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21. 发明授权

US07858568B2 Single phase color change agents 有权
标题翻译：单相变色剂
公开(公告)号：US07858568B2
公开(公告)日：2010-12-28
申请号：US12692003
申请日：2010-01-22
申请人： John Gavin MacDonald , Yanbin Huang , Kaiyuan Yang , Jaeho Kim , Ning Wei
发明人： John Gavin MacDonald , Yanbin Huang , Kaiyuan Yang , Jaeho Kim , Ning Wei
IPC分类号： A61K7/00
CPC分类号： C11D3/221 , C11D3/0042 , C11D3/40
摘要： There is provided a color change composition that remains stable in a single phase and that contains an indicator that produces an observable color change after a period of time to show that sufficient cleaning has been done or to indicate the thoroughness of the cleaning. This use indicating color change is useful for, for example, in soap for teaching children to wash their hands for a sufficient period of time. This composition may be added to many different base materials to indicate time of use or as a way to introduce enjoyment to the activity.
摘要翻译：提供了颜色变化组合物，其在单一相中保持稳定，并且包含在一段时间之后产生可观察到的颜色变化的指示剂，以显示已经进行足够的清洁或指示清洁的彻底性。指示颜色变化的这种用途对于例如在肥皂中教孩子们洗手足够长时间是有用的。这种组合物可以添加到许多不同的基础材料中以指示使用时间或作为向活动引入享受的方式。

22. 发明授权

US07838258B2 Meter strip and method for lateral flow assay devices 有权
标题翻译：用于侧流测定装置的仪表条和方法
公开(公告)号：US07838258B2
公开(公告)日：2010-11-23
申请号：US12570713
申请日：2009-09-30
申请人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
发明人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0681 , B01L2300/0825 , B01L2300/0867 , B01L2400/0406 , B01L2400/0683 , G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清从过滤部分。壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

23. 发明申请

US20100323392A1 Metering Technique for Lateral Flow Assay Devices 有权
标题翻译：侧流测试装置的计量技术
公开(公告)号：US20100323392A1
公开(公告)日：2010-12-23
申请号：US12872225
申请日：2010-08-31
申请人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
发明人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
IPC分类号： C12Q1/04
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较小体积（例如小于约100微升），在一些实施方案中为约0.5至约25微升，且在一些实施方案中为约1至约10 微升。例如，从具有柳叶刀的患者获得的全血滴通常具有小于约3微升的体积。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

24. 发明申请

US20070135777A1 Therapeutic article including a personal care composition and methods of making the therapeutic article 有权
标题翻译：包括个人护理组合物和制备治疗用品的方法的治疗用品
公开(公告)号：US20070135777A1
公开(公告)日：2007-06-14
申请号：US11300601
申请日：2005-12-14
申请人： Sharon Greene , Kaiyuan Yang , Shu-Ping Yang , Ning Wei , Jai Kyung , Jeffrey Fish
发明人： Sharon Greene , Kaiyuan Yang , Shu-Ping Yang , Ning Wei , Jai Kyung , Jeffrey Fish
IPC分类号： A61F13/00
CPC分类号： A61K9/70 , A61F2013/00646 , A61F2013/00727 , A61M35/00
摘要： A therapeutic article includes a skin contact layer having a plurality of fibers forming a plurality of point-bearing surfaces configured for wear against a user's skin; a personal care composition disposed proximate the fibers; an external layer attached to the skin contact layer; and an intermediate layer interposed between the skin contact layer and the external layer, the intermediate layer being configured to activate the personal care composition, the external layer being configured to direct the activated personal care composition through the skin contact layer to treat the user.
摘要翻译：治疗用品包括皮肤接触层，所述皮肤接触层具有多个纤维，所述多个纤维形成用于对使用者的皮肤的磨损的多个点支承表面; 设置在纤维附近的个人护理组合物; 附着于皮肤接触层的外层; 以及介于皮肤接触层和外层之间的中间层，所述中间层被配置为激活个人护理组合物，所述外层被配置为引导所述活化的个人护理组合物通过所述皮肤接触层以治疗所述使用者。

25. 发明申请

US20050049157A1 Single phase color change agents 有权
标题翻译：单相变色剂
公开(公告)号：US20050049157A1
公开(公告)日：2005-03-03
申请号：US10651421
申请日：2003-08-29
申请人： John MacDonald , Yanbin Huang , Kaiyuan Yang , Jaeho Kim , Ning Wei
发明人： John MacDonald , Yanbin Huang , Kaiyuan Yang , Jaeho Kim , Ning Wei
IPC分类号： C11D3/00 , C11D3/22 , C11D3/40 , C11D1/00 , A61K7/50
CPC分类号： C11D3/221 , C11D3/0042 , C11D3/40
摘要： There is provided a color change composition that remains stable in a single phase and that contains an indicator that produces an observable color change after a period of time to show that sufficient cleaning has been done or to indicate the thoroughness of the cleaning. This use indicating color change is useful for, for example, in soap for teaching children to wash their hands for a sufficient period of time. This composition may be added to many different base materials to indicate time of use or as a way to introduce enjoyment to the activity.
摘要翻译：提供了颜色变化组合物，其在单一相中保持稳定，并且包含在一段时间之后产生可观察到的颜色变化的指示剂，以显示已经进行足够的清洁或指示清洁的彻底性。指示颜色变化的这种用途对于例如在肥皂中教孩子们洗手足够长时间是有用的。这种组合物可以添加到许多不同的基础材料中以指示使用时间或作为向活动引入享受的方式。

26. 发明授权

US08377379B2 Lateral flow assay device 有权
标题翻译：侧流测定装置
公开(公告)号：US08377379B2
公开(公告)日：2013-02-19
申请号：US11640435
申请日：2006-12-15
申请人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
发明人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
IPC分类号： G01N30/96
CPC分类号： B01L3/5023 , A61B5/150022 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150824 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15186 , A61B5/1519 , A61B5/157 , B01L2200/0605 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0683 , G01N33/491
摘要： A lateral flow assay device includes a housing, and a test strip disposed within the housing having a membrane with a detection region and a collection region. A sample meter includes a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed adjacent the collection region of the membrane. The test sample component is transferable from the storage section to the collection region for subsequent migration to the detection region. An activatable isolation mechanism is provided within the housing and is disposed so as to isolate portions of the sample meter storage section upon activation thereof such that a defined length of the storage section is presented to the collection region of the membrane.
摘要翻译：侧流测定装置包括壳体和设置在壳体内的测试条，其具有带有检测区域和收集区域的膜。样品计量器包括用于吸收测试样品的第一端和接收并存储至少测试样品的组分的存储部分。壳体中的开口的尺寸用于将样品计量器插入到壳体中，使得样品计量器的存储部分邻近膜的收集区域设置。测试样本组件可从存储部分转移到收集区域，以便随后迁移到检测区域。在壳体内提供可激活的隔离机构，并且被设置成在启动时分离样品计量存储部分的部分，使得存储部分的限定长度被呈现给膜的收集区域。

27. 发明授权

US07803319B2 Metering technique for lateral flow assay devices 有权
标题翻译：侧流测定装置的计量技术
公开(公告)号：US07803319B2
公开(公告)日：2010-09-28
申请号：US11118079
申请日：2005-04-29
申请人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
发明人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
IPC分类号： G01N21/00 , B01L3/00
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments less than about 25 microliters, and in some embodiments, less than about 10 microliters. For example, whole blood drops obtained from patients with a lancet from low-pain areas (due to reduced nerve endings than finger), such as the forearm, thigh, or other alternate sites, may have a volume of from about 0.1 to about 5 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较低的体积，例如小于约100微升，在一些实施方案中小于约25微升，在一些实施方案中小于约10微升的实施方案是特别有效的。例如，从患有低疼痛区域的刺血针（由于神经末梢比手指减少）的患者（例如前臂，大腿或其他替代部位）获得的全血滴可具有约0.1至约5的体积微升。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

28. 发明授权

US07790471B2 Metering technique for lateral flow assay devices 有权
标题翻译：侧流测定装置的计量技术
公开(公告)号：US07790471B2
公开(公告)日：2010-09-07
申请号：US11867788
申请日：2007-10-05
申请人： James M. Takeuchi , Xuedong Song , Kaiyuan Yang , Ning Wei , Shawn R. Feaster
发明人： James M. Takeuchi , Xuedong Song , Kaiyuan Yang , Ning Wei , Shawn R. Feaster
IPC分类号： G01N21/00 , G01N15/06 , G01N33/53 , G01N31/00 , G01N33/566 , G01N33/543 , B01L3/00 , B01L3/02 , C12Q1/00 , C12M1/34 , C12M1/36 , C12M3/00
CPC分类号： G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331 , Y10T436/25375 , Y10T436/25625
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。在收集区域和检测区域之间限定屏障。收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。

29. 发明申请

US20100120644A1 Single Phase Color Change Agents 有权
标题翻译：单相变色剂
公开(公告)号：US20100120644A1
公开(公告)日：2010-05-13
申请号：US12692003
申请日：2010-01-22
申请人： John Gavin MacDonald , Yanbin Huang , Kaiyuan Yang , Jaeho Kim , Ning Wei
发明人： John Gavin MacDonald , Yanbin Huang , Kaiyuan Yang , Jaeho Kim , Ning Wei
IPC分类号： C11D3/40
CPC分类号： C11D3/221 , C11D3/0042 , C11D3/40
摘要： There is provided a color change composition that remains stable in a single phase and that contains an indicator that produces an observable color change after a period of time to show that sufficient cleaning has been done or to indicate the thoroughness of the cleaning. This use indicating color change is useful for, for example, in soap for teaching children to wash their hands for a sufficient period of time. This composition may be added to many different base materials to indicate time of use or as a way to introduce enjoyment to the activity.
摘要翻译：提供了颜色变化组合物，其在单一相中保持稳定，并且包含在一段时间之后产生可观察到的颜色变化的指示剂，以显示已经进行足够的清洁或指示清洁的彻底性。指示颜色变化的这种用途对于例如在肥皂中教孩子们洗手足够长时间是有用的。这种组合物可以添加到许多不同的基础材料中以指示使用时间或作为向活动引入享受的方式。

30. 发明授权

US07713252B2 Therapeutic article including a personal care composition and methods of making the therapeutic article 有权
标题翻译：包括个人护理组合物和制备治疗用品的方法的治疗用品
公开(公告)号：US07713252B2
公开(公告)日：2010-05-11
申请号：US11300601
申请日：2005-12-14
申请人： Sharon L. Greene , Kaiyuan Yang , Shu-Ping Yang , Ning Wei , Jai Kyung , Jeffrey E. Fish
发明人： Sharon L. Greene , Kaiyuan Yang , Shu-Ping Yang , Ning Wei , Jai Kyung , Jeffrey E. Fish
IPC分类号： A61M35/00 , A01N25/34
CPC分类号： A61K9/70 , A61F2013/00646 , A61F2013/00727 , A61M35/00
摘要： A therapeutic article includes a skin contact layer having a plurality of fibers forming a plurality of point-bearing surfaces configured for wear against a user's skin; a personal care composition disposed proximate the fibers; an external layer attached to the skin contact layer; and an intermediate layer interposed between the skin contact layer and the external layer, the intermediate layer being configured to activate the personal care composition, the external layer being configured to direct the activated personal care composition through the skin contact layer to treat the user.
摘要翻译：治疗用品包括皮肤接触层，所述皮肤接触层具有多个纤维，所述多个纤维形成用于对使用者的皮肤的磨损的多个点支承表面; 设置在纤维附近的个人护理组合物; 附着于皮肤接触层的外层; 以及介于所述皮肤接触层和所述外层之间的中间层，所述中间层被配置为激活所述个人护理组合物，所述外层被配置为引导所述活化的个人护理组合物通过所述皮肤接触层以治疗所述使用者。

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