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21. 发明申请

US20120009588A1 LIVE BIOLOAD DETECTION USING MICROPARTICLES 有权
标题翻译：使用微生物进行实时荧光检测
公开(公告)号：US20120009588A1
公开(公告)日：2012-01-12
申请号：US13142290
申请日：2009-12-31
申请人： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
发明人： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
IPC分类号： C12Q1/66 , C12M1/34 , C12Q1/68 , C12Q1/48 , C12Q1/04 , G01N33/569
CPC分类号： C12Q1/04 , A61B10/0045 , A61B10/02 , B01L3/5082 , B01L2200/026 , B01L2200/10 , C12M23/08 , C12M23/32 , C12M23/34 , C12M33/02 , G01N33/56916 , G01N2333/245
摘要： The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.
摘要翻译：本发明提供了将细胞浓缩到微粒上，浓缩微粒并检测细胞的方法。本发明还包括根据该方法使用的单一样品制备和检测装置。

22. 发明申请

US20120003686A1 CULTURE PLATE HOLDER 审中-公开
标题翻译：文化板夹
公开(公告)号：US20120003686A1
公开(公告)日：2012-01-05
申请号：US13152303
申请日：2011-06-03
申请人： Manjiri T. Kshirsagar , Kurt J. Halverson , James E. Aysta
发明人： Manjiri T. Kshirsagar , Kurt J. Halverson , James E. Aysta
IPC分类号： C12M1/22 , C12M1/00 , C12Q1/04 , C12M1/34
CPC分类号： B01L3/0217 , B01L9/54 , B01L2200/025 , B01L2200/0605 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/043 , B01L2300/044 , B01L2300/16 , B01L2400/0457 , B01L2400/0644 , C12M23/04 , C12M23/48
摘要： The present disclosure describes holder devices, testing kits that include the holder devices, and methods for using the holder devices to allow a user to dispense an aqueous test sample from a sampling device onto a culture plate device having a cover sheet, whereby the cover sheet is supported in an open position by the holder while the user dispenses the aqueous test sample onto a base member of the culture plate device.
摘要翻译：本公开描述了保持器装置，包括保持器装置的检测试剂盒以及使用保持器装置以允许使用者将取样装置的水性测试样品分配到具有覆盖片的培养板装置上的方法，由此覆盖片当使用者将水性测试样品分配到培养板装置的基底构件上时，由支架支撑在打开位置。

23. 发明授权

US08003051B2 Thermal structure for sample processing systems 有权
标题翻译：样品处理系统的热结构
公开(公告)号：US08003051B2
公开(公告)日：2011-08-23
申请号：US12491959
申请日：2009-06-25
申请人： William Bedingham , James E. Aysta , Barry W. Robole
发明人： William Bedingham , James E. Aysta , Barry W. Robole
IPC分类号： G01N35/00 , F27D11/12
CPC分类号： B01L3/50851 , B01L7/52 , B01L7/54 , B01L9/523 , B01L2300/0803 , B01L2300/1861 , G01N35/025 , G01N2035/00326 , Y10T436/111666
摘要： Sample processing systems for processing sample materials located in sample processing devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate with raised and/or non-planar thermal structures on which the sample processing devices are located during operation of the systems. The systems may also include structure to urge the sample processing devices against the base plate and thermal structures.
摘要翻译：公开了用于处理位于与系统分开的样品处理装置中的样品的样品处理系统。样品处理系统包括具有凸起和/或非平面热结构的旋转底板，其中样品处理装置在系统的操作期间位于其上。该系统还可以包括将样品处理装置推靠在基板和热结构上的结构。

24. 发明申请

US20100240124A1 SAMPLE PROCESSING DEVICE COMPRESSION SYSTEMS AND METHODS 有权
标题翻译：样品加工装置压缩系统和方法
公开(公告)号：US20100240124A1
公开(公告)日：2010-09-23
申请号：US12793714
申请日：2010-06-04
申请人： James E. Aysta , William Bedingham , Barry W. Robole
发明人： James E. Aysta , William Bedingham , Barry W. Robole
IPC分类号： C12M1/00
CPC分类号： B01L9/52 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/041 , B01L2300/0803 , B01L2300/1805 , B01L2300/1861 , G01N35/025 , G01N2035/00366 , Y10S435/809
摘要： Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface.
摘要翻译：公开了使用这些系统来处理位于样品处理装置中的样品材料的样品处理系统和方法。样品处理系统包括在系统操作期间样品处理装置位于其上的旋转底板。该系统还包括设计成迫使样品处理装置朝向底板的盖和压缩结构。优选的结果是，样品处理装置被迫与基板上的热结构接触。本发明的系统和方法可以包括以下特征中的一个或多个，以增强热结构和样品处理装置之间的热耦合：成形转印表面，磁性压缩结构以及浮动或弹性安装的热结构。该方法可以优选地包括样品处理装置的一部分的变形以符合成形的转印表面。

25. 发明授权

US07754474B2 Sample processing device compression systems and methods 有权
标题翻译：样品处理设备压缩系统和方法
公开(公告)号：US07754474B2
公开(公告)日：2010-07-13
申请号：US11174757
申请日：2005-07-05
申请人： James E. Aysta , William Bedingham , Barry W. Robole
发明人： James E. Aysta , William Bedingham , Barry W. Robole
IPC分类号： C12M3/00
CPC分类号： B01L9/52 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/041 , B01L2300/0803 , B01L2300/1805 , B01L2300/1861 , G01N35/025 , G01N2035/00366 , Y10S435/809
摘要： Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface.
摘要翻译：公开了使用这些系统来处理位于样品处理装置中的样品材料的样品处理系统和方法。样品处理系统包括在系统操作期间样品处理装置位于其上的旋转底板。该系统还包括设计成迫使样品处理装置朝向底板的盖和压缩结构。优选的结果是，样品处理装置被迫与基板上的热结构接触。本发明的系统和方法可以包括以下特征中的一个或多个，以增强热结构和样品处理装置之间的热耦合：成形转印表面，磁性压缩结构以及浮动或弹性安装的热结构。该方法可以优选地包括样品处理装置的一部分的变形以符合成形的转印表面。

26. 发明授权

US5764355A Spectroscopic sample holder 失效
标题翻译：光谱样品架
公开(公告)号：US5764355A
公开(公告)日：1998-06-09
申请号：US587316
申请日：1996-01-12
申请人： David R. Gagnon , Richard M. Pieper , James E. Aysta
发明人： David R. Gagnon , Richard M. Pieper , James E. Aysta
IPC分类号： G01N21/64 , G01N21/01 , G01N21/33 , G01N21/35 , G01N21/65 , G01N33/483
CPC分类号： G01N21/01
摘要： A device for holding a sample to be spectroscopically analyzed in which the sample is retained within a defined area. The device includes a receiving medium on which the sample is held. When this receiving medium is mounted in a frame (an optional feature), it extends across an aperture in the frame. In/on the receiving medium is a sample confining region that keeps any sample placed on the receiving medium from migrating outside a defined area. By keeping the sample within a defined area, quantitative measurements of the sample can be obtained.
摘要翻译：用于保持样品被光谱分析的装置，其中样品保持在限定区域内。该装置包括保持样品的接收介质。当该接收介质安装在框架（可选特征）中时，其延伸穿过框架中的孔。接收介质中的/在接收介质上的样本限制区域使得放置在接收介质上的任何样品不被迁移到限定区域之外。通过将样品保持在限定的区域内，可以获得样品的定量测量。

27. 发明授权

US5019084A Corneal holder 失效
标题翻译：角膜架
公开(公告)号：US5019084A
公开(公告)日：1991-05-28
申请号：US893785
申请日：1986-08-06
申请人： James E. Aysta , Richard L. Lindstrom , Debra L. Skelnik
发明人： James E. Aysta , Richard L. Lindstrom , Debra L. Skelnik
IPC分类号： A61F9/00 , A01N1/02 , A61F2/14
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0263 , A61B17/32 , A61F2/14 , A61F2/142
摘要： A corneal holder, amenable for use in both a corneal storage system and a corneal cutting system with minimal physical manipulation of the corneal tissue itself. The holder provides a passageway through the apertures of both a base member and a cap member that is configured to allow a cutting device to be passed into cutting contact with a predetermined portion of the corneal tissue. The holder allows radial orientation of the predetermined portion in order to limit astigmatism; as well as constriction of the periphery of the corneal tissue during storage in order to alleviate swelling of the tissue due to fluid absorption.
摘要翻译：角膜保持器（10），适用于角膜存储系统和角膜切割系统，其角膜组织（16）自身的物理操作最小。保持器提供穿过基部构件（12）和盖构件（14）的孔的通道，该构件构造成允许切割装置与角膜组织（16）的预定部分切割接触。保持器允许预定部分的径向取向以限制散光; 以及在储存期间角膜组织（16）的周边的收缩，以便减轻由于流体吸收引起的组织肿胀。

28. 发明授权

US09284593B2 Live bioload detection using microparticles 有权
标题翻译：使用微粒的活生物体检测
公开(公告)号：US09284593B2
公开(公告)日：2016-03-15
申请号：US13519270
申请日：2010-12-30
申请人： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
发明人： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
IPC分类号： C12M1/34 , C12Q1/04 , B01L3/00 , G01N33/50
CPC分类号： C12Q1/04 , B01L3/502 , B01L3/5029 , B01L3/5082 , B01L2300/042 , B01L2300/046 , B01L2300/0672 , B01L2300/087 , B01L2400/0478 , B01L2400/0644 , B01L2400/0683 , G01N33/5005
摘要： The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.
摘要翻译：本发明提供了将细胞浓缩到微粒上，浓缩微粒并检测细胞的方法。本发明还包括根据该方法使用的单一样品制备和检测装置。

29. 发明申请

US20130130270A1 FILTRATION METHODS AND DEVICES 审中-公开
标题翻译：过滤方法和设备
公开(公告)号：US20130130270A1
公开(公告)日：2013-05-23
申请号：US13700910
申请日：2011-06-06
申请人： Raj Rajagopal , Wensheng Xia , Jinsheng Zhou , James E. Aysta , Guoping Mao
发明人： Raj Rajagopal , Wensheng Xia , Jinsheng Zhou , James E. Aysta , Chunmei Guo
IPC分类号： C12Q1/24
CPC分类号： C12Q1/24 , C12Q1/04 , G01N33/56911 , G01N2001/4088
摘要： A method of filtering a liquid sample that includes passing a sample comprising at least one biological organism through a filter membrane at a water volume flux of at least 100 L/m2.h.psi, where the filter membrane comprises a Bubble Point pore size of no more than 1.0 μm and where at least one biological organism is retained on the surface of the membrane. The method further includes detecting the at least one biological organism retained on the surface of the filter membrane.
摘要翻译：一种过滤液体样品的方法，其包括使包含至少一种生物体的样品通过过滤膜以至少100L / m2.h.psi的水体积通量通过，其中过滤膜包括泡沫点孔径不超过1.0μm，并且其中至少一个生物有机体保留在膜的表面上。该方法还包括检测保留在过滤膜表面上的至少一个生物体。

30. 发明申请

US20130122508A1 METHODS AND ARTICLES FOR SAMPLE PROCESSING 审中-公开
标题翻译：用于样品加工的方法和文章
公开(公告)号：US20130122508A1
公开(公告)日：2013-05-16
申请号：US13699761
申请日：2011-05-23
申请人： William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood , Theresa J. Gerten , Christopher R. Kokaisel , David J. Franta , Kurt J. Halverson , Joel R. Dufresne
发明人： William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood , Theresa J. Gerten , Christopher R. Kokaisel , David J. Franta , Kurt J. Halverson , Joel R. Dufresne
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： G01N1/28 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L3/523 , B01L7/52 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , G01N2035/00158 , Y10T436/25
摘要： Methods and devices for the thermal processing of samples are disclosed, including sample processing devices featuring an overflow region for retaining excess fluid, as well as portable sealing apparatuses for occluding channels in a sample processing device.
摘要翻译：公开了用于样品的热处理的方法和装置，包括具有用于保留过量流体的溢流区域的样品处理装置，以及用于封闭样品处理装置中的通道的便携式密封装置。

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