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    • 3. 发明授权
    • Radiometal-labeled amino acid analogs, imaging and therapeutic agents incorporating the same, and methods using the same
    • 包含其的放射性标记的氨基酸类似物,成像和治疗剂以及使用其的方法
    • US08293207B2
    • 2012-10-23
    • US12562788
    • 2009-09-18
    • Valery ZavarzinIrving Weinberg
    • Valery ZavarzinIrving Weinberg
    • A61K51/00A61M36/14
    • A61K51/0497A61K51/0406C07B59/002
    • An amino acid analog is provided, in syn-stereoisomeric form, anti-stereoisomeric form, or a combination thereof. The amino acid analog includes a cyclobutane ring with at least one of an amine group and a carboxyl group attached to one carbon node of the cyclobutane ring. A chain of moieties X, Y, and Z attached to one of remaining three carbon nodes of the cyclobutane ring. X is a chelating agent selected from a group comprising DCTA, DOTA, DTPA, EDTA, NOTA, PCTA, and TETA. Y is a linking moiety selected from a group comprising —NH—CO— and —NH-p-CHSN-Bn- where the linking moiety facilitates incorporation of the chelating agent into the amino acid analog. Z is a metal radioisotope selected from a group comprising Cu-60, Cu-61, Cu-62, Cu-64, Cu-67, Ga-67, Ga-68, Y-86, Y-88, Y-90, Sr-85, Sr-89, Gd-153, Gd-157, Sm-153, Lu-177, W-185, Re-186, Re-188, and Ir-192.
    • 以立体立体异构形式提供氨基酸类似物,抗立体异构形式或其组合。 氨基酸类似物包括与环丁烷环的一个碳结点连接的胺基和羧基中的至少一个的环丁烷环。 连接到环丁烷环的剩余三个碳结点之一的部分X,Y和Z链。 X是选自DCTA,DOTA,DTPA,EDTA,NOTA,PCTA和TETA的螯合剂。 Y是选自-NH-CO-和-NH-p-CHSN-Bn-的基团的连接部分,其中连接部分促进螯合剂并入氨基酸类似物。 Z是选自Cu-60,Cu-61,Cu-62,Cu-64,Cu-67,Ga-67,Ga-68,Y-86,Y-88,Y-90, Sr-85,Sr-89,Gd-153,Gd-157,Sm-153,Lu-177,W-185,Re-186,Re-188和Ir-192。
    • 7. 发明授权
    • Radiation detector assembly, radiation detector, and method for radiation detection
    • 辐射探测器组件,辐射探测器和辐射探测方法
    • US07977643B2
    • 2011-07-12
    • US12123412
    • 2008-05-19
    • Irving Weinberg
    • Irving Weinberg
    • G01T1/24
    • G01T1/16G01T1/24G01T1/242G01T3/08
    • An assembly for detecting radiation is described. The assembly includes a host matrix with particles suspended within the host matrix. The particles are capable of generating a charge carrier upon interaction with the radiation. A first electrode is disposed adjacent to a first surface of the host matrix, and a second electrode disposed adjacent to a second surface of the host matrix. A power source operatively connects to one of the first or second electrodes. The power source establishes an electric field between the first and second electrodes such that a ratio of a mobility-lifetime-field strength product of the charge carrier to the thickness of the host matrix is greater than or equal to 0.1. A radiation detector and a method for detecting radiation are also described.
    • 描述了一种用于检测辐射的组件。 组件包括具有悬浮在主体基质内的颗粒的主体基质。 颗粒在与辐射相互作用时能够产生电荷载体。 第一电极设置成与主体矩阵的第一表面相邻,以及邻近主体基质的第二表面设置的第二电极。 电源可操作地连接到第一或第二电极之一。 电源在第一和第二电极之间建立电场,使得电荷载流子的迁移率 - 场强强度乘积与主体矩阵的厚度之比大于或等于0.1。 还描述了辐射检测器和用于检测辐射的方法。
    • 8. 发明申请
    • APPARATUS AND METHOD FOR WOUND WEAVING AND HEALING
    • 用于创伤和治疗的装置和方法
    • US20100256672A1
    • 2010-10-07
    • US12750034
    • 2010-03-30
    • Irving WeinbergMario UrdanetaPavel StepanovElisabeth Smela
    • Irving WeinbergMario UrdanetaPavel StepanovElisabeth Smela
    • A61B17/03
    • A61B17/00A61B17/08A61B2017/308
    • A method and apparatus for closing a gap between tissues, comprising introducing a device head into the gap, applying a force to a portion of one tissue with the device head, applying a force to a portion of the other tissue with the device head, moving, via the device head, the first tissue into close proximity to the second tissue, maintaining, for a predetermined period of time via the device head, the one tissue and the other tissue in close proximity until the portion of the one tissue and the portion of the other tissue become cellularly adhered to one another, thereby forming a cellular aggregate connecting the tissues, and releasing from the device head the portion of the one tissue, the portion of the other tissue, and the cellular aggregate after a predetermined period of time of less than about one minute.
    • 一种用于关闭组织之间的间隙的方法和装置,包括将装置头引入所述间隙中,向所述装置头部的一个组织的一部分施加力,用所述装置头向另一组织的一部分施加力,移动 经由装置头部将第一组织靠近第二组织,经由装置头部保持一段预定的时间段,一个组织和另一个组织紧邻,直到一个组织的部分和部分 从而形成连接组织的细胞聚集体,并且在预定时间段之后从装置头部释放一个组织的一部分,另一个组织的该部分和细胞聚集体 不到一分钟。