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21. 发明授权

US07619082B2 Process for the preparation of 3-spiro′cyclohexan-1,3′-′3H!indolin-2′-one! derivatives 失效
标题翻译： 3-螺环己烷-1,3' - '3H'二氢吲哚-2'-酮的制备方法衍生品
公开(公告)号：US07619082B2
公开(公告)日：2009-11-17
申请号：US10485133
申请日：2002-07-25
申请人： Eva Csikós , Csaba Gönczi , Felix Hajdú , István Hermecz , Gergely Héja , Gergelyné Héja , Csilla Majláth , Lajos Nagy , Andrea Sántáné Csutor , Tiborné Szomor , Györgyné Szvoboda
发明人： Eva Csikós , Csaba Gönczi , Felix Hajdú , István Hermecz , Gergely Héja , Gergelyné Héja , Csilla Majláth , Lajos Nagy , Andrea Sántáné Csutor , Tiborné Szomor , Györgyné Szvoboda
IPC分类号： C07D273/01
CPC分类号： C07D209/96
摘要： The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of the formula (III) characterized by dissolving the compounds of the formula (II) and formula (III) in a water-inmiscible organic solvent in the presence of a phase transfer catalyst, reacting with a.) an aqeuos solution of a base, or b.) a base in solid form directly and if desired transforming the compound of formula (I) thus obtained into its salt.
摘要翻译：本发明涉及一种制备式（I）化合物的方法，该方法是使式（Ⅱ）化合物与式（Ⅲ）化合物反应，其特征在于将式（Ⅱ）和式（III）在相互转移催化剂存在下在水不混溶的有机溶剂中反应，与a）的碱溶液反应，或b）直接固体形式的碱，如果需要，将式（III）化合物 I）得到的盐。

22. 发明授权

US06884895B2 Process for the preparation of spiro[(4-cyclohexanone)-[3]indol]-2′[1′H]-one derivatives 失效
标题翻译：制备螺[（4-环己酮） - [3]吲哚] -2'[1'H] - 酮衍生物的方法
公开(公告)号：US06884895B2
公开(公告)日：2005-04-26
申请号：US10409488
申请日：2003-04-08
申请人： Csaba Gönczi , Éva Csikós , István Hermecz , Gergely Héja , Árpád Illár , Lajos Nagy , Andrea Sántáné Csutor , Attila Simon , Kálmán Simon , Ágota Smelkóné Esek , Tiborné Szomor , Györgyné Szvoboda
发明人： Csaba Gönczi , Éva Csikós , István Hermecz , Gergely Héja , Árpád Illár , Lajos Nagy , Andrea Sántáné Csutor , Attila Simon , Kálmán Simon , Ágota Smelkóné Esek , Tiborné Szomor , Györgyné Szvoboda
IPC分类号： C07B61/00 , C07D209/34 , C07D209/96 , C07D405/04 , C07D209/54
CPC分类号： C07D405/04 , C07D209/34 , C07D209/96 , Y02P20/55
摘要： The invention relates to a process for the preparation of spiro[(4-cyclohexanone)-[3H]indol]-2′[1′H]-one derivatives of the general formula I wherein R1 and R2 independently stand for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluoroalkyl, C1-4polyfluoroalkoxy, C3-7cycloalkyloxy, C3-7cycloalkylthio, phenoxy, benzyloxy or nitro group—, characterized by reacting an indolin-2-one derivative of the general formula II wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, selected from 2-tetrahydropyranyl, 1-diethoxy-methylene or C1-4alkoxycarbonylethyl group, coupling the compound of general formula III, thus obtained—wherein R1 and R2 are as defined above and A stands for a protective group, selected from 2-tetrahydropyranyl, 1-diethoxy-methylene or C1-4alkoxycarbonylethyl group—with an acrylic acid C1-4ester, cyclizing the resulting compound of the general formula IV wherein R1, R2 and A are as defined above, R3 stands for C1-4 alkyl group—, eliminating the —COOR3 group and the A protective group of the keto-ester of general formula V wherein R1, R2, R3 and A are as defined above, optionally without isolation of the compounds of the general formulae IV
摘要翻译：本发明涉及制备通式I的螺[（4-环己酮） - [3 H]吲哚] -2'[1'H] - 酮衍生物的方法，其中R 1和 R 2独立地代表氢，C 1-4烷基，C 1-4 - 烷氧基，C 1-4 - 烷基 >烷硫基，C 1-4 - 多氟烷基，C 1-4 - 多氟烷氧基，C 3-7环烷氧基，C 3-7 - 其中R 1和R 2各自独立地表示：其中R 1，R 2和R 2各自为与可以引入选自2-四氢吡喃基，1-二乙氧基 - 亚甲基或C 1-4烷氧基羰基乙基的保护基的化合物，将由此得到的通式III的化合物 - 其中R 1和R 2如上定义，A代表保护基团，其选自2-四氢吡喃基，1-二乙氧基 - 亚甲基或C 1〜 4烷氧基羰基与丙烯酸C 1-4 - 酯反应，将得到的通式Ⅳ化合物环化，其中R 1，R 2和R 2， A如上所定义，R 3代表C 1-4烷基，除去-COOR 3 O 3基团和A保护基团的通式V的酮酯，其中R 1，R 2，R 3和A如上所定义，任选地不分离通式IV的化合物

23. 发明授权

US5153349A Process for the preparation of cypermethrine isomers 失效
标题翻译：制备CYPERMETHRINE异构体的方法
公开(公告)号：US5153349A
公开(公告)日：1992-10-06
申请号：US601767
申请日：1990-10-19
申请人： Sandor Zoltan , Gyorgy Hidasi , Bela Bertok , Istavan Szekely , Janis Hajimichael , Sandor Botar , Lajos Nagy , Eva Somfai , Istvan Lak , Andras Rapi , Antal Gajary , Agnes Hegedus , Maria Tary
发明人： Sandor Zoltan , Gyorgy Hidasi , Bela Bertok , Istavan Szekely , Janis Hajimichael , Sandor Botar , Lajos Nagy , Eva Somfai , Istvan Lak , Andras Rapi , Antal Gajary , Agnes Hegedus , Maria Tary
IPC分类号： A01N53/00 , C07C255/14
CPC分类号： A01N53/00
摘要： The invention relates to a process for the preparation of such isomer mixtures of cypermethrine of the Formula (I) ##STR1## wherein carbon atoms indicated by 1, 3 and .alpha. stand for a chiral carbon atom and the wavy line indicates cis or trans configuration related to the cyclopropane ring--which contains out of the theoretically possible 8-isomers of cypermethrine at least 95% of 1RtransS and 1StransR (Ib) isomer pair or only a mixture of 1RcisC and 1ScisR (Ia) and the isomer pair (Ib) of the ratio (Ia):(Ib)=55:45-25:75 by asymmetric transformation of second order performed in the presence of an amine base and solvent from a starting cypermethrine isomer mixture which contains next to the isomer pair (Ib) cis and other trans isomers or the isomer pair Ia+Ib at an undesired ratio.
摘要翻译： PCT No.PCT / HU90 / 00006 Sec。 371 1990年10月19日第 102（e）1990年10月19日PCT PCT 1990年1月17日PCT公布。出版物WO90 / 08132 日本1990年7月26日。本发明涉及一种制备式（I）的氯氰菊酯的异构体混合物的方法，其中由1,3和α表示的碳原子代表手性碳原子并且波浪线表示与环丙烷环有关的顺式或反式构型，其中含有理论上可能的氯氰菊酯的8-异构体至少95％的1RtransS和1StransR（Ib）异构体对，或仅包含1RcisC和1ScisR（Ia ）和通过在胺碱和溶剂的存在下由起始氯氰菊酯异构体混合物进行的二级的不对称转化，比率（Ia）：（Ib）= 55:45-25:75的异构体对（Ib）= 55：45-25：异构体对（Ib）顺式和其他反式异构体或异构体对Ia + Ib处于不期望的比例。

24. 发明授权

US4960913A Process for the preparation of pharmaceutical compositions 失效
标题翻译：制备药物组合物的方法
公开(公告)号：US4960913A
公开(公告)日：1990-10-02
申请号：US353657
申请日：1989-05-05
申请人： Erzsebet Szalay , Gyorgy Lugosi , Tamas U. Kallay , Zsuzsanna Nad , Istvan Jelinek , Vilmos Simonidesz , Peter Gyory , Lajos Nagy , Marta Lugosi , Ilona Santa nee Singola , Gabor Besenyei , Laszlo Simandi
发明人： Erzsebet Szalay , Gyorgy Lugosi , Tamas U. Kallay , Zsuzsanna Nad , Istvan Jelinek , Vilmos Simonidesz , Peter Gyory , Lajos Nagy , Marta Lugosi , Ilona Santa nee Singola , Gabor Besenyei , Laszlo Simandi
IPC分类号： B01J27/057 , C07B61/00 , C07C231/12 , C07C233/00 , C07C237/26 , C07D237/26
CPC分类号： C07C233/00
摘要： The invention relates to a process for the preparation of tetracycline derivatives of the formula ##STR1## and acid addition salts thereof --wherein R stands for --CH.sub.3 or .dbd.CH.sub.2 --by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula ##STR2## or by hydrating methacycline or acid addition salts thereof of the formula ##STR3## by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.
摘要翻译： PCT No.PCT / HU88 / 00063 Sec。 371日期1989年5月5日 102（e）日期1989年5月5日PCT提交1988年9月16日PCT公布。公开号WO89 / 02429 1989年3月23日。本发明涉及一种制备式I的四环素衍生物及其酸加成盐的方法，其中R代表-CH 3或= CH 2 - 通过脱氯和氢化氯代甲环素或酸其加成盐具有式 II。或通过水合式（III）的甲卡环素或其酸加成盐。在贵金属合金催化剂存在下，在载体和有机溶剂的存在下，通过氢气处理，其中包括在合金催化剂组成的合金催化剂的作用下，在0.1-1.0MPa的压力下，用合金催化剂和硒和/或碲与起始四环素的量相关的1：0.01-0.5的比例，如果需要，在一步中进行脱卤和氢化。

25. 发明授权

US4954628A Process for preparing N-sulphonyl-ureas 失效
标题翻译：制备N-磺酰脲的方法
公开(公告)号：US4954628A
公开(公告)日：1990-09-04
申请号：US317769
申请日：1989-03-02
申请人： Gabor Besenyei , Sandor Nemeth , Laszlo Simandi , Maria Belak , Maria Szabo , Jozsef Dukai , Lajos Nagy , Elemer Tomordi , Csaba Soptei , Erzsebet E. Dioszegine
发明人： Gabor Besenyei , Sandor Nemeth , Laszlo Simandi , Maria Belak , Maria Szabo , Jozsef Dukai , Lajos Nagy , Elemer Tomordi , Csaba Soptei , Erzsebet E. Dioszegine
IPC分类号： C07D251/16 , B01J27/13 , B01J31/16 , C07B61/00 , C07C311/60 , C07D213/75 , C07D239/42 , C07D251/18 , C07D251/22 , C07D251/46 , C07D333/34 , C07D521/00
CPC分类号： C07D521/00 , C07C311/60
摘要： The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar.sub.1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms,Ar.sub.2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C.sub.1-4 (halo)alkyl, C.sub.1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms.According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner.The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.
摘要翻译：本发明涉及一种制备通式（I）的磺酰脲的方法，其中Ar 1表示苯基，萘基或噻吩基，其衍生物被C 1-4烷基，C 1-4卤代烷基，（卤代）烷氧基羰基，（卤代）烷氧基，硝基，氰基以及卤素原子，Ar 2表示苯基，吡啶基，吡啶基或三嗪基，其衍生物被C 1-4（卤代）烷基，卤代）烷氧基，氨基，O-酰基，O-芳基磺酰基，O-（取代的氨基甲酰基）基团以及卤素原子。根据本发明，N-卤素芳基磺酰胺酸酯在羰基化催化剂，一氧化碳和芳族胺的存在下，任选地在相转移催化剂存在下反应，或N-卤素芳基磺酰胺盐与一氧化碳在存在下反应的羰基化催化剂，并且任选地在相转移催化剂存在下，然后将所得反应混合物进一步与芳族胺反应或N-卤素 - 芳基胺 - 碱金属盐在芳基 - 磺酰胺存在下与羰基化催化剂，一氧化碳和任选在相转移催化剂或胺，胺二卤代芳基磺酰胺存在下，在羰基化催化剂和一氧化碳的存在下反应，并将所得反应混合物以已知方式处理。如此制备的磺酰脲是生物活性化合物，其用于制药工业和调节植物生长。

26. 发明授权

US4229366A Process for heterogeneous nucleophilic substitution reactions 失效
标题翻译：非均相亲核取代反应的方法
公开(公告)号：US4229366A
公开(公告)日：1980-10-21
申请号：US953164
申请日：1978-10-20
申请人： Laszlo Toke , Gabor T. Szabo , Gabor Szabo , Lajos Nagy , Istvan Rusznak
发明人： Laszlo Toke , Gabor T. Szabo , Gabor Szabo , Lajos Nagy , Istvan Rusznak
IPC分类号： C07B61/00 , C07C17/20 , C07C29/58 , C07C41/01 , C07C67/00 , C07C69/14 , C07C69/157 , C07C255/32 , C07C255/53 , C07C120/04
CPC分类号： C07C253/14
摘要： The invention relates to a process for nucleophilic substitution reactions. According to the invention the reaction is carried out in a heterogeneous system, consisting of a solid and a dissolved reactant, one or several organic solvents, one or several linear polyether derivatives, and/or amino compounds and water.The volume of the water is preferably at the most 100% of the volume of the organic solvent and more preferably 5%.According to the invention the anhydrous reaction medium which is difficult to ensure, is not necessary and the use of the expensive and in industrial scales unavailable crown ethers is eliminated.
摘要翻译：本发明涉及亲核取代反应的方法。根据本发明，反应在异质体系中进行，其由固体和溶解的反应物，一种或几种有机溶剂，一种或多种线性聚醚衍生物和/或氨基化合物和水组成。水的体积优选为有机溶剂体积的至多100％，更优选为5％。根据本发明，难以确保的无水反应介质是不必要的，并且消除了昂贵和在工业规模中不能使用冠醚的用途。

27. 发明授权

US4146570A Automatic steam sterilizer having air exhaust valve 失效
标题翻译：具有空气排气阀的自动蒸汽灭菌器
公开(公告)号：US4146570A
公开(公告)日：1979-03-27
申请号：US779021
申请日：1977-03-11
申请人： Lajos Nagy
发明人： Lajos Nagy
IPC分类号： A61L2/00 , A61L2/24 , A61L3/00 , A61L3/02
CPC分类号： A61L2/24
摘要： Automatic sterilizer apparatus having an enclosed sterilizing chamber and a heater for vaporizing water placed in the chamber. An air exhaust valve is connected at the chamber and comprises a valve housing, a heat-expanding valve body of smaller cross-section than the housing, and a valve seat the position of which can be adjusted, these parts constituting an air/steam shut-off valve.

28. 发明申请

US20050130981A1 Compounds 失效
标题翻译：化合物
公开(公告)号：US20050130981A1
公开(公告)日：2005-06-16
申请号：US10507005
申请日：2003-03-04
申请人： Peter Aranyl , Laszlo Balazs , Imre Bata , Sandor Batori , Eva Boronkay , Philippe Bovy , Karoly Kanai , Zoltan Kapui , Edit Susan , Tibor Szabo , Lajos Nagy , Katalin Urban-Szabo , Marton Varga
发明人： Peter Aranyl , Laszlo Balazs , Imre Bata , Sandor Batori , Eva Boronkay , Philippe Bovy , Karoly Kanai , Zoltan Kapui , Edit Susan , Tibor Szabo , Lajos Nagy , Katalin Urban-Szabo , Marton Varga
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/501 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D451/14 , C07D43/14 , A61K31/506
CPC分类号： C07D451/04 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/14
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
摘要翻译：本发明涉及含有氟原子的新的具有通式（I）的DPP-IV酶抑制剂。

29. 发明授权

US5390526A Double-profile drawing tool 失效
标题翻译：双轮廓绘图工具
公开(公告)号：US5390526A
公开(公告)日：1995-02-21
申请号：US150661
申请日：1993-11-09
申请人： Gyorgy Balazs , Sandor Cebely , Jeno Jadi, deceased , Janos Kusz , Andras Monus , Lajos Nagy , Jozsef Varga
发明人： Gyorgy Balazs , Sandor Cebely , Jeno Jadi, deceased , Janos Kusz , Andras Monus , Lajos Nagy , Jozsef Varga
IPC分类号： B21C3/02 , B21C3/12 , B21C3/16 , B21K25/00
CPC分类号： B21K25/00 , B21C3/02 , B21C3/12
摘要： A double profile drawing tool includes a mandrel having a profile drawing die formed therein with first and second portions extending in opposite directions, associated therewith. The mandrel is disposed in a supported surrounding manner within a structure including a housing body and an embedding component. The embedding component is securely fixed within the housing body by way of a support plate which is joined to the housing body in a shrink fit manner. The structure formed by the housing body, support plate, with the mandrel and embedding component contained therein, is then securely mounted within a U-shaped outer housing member. First and second tapered openings are formed on opposite sides and along the longitudinal axis of the double profile drawing tool, such tapered openings providing communication to the first and second portions of the profile drawing die from opposite directions. The double profile drawing tool can be reversed for operation in an opposite direction once it has been determined that one portion of the profile drawing die has been worn. In either direction of operation, the mandrel is positively supported so as to prevent movement and to insure that a substantial portion of loading forces are directed away from the profile drawing die.
摘要翻译：双轮廓拉伸工具包括具有形成在其中的与其相反的相反方向延伸的第一和第二部分的轮廓拉伸模头的心轴。心轴以支撑的周围方式设置在包括壳体和嵌入部件的结构内。嵌入部件通过支撑板牢固地固定在壳体内，该支撑板以收缩配合的方式接合到壳体。然后将壳体，支撑板，其中容纳有心轴和嵌入部件的结构形成的结构牢固地安装在U形外壳体内。第一和第二锥形开口形成在双轮廓拉伸工具的相对侧和纵向轴线上，这样的锥形开口提供与轮廓拉伸模具的第一和第二部分相反的方向的连通。一旦已经确定轮廓拉伸模具的一部分已经被磨损，双轮廓拉伸工具可以反转以在相反的方向上操作。在任何一个操作方向上，心轴被可靠地支撑，以防止移动并且确保大部分的加载力被引导离开轮廓拉拔模具。

30. 发明申请

US20100083627A1 HARVESTER ADAPTER WITH STALK SHREDDER FOR HARVESTING GRAIN CROPS, PARTICULARLY SUNFLOWER 有权
标题翻译：收割机用于收割谷物，特别是SUNFLOWER的收割机
公开(公告)号：US20100083627A1
公开(公告)日：2010-04-08
申请号：US12524560
申请日：2008-01-25
申请人： Lajos Nagy , Kornel Gyenes , Gyorgy Lipusz , Gabor Sagi , Imre Takacs , Gabor Kincses , Laszlo Szalkai
发明人： Lajos Nagy , Kornel Gyenes , Gyorgy Lipusz , Gabor Sagi , Imre Takacs , Gabor Kincses , Laszlo Szalkai
IPC分类号： A01D45/00
CPC分类号： A01D45/021 , A01D34/8355
摘要： The invention relates to a harvester adapter with stalk shredder for harvesting grain crops, particularly sunflower, comprising a frame structure attached to a combine harvester, and at least two crop gathering units having a snout, where the crop gathering units are secured to the frame structure. Neighbouring crop gathering units are arranged such that a channel with an open leading end is formed between them, with a stalk gathering unit being disposed in driving connection with a harvesting mechanism on at least one side of the channels. The adapter has a collecting auger disposed rearward from the harvesting mechanism and at least one stalk shredder unit attached to the frame structure. The speed of the stalk gathering unit (5) is continuously adjustable by control orders given by the combine harvester and/or by a speed meter disposed on the adapter and/or by the operator, and the stalk shredder units (16) are attached to the frame structure (3) such that their position is adjustable in a direction perpendicular to the direction of travel.
摘要翻译：本发明涉及一种具有秸秆粉碎机的收割机适配器，用于收获粮食作物，特别是向日葵，包括连接在联合收割机上的框架结构，以及至少两个具有鼻孔的收割单元，其中收割单元固定在框架结构。相邻的作物收集单元布置成使得在它们之间形成具有开放前端的通道，其中杆收集单元设置成与通道的至少一侧上的收获机构驱动连接。适配器具有从收获机构向后设置的收集螺旋钻和连接到框架结构的至少一个秸秆切碎机单元。秸秆收集单元（5）的速度可以通过由联合收割机给出的控制命令和/或通过设置在适配器和/或操作者上的速度计来连续调节，并且秸秆切碎机单元（16）附接到框架结构（3）使得它们的位置在垂直于行进方向的方向上是可调节的。

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