声音监测心脏和呼吸道条件的方法和装置
公开(公告)号：US20130060149A1
公开(公告)日：2013-03-07
申请号：US13456346
申请日：2012-04-26
申请人： Zhendong Song , Xiaohong Zhou
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61B7/00 , A61B5/0205
摘要： A medical device system and associated method discriminate respiratory and cardiac conditions using respiratory sounds. A sensing module acquires a first signal and a second signal, at least the second signal acquired from an acoustic transducer. A processor is configured to receive the first signal and to control the sensing module to acquire the second acoustic signal in response to a change in the first signal. The processor discriminates between a cardiac condition and a respiratory condition as a cause of the change in the first signal in response to the second acoustic signal.
摘要翻译：医疗设备系统和相关方法使用呼吸音来辨别呼吸和心脏病状。感测模块至少从声换能器获取的第二信号获取第一信号和第二信号。处理器被配置为接收第一信号并且响应于第一信号的改变来控制感测模块获取第二声信号。处理器根据第二声信号，将心脏状况与呼吸状况鉴别为第一信号的变化的原因。

9. 发明授权

US08260412B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US08260412B2
公开(公告)日：2012-09-04
申请号：US12362809
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3688
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

10. 发明授权

US08249708B2 Implantable medical device crosstalk evaluation and mitigation 有权
标题翻译：植入式医疗器械串扰评估和缓解
公开(公告)号：US08249708B2
公开(公告)日：2012-08-21
申请号：US12362822
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61N1/3605 , A61N1/36114 , A61N1/36521 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

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