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21. 发明授权

US4361468A Flue housing for a coke oven 失效
标题翻译：焦炉烟道
公开(公告)号：US4361468A
公开(公告)日：1982-11-30
申请号：US177992
申请日：1980-08-15
申请人： Alfred Mertens , Franz Schafer
发明人： Alfred Mertens , Franz Schafer
IPC分类号： C10B29/00 , C10B21/16 , C10B21/10 , C10B21/14
CPC分类号： C10B21/16
摘要： A regulating device for the flue housing of a coke oven for alternately opening and closing channels of the flue housing including a rotatable shaft, frames mounted on the shaft, preferably, 90.degree. relative to each other, in alternating sequence along the shaft, peripheral seals about the frames for sealing a channel when the frame is disposed across it. The seals are arcuate in configuration and lie on a circle having its center at the center axis of the shaft. Rotation of the shaft selectively opens and closes alternate channels of the flue housing.
摘要翻译：一种用于焦炉的烟道壳体的调节装置，用于交替地打开和关闭烟道外壳的通道，包括可旋转的轴，相对于彼此安装在轴上的框架优选地相对于彼此以90°交替顺序地沿着轴，周边密封关于当框架布置在其上时用于密封通道的框架。密封件呈弓形构型并且位于其轴线的中心轴线上的圆形上。轴的旋转选择性地打开和关闭烟道外壳的交替通道。

22. 发明授权

US07572809B2 Isoquinoline aminopyrazole derivatives 失效
标题翻译：异喹啉氨基吡唑衍生物
公开(公告)号：US07572809B2
公开(公告)日：2009-08-11
申请号：US11637733
申请日：2006-12-12
申请人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
发明人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
IPC分类号： C07D403/14 , A61K31/4709
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，这些化合物的制备，含有它们的药物组合物及其制备，以及这些化合物在对照中的用途或预防癌症等疾病。

23. 发明授权

US5116843A Tricyclic benzimidazole compounds, pharmaceutical compositions and methods of use 失效
标题翻译：三聚苯并咪唑化合物，药物组合物及其使用方法
公开(公告)号：US5116843A
公开(公告)日：1992-05-26
申请号：US543350
申请日：1990-06-25
申请人： Alfred Mertens , Wolfgang von der Saal , Erwin Boehm , Klaus Strein
发明人： Alfred Mertens , Wolfgang von der Saal , Erwin Boehm , Klaus Strein
IPC分类号： A61K31/47 , A61K31/495 , A61P7/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： The present invention provides tricyclic benzimidazoles of the formula ##STR1## wherein R.sub.1 is a phenyl radical of the general formula: ##STR2## wherein R.sub.2, R.sub.3 and R.sub.4 can be the same or different as in claim 1. For A, B, C and D are understood those compounds where one or two of A, B, C or D are nitrogen. These compounds are useful to inhibit the aggregation of thrombocytes and erythrocytes, lower blood pressure and can increase the power of the heart.

24. 发明授权

US4981864A Method for inhibition of erythrocyte aggregation using anellated tricyclic compounds 失效
标题翻译：使用安定的三环化合物抑制红细胞聚集的方法
公开(公告)号：US4981864A
公开(公告)日：1991-01-01
申请号：US278190
申请日：1988-11-30
申请人： Wolfgang von der Saal , Alfred Mertens , Jens-Peter Hoelck , Erwin Boehm , Ulrich Martin
发明人： Wolfgang von der Saal , Alfred Mertens , Jens-Peter Hoelck , Erwin Boehm , Ulrich Martin
IPC分类号： C07D487/04 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/50 , A61P1/04 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P17/00 , A61P25/02 , A61P29/00 , A61P35/00 , C07D498/04 , C07D513/04
CPC分类号： A61K31/44 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/50
摘要： The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein R.sub.1 is a phenyl radical of the general formula: ##STR2## or R.sub.1 is a 5 or 6 membered heterocycle or when X is a valency bond R.sub.1 is also H, OH, mercapto, amino, alkyl, alkenyl, alkynyl, haloalkyl, alkylthio, formylaminoalkyl, pyridylcarbonylamino, cycloalkyl, or cycloalkenyl, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl or hydroxyalkyl of claim 1 or 2 for the preparation of pharmaceutical compositions with an erythrocyte aggregation inhibition action useful, for example, in states of shock or circulatory disturbance.
摘要翻译：本发明涉及以下通式的化合物的用途：其中R 1为下列通式的苯基或其中R 1为5或6元杂环，或当X为化合价时键R1也是权利要求1或2的H，OH，巯基，氨基，烷基，烯基，炔基，卤代烷基，烷硫基，甲酰基氨基烷基，吡啶基羰基氨基，环烷基或环烯基，烷氧基烷基，羧基烷基，烷氧基羰基烷基或羟烷基，用于制备具有红细胞聚集抑制作用可用于例如休克或循环障碍的状态。

25. 发明授权

US4863945A Pyrrolobenzimidazoles and pharmaceutical compositions containing them 失效
标题翻译：吡咯并苯并咪唑和含有它们的药物组合物
公开(公告)号：US4863945A
公开(公告)日：1989-09-05
申请号：US131367
申请日：1987-12-10
申请人： Walter-Gunar Friebe , Alfred Mertens , Klaus Strein , Erwin Boehm
发明人： Walter-Gunar Friebe , Alfred Mertens , Klaus Strein , Erwin Boehm
IPC分类号： A61K31/40 , A61P7/02 , A61P9/04 , A61P9/12 , C07D487/04
CPC分类号： C07D487/04
摘要： Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R.sub.1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered heterocyclic group which can be condensed with a phenyl ring to form a bicyclic radical. R.sub.2 is hydrogen, alkyl, alkenyl or cycloalkenyl; R.sub.3 is alkyl, alkenyl or hydroxyalkyl or with R.sub.2 together forms cycloakylene; or R.sub.2 and R.sub.3 together form alkylidene or cycloalkylidene. R.sub.4 is hydrogen or lower alkanoyl. X is a valency bond, alkylene, vinylene, imino or carbonylamino. T stands for two hydrogen atoms. When X is a valency bond, R.sub.1 can also be hydrogen, hydrocarbyl which may also contain oxygen, amino, sulfur, carbonyl and sulfonyl groups. When X is imino or carbonylamino or when R.sub.1 is a bicyclic radical, T can also be oxygen. The compounds also include the tautomers and physiologically acceptable salts with inorganic and organic acids.
摘要翻译：下式的吡咯并苯并咪唑：可用于治疗心脏和循环系统疾病。 R1是取代的苯基; 或任选取代的萘基或可与苯环缩合形成双环基团的五元或六元杂环基。 R2是氢，烷基，烯基或环烯基; R3是烷基，烯基或羟基烷基或与R2一起形成亚环烷基; 或者R 2和R 3一起形成亚烷基或亚环烷基。 R4是氢或低级烷酰基。 X是价键，亚烷基，亚乙烯基，亚氨基或羰基氨基。 T代表两个氢原子。当X是价键时，R 1也可以是氢，也可以含有氧，氨基，硫，羰基和磺酰基的烃基。当X是亚氨基或羰基氨基时，或当R1是双环基时，T也可以是氧。化合物还包括与无机和有机酸形成的互变异构体和生理上可接受的盐。

26. 发明授权

US4710510A Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases 失效
标题翻译：吡咯并苯并咪唑，含有它们的药物组合物，以及它们用于治疗某些心脏和循环系统疾病
公开(公告)号：US4710510A
公开(公告)日：1987-12-01
申请号：US807260
申请日：1985-12-10
申请人： Alfred Mertens , Jens-Peter Holck , Wolfgang Kampe , Bernd Muller-Beckmann , Klaus Strein , Wolfgang Schaumann
发明人： Alfred Mertens , Jens-Peter Holck , Wolfgang Kampe , Bernd Muller-Beckmann , Klaus Strein , Wolfgang Schaumann
IPC分类号： A61K31/415 , A61K31/4184 , A61P9/00 , A61P9/04 , C07D209/34 , C07D209/42 , C07D487/04 , A61K31/55
CPC分类号： C07D487/04 , C07D209/34 , C07D209/42
摘要： The present invention provides new pyrrolobenzimidazoles of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical; R.sub.2 is a hydrogen atom, cyano group or alkyl or alkenyl radical or a carbonyl group substituted by hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino or together with R.sub.1 forms a cycloalkylene radical or R.sub.1 and R.sub.2 together form an alkylidene or cycloalkylidene radical; R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, each represent a hydrogen atom or an alkanesulphonyloxy, trifluoromethanesulphonyloxy, alkanesulphonylamino, trifluoromethanesulphonylamino, N-alkyl-alkanesulphonylamino, N-alkyl-trifluoromethanesulphonylamino, alkylsulphenylmethyl, alkylsulphinylmethyl or alkylsulphonylmethyl radical, a carbonyl group substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino, a sulphonyl group substituted by amino, alkylamino, dialkylamino or cyclic imino, whereby a methylene group in the 4-position can be replaced by a sulphur or oxygen atom, an alkylcarbonylamino, aminocarbonylamino or alkylaminocarbonylamino radical, an alkylthio, alkylsulphinyl or alkylsulphonyl radical, a nitro, halogen, amino, hydroxyl, alkyl, trifluoromethyl, alkoxy, alkenyloxy, alkynyloxy, cyanoalkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, dialkylamino, 1-imidazolyl or cyano group; X is a valency bond, a C.sub.1 -C.sub.4 alkylene radical or a vinyl radical; and T is an oxygen or sulphur atom; the tautomers thereof and the physiologically acceptable salts thereof with inorganic and organic acids.The present invention also provides processes for the preparation of these compounds and pharmaceuticals containing them for the prophylaxis and treatment of heart and circulatory diseases.
摘要翻译：本发明提供了以下通式的新的吡咯并苯并咪唑：其中R 1是氢原子或烷基，烯基或环烷基; R2是氢原子，氰基或烷基或烯基或被羟基，烷基，烷氧基，氨基，烷基氨基，二烷基氨基或肼基取代的羰基或与R1一起形成亚环烷基，或者R 1和R 2一起形成亚烷基或亚环烷基激进; 可以相同或不同的R 3，R 4和R 5各自表示氢原子或烷磺酰氧基，三氟甲磺酰氧基，烷磺酰氨基，三氟甲磺酰氨基，N-烷基 - 烷磺酰氨基，N-烷基 - 三氟甲磺酰氨基，烷基亚磺酰基甲基，烷基亚磺酰基甲基或烷基磺酰基甲基，羰基被羟基，烷氧基，氨基，烷基氨基或二烷基氨基取代的基团，被氨基，烷基氨基，二烷基氨基或环状亚氨基取代的磺酰基，其中4-位中的亚甲基可以被硫或氧原子，烷基羰基氨基，氨基羰基氨基或烷基氨基羰基氨基，烷硫基，烷基亚磺酰基或烷基磺酰基，硝基，卤素，氨基，羟基，烷基，三氟甲基，烷氧基，烯氧基，炔氧基，氰基烷氧基，羧基烷氧基，烷氧基羰基烷氧基，二烷基氨基，1-咪唑基或氰基; X是价键，C1-C4亚烷基或乙烯基; 和T是氧或硫原子; 其互变异构体及其与无机和有机酸的生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物用于预防和治疗心脏和循环系统疾病。

27. 发明申请

US20130288266A1 DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BI-VALENT BINDING AGENT 审中-公开
标题翻译：通过一个双向绑定剂检测后置改性的多肽
公开(公告)号：US20130288266A1
公开(公告)日：2013-10-31
申请号：US13923618
申请日：2013-06-21
申请人： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
发明人： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , G01N33/531
摘要： A bi-valent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bi-valent binding agent, and for use of the disclosed bi-valent binding agent in histological staining procedures.
摘要翻译：具有结合靶多肽的多肽表位的第一单价结合剂的双价结合剂，与靶多肽上的翻译后多肽修饰结合的第二单价粘合剂和接头。进一步公开的是用于检测翻译后修饰的靶多肽，用于制备所公开的双价结合剂的方法，以及用于所公开的双价结合剂在组织学染色程序中的方法。

28. 发明申请

US20070179151A1 Isoquinoline aminopyrazole derivatives 失效
标题翻译：异喹啉氨基吡唑衍生物
公开(公告)号：US20070179151A1
公开(公告)日：2007-08-02
申请号：US11637733
申请日：2006-12-12
申请人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
发明人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
IPC分类号： A61K31/496 , A61K31/5377 , A61K31/4709 , C07D403/14 , C07D409/14 , C07D403/02
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，这些化合物的制备，含有它们的药物组合物及其制备，以及这些化合物在对照中的用途或预防癌症等疾病。

29. 发明授权

US5599826A Thiazolidinediones and drugs containing them 失效
标题翻译：噻唑烷二酮类和含有它们的药物
公开(公告)号：US5599826A
公开(公告)日：1997-02-04
申请号：US578561
申请日：1995-11-21
申请人： Alfred Mertens , Hans-Peter Wolff , Peter Freund
发明人： Alfred Mertens , Hans-Peter Wolff , Peter Freund
IPC分类号： C07D277/20 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/427 , A61P3/06 , A61P3/10 , C07D277/34 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12
摘要： Compounds of formula I ##STR1## in which A denotes a carbocyclic ring with 5 or 6 carbon atoms or a heterocyclic ring with a maximum of 4 heteroatoms in which the heteroatoms can be the same or different and denote oxygen, nitrogen or sulphur and the heterocycles can if desired carry an oxygen atom on one or several nitrogen atoms,B denotes --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N--, O or S,W denotes CH.sub.2, O, CH(OH), CO or --CH.dbd.CH--,X denotes S, O or NR.sup.2 in which the residue R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl,Y is CH or N,R denotes naphthyl, pyridyl, furyl, thienyl or phenyl which if desired is mono- or disubstituted with C.sub.1 -C.sub.3 alkyl, CF.sub.3, C.sub.1 -C.sub.3 alkoxy, F, Cl or bromine,R.sup.1 denotes hydrogen or C.sub.1 -C.sub.6 alkyl andn equals 1-3as well as their tautomers, enantiomers, diastereomers and physiologically tolerated salts,processes for their production as well as pharmaceutical agents that contain these compounds for the treatment of diabetes.
摘要翻译： PCT No.PCT / EP94 / 01619 Sec。 371日期：1995年11月21日 102（e）日期1995年11月21日PCT 1994年5月19日PCT PCT。第WO94 / 27995号公报日期1994年12月8日，式I的化合物（I）其中A表示碳原子数5或6的碳环或最多有4个杂原子的杂环，其中杂原子可以相同或不同，表示氧，氮或硫，如果需要，可以在一个或多个氮原子上带有氧原子，B表示-CH = CH-，-N = CH-，-CH = N-，O或S，W表示CH 2， O，CH（OH），CO或-CH = CH-，X表示残基R2为氢或C1-C6烷基，Y为CH或N的S，O或NR2，R为萘基，吡啶基，呋喃基，噻吩基或苯基，如果需要，可以被C 1 -C 3烷基，CF 3，C 1 -C 3烷氧基，F，Cl或溴单取代或被二取代，R 1表示氢或C 1 -C 6烷基，n等于1-3，以及它们的互变异构体，对映异构体，非对映异构体和生理上耐受的盐，其生产方法以及含有这些化合物用于治疗糖尿病的药剂。

30. 发明授权

US4882342A 5-alkylbenzimidazoles, method of use and pharmaceutical compositions 失效
标题翻译： 5-烷基苯并咪唑，使用方法和药物组合物
公开(公告)号：US4882342A
公开(公告)日：1989-11-21
申请号：US106413
申请日：1987-10-06
申请人： Wolfgang von der Saal , Jens-Peter Holck , Alfred Mertens , Bernd Muller-Beckmann , Lothar Kling
发明人： Wolfgang von der Saal , Jens-Peter Holck , Alfred Mertens , Bernd Muller-Beckmann , Lothar Kling
IPC分类号： C07D235/14 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/496 , A61K31/505 , A61P7/02 , A61P9/04 , A61P9/12 , C07D235/08 , C07D235/18 , C07D235/26 , C07D235/28 , C07D235/30 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04
CPC分类号： C07D401/04 , C07D235/08 , C07D235/18 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention concerns new 5-alkylbenzimidazoles of the formula: ##STR1## wherein R.sub.1 is a phenyl ring of the formula: ##STR2## or R.sub.1 is naphthyl, heterocycle or a bicyclic heterocycle and R.sub.1 -R.sub.7 are described in claim 1.These compounds are useful for prophylaxis or treatment of heart and circulatory disease especially to increase contractility of the heart, lower blood pressure and/or influence the thrombocyte function and improve the microcirculation.
摘要翻译：本发明涉及下式的新的5-烷基苯并咪唑：其中R 1是下式的苯环：（II）或R 1是萘基，杂环或双环杂环，并且R 1 -R 7被描述这些化合物可用于预防或治疗心脏和血液循环疾病，特别是增加心脏的收缩力，降低血压和/或影响血小板功能并改善微循环。

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