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21. 发明申请

US20080143957A1 Surface Treatment of Biomedical Devices 失效
标题翻译：生物医学器械的表面处理
公开(公告)号：US20080143957A1
公开(公告)日：2008-06-19
申请号：US11874427
申请日：2007-11-20
申请人： Jeffrey G. Linhardt , Jay F. Kunzler
发明人： Jeffrey G. Linhardt , Jay F. Kunzler
IPC分类号： G02C7/04 , B01J19/00
CPC分类号： C09D133/02 , A61L27/18 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08J7/047 , C08J2433/00 , G02B1/043 , C08L83/04
摘要： A surface modified biomedical device is provided comprising a biomedical device having a coating on at least a portion thereof, the coating comprising a polymer or copolymer having one or more repeating units of the formula: wherein R independently is a C2-C20 hydrocarbon radical and n is an integer of 2 to 5000.
摘要翻译：提供了表面改性的生物医学装置，其包括在其至少一部分上具有涂层的生物医学装置，所述涂层包含具有一个或多个下式重复单元的聚合物或共聚物：其中R独立地为C 2 - SO 2 -C 20烃基，n为2〜5000的整数。

22. 发明申请

US20110009658A1 Mono Ethylenically Unsaturated Polycarbosiloxane Monomers 有权
标题翻译：单烯键式不饱和聚碳硅氧烷单体
公开(公告)号：US20110009658A1
公开(公告)日：2011-01-13
申请号：US12499854
申请日：2009-07-09
申请人： Alok Kumar Awasthi , Jason K. Stanbro , Jay F. Kunzler , Jeffrey G. Linhardt
发明人： Alok Kumar Awasthi , Jason K. Stanbro , Jay F. Kunzler , Jeffrey G. Linhardt
IPC分类号： C07F7/18 , C07F7/10
CPC分类号： C08G77/50 , C07F7/0838 , C08G77/20
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.
摘要翻译：本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。更具体地说，本发明涉及能够聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些单烯属不饱和聚碳硅氧烷单体。

23. 发明申请

US20100318185A1 Biomedical Devices 有权
标题翻译：生物医学设备
公开(公告)号：US20100318185A1
公开(公告)日：2010-12-16
申请号：US12456423
申请日：2009-06-16
申请人： Ivan M. Nunez , Jay F. Kunzler , Jeffrey G. Linhardt , Jennifer Hunt
发明人： Ivan M. Nunez , Jay F. Kunzler , Jeffrey G. Linhardt , Jennifer Hunt
IPC分类号： A61F2/16 , G02B1/04 , A61F2/14 , G02C7/04
CPC分类号： G02B1/043 , A61L27/18 , A61L27/52 , A61L29/06 , A61L29/145 , C08L83/10 , C08L83/04
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a multi-armed macromonomer comprising multiple side chains attached to a nucleus, wherein each side chain comprises a thio carbonyl thio fragment of the same or different reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.
摘要翻译：生物医学装置，例如由混合物的聚合产物形成的隐形眼镜，所述混合物包含（a）包含连接到核的多个侧链的多臂大分子单体，其中每个侧链包含相同或不同的可逆加成断裂的硫代羰基硫代片段链转移（“RAFT”）代理; 和（b）公开了一种或多种生物医学装置形成单体。

24. 发明授权

US07837934B2 Packaging solutions 有权
标题翻译：包装解决方案
公开(公告)号：US07837934B2
公开(公告)日：2010-11-23
申请号：US12258916
申请日：2008-10-27
申请人： Jeffrey G. Linhardt , Jay F. Kunzler
发明人： Jeffrey G. Linhardt , Jay F. Kunzler
IPC分类号： A61L12/08
CPC分类号： C11D3/0078 , A45C11/005 , A61L12/04 , B65B25/008 , B65B55/06 , C11D1/82 , C11D17/041 , Y10S514/84
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a substantially water-soluble silicone-containing surfactant. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.
摘要翻译：公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。包装系统包括存储在包含基本上水溶性的含硅氧烷表面活性剂的水性包装溶液中的眼科装置。这种溶液长时间保留在未使用的镜片的表面上，导致眼睛中持续存在的表面改性，这可以显着改善首次使用的新鲜隐形眼镜的润湿性能，此外甚至镜片插入后数小时，防止干燥，提高润滑性。

25. 发明授权

US08349303B1 Polymeric quaternium compounds 失效
标题翻译：聚合季铵化合物
公开(公告)号：US08349303B1
公开(公告)日：2013-01-08
申请号：US12758860
申请日：2010-04-13
申请人： Eric Phillips , Jay F. Kunzler , Alok Kumar Awasthi
发明人： Eric Phillips , Jay F. Kunzler , Alok Kumar Awasthi
IPC分类号： A61K31/74
CPC分类号： C11D3/0078 , C11D3/3723
摘要： A topical pharmaceutical composition comprising a pharmaceutical active and a polymer of general formula I or general formula II wherein Ck is a saturated or unsaturated, five, six or seven-membered ring; R is a C1-C3alkyl; n is 1, 2, 3, 4 or 5 and m provides a number average molecular weight of the polymer of from 2000 to 80,000.
摘要翻译：一种局部药物组合物，其包含药物活性物质和通式I或通式II的聚合物，其中Ck为饱和或不饱和的，5,6或7元环; R是C1-C3烷基; n为1,2,3,4或5，并且m提供的聚合物的数均分子量为2000至80,000。

26. 发明授权

US08133512B2 Drug delivery systems based on catonic siloxanyl macromonomers 失效
标题翻译：基于催化骨架大分子单体的药物输送系统
公开(公告)号：US08133512B2
公开(公告)日：2012-03-13
申请号：US12459779
申请日：2009-07-08
申请人： Jay F. Kunzler , Derek Schorzman , Daniel M. Ammon, Jr.
发明人： Jay F. Kunzler , Derek Schorzman , Daniel M. Ammon, Jr.
IPC分类号： A61K9/14 , C08G77/26 , G02B1/04
CPC分类号： A61K9/0051 , A61K47/34
摘要： Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X−, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.
摘要翻译：基于一种或多种以下通式的含硅单体的基质控制扩散药物递送系统：其中L，X-，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和V如本文所述。

27. 发明申请

US20110146206A1 SYNTHESIS OF CATIONIC SILOXANE PREPOLYMERS 有权
标题翻译：阳离子硅氧烷预聚物的合成
公开(公告)号：US20110146206A1
公开(公告)日：2011-06-23
申请号：US13039912
申请日：2011-03-03
申请人： Jason K. Stanbro , Ivan M. Nunez , Jay F. Kunzler , Derek A. Schorzman
发明人： Jason K. Stanbro , Ivan M. Nunez , Jay F. Kunzler , Derek A. Schorzman
IPC分类号： B65B55/02 , C08F222/14 , G02C7/04
CPC分类号： C08G77/388 , G02B1/043 , C08L83/08
摘要： This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.
摘要翻译：本申请涉及一种改进的合成阳离子硅氧烷预聚物的方法以及具有改进的与单官能硅氧烷基甲基丙烯酸酯单体的相容性和含有阳离子硅氧烷预聚物的医疗装置的特异性阳离子硅氧烷预聚物。

28. 发明申请

US20090168013A1 Trimethylsilyl-Capped Polysiloxane Macromonomers Containing Polar Fluorinated Side-Chains 审中-公开
标题翻译：含有极性氟化侧链的三甲基甲硅烷基封端的聚硅氧烷大分子单体
公开(公告)号：US20090168013A1
公开(公告)日：2009-07-02
申请号：US12269442
申请日：2008-11-12
申请人： Jay F. Kunzler , Richard M. Ozark , Joseph A. McGee , Joseph C. Salamone
发明人： Jay F. Kunzler , Richard M. Ozark , Joseph A. McGee , Joseph C. Salamone
IPC分类号： G02C7/04 , C07F7/02 , C08F290/06
CPC分类号： C08F290/068 , C08G77/20 , C08G77/385 , G02B1/043 , C08L51/085
摘要： A method for reducing the modulus of polymer siloxane hydrogel compositions by employing monomeric polysiloxanes endcapped with trimethylsilyl to reduce the crosslinking density of the hydrogel. The synthesis consists of a single vessel acid catalyzed ring opening polymerization and may be employed to produce copolymers useful as hydrogel contact lens materials.
摘要翻译：通过使用用三甲基甲硅烷基封端的单体聚硅氧烷降低聚合物硅氧烷水凝胶组合物的模量以降低水凝胶的交联密度的方法。该合成由单容器酸催化的开环聚合组成，可用于产生可用作水凝胶隐形眼镜材料的共聚物。

29. 发明申请

US20090143858A1 OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX 有权
标题翻译：光学材料和修正折射指数的方法
公开(公告)号：US20090143858A1
公开(公告)日：2009-06-04
申请号：US11948298
申请日：2007-11-30
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
IPC分类号： A61F2/16 , G02B1/12
CPC分类号： A61F2/1613 , A61B18/20 , A61F2/14 , A61F2/16 , A61F2/1627 , A61F2/1635 , B29D11/00461 , B29D11/023 , C08J7/12 , C08J7/123 , G02C2202/14
摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.
摘要翻译：用于改变光学聚合物材料的折射率的方法。该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。照射导致折射光学结构的形成，其特征在于折射率的变化，显示很少或没有散射损失，并且在拉曼光谱方面相对于未照射的光学聚合物材料没有显着差异。该方法可以用于在人眼中手术植入人工晶状体后修改眼内透镜的折射率。本发明还涉及一种包括折射光学结构的光学器件，其中折射结构的特征在于折射率的变化，表现出很少的或没有散射损耗，并且在拉曼光谱方面相对于未辐照的表现没有显着的差异光学，聚合材料。

30. 发明申请

US20090142485A1 Process for Making Biomedical Devices 审中-公开
标题翻译：制造生物医学设备的过程
公开(公告)号：US20090142485A1
公开(公告)日：2009-06-04
申请号：US12273192
申请日：2008-11-18
申请人： Yu-Chin Lai , Edmond T. Quinn , Weihong Lang , Daniel M. Ammon, JR. , Jay F. Kunzler
发明人： Yu-Chin Lai , Edmond T. Quinn , Weihong Lang , Daniel M. Ammon, JR. , Jay F. Kunzler
IPC分类号： B05D5/06
CPC分类号： G02B1/043 , A61L27/18 , A61L27/34 , B29D11/00067 , C08L83/04
摘要： A process for treating a silicone hydrogel biomedical device, especially an ophthalmic lens such as a contact lens, involves: immersing the silicone hydrogel biomedical device with a mixture of an organic solvent and a hydrophilic, polymeric material, for a sufficient time that the device is swollen in volume by at least 30%; and removing the organic solvent from the device while retaining at least a portion of the hydrophilic polymeric material therein.
摘要翻译：用于处理硅酮水凝胶生物医学装置，特别是诸如隐形眼镜的眼用透镜的方法包括：将硅酮水凝胶生物医学装置与有机溶剂和亲水性聚合物材料的混合物浸渍足够的时间，使该装置为体积膨胀至少30％; 并从装置中除去有机溶剂，同时将至少一部分亲水性聚合物材料保持在其中。

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