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1. 发明授权

US08703200B2 Inhibition of neovascularization by cerium oxide nanoparticles 有权
标题翻译：通过氧化铈纳米颗粒抑制新生血管形成
公开(公告)号：US08703200B2
公开(公告)日：2014-04-22
申请号：US12429650
申请日：2009-04-24
申请人： James F. McGinnis , Xiaohong Zhou , Lily L. Wong , Sudipta Seal
发明人： James F. McGinnis , Xiaohong Zhou , Lily L. Wong , Sudipta Seal
IPC分类号： A61K9/14 , A01N59/16 , A61K33/24
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

2. 发明申请

US20120093931A9 Inhibition of Neovascularization by Cerium Oxide Nanoparticles 有权
标题翻译：通过氧化铈纳米颗粒抑制新血管形成
公开(公告)号：US20120093931A9
公开(公告)日：2012-04-19
申请号：US12429650
申请日：2009-04-24
申请人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou , Sudipta Seal
发明人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou , Sudipta Seal
IPC分类号： A61K33/24 , A61P29/00 , A61P17/00 , A61P9/00 , A61P19/02 , A61P1/00 , A61K9/14 , A61P27/02
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

3. 发明申请

US20110111007A1 INHIBITION OF RETINAL CELL DEGENERATION OR NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES 审中-公开
标题翻译：通过氧化氮纳米颗粒抑制细胞衰老或新生血管细胞
公开(公告)号：US20110111007A1
公开(公告)日：2011-05-12
申请号：US12772523
申请日：2010-05-03
申请人： James F. McGinnis , Xiaohong Zhou , Lily L. Wong , Sudipta Seal
发明人： James F. McGinnis , Xiaohong Zhou , Lily L. Wong , Sudipta Seal
IPC分类号： A61F2/14 , A61K33/24 , A61P27/02 , A61P27/06 , A61P29/00 , A61P19/02 , A61P1/00 , A61P17/00 , A61K9/14 , B82Y5/00
CPC分类号： A61K33/00
摘要： The presently claimed and disclosed inventive concept(s) provides methods for reducing, reversing or inhibiting retinal cell degeneration, or neovascularization in tissues of a mammalian subject having a pathological condition involving neovascularization, by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the presently claimed and disclosed inventive concept(s) is useful, for example, for reducing, treating, reversing or inhibiting degeneration of retinal cells such as photoreceptor cells or neovascularization in ocular tissue such as the retina, macula or cornea; or other tissues such as, but not limited to, skin, synovial tissue, intestinal tissue, or bone. In addition, the method of the presently claimed and disclosed inventive concept(s) is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the presently claimed and disclosed inventive concept(s) is directed to using compositions containing nanoceria particles to reduce, treat, reverse or inhibit angiogenesis in a mammalian subject.
摘要翻译：目前要求权利要求和公开的发明构思通过在体内施用纳米颗粒（二氧化铈纳米颗粒）至哺乳动物受试者具有新生血管形成病理状态的组织中的视网膜细胞变性或新生血管形成，主题。目前权利要求和公开的发明构思的方法可用于例如减少，治疗，逆转或抑制视网膜细胞如感光细胞的变性或眼组织如视网膜，黄斑或角膜中的新生血管形成; 或其它组织，例如但不限于皮肤，滑膜组织，肠组织或骨。此外，本发明权利要求和公开的发明构思的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，所述肿瘤可能是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，目前要求保护和公开的发明构思涉及使用含有纳米颗粒的组合物来减少，治疗，逆转或抑制哺乳动物受试者的血管发生。

4. 发明申请

US20090269410A1 Inhibition of Neovascularization by Cerium Oxide Nanoparticles 有权
标题翻译：通过氧化铈纳米颗粒抑制新血管形成
公开(公告)号：US20090269410A1
公开(公告)日：2009-10-29
申请号：US12429650
申请日：2009-04-24
申请人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou
发明人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou
IPC分类号： A61K33/24 , A61K9/14 , A61P29/00 , A61P27/02 , A61P9/00 , A61P19/02 , A61P1/00 , A61P17/00
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

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