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    • 21. 发明申请
    • Radiation Detector Assembly, Radiation Detector, and Method for Radiation Detection
    • 辐射检测器组件,辐射检测器和辐射检测方法
    • US20090179155A1
    • 2009-07-16
    • US12123412
    • 2008-05-19
    • Irving Weinberg
    • Irving Weinberg
    • G01T1/24
    • G01T1/16G01T1/24G01T1/242G01T3/08
    • An assembly for detecting radiation is described. The assembly includes a host matrix with particles suspended within the host matrix. The particles are capable of generating a charge carrier upon interaction with the radiation. A first electrode is disposed adjacent to a first surface of the host matrix, and a second electrode disposed adjacent to a second surface of the host matrix. A power source operatively connects to one of the first or second electrodes. The power source establishes an electric field between the first and second electrodes such that a ratio of a mobility-lifetime-field strength product of the charge carrier to the thickness of the host matrix is greater than or equal to 0.1. A radiation detector and a method for detecting radiation are also described.
    • 描述了一种用于检测辐射的组件。 组件包括具有悬浮在主体基质内的颗粒的主体基质。 颗粒在与辐射相互作用时能够产生电荷载体。 第一电极设置成与主体矩阵的第一表面相邻,以及邻近主体基质的第二表面设置的第二电极。 电源可操作地连接到第一或第二电极之一。 电源在第一和第二电极之间建立电场,使得电荷载流子的迁移率 - 场强强度乘积与主体矩阵的厚度之比大于或等于0.1。 还描述了辐射检测器和用于检测辐射的方法。
    • 22. 发明申请
    • Novel F-18 labeled annexin V, synthesis thereof, and use thereof
    • 新型F-18标记的膜联蛋白V,其合成及其用途
    • US20070031333A1
    • 2007-02-08
    • US10740688
    • 2003-12-22
    • Ronnie MeaseJeffrey ToretskyIrving Weinberg
    • Ronnie MeaseJeffrey ToretskyIrving Weinberg
    • A61K51/00
    • A61K51/088A61K51/087
    • A method for noninvasive measurement of apoptosis is described. The method includes the steps of labeling Annexin V with a positron emitter, injecting the labeled Annexin V into a target cell group, obtaining an image of the target cell group using a positron emission tomography scanner, and evaluating the image to determine an amount of cell death within the target cell group. The target cell group may be a lesion or a suspected tumor. The positron emitter may be F-18. The step of labeling Annexin V with F-18 may include the steps of selecting an F-18 labeled small molecule containing a protein conjugating group, synthesizing and purifying the selected molecule, producing a high specific activity prosthetic group as a result of the synthesizing and purifying step, and conjugating the prosthetic group to the Annexin V. The produced prosthetic group may be N-succinimidyl-4-[18F]fluorobenzoate (SFB).
    • 描述了一种用于无创测量细胞凋亡的方法。 该方法包括用正电子发射体标记膜联蛋白V的步骤,将标记的膜联蛋白V注射到靶细胞组中,使用正电子发射断层扫描仪获得靶细胞组的图像,并评估图像以确定细胞数量 靶细胞组内死亡。 靶细胞组可能是病变或疑似肿瘤。 正电子发射体可以是F-18。 用F-18标记膜联蛋白V的步骤可以包括选择含有蛋白质缀合基团的F-18标记的小分子,合成和纯化所选择的分子,作为合成结果产生高比活性假体基团的步骤,以及 纯化步骤,并将假体基团与膜联蛋白V缀合。所制备的假基团可以是N-琥珀酰亚胺基-4- [[18 F]氟代苯甲酸酯(SFB))。
    • 23. 发明授权
    • Dedicated apparatus and method emission mammography
    • 专用仪器和方法放射乳腺摄影术
    • US06229145B1
    • 2001-05-08
    • US09415979
    • 1999-10-12
    • Irving Weinberg
    • Irving Weinberg
    • G01T1161
    • A61B6/0414A61B6/4258A61B6/502A61B6/547G01T1/1642
    • The present invention is an apparatus for examining a body part. The apparatus comprises a mechanism for immobilizing and compressing the body part. The apparatus also comprises a mechanism for providing an internal anatomical image of the body part and a mechanism for detecting single gamma-rays emitted by a radiotracer infiltrated into the body part. The detecting mechanism is disposed in an adjacent relationship with the mechanism for providing an internal anatomic image so that the body part remains in the same position during and between anatomic and radiotracer imaging. In one embodiment, the detecting mechanism includes a detector module disposed on one side of the immobilizing mechanism. The detector module preferably has at least one array of gamma ray sensitive material in communication with a position detector. In another embodiment, the detecting mechanism includes a pair of detector modules disposed one on each side of the immobilizing mechanism. The present invention is also an apparatus for examining a body part which comprises a mechanism for immobilizing and compressing the body part and a mechanism for providing a stereotactic internal anatomical image of the body part. The apparatus also comprises a mechanism for providing a stereotactic physiological image of the body part in an adjacent relationship with the mechanism for providing an internal anatomic image such that the body part remains in the same position during and between stereotactic anatomic and radiotracer imaging.
    • 本发明是用于检查身体部位的装置。 该装置包括用于固定和压缩身体部分的机构。 该装置还包括用于提供身体部分的内部解剖图像的机构和用于检测由渗透入身体部位的放射性示踪器发射的单个γ射线的机构。 检测机构与用于提供内部解剖图像的机构相邻地设置,使得身体部分在解剖和放射性示踪器成像期间和之间保持在相同的位置。 在一个实施例中,检测机构包括设置在固定机构一侧的检测器模块。 检测器模块优选地具有与位置检测器连通的至少一个伽马射线敏感材料阵列。 在另一个实施例中,检测机构包括一对在固定机构的每一侧上设置的检测器模块。 本发明还是一种用于检查身体部位的装置,其包括用于固定和压缩身体部位的机构以及用于提供身体部位的立体定向内部解剖图像的机构。 该装置还包括用于提供与用于提供内部解剖图像的机构相邻关系的身体部位的立体定向生理图像的机构,使得身体部分在立体定向解剖和放射性示踪剂成像期间和之间保持在相同的位置。
    • 24. 发明授权
    • Dedicated apparatus and method for emission mammography
    • 用于放射乳腺摄影术的专用仪器和方法
    • US5252830A
    • 1993-10-12
    • US824804
    • 1992-01-22
    • Irving Weinberg
    • Irving Weinberg
    • A61B6/00G01T1/161
    • A61B6/502A61B6/4258G01T1/161
    • The present invention is an apparatus for examining a body part. The apparatus comprises a device for providing an anatomical image of the body part, such as an x-ray and a device for providing a physiological image of the body part in an adjacent relationship with said means for providing an anatomic image such that the body part remains in the same position during and between anatomic and physiological imaging. Preferably, the body part is infiltrated with a radiotracer and the device for providing a physiological image includes a device for detecting emissions of the radiotracers from the body part. In an alternative embodiment, the apparatus for examining a body part has a device for immobilizing the body part and a device for providing a physiological image of the body part. The providing device is in an adjacent relationship with the immobilizing means. Preferably, the apparatus includes a device for providing an anatomical image of the body part and the device for producing a physiological image includes means for detecting emissions of a radiotracer from the body part. The present invention is also a method for examining a body part of a patient which has the first step of obtaining an anatomical image of the body part. Then, there is the step of obtaining a physiological image of the body part such that the body part remains in the same position during and between anatomical and physiological imaging.
    • 本发明是用于检查身体部位的装置。 该装置包括用于提供身体部位的解剖图像的装置,例如x射线和用于以与所述用于提供解剖图像的装置相邻的关系提供身体部分的生理图像的装置,使得身体部位 在解剖和生理成像期间和之间保持相同的位置。 优选地,身体部分被放射线示踪器渗透,并且用于提供生理图像的装置包括用于检测来自身体部位的放射性示踪剂的排放物的装置。 在替代实施例中,用于检查身体部位的装置具有用于固定身体部位的装置和用于提供身体部位的生理图像的装置。 提供装置与固定装置处于相邻的关系。 优选地,该装置包括用于提供身体部位的解剖图像的装置和用于产生生理图像的装置,包括用于从身体部分检测放射性示踪剂的排放的装置。 本发明也是一种用于检查患者身体部位的方法,其具有获得身体部位的解剖图像的第一步骤。 然后,存在获得身体部位的生理图像的步骤,使得身体部分在解剖和生理成像期间以及解剖和生理成像之间保持在相同的位置。