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21. 发明申请

US20120156296A1 ANTIOXIDANTS IN FISH OIL POWDER AND TABLETS 审中-公开
标题翻译：鱼油粉和片剂中的抗氧化剂
公开(公告)号：US20120156296A1
公开(公告)日：2012-06-21
申请号：US13333410
申请日：2011-12-21
申请人： Trine-Lise Torgersen , Jo Klaveness , Astrid Hilde Myrset
发明人： Trine-Lise Torgersen , Jo Klaveness , Astrid Hilde Myrset
IPC分类号： A61K31/232 , A61K9/00 , A61K9/28 , A61K9/36 , A61K9/32 , A61K9/40 , A61K9/30 , A61P3/04 , A61P3/00 , A61P3/10 , A61P3/06 , A61P9/10 , A61P7/02 , A61P29/00 , A61K31/724
CPC分类号： C11B5/0092 , A23D7/0053 , A23D7/04 , A23D9/007 , A23D9/05 , A23L3/3508 , A23L33/115 , A23L33/12 , A23L33/15 , A23V2002/00 , A61K9/0007 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K9/2018 , A61K9/4825 , A61K35/655 , A61K47/6951 , C08B15/00 , C08B37/0015 , C08L1/04 , C08L5/16 , C11B5/0021 , C11B5/0028 , C11B5/005 , A23V2200/02 , A23V2200/214 , A23V2250/1882 , A23V2250/5112 , A23V2250/708 , A61K2300/00
摘要： This invention relates to antioxidants and combinations of antioxidants used to prevent oxidation of pharmaceutical and nutraceutical products in the form of powders, granulates, tablets, emulsions, gels and the like comprising one or more fatty acids and/or fatty acid derivatives and, optionally, at least one carbohydrate carrier alone or together with vitamins, minerals and/or pharmaceuticals. In particular, the invention concerns the use of antioxidants to reduce oxidation of powders, tablets, gels and emulsions comprising high concentrations and high doses of omega-3 fatty acids or derivatives thereof.
摘要翻译：本发明涉及抗氧化剂和抗氧化剂的组合，其用于防止包含一种或多种脂肪酸和/或脂肪酸衍生物的粉末，颗粒，片剂，乳剂，凝胶等形式的药物和营养产品的氧化，至少一种碳水化合物载体单独或与维生素，矿物质和/或药物一起。特别地，本发明涉及使用抗氧化剂来减少包含高浓度和高剂量的ω-3脂肪酸或其衍生物的粉末，片剂，凝胶和乳液的氧化。

22. 发明申请

US20120094989A1 5-HT RECEPTOR MODULATING COMPOUNDS 审中-公开
标题翻译： 5-HT受体调节化合物
公开(公告)号：US20120094989A1
公开(公告)日：2012-04-19
申请号：US13262356
申请日：2010-04-01
申请人： Jo Klaveness , Bjame Brudeli , Finn Olav Levy , Lise Roman Moltzau , Trygve Gulbrandsen
发明人： Jo Klaveness , Bjame Brudeli , Finn Olav Levy , Lise Roman Moltzau , Trygve Gulbrandsen
IPC分类号： A61K31/5365 , C07D211/58 , C07D401/10 , C07D211/34 , A61P13/00 , A61K31/454 , A61K31/445 , A61P9/00 , A61P1/00 , C07D498/04 , A61K31/4468
CPC分类号： C07D498/04 , C07D211/34
摘要： The present invention relates to compounds having 5-hydroxytryptamine receptor modulating activity, in particular compounds having an acidic moiety held distant from the 5-HT pharmacophore by a rigid linker group, to compositions containing such compounds and methods of treatment using them. Such compounds have an increased affinity for the 5-HT receptor and a reduced hERG effect. Certain compounds of the invention further exhibit an angiotensin II receptor modulating activity. Claimed are compounds of formula (I): HT-L-A. HT is a 5-HT receptor modulating moiety containing a basic nitrogen atom; A is an acid moiety; L is a linker moiety.
摘要翻译：本发明涉及具有5-羟色胺受体调节活性的化合物，特别是具有通过刚性连接基保持远离5-HT药效团的酸性部分的化合物，含有这些化合物的组合物和使用它们的治疗方法。这样的化合物对5-HT受体的亲和力增加并且hERG效应降低。本发明的某些化合物还表现出血管紧张素II受体调节活性。要求的是式（I）的化合物：HT-L-A。 HT是含有碱性氮原子的5-HT受体调节部分; A是酸性部分; L是连接体部分。

23. 发明授权

US07563819B1 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy 失效
标题翻译： 5-氨基乙酰丙酸的酯类作为光化学疗法中的光敏剂
公开(公告)号：US07563819B1
公开(公告)日：2009-07-21
申请号：US11786878
申请日：2007-04-13
申请人： Jo Klaveness , Nils Olav Nilsen , Jon Erik Braenden , Aslak Godal
发明人： Jo Klaveness , Nils Olav Nilsen , Jon Erik Braenden , Aslak Godal
IPC分类号： A61K31/21 , A61K31/22 , C07C229/00
CPC分类号： C07D213/30 , A61K31/195 , A61K41/0061 , A61K49/0021 , C07C229/22
摘要： The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention provides compounds of formula (I): R22N—CH2COCH2CH2CO—OR1 (wherein R1 represents an optionally substituted branched alkyl (e.g. C5-30 alkyl) group, or a substituted alkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group, preferably a group R1; wherein said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo, fluoro, —SR3, —NR32 and PR32 groups, and each alkyl group is optionally interrupted by one or more O—, —NR3—, —S— or —PR3— groups; and R3 represents a hydrogen atom or a C1-6 alkyl group) and salts thereof for us in diagnosis and photochemotherapy of disorders of abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
摘要翻译：本发明提供用于光化学疗法或诊断的化合物，所述化合物为支链烷基酯或5-氨基乙酰丙酸的取代烷基酯，或其衍生物或药学上可接受的盐。特别地，本发明提供式（I）的化合物：R 22 N-CH 2 COCH 2 CH 2 CO-OR 1（其中R 1表示任选取代的支链烷基（例如C 5-30烷基）或取代的烷基; R 2，其各自可以是相同或不同，表示氢原子或任选取代的烷基，优选基团R 1;其中所述取代基选自羟基，烷氧基，酰氧基，烷氧基羰基氧基，氨基，芳基，硝基，氧代，氟，-SR 3，-NR 32和 PR32基团，并且每个烷基任选地被一个或多个O-，-NR 3 - ，-S-或-PR 3 - 基团间隔;并且R 3表示氢原子或C 1-6烷基）及其盐身体外表面或内表面异常障碍的诊断和光化学治疗，以及用于实施本发明的产品和试剂盒。

24. 发明授权

US07413727B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US07413727B2
公开(公告)日：2008-08-19
申请号：US10462836
申请日：2003-06-17
申请人： Jo Klaveness , Anne Naevestad , Helge Tolleshaug
发明人： Jo Klaveness , Anne Naevestad , Helge Tolleshaug
IPC分类号： A61K49/00
CPC分类号： A61K51/1255 , A61K49/0002 , A61K49/0017 , A61K49/0089 , A61K49/085 , A61K49/10 , A61K51/0459 , A61K51/0497 , A61K51/088 , A61K51/1241
摘要： The invention provides a composition of matter of the formula (I): V-L-R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterised in that V is a non-peptidic organic group, or V is peptidic and R is a macromolecular or particulate species providing a multiplicity of labels detectable in in vivo imaging.
摘要翻译：本发明提供式（I）的物质组合物：VLR，其中V是对血管生成相关内皮细胞受体具有亲和性的载体部分，L是连接体部分或键，R是可检测部分，其特征在于 V是非肽类有机基团，或V是肽类，R是提供在体内成像中可检测到的多种标记物的大分子或微粒物质。

25. 发明申请

US20080044350A1 Optical Imaging Contrast Agents for Imaging Lung Cancer 审中-公开
标题翻译：用于成像肺癌的光学成像对比剂
公开(公告)号：US20080044350A1
公开(公告)日：2008-02-21
申请号：US10582842
申请日：2004-12-17
申请人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
发明人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0043 , A61K49/0052
摘要： The invention provides contrast agents for optical imaging of prostate cancer in patients. The contrast agents may be used in diagnosis of prostate cancer, for follow up of progress in disease development, for follow up of treatment of prostate cancer and for surgical guidance. Further, the invention provides methods for optical imaging of prostate cancer in patients.
摘要翻译：本发明提供了用于患者前列腺癌的光学成像的造影剂。造影剂可用于诊断前列腺癌，用于跟踪疾病发展的进展，后续治疗前列腺癌和手术指导。此外，本发明提供了患者前列腺癌的光学成像方法。

26. 发明申请

US20070003485A1 Contrast agents 审中-公开
标题翻译：对比剂
公开(公告)号：US20070003485A1
公开(公告)日：2007-01-04
申请号：US11448601
申请日：2006-06-06
申请人： Jo Klaveness , Pal Rongved , Per Strande
发明人： Jo Klaveness , Pal Rongved , Per Strande
IPC分类号： A61K49/00
CPC分类号： A61K49/225 , A61K47/26 , A61K47/42 , A61K49/223 , C07C69/96
摘要： The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.
摘要翻译：本发明涉及包含囊泡的超声波造影剂，其包含能形成含气囊泡的蛋白质，其中囊泡含有包含六氟化硫或低分子量氟化烃的气体。这些造影剂在施用时在体内表现出稳定性，以便允许超声可视化，同时允许从系统快速随后的消除。

27. 发明授权

US07014839B2 Light imaging contrast agents 失效
公开(公告)号：US07014839B2
公开(公告)日：2006-03-21
申请号：US10286988
申请日：2002-11-01
申请人： Jo Klaveness , Bjorn Fuglaas , Pål Rongved , Edvin Johannesen , Paul Mark Henrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
发明人： Jo Klaveness , Bjorn Fuglaas , Pål Rongved , Edvin Johannesen , Paul Mark Henrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
IPC分类号： A61K49/00
CPC分类号： B82Y5/00 , A61K49/001 , A61K49/0015 , A61K49/0032 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0078 , A61K49/0082 , A61K49/0084 , A61K49/0433 , A61K49/0461 , A61K49/0466 , A61K49/0485 , A61K49/223 , A61K49/227
摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

28. 发明申请

US20050232865A1 Contrast agents 审中-公开
标题翻译：对比剂
公开(公告)号：US20050232865A1
公开(公告)日：2005-10-20
申请号：US11055543
申请日：2005-02-10
申请人： Jo Klaveness , Pal Rongved , Per Strande
发明人： Jo Klaveness , Pal Rongved , Per Strande
IPC分类号： A61K49/00 , A61K47/26 , A61K47/42 , A61K49/04 , A61K49/22 , C07C69/96
CPC分类号： A61K49/225 , A61K47/26 , A61K47/42 , A61K49/223 , C07C69/96
摘要： The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.
摘要翻译：本发明涉及包含囊泡的超声波造影剂，其包含能形成含气囊泡的蛋白质，其中囊泡含有包含六氟化硫或低分子量氟化烃的气体。这些造影剂在施用时在体内表现出稳定性，以便允许超声可视化，同时允许从系统快速随后的消除。

29. 发明申请

US20050002865A1 Diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂
公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

30. 发明授权

US06540981B2 Light imaging contrast agents 失效
标题翻译：光成像造影剂
公开(公告)号：US06540981B2
公开(公告)日：2003-04-01
申请号：US09732917
申请日：2000-12-11
申请人： Jo Klaveness , Bjorn Fuglass , Pål Rongved , Edvin Johannesen , Paul Mark Hendrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
发明人： Jo Klaveness , Bjorn Fuglass , Pål Rongved , Edvin Johannesen , Paul Mark Hendrichs , Wolfgang Hans Heinrich Gunther , Edward Richard Bacon , John Luke Toner , Gregory Lynn McIntire , Vinay C. Desai
IPC分类号： A61K4900
CPC分类号： B82Y5/00 , A61K49/001 , A61K49/0015 , A61K49/0032 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0078 , A61K49/0082 , A61K49/0084 , A61K49/0433 , A61K49/0461 , A61K49/0466 , A61K49/0485 , A61K49/223 , A61K49/227
摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.
摘要翻译：本发明涉及在体内光成像中使用颗粒材料作为造影剂。

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