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21. 发明授权

US07084140B2 Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds 失效
标题翻译：芳基酰胺衍生物，所述衍生物的制备方法和含有这些化合物的药物组合物
公开(公告)号：US07084140B2
公开(公告)日：2006-08-01
申请号：US10235053
申请日：2002-09-05
申请人： Franz Esser , Gerd Schnorrenberg , Kurt Schromm , Horst Dollinger , Birgit Jung , Georg Speck
发明人： Franz Esser , Gerd Schnorrenberg , Kurt Schromm , Horst Dollinger , Birgit Jung , Georg Speck
IPC分类号： A61P25/00 , A61K31/535 , A61K31/445 , C07D211/00 , C07D413/00
CPC分类号： C07D221/14 , C07D211/46 , C07D211/58 , C07D213/74 , C07D239/42 , C07D241/08 , C07D243/08 , C07D295/145 , C07D295/185 , C07D295/30 , C07D317/60
摘要： The invention relates to new arylglycinamide derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula in which R3, R4, R5, Ar, R6, R7, R8, R9, R10, R11, r, s and t have the meanings given in the specification and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin) antagonists.
摘要翻译：本发明涉及通式I的新型芳基甘氨酰胺衍生物及其药学上可接受的盐，其中R 1和R 2与它们所连接的N一起形成环其中R 3，R 4，R 5，Ar，R 6，R SUP， R 7，R 9，R 9，R 10，R 11，R 11，R 9，并且具有说明书及其制备和使用中给出的含义。新化合物是有价值的神经激肽（速激肽）拮抗剂。

22. 发明授权

US06528491B2 Pyranoside derivatives 有权
标题翻译：吡喃糖苷衍生物
公开(公告)号：US06528491B2
公开(公告)日：2003-03-04
申请号：US10047526
申请日：2001-10-23
申请人： Ralf Anderskewitz , Kurt Schromm , Franz Birke , Hans Michael Jennewein
发明人： Ralf Anderskewitz , Kurt Schromm , Franz Birke , Hans Michael Jennewein
IPC分类号： A01N4304
CPC分类号： C07H15/203
摘要： The present invention relates to new pyranoside derivatives of general formula I, processes for preparing them as well as their use as medicaments:
摘要翻译：本发明涉及通式I的新的吡喃糖苷衍生物，其制备方法以及它们作为药物的用途：

23. 发明授权

US4720496A Pyridotriazoloquinazolines and triazolopyridoquinazolines useful as antiallergics 失效
标题翻译：吡唑并三唑喹唑啉和三唑并吡啶喹唑啉可用作抗过敏药
公开(公告)号：US4720496A
公开(公告)日：1988-01-19
申请号：US870365
申请日：1986-06-04
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
IPC分类号： C07D487/04 , A61K31/505 , A61K31/517 , A61P9/08 , A61P11/00 , A61P11/08 , A61P37/08 , C07D471/14
CPC分类号： C07D471/14
摘要： Compounds of the formula ##STR1## wherein (a)R.sub.1 is hydrogen, lower alkyl, lower alkoxy or 8-halo;R.sub.2 is hydrogen, lower alkyl, lower alkoxy or a fused benzene ring; andR.sub.3 and R.sub.4, together with each other, are --N.dbd.N--NH--; or(b)R.sub.1 and R.sub.2, together with each other, are --N.dbd.N--NH--;R.sub.3 is hydrogen, lower alkyl, lower alkoxy, 2-halo, 3-halo or 4-halo; andR.sub.4 is hydrogen, lower alkyl, lower alkoxy or a fused benzene ring;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as antiallergics.
摘要翻译：式（Ia）的化合物，其中（a）R 1是氢，低级烷基，低级烷氧基或8-卤素; R2是氢，低级烷基，低级烷氧基或稠合苯环; 并且R 3和R 4彼此一起是-N = N-NH-; 或（b）R 1和R 2彼此一起为-N = N-NH-; R3是氢，低级烷基，低级烷氧基，2-卤代，3-卤代或4-卤素; R4为氢，低级烷基，低级烷氧基或稠合苯环; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作抗过敏药。

24. 发明授权

US4558061A Bronchospasmolytic 1-(3-methanesulfonamido-4-hydroxyphenyl)-2-[(3-(4-acyl-aminophenyl)-imid azolidin-2-one-1-yl)-alkylamino]-ethanols 失效
标题翻译：支气管痉挛性1-（3-甲磺酰氨基-4-羟基苯基）-2 - [（3-（4-酰基 - 氨基苯基） - 咪唑烷-2-酮-1-基） - 烷基氨基] - 乙醇
公开(公告)号：US4558061A
公开(公告)日：1985-12-10
申请号：US628383
申请日：1984-07-06
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Gojko Muacevic , Armin Fugner
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Gojko Muacevic , Armin Fugner
IPC分类号： C07D233/34 , A61K31/415 , A61K31/4166 , A61P9/08 , A61P11/00 , A61P11/08 , A61P25/24 , A61P25/26 , C07D233/30 , C07D233/36
CPC分类号： C07D233/36
摘要： Compounds of the formula ##STR1## wherein n is 1 or 2, R.sub.1 is hydrogen, --CO--R.sub.2 or --SO.sub.2 R.sub.3,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or (alkyl of 1 to 4 carbon atoms)amino, andR.sub.3 is alkyl of 1 to 4 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bronchospasmolytics.
摘要翻译：其中n为1或2，R1为氢，-CO-R2或-SO2R3，R2为氢，1至4个碳原子的烷基，1至4个碳原子的烷氧基的化合物或（1〜4个碳原子的烷基）氨基，R3为1〜4个碳原子的烷基，以及无毒的药学上可接受的酸加成盐。化合物及其盐可用作支气管痉挛溶解剂。

25. 发明授权

US4546102A 1-(6,7-Dimethoxyquinazol-4-yl)semicarbazides 失效
标题翻译： 1-（6,7-二甲氧基喹唑啉-4-基）氨基脲
公开(公告)号：US4546102A
公开(公告)日：1985-10-08
申请号：US546864
申请日：1983-10-31
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Werner Traunecker , Richard Reichl
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Werner Traunecker , Richard Reichl
IPC分类号： A61K31/505 , A61K31/517 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/12 , A61P43/00 , C07D239/94
CPC分类号： C07D239/94
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, methyl or ethyl;R.sub.5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; orR.sub.4 and R.sub.5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by --O-- or --NR.sub.6 --, where R.sub.6 is alkyl of 1 to 4 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.
摘要翻译：其中R 1为氢，1至4个碳原子的烷基或三氟甲基的化合物＆lt; IMAGE＆gt; R2，R3和R4各自独立地为氢，甲基或乙基; R5是氢，1至8个碳原子的烷基，苯基（1至8个碳原子的烷基），3至7个碳原子的环烷基，（1至4个碳原子的烷氧基）羰基 - 甲基，苯基，取代的苯基，萘基或取代的萘基; 或R 4和R 5彼此一起是4至5个碳原子的亚烷基，任选被-O-或-NR 6 - 间隔，其中R 6是具有1至4个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂。

26. 发明授权

US4378361A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US4378361A
公开(公告)日：1983-03-29
申请号：US285713
申请日：1981-07-22
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00 , C07D239/72
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R.sub.1 is H or acyl,R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN,R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7,R.sub.2 and R.sub.3 together with each other are ##STR3## R.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5, R.sub.5 and R.sub.6 are each H or --CH.sub.3,R.sub.7 is C.sub.1 -C.sub.4 alkyl,R.sub.8 is H or C.sub.1 -C.sub.4 alkyl,R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen,R.sub.10 and R.sub.12 are each H, CH.sub.3, Cl or OCH.sub.3, or together methylenedioxy,X is ##STR4## or N, and Z is --CH.sub.2 or --CO;in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het为1至4的整数，包括端值，优选2或3，R 1为H或酰基，R 2为H，R 1 O - ， - NHSO2R7，-NHCOR8，-NHCONHR8，-NH-CH2-C6H4-R9，-CH2OH，-CH2SO2R7，-CONHR8，卤素或-CN，R3是H，卤素，R7或-OR7，R2和R3彼此是 R4是H，-CH3或-C2H5，R5和R6分别是H或-CH3，R7是C1-C4烷基，R8是H或C1-C4烷基，R9是H，C1-C4烷基或C1- 任选被氧中断的C 4烷氧基，R 10和R 12各自为H，CH 3，Cl或OCH 3，或一起为亚甲二氧基，X为N或N，并且Z为-CH 2或-CO; 以外消旋物，对映异构体，非对映异构体对映体对及其无毒的药学上可接受的酸加成盐的形式存在。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

27. 发明授权

US4363814A Aminoalkyl-substituted heterocycles 失效
标题翻译：氨基烷基取代的杂环
公开(公告)号：US4363814A
公开(公告)日：1982-12-14
申请号：US218786
申请日：1980-12-22
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic or optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl, orR.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy;n is an integer from 2 to 6, inclusive; andR is hydrogen, benzyl or ##STR2## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS-stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋或旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，或R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基; n为2〜6的整数，包括0〜6; 并且R是氢，苄基或者它们的无毒的药学上可接受的酸加成盐。化合物及其盐可用作血管扩张剂和CNS刺激剂。

28. 发明授权

US4271158A Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones 失效
标题翻译：血管舒张或抗抑郁药苯烷醇氨基烷基取代的咪唑啉酮
公开(公告)号：US4271158A
公开(公告)日：1981-06-02
申请号：US102904
申请日：1979-12-13
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12 , A61K31/535
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic and optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--RwhereinQ is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atomsor trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,n is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, R.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also--NR.sub.3 R.sub.9, whereR.sub.3 has the meanings defined above,R.sub.8 is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms, or aralkyl, andR.sub.9 is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 or 5 carbon atoms, andR.sub.5 and R.sub.6, together with each other, are --O--CH.sub.2 --O, --O--CH.sub.2 --CH.sub.2 --O--, --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --CONH--, --CH.sub.2 --CH.sub.2 --CONH-- or --O--CO--NH--, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS- stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋和旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基，A是-O-，-CH 2 -CH 2 - 或 - NR 3 - 其中R 3是氢或1至4个碳原子的烷基，n是2-6的整数，包括2和6，R是氢，苄基或者其中R 4是氢，甲基或乙基，R 5，R 6和R 7 可以相同或不同，分别为氢，卤素，羟甲基，三氟甲基，1至4个碳原子的烷基，1至4个碳原子的烷氧基，硝基，氰基，-CONHR 3，-CONHOH，-COOR 3 ，R8O-，甲基磺酰基甲基，或当R 5至R 7中的一个或两个不是卤素或三氟甲基时，还有-NR 3 R 9，其中R 3具有上述定义，R 8是氢， 1至20个碳原子的芳基，1至4个碳原子的烷基或芳烷基，R 9是氢，低级烷酰基，甲磺酰基，氨基甲酰基，二甲基氨磺酰基或2或5个碳原子的烷氧基羰基，以及R 5和R 6 另一个是-O-CH 2 -O，-O-CH 2 -CH 2 -O - ， - CH = CH-CH = CH-，-O-CH 2 -CONH - ， - CH 2 -CH 2 -CONH-或-O-CO -NH-和无毒的药学上可接受的酸加成盐。化合物及其盐可用作血管扩张剂和CNS刺激剂。

29. 发明授权

US4256756A 1-Aryloxy-2-hydroxy-3-[(substituted phenyl-donidazalidinon-2-yl)-alkyl-amino]-propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 - [（取代的苯基 - 咪唑烷酮-2-基） - 烷基 - 氨基] - 丙烷及其盐
公开(公告)号：US4256756A
公开(公告)日：1981-03-17
申请号：US004279
申请日：1979-01-17
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢; 1至5个碳原子的烷基; 或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

30. 发明授权

US4146638A N-(3-phenoxy-2-hydroxy-propyl)-N-(2-phenyl-2-hydroxy-ethyl)-amines 失效
标题翻译： N-（3-苯氧基-2-羟基丙基）-N-（2-苯基-2-羟基乙基） - 胺
公开(公告)号：US4146638A
公开(公告)日：1979-03-27
申请号：US905593
申请日：1978-05-15
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Herbert Koppe , Richard Reichl
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Herbert Koppe , Richard Reichl
IPC分类号： A61K31/24 , A61K31/245 , C07C233/16 , C07C93/06 , A61K31/135 , A61K31/275 , C07C121/80
CPC分类号： A61K31/24 , A61K31/245 , C07C233/16
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is halogen, hydroxyl, amino, alkyl, alkoxy or acylamido,R.sub.2 is hydrogen, hydroxyl, alkyl, alkoxy or carboxamido,R.sub.3 is hydrogen, halogen, alkyl or alkoxy,R.sub.4 is hydrogen, methyl or ethyl, andR.sub.5 and R.sub.6 are each hydrogen, halogen, alkyl, alkoxy, benzyloxy, hydroxyl, amino, cyano, carboxyl, carbalkoxy, carboxamido, alkylenecarboxamido or acylamido,Provided, however, that, when R.sub.1 is 4-hydroxyl or 4-chloro, R.sub.2 and R.sub.3 are hydrogen, R.sub.4 is methyl and R.sub.5 is halogen or 2-halo, R.sub.6 is other than 4-hydroxyl or 4-benzyloxy; and nontoxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, vasodilators, hypotensives and antiarrhythmics.

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