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21. 发明授权

US5066427A Eicosatriynoic acid esters and their application in pharmaceutical and cosmetic practice 失效
标题翻译：药用植物油酸酯及其在药物和化妆品实践中的应用
公开(公告)号：US5066427A
公开(公告)日：1991-11-19
申请号：US411043
申请日：1989-09-22
申请人： Braham Shroot , Christopher Hensby , Jean Maignan , Gerard Lang , Serge Restle , Michel Colin
发明人： Braham Shroot , Christopher Hensby , Jean Maignan , Gerard Lang , Serge Restle , Michel Colin
IPC分类号： A61K8/00 , A61K8/11 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/37 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/16 , A61K31/165 , A61K31/195 , A61K31/20 , A61K31/202 , A61K31/22 , A61K31/23 , A61K31/40 , A61K31/445 , A61K31/495 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q5/00 , A61Q19/00 , C07C17/26 , C07C51/353 , C07C57/18 , C07C57/68 , C07C67/00 , C07C69/606 , C07C231/00 , C07C231/02 , C07C233/02 , C07C233/09 , C07C233/16 , C07C233/20 , C07D295/16 , C07D295/18 , C07D295/185 , C07D317/20 , C12N9/99
CPC分类号： A61K8/375 , A61K8/42 , A61Q19/00 , A61Q19/004 , C07C17/26 , C07C57/18 , C07C57/68 , C07D295/185 , C07D317/20 , Y10S514/886
摘要： Compound, corresponding to the formulaC.sub.8 H.sub.17 (C.tbd.C--CH.sub.2).sub.3 CH.sub.2 CH.sub.2 COR (I)in which R is a C.sub.1 -C.sub.8 lower alkoxy or C.sub.4 -C.sub.6 cycloaly group, substituted with one or more hydroxyl groups and/or interrupted by one or more hetero atoms chosen from oxygen and sulphur, an amino group of structure ##STR1## in which R.sub.1 or R.sub.2, which may be identical or different, denote a hydrogen atom or a linear or branched C.sub.1 -C.sub.8 lower alkyl radical, optionally interrupted by one or more hetero atoms chosen from oxygen, sulphur and nitrogen, this alkyl radical being able to be substituted with one or more hydroxyl groups, R.sub.1 and R.sub.2 not being able to denote hydrogen simultaneously, or alternatively R.sub.1 and R.sub.2 form, together with the nitrogen atom, a heterocyclic system optionally containing oxygen, sulphur or nitrogen as an additional hetero atom, one of the radicals R.sub.1 and R.sub.2 also being able to denote, when the other is a hydrogen atom, an aryl radical of formula (II): ##STR2## or alternatively a benzyl radical of formula (III): ##STR3## in which formulae R.sub.3 and R.sub.4, denote, independently of each other, a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical, a hydroxyl group, a halogen atom or a carboxyl or trifluoromethyl group, the amine group also being able to originate from a sugar, and also the isomers and salts thereof which are pharmaceutically and cosmetically acceptable.

22. 发明授权

US4985563A Process for the preparation of 6-piperidino-2,4-diamino pyrimidine-3-oxide 失效
标题翻译： 6-哌啶基-2,4-二氨基嘧啶-3-氧化物的制备方法
公开(公告)号：US4985563A
公开(公告)日：1991-01-15
申请号：US225819
申请日：1988-07-29
申请人： Jean Maignan , Serge Restle , Gerard Lang
发明人： Jean Maignan , Serge Restle , Gerard Lang
IPC分类号： A61K8/00 , A61K8/49 , A61Q5/00 , C07D239/48 , C07D239/50 , C07D239/52
CPC分类号： C07D239/48 , C07D239/50 , Y02P20/55
摘要： In a first stage of a process for the preparation of 6-piperidino-2,4-diaminopyrimidine-3-oxide at least one of the two amino groups of a compound having formula (1): ##STR1## where x represents a halogen atom or OH group, is protected by an addition reaction with an isocyanate having formula:R--N=C=OIn this formula R represents an alkyl group, or one of the amino groups. The resulting urea derivative is then oxidized to produce the corresponding N-oxide which is then reacted with piperidine. The protective group(s) are then eliminated by reaction with an organic or inorganic base.
摘要翻译：在制备具有式（1）的化合物的两个氨基中的至少一个的6-哌啶基-2,4-二氨基嘧啶-3-氧化物的方法的第一阶段：其中x表示通过与具有下式的异氰酸酯的加成反应来保护卤素原子或OH基团：RN = C = O在该式中，R表示烷基或氨基之一。然后将所得的脲衍生物氧化以产生相应的N-氧化物，然后与哌啶反应。然后通过与有机或无机碱反应除去保护基。

23. 发明授权

US4945093A Novel derivatives of ureylene, 2,4-triaminopyrimidine-3- oxide, their preparation and use in cosmetic and pharmaceutical compositions 失效
标题翻译：乙烯，2,4-三氨基嘧啶-3-氧化物的新型衍生物，它们在化妆品和药物组合物中的制备和用途
公开(公告)号：US4945093A
公开(公告)日：1990-07-31
申请号：US225849
申请日：1988-07-29
申请人： Jean Maignan , Serge Restle , Gerard Lang
发明人： Jean Maignan , Serge Restle , Gerard Lang
IPC分类号： A61K8/49 , A01N43/90 , A61K8/00 , A61K8/04 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/42 , A61K31/505 , A61P17/00 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q7/00 , C07D239/49 , C07D239/50 , C07D498/04 , C11D9/50
CPC分类号： A61Q5/00 , A61K8/4953 , A61Q7/00 , C07D239/50 , Y10S514/88 , Y10S514/881
摘要： A compound having formula: ##STR1## is described, where R.sub.3 and R.sub.4 may be identical or different and represent a hydrogen atom, alkyl, alkenyl, cycloalkyl;or R.sub.3 and R.sub.4 represent aryl aralkyl;or R.sub.3 and R.sub.4 together with the nitrogen atom linked thereto form a heterocycle;R.sub.1 and/or R.sub.2, independent of each other, represent hydrogen or carbanoyl having formula: ##STR2## where R.sub.7 represents alkyl, alkenyl, cycloalkyl, aryl or aralkyl. The compounds of formula (I) can be used in cosmetic or pharmaceutical compositions for the cosmetic treatment of hair, the treatment of alopecia, and also for the treatment of desquamating dermatitis.
摘要翻译：描述了具有下式的化合物：其中R 3和R 4可以相同或不同，表示氢原子，烷基，烯基，环烷基; 或R 3和R 4表示芳基芳烷基; 或R 3和R 4与连接的氮原子一起形成杂环; R 1和/或R 2彼此独立地表示氢或具有式（Ⅷ）的咔唑基，其中R 7表示烷基，烯基，环烷基，芳基或芳烷基。式（I）化合物可以用于化妆品或药物组合物中，用于美容治疗毛发，治疗脱发，以及用于治疗脱屑性皮炎。

24. 发明授权

US4931589A Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them 失效
标题翻译：苯并降冰片烯衍生物，其制备方法和含有它们的药物和化妆品组合物
公开(公告)号：US4931589A
公开(公告)日：1990-06-05
申请号：US218204
申请日：1988-07-13
申请人： Gerard Lang , Jean Maignan , Serge Restle , Braham Shroot
发明人： Gerard Lang , Jean Maignan , Serge Restle , Braham Shroot
IPC分类号： A61K31/10 , A61K8/00 , A61K31/045 , A61K31/075 , A61K31/11 , A61K31/12 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/21 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/255 , A61K31/70 , A61K31/7024 , A61P17/00 , A61P27/02 , A61P27/14 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61Q19/00 , C07C1/00 , C07C13/605 , C07C17/00 , C07C25/22 , C07C27/00 , C07C29/143 , C07C33/34 , C07C33/50 , C07C43/14 , C07C43/20 , C07C45/00 , C07C47/238 , C07C47/546 , C07C49/225 , C07C49/237 , C07C49/252 , C07C49/255 , C07C49/76 , C07C49/792 , C07C49/813 , C07C49/84 , C07C57/50 , C07C57/62 , C07C59/54 , C07C59/72 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/28 , C07C67/00 , C07C69/017 , C07C69/618 , C07C69/76 , C07C233/05 , C07C233/11 , C07C233/65 , C07C313/00 , C07C315/04 , C07C317/14 , C07C317/22 , C07C321/28 , C07C323/09 , C07C323/18 , C07H13/04 , C11D9/50
CPC分类号： C07C49/792 , C07C47/546 , C07C49/813 , C07C49/84
摘要： A compound of formula (I) ##STR1## its isomers and its salts in which R.sub.1, R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, halogen, C.sub.1 -C.sub.8 acyloxy or hydroxyl;R' is hydrogen or C.sub.1 -C.sub.6 -alkyl;R" is either a polyene chain or a benzene ring are useful in cosmetics and in the treatment of various dermatological and other complaints.

25. 发明授权

US5043482A New derivatives of 5,6,7,8-tetrahydro-1-naphthalenol, a process for their preparation and cosmetic and pharmaceutical compositions containing them 失效
标题翻译： 5,6,7,8-四氢-1-萘酚的新衍生物，其制备方法和含有它们的化妆品和药物组合物
公开(公告)号：US5043482A
公开(公告)日：1991-08-27
申请号：US535202
申请日：1990-06-08
申请人： Jean Maignan , Gerard Malle , Andre Deflandre , Gerard Lang
发明人： Jean Maignan , Gerard Malle , Andre Deflandre , Gerard Lang
IPC分类号： A61K31/045 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/41 , A61K8/92 , A61K31/05 , A61K31/085 , A61K31/12 , A61K31/135 , A61K31/19 , A61K31/215 , A61K47/10 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/08 , A61Q17/00 , C07C37/06 , C07C39/08 , C07C39/17 , C07C41/26 , C07C41/30 , C07C43/21 , C07C43/23 , C07C45/27 , C07C45/46 , C07C45/68 , C07C49/83 , C07C49/84 , C07C50/10 , C07C65/17 , C07C65/26 , C09K15/08
CPC分类号： A61Q17/00 , A61K8/347 , C07C39/17 , C07C43/23 , C07C45/27 , C07C45/46 , C07C49/84 , C07C50/10 , C07C65/26 , A61K2800/522 , C07C2102/10 , Y10S514/887 , Y10S514/97
摘要： A 5,6,7,8-tetrahydro-1-naphthalenol derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent lower alkyl,R.sub.5 and R.sub.6 represent hydrogen or lower alkyl,R represents hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkyl substituted by one or more hydroxyl groups, C.sub.3 -C.sub.18 alkenyl, C.sub.2 -C.sub.18 acyl, benzyl, benzoyl, carboxyl and carboxylic salts of an alkali or alkaline earth metal or of an organic amine.The derivative is useful as an antioxidant in cosmetic compositions and in pharmaceutical compositions for the preventive treatment of cutaneous inflammations and allergies or certain forms of cancer.
摘要翻译：式（I）的5,6,7,8-四氢-1-萘酚衍生物其中R 1，R 2，R 3和R 4表示低级烷基，R 5和R 6表示氢或低级烷基，R表示氢，C 1 -C 18烷基，被一个或多个羟基取代的C 2 -C 18烷基，C 3 -C 18烯基，C 2 -C 18酰基，苄基，苯甲酰基，碱金属或碱土金属的羧基和羧酸盐或有机胺。该衍生物可用作化妆品组合物中的抗氧化剂和用于预防性治疗皮肤炎症，过敏或某些形式的癌症的药物组合物。

26. 发明授权

US5158977A Cosmetic and pharmaceutical compositions containing naphthalenol derivatives 失效
标题翻译：包含萘酚衍生物的化妆品和药物组合物
公开(公告)号：US5158977A
公开(公告)日：1992-10-27
申请号：US711883
申请日：1991-06-07
申请人： Jean Maignan , Gerard Malle , Andre Deflandre , Gerard Lang
发明人： Jean Maignan , Gerard Malle , Andre Deflandre , Gerard Lang
IPC分类号： A61K31/045 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/41 , A61K8/92 , A61K31/05 , A61K31/085 , A61K31/12 , A61K31/135 , A61K31/19 , A61K31/215 , A61K47/10 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/08 , A61Q17/00 , C07C37/06 , C07C39/08 , C07C39/17 , C07C41/26 , C07C41/30 , C07C43/21 , C07C43/23 , C07C45/27 , C07C45/46 , C07C45/68 , C07C49/83 , C07C49/84 , C07C50/10 , C07C65/17 , C07C65/26 , C09K15/08
CPC分类号： A61Q17/00 , A61K8/347 , C07C39/17 , C07C43/23 , C07C45/27 , C07C45/46 , C07C49/84 , C07C50/10 , C07C65/26 , A61K2800/522 , C07C2102/10 , Y10S514/887 , Y10S514/97
摘要： A 5,6,7,8-tetrahydro-1-naphthalenol derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent lower alkyl,R.sub.5 and R.sub.6 represent hydrogen or lower alkyl,R represents hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkyl substituted by one or more hydroxyl groups, C.sub.3 -C.sub.18 alkenyl, C.sub.2 -C.sub.18 acyl, benzyl, benzoyl, carboxyl and carboxylic salts of an alkali or alkaline earth metal or of an organic amine.The derivative is useful as an antioxidant in cosmetic compositions and in pharmaceutical compositions for the preventive treatment of cutaneous inflammations and allergies or certain forms of cancer.
摘要翻译：式（I）的5,6,7,8-四氢-1-萘酚衍生物其中R 1，R 2，R 3和R 4表示低级烷基，R 5和R 6表示氢或低级烷基，R表示氢，C 1 -C 18烷基，被一个或多个羟基取代的C 2 -C 18烷基，C 3 -C 18烯基，C 2 -C 18酰基，苄基，苯甲酰基，碱金属或碱土金属的羧基和羧酸盐或有机胺。该衍生物可用作化妆品组合物中的抗氧化剂和用于预防性治疗皮肤炎症，过敏或某些形式的癌症的药物组合物。

27. 发明授权

US5106612A N-(mercaptoalkyl).omega.-hydroxyalkylamides and their use as a reducing agent in a process for permanently deforming hair 失效
标题翻译： N-（MERCAPTOALKYL）（OMEGA） - 羟基甲酰胺及其用作永久性变形毛发的方法中的还原剂
公开(公告)号：US5106612A
公开(公告)日：1992-04-21
申请号：US664785
申请日：1991-03-05
申请人： Jean Maignan , Gerard Lang , Gerard Malle
发明人： Jean Maignan , Gerard Lang , Gerard Malle
IPC分类号： A61K8/00 , A61K8/46 , A61K8/64 , A61Q5/04 , C07C235/06 , C07C323/25 , C07C323/41
CPC分类号： A61Q5/04 , A61K8/46 , C07C323/41
摘要： An N-(mercaptoalkyl).omega.-hydroxyalkylamide having the formula, ##STR1## wherein n is 2 or 3 and m is 2 or 5 inclusive is employed as a reducing agent in the first stage reducing operation of permanently deforming hair.

28. 发明授权

US5084579A Benzofuran compounds 失效
标题翻译：苯佐芬化合物
公开(公告)号：US5084579A
公开(公告)日：1992-01-28
申请号：US670190
申请日：1991-03-14
申请人： Gerard Lang , Serge Forestier , Alain Lagrange , Jean Maignan , Gerard Malle
发明人： Gerard Lang , Serge Forestier , Alain Lagrange , Jean Maignan , Gerard Malle
IPC分类号： C07D307/93 , A61K8/00 , A61K8/04 , A61K8/25 , A61K8/31 , A61K8/36 , A61K8/49 , A61K8/65 , A61K8/67 , A61K8/73 , A61K8/86 , A61K31/34 , A61K31/343 , A61K31/38 , A61P3/02 , A61P17/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q90/00 , C07D307/94 , C07D409/04 , C07D409/10 , C07D413/00
CPC分类号： C07D409/04 , A61K8/49 , A61K8/4973 , A61K8/671 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/08 , A61Q7/00 , C07D307/94 , A61Q17/04
摘要： A benzofuran compound of the formula ##STR1## wherein A represents ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, B and D have various meanings. The benzofuran compound is usefully employed in pharmaceutical and cosmetic compositions.

29. 发明授权

US5075331A Benzofuran compounds, compositions containing them and processes for using the compositions 失效
标题翻译：苯并呋喃化合物，含有它们的组合物和使用组合物的方法
公开(公告)号：US5075331A
公开(公告)日：1991-12-24
申请号：US407155
申请日：1989-09-14
申请人： Gerard Lang , Serge Forestier , Alain Lagrange , Jean Maignan , Gerard Malle
发明人： Gerard Lang , Serge Forestier , Alain Lagrange , Jean Maignan , Gerard Malle
IPC分类号： C07D307/93 , A61K8/00 , A61K8/04 , A61K8/25 , A61K8/31 , A61K8/36 , A61K8/49 , A61K8/65 , A61K8/67 , A61K8/73 , A61K8/86 , A61K31/34 , A61K31/343 , A61K31/38 , A61P3/02 , A61P17/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q90/00 , C07D307/94 , C07D409/04 , C07D409/10 , C07D413/00
CPC分类号： C07D409/04 , A61K8/49 , A61K8/4973 , A61K8/671 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/08 , A61Q7/00 , C07D307/94 , A61Q17/04
摘要： A benzofuran compound of the formula ##STR1## wherein A represents ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, B and D have various meanings. The benzofuran compound is usefully employed in pharmaceutical and cosmetic compositions.
摘要翻译：（IV）其中R 1，R 2，R 3，B和D具有各种含义，其中A表示下式的苯并呋喃化合物。苯并呋喃化合物有用地用于药物和化妆品组合物中。

30. 发明授权

US5068393A Aromatic derivatives of butyric acid, a process for their preparation and their use in cosmetics and in human and veterinary medicine 失效
标题翻译：丁酸的芳香衍生物，其制备方法及其在化妆品和人体和兽医学中的应用
公开(公告)号：US5068393A
公开(公告)日：1991-11-26
申请号：US181017
申请日：1988-04-04
申请人： Jean Maignan , Gerard Malle , Gerard Lang
发明人： Jean Maignan , Gerard Malle , Gerard Lang
IPC分类号： C07C57/50 , C07C59/54 , C07C59/86 , C07C59/90 , C07D295/185
CPC分类号： C07D295/185 , C07C57/50 , C07C59/54 , C07C59/86 , C07C59/90 , C07C69/738 , C07C2102/08 , C07C2102/10 , Y10S514/844
摘要： An aromatic deviative of butyric acid has the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, each independently, represent hydrogen or alkyl, with at least two of R.sub.1 -R.sub.4 being other than hydrogen,A represents methylene or dimethylene; when A represents dimethylene, R.sub.1 and R.sub.3 can together form methylene or dimethylene,R.sub.5 and R.sub.6 represent hydrogen, halogen, alkyl, alkoxy or hydroxy,R' represents hydrogen, hydroxy, alkoxy or acyloxy,R" represents hydrogen or alkoxy, or R' and R" taken together form oxo or hydroxyimino,R.sub.8 represents hydrogen or alkyl andR.sub.7 represents --OR.sub.9 or ##STR2## R.sub.9 represents hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl, optionally substituted, a sugar residue, carboxyalkyl or alkoxycarbonylalkyl,r' and r" represent hydrogen, alkyl, monohydroxyalkyl optionally interrupted by a heteroatom, polyhydroxyalkyl, aryl or benzyl optionally substituted, amino acid residue or aminated sugar residue, or r' and r" taken together form a heterocycle, optionally substituted by a C.sub.1 -C.sub.3 hydroxyalkyl, and to the salts of the compounds of formula I, to their optical isomers as well as the tautomers of the compounds of formula I. These aromatic derivatives of butyric acid are useful in human and veterinary medicines as well as in cosmetic compositions.
摘要翻译：丁酸的芳族偏差具有式（I）其中R 1，R 2，R 3和R 4各自独立地表示氢或烷基，其中R 1 -R 4中的至少两个不是氢，A表示亚甲基或二亚甲基 ; 当A表示二亚甲基时，R 1和R 3可以一起形成亚甲基或二亚甲基，R 5和R 6表示氢，卤素，烷基，烷氧基或羟基，R'表示氢，羟基，烷氧基或酰氧基，R“表示氢或烷氧基，或R '和R'一起形成氧代或羟基亚氨基，R8代表氢或烷基，R7代表-OR9或R9代表氢，烷基，一羟基烷基，多羟基烷基，芳基或芳烷基，任选被取代，糖残基，羧烷基或烷氧基羰基，r'和r“代表氢，烷基，任选被杂原子间隔的单羟基烷基，多羟基烷基，芳基或苄基任选取代的氨基酸残基或胺化糖残基，或者r'和r”一起形成杂环，通过C 1 -C 3羟烷基和式I化合物的盐与其旋光异构体以及式I化合物的互变异构体反应。这些丁酸的芳族衍生物可用于人和兽药以及化妆品组合物。

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