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21. 发明授权

US07396652B2 Chemokine PANEC-2 polypeptides and compositions and methods related thereto 失效
标题翻译：趋化因子PANEC-1多肽及其相关的组合物和方法
公开(公告)号：US07396652B2
公开(公告)日：2008-07-08
申请号：US11604251
申请日：2006-11-27
申请人： Roger T. Coleman , Olga Bandman , Craig G. Wilde
发明人： Roger T. Coleman , Olga Bandman , Craig G. Wilde
IPC分类号： A61K38/00 , A61K49/00
CPC分类号： C07K16/24 , A61K38/00 , C07K1/22 , C07K14/523 , C12Q1/68 , C12Q2600/118 , G01N33/6863 , G01N33/6893 , G01N2800/067
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
摘要翻译：本发明提供鉴定和编码来自人胰腺细胞的新型表达趋化因子（PANEC-1和PANEC-2）的核苷酸和氨基酸序列。本发明还提供编码PANEC-1和PANEC-2的核苷酸序列的反义分子，用于产生纯化的PANEC-1和PANEC-2的表达载体，能够特异性结合PANEC-1和PANEC-2的抗体，用于检测PANEC-1或PANEC-2编码核苷酸序列的杂交探针或寡核苷酸，用于表达PANEC-1和PANEC-2的遗传工程改造的宿主细胞，基于PANEC-1的趋化因子激活的诊断试验和编码PANEC-2的核酸分子和能够特异性结合蛋白质的抗体。

22. 发明授权

US5470825A Basophil granule proteins 失效
标题翻译：嗜碱性粒细胞蛋白
公开(公告)号：US5470825A
公开(公告)日：1995-11-28
申请号：US259564
申请日：1994-06-15
申请人： Randy W. Scott , Gerald J. Gleich , Craig G. Wilde
发明人： Randy W. Scott , Gerald J. Gleich , Craig G. Wilde
IPC分类号： A61K38/00 , A61K39/395 , A61P29/00 , A61P33/10 , A61P35/02 , C07K14/47 , C07K16/00 , C07K16/18 , C12N1/21 , C12N9/22 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/53 , A61K38/02 , C07K2/00
CPC分类号： C12N9/22 , C07K14/47 , C07K16/18 , A61K38/00
摘要： Several natural polypeptides (basophil granule proteins, "BGP") derived from the cytoplasmic granules of human basophils, and modified forms thereof, are described. These polypeptides, the DNA which encodes them and antibodies which recognize them, are useful as diagnostics for, and treatments for, pathologies involving inflammatory and IgE-mediated responses, parasitic and helminthic infections, hypersensitivity reactions and certain types of leukocytic leukemias.
摘要翻译：描述了衍生自人嗜碱性粒细胞的细胞质颗粒的几种天然多肽（嗜碱性粒细胞颗粒蛋白，“BGP”）及其修饰形式。这些多肽，编码它们的DNA和识别它们的抗体可用作涉及炎症和IgE介导的应答，寄生虫和蠕虫感染，超敏反应和某些类型的白细胞性白血病的病理学的诊断和治疗。

23. 发明授权

US08617551B2 Methods of diagnosing pancreatic inflammation by using chemokine PANEC-1 antibodies 失效
标题翻译：通过使用趋化因子PANEC-1抗体诊断胰腺炎症的方法
公开(公告)号：US08617551B2
公开(公告)日：2013-12-31
申请号：US12854005
申请日：2010-08-10
申请人： Roger T. Coleman , Olga Bandman , Craig G. Wilde
发明人： Roger T. Coleman , Olga Bandman , Craig G. Wilde
IPC分类号： A61K39/00 , A61K39/395 , C07K16/24 , C07K16/00
CPC分类号： C07K16/24 , A61K38/00 , C07K1/22 , C07K14/523 , C12Q1/68 , C12Q2600/118 , G01N33/6863 , G01N33/6893 , G01N2800/067
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
摘要翻译：本发明提供鉴定和编码来自人胰腺细胞的新型表达趋化因子（PANEC-1和PANEC-2）的核苷酸和氨基酸序列。本发明还提供编码PANEC-1和PANEC-2的核苷酸序列的反义分子，用于产生纯化的PANEC-1和PANEC-2的表达载体，能够特异性结合PANEC-1和PANEC-2的抗体，用于检测PANEC-1或PANEC-2编码核苷酸序列的杂交探针或寡核苷酸，用于表达PANEC-1和PANEC-2的遗传工程改造的宿主细胞，基于PANEC-1的趋化因子激活的诊断试验和编码PANEC-2的核酸分子和能够特异性结合蛋白质的抗体。

24. 发明授权

US06197519B1 Pancreas-derived serpin 失效
标题翻译：胰腺来源的丝氨酸蛋白酶抑制剂
公开(公告)号：US06197519B1
公开(公告)日：2001-03-06
申请号：US09361773
申请日：1999-07-27
申请人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
发明人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
IPC分类号： C12Q168
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel pancreas-derived serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.
摘要翻译：本发明提供鉴定和编码在人胰腺中表达的新型胰腺来源的丝氨酸蛋白酶抑制剂（PDS）的核苷酸和氨基酸序列。本发明还提供编码PDS的核苷酸序列的反义分子，用于产生纯化的PDS的表达载体，能够特异性结合PDS的抗体，用于检测PDS-编码核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达PDS的细胞，基于PDS编码核酸分子的诊断试验和含有能够特异性结合丝氨酸蛋白酶的PDS的药物组合物。

25. 发明授权

US5032574A Novel antimicrobial peptide 失效
标题翻译：新型抗菌肽
公开(公告)号：US5032574A
公开(公告)日：1991-07-16
申请号：US199206
申请日：1988-05-26
申请人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
发明人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
IPC分类号： C12N15/09 , A61K38/00 , A61P31/04 , C07K1/14 , C07K1/18 , C07K1/20 , C07K14/47 , C12N5/10 , C12P21/02 , C12R1/91
CPC分类号： C07K14/4723 , A61K38/00
摘要： This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu- leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-try-cys-thr-arg-val. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.
摘要翻译：本发明提供了可用作抗微生物剂的纯化多肽。该纯化的多肽已经衍生自人粒细胞，分子量约为3,700道尔顿，N-末端氨基酸序列为val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr -glu-leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-try-cys-thr-ar-val-val。本发明还提供了生产该多肽的方法，含该多肽的药物组合物及其用途。

26. 发明授权

US5804376A Pancreas-derived serpin 失效
公开(公告)号：US5804376A
公开(公告)日：1998-09-08
申请号：US434881
申请日：1995-05-02
申请人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
发明人： Scott Michael Braxton , Craig G. Wilde , Dinh Diep
IPC分类号： G01N33/566 , A61K31/70 , A61K38/00 , A61K48/00 , A61P1/00 , C07K14/81 , C07K16/38 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/15 , C12Q1/68 , G01N33/573 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel pancreas-derived serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.

27. 发明授权

US5747283A Basophil granule proteins 失效
公开(公告)号：US5747283A
公开(公告)日：1998-05-05
申请号：US573675
申请日：1995-12-18
申请人： Randy W. Scott , Gerald J. Gleich , Craig G. Wilde
发明人： Randy W. Scott , Gerald J. Gleich , Craig G. Wilde
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C12N9/22 , C12P21/06 , C07H21/04 , C12N1/20
CPC分类号： C12N9/22 , C07K14/47 , C07K16/18 , A61K38/00 , Y10S530/829 , Y10S530/837 , Y10S530/838
摘要： Several natural polypeptides (basophil granule proteins, "BGP") derived from the cytoplasmic granules of human basophils, and modified forms thereof, are described. These polypeptides, the DNA which encodes them and antibodies which recognize them, are useful as diagnostics for, and treatments for, pathologies involving inflammatory and IgE-mediated responses, parasitic and helminthic infections, hypersensitivity reactions and certain types of leukocytic leukemias.

28. 发明授权

US5210027A DNA encoding novel antimicrobial polypeptide and methods for obtaining such polypeptide 失效
标题翻译：编码新型抗微生物多肽的DNA和获得这种多肽的方法
公开(公告)号：US5210027A
公开(公告)日：1993-05-11
申请号：US730341
申请日：1991-07-15
申请人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
发明人： Craig G. Wilde , Joseph E. Griffith , Marian N. Marra , Randal W. Scott
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12
CPC分类号： C07K14/4723 , A61K38/00
摘要： This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu-leu-arg-val-gly-asn-cys-leu-ilu-gly-gly-val-ser-phe-thr-tyr-cys-cys-thr-arg-val. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.
摘要翻译：本发明提供了可用作抗微生物剂的纯化多肽。该纯化的多肽已经衍生自人粒细胞，分子量约为3,700道尔顿，N-末端氨基酸序列为val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr -glu-leu-arg-val-gly-作为n-cys-leu-ilu-gly-gly-val-ser-phe-thr-tyr-cys-cys-thr-arg-val。本发明还提供了生产该多肽的方法，含该多肽的药物组合物及其用途。

29. 发明申请

US20080292636A1 Chemokine panec-2 polynuleotides, polypeptides, antibodies and methods of making and using them 有权
标题翻译：趋化因子panec-2多核苷酸，多肽，抗体以及制备和使用它们的方法
公开(公告)号：US20080292636A1
公开(公告)日：2008-11-27
申请号：US12153507
申请日：2008-05-20
申请人： Roger Coleman , Olga Bandman , Craig G. Wilde
发明人： Roger Coleman , Olga Bandman , Craig G. Wilde
IPC分类号： A61K39/395 , C07K14/47 , G01N33/566
CPC分类号： C07K16/24 , A61K38/00 , C07K1/22 , C07K14/523 , C12Q1/68 , C12Q2600/118 , G01N33/6863 , G01N33/6893 , G01N2800/067
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
摘要翻译：本发明提供鉴定和编码来自人胰腺细胞的新型表达趋化因子（PANEC-1和PANEC-2）的核苷酸和氨基酸序列。本发明还提供编码PANEC-1和PANEC-2的核苷酸序列的反义分子，用于产生纯化的PANEC-1和PANEC-2的表达载体，能够特异性结合PANEC-1和PANEC-2的抗体，用于检测PANEC-1或PANEC-2编码核苷酸序列的杂交探针或寡核苷酸，用于表达PANEC-1和PANEC-2的遗传工程改造的宿主细胞，基于PANEC-1的趋化因子激活的诊断试验和编码PANEC-2的核酸分子和能够特异性结合蛋白质的抗体。

30. 发明授权

US07005509B1 Chemokine PANEC-1 polynucleotides and compositions and methods related thereto 失效
标题翻译：趋化因子PANEC-1多核苷酸及其组合物和方法
公开(公告)号：US07005509B1
公开(公告)日：2006-02-28
申请号：US08390740
申请日：1995-02-17
申请人： Roger Coleman , Olga Bandman , Craig G. Wilde
发明人： Roger Coleman , Olga Bandman , Craig G. Wilde
IPC分类号： C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： C07K16/24 , A61K38/00 , C07K1/22 , C07K14/523 , C12Q1/68 , C12Q2600/118 , G01N33/6863 , G01N33/6893 , G01N2800/067
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
摘要翻译：本发明提供鉴定和编码来自人胰腺细胞的新型表达趋化因子（PANEC-1和PANEC-2）的核苷酸和氨基酸序列。本发明还提供编码PANEC-1和PANEC-2的核苷酸序列的反义分子，用于产生纯化的PANEC-1和PANEC-2的表达载体，能够特异性结合PANEC-1和PANEC-2的抗体，用于检测PANEC-1或PANEC-2编码核苷酸序列的杂交探针或寡核苷酸，用于表达PANEC-1和PANEC-2的遗传工程改造的宿主细胞，基于PANEC-1的趋化因子激活的诊断试验和编码PANEC-2的核酸分子和能够特异性结合蛋白质的抗体。

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