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21. 发明授权

US07740472B2 Method and device for flowing a liquid on a surface 有权
标题翻译：用于在表面上流动液体的方法和装置
公开(公告)号：US07740472B2
公开(公告)日：2010-06-22
申请号：US11836259
申请日：2007-08-09
申请人： Emmanuel Delamarche , David Juncker , Bruno Michel , Heinz Schmid
发明人： Emmanuel Delamarche , David Juncker , Bruno Michel , Heinz Schmid
IPC分类号： B28B13/00 , B05C3/00
CPC分类号： B01L3/0262 , B01J2219/00369 , B01J2219/0038 , B01J2219/0043 , B01L3/5027 , B01L2200/025 , B01L2300/0809 , B01L2300/089 , B01L2300/10 , B01L2400/022 , B01L2400/0403 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B05C5/02 , C40B60/14 , Y10T137/9682 , Y10T436/2575
摘要： A device for flowing a liquid on a surface comprises: a flow path. A first port supplies the liquid to one end of the flow path and applies a first port pressure for retaining the liquid when the flow path is remote from the surface. A second port receives the liquid from the other end of the flow path and applies a second port pressure such that the difference between the first and second negative port pressures is oriented to promote flow of the liquid from the first port to the second port via the flow path in response to the flow path being located proximal to the surface and the liquid in the device contacting the surface. The first and second port pressures are such that the liquid is drawn towards at least the second port in response to withdrawal of the flow path from the surface. Such devices may employ microfluidic technology and find application in surface patterning.
摘要翻译：用于在表面上流动液体的装置包括：流动路径。第一端口将液体供应到流路的一端，并且当流动路径远离表面时施加用于保持液体的第一端口压力。第二端口从流动路径的另一端接收液体并施加第二端口压力，使得第一和第二负压力压力之间的差定向为促进液体从第一端口流经第二端口经由响应于流动路径位于表面附近的流动路径以及与表面接触的装置中的液体。第一和第二端口压力使得响应于流动路径从表面的撤回而将液体吸向至少第二端口。这样的装置可以采用微流控技术并在表面图案化中找到应用。

22. 发明授权

US07695687B2 Capillary system for controlling the flow rate of fluids 有权
标题翻译：用于控制流体流量的毛细管系统
公开(公告)号：US07695687B2
公开(公告)日：2010-04-13
申请号：US11427811
申请日：2006-06-30
申请人： Emmanuel Delamarche , Heinz Schmid , David Juncker
发明人： Emmanuel Delamarche , Heinz Schmid , David Juncker
IPC分类号： B01L11/00 , B01L3/02 , G01N1/10 , B01D57/02
CPC分类号： B01L3/50273 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , B01L2400/086 , Y10T436/2575
摘要： A capillary system for performing surface assays comprising a capillary pump containing at least two zones having different capillary pressures for obtaining controlled flow rate of liquids. The different pressure zones may be created by various means such as by creating posts in the walls of the capillary pump, by having different sized capillary of the different zones, by changing the wetting properties, by defining friction at the walls of the pump or by combinations of any of the above. The capillary system finds use in various surface assays and can be programmed for defining the volume and rate of liquid flowing through the test sites. A microfluidic chip containing assembly of programmed capillary systems for performing need based specific assays and modifications thereof.
摘要翻译：一种用于进行表面测定的毛细管系统，其包括含有至少两个具有不同毛细管压力的区域的毛细管泵，以获得受控的液体流速。不同的压力区可以通过各种方式产生，例如通过在不同区域的壁上形成不同尺寸的毛细管，通过改变润湿特性，通过在泵的壁处限定摩擦或通过以上任何一种的组合。毛细管系统可用于各种表面测定，并可编程为定义流经测试位点的液体的体积和速率。一种含有编程毛细管系统组件的微流体芯片，用于执行基于需要的具体测定及其修改。

23. 发明申请

US20060096477A1 Printing in a medium 有权
公开(公告)号：US20060096477A1
公开(公告)日：2006-05-11
申请号：US10527277
申请日：2003-08-28
申请人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
发明人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
IPC分类号： B41K1/38
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.

24. 发明授权

US08267011B2 Stamp with drainage channels for transferring a pattern in the presence of a third medium 有权
标题翻译：在第三种介质的存在下用排水通道印上图案
公开(公告)号：US08267011B2
公开(公告)日：2012-09-18
申请号：US12748624
申请日：2010-03-29
申请人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
发明人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
IPC分类号： B41K1/02 , B41K1/36
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译：描述了在存在第三介质的情况下将图案从弹性印模转移到基板的方法。在印模和基板之间实现接近接触。将印模和基板之间的第三介质层控制到预定厚度。还描述了用于执行该方法的邮票。

25. 发明授权

US07891295B2 Printing in a medium 有权
标题翻译：在媒体上打印
公开(公告)号：US07891295B2
公开(公告)日：2011-02-22
申请号：US12249322
申请日：2008-10-10
申请人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
发明人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
IPC分类号： B41M9/00
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译：描述了在存在第三介质的情况下将图案从弹性印模转移到基板的方法。在印模和基板之间实现接近接触。将印模和基板之间的第三介质层控制到预定厚度。还描述了用于执行该方法的邮票。

26. 发明申请

US20100180782A1 Printing in a Medium 有权
标题翻译：在中等印刷
公开(公告)号：US20100180782A1
公开(公告)日：2010-07-22
申请号：US12748624
申请日：2010-03-29
申请人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
发明人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
IPC分类号： B41K1/42
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译：描述了在存在第三介质的情况下将图案从弹性印模转印到基板上的方法。在印模和基板之间实现接近接触。将印模和基板之间的第三介质层控制到预定厚度。还描述了用于执行该方法的邮票。

27. 发明授权

US07434512B2 Printing in a medium 有权
标题翻译：在媒体上打印
公开(公告)号：US07434512B2
公开(公告)日：2008-10-14
申请号：US10527277
申请日：2003-08-28
申请人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
发明人： Alexander Bietsch , Emmanuel Delamarche , Bruno Michel , Heinz Schmid , Heiko Wolf
IPC分类号： H01L21/027
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译：描述了在存在第三介质的情况下将图案从弹性印模转移到基板的方法。在印模和基板之间实现接近接触。将印模和基板之间的第三介质层控制到预定厚度。还描述了用于执行该方法的邮票。

28. 发明申请

US20050247673A1 Confinement of fluids on surfaces 审中-公开
标题翻译：在表面上限制流体
公开(公告)号：US20050247673A1
公开(公告)日：2005-11-10
申请号：US10841390
申请日：2004-05-07
申请人： Emmanuel Delamarche , David Juncker , Heinz Schmid
发明人： Emmanuel Delamarche , David Juncker , Heinz Schmid
IPC分类号： B01J19/00 , B01L3/02 , B05C5/02 , C40B40/06 , C40B50/14 , C40B60/14 , H01L21/027 , B44C1/22 , C23F1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00353 , B01J2219/00367 , B01J2219/00369 , B01J2219/0038 , B01J2219/00418 , B01J2219/00468 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00675 , B01J2219/00677 , B01J2219/00722 , B01J2219/00743 , C23F1/08 , C40B40/06 , C40B50/14 , C40B60/14
摘要： The invention is directed to a device for applying a fluid to a surface, the device comprising a first conduit for directing a flow of a first fluid towards the surface and a second conduit for directing a flow of a second fluid away from the surface, the first conduit being arranged relative to the second conduit such that in operation of the device the second fluid comprises substantially the first fluid, and wherein said first conduit comprises a first aperture and the second conduit comprises a second aperture, the first aperture arranged at a distance from the second aperture.
摘要翻译：本发明涉及一种用于将流体施加到表面的装置，该装置包括用于将第一流体的流动引向表面的第一导管和用于将第二流体的流动引导离开表面的第二导管，第一管道相对于第二管道布置，使得在装置的操作中，第二流体基本上包括第一流体，并且其中所述第一管道包括第一孔，第二管道包括第二孔，第一孔以一定距离布置从第二个孔。

29. 发明授权

US09110056B2 Surface treatment 有权
标题翻译：表面处理
公开(公告)号：US09110056B2
公开(公告)日：2015-08-18
申请号：US12540526
申请日：2009-08-13
申请人： Sergey Amontov , Emmanuel Delamarche , Bruno Michel
发明人： Sergey Amontov , Emmanuel Delamarche , Bruno Michel
IPC分类号： C12M3/00 , G01N33/543
CPC分类号： G01N33/54366
摘要： A biosensor comprising surface treated with a method for producing a monolayer of molecules on a surface, the method comprising loading a stamp with seed molecules, transferring seed molecules from the stamp to the surface, wherein transferring comprises transferring a fraction of the seed molecules loaded on the stamp to the surface and adsorbing the seed molecules to the stamp and adsorbing the seed molecules to the surface, the adsorption of the seed molecules to the stamp being stronger than the adsorption of the seed molecules to the surface, self-completing amplification of the seed molecules via an amplifying reaction to produce the monolayer on a flat surface, wherein self-completing amplification comprises producing a homogeneous area, wherein the homogeneous area comprises a monolayer of molecules on the surface, and wherein the monolayer of molecules on the surface has no diffusive component that can relocate and destroy amplification accuracy.
摘要翻译：一种生物传感器，包括用在表面上产生单层分子的方法进行表面处理的方法，所述方法包括用种子分子加载印模，将种子分子从印模转移到表面，其中转印包括转移一部分加载的种子分子将表面吸附并将种子分子吸附到印模上并将种子分子吸附到表面，种子分子对印模的吸附比种子分子吸附到表面更强，自我完成的扩增种子分子通过扩增反应在平坦表面上产生单层，其中自我完成扩增包括产生均匀区域，其中均匀区域包括表面上的单分子层，并且其中表面上的单分子层没有扩散成分可以重新定位并破坏放大精度。

30. 发明授权

US08641973B2 Micro-fluidic test apparatus and method 有权
标题翻译：微流体试验装置及方法
公开(公告)号：US08641973B2
公开(公告)日：2014-02-04
申请号：US13410910
申请日：2012-03-02
申请人： Govindarajan Natarajan , Emmanuel Delamarche , Eric A. Eckberg , James N. Humenik , Kathleen A. McGroddy-Goetz , Scott Partington , Christopher F. Perrera , Marco G. Trivella , Timothy M. Wiwel
发明人： Govindarajan Natarajan , Emmanuel Delamarche , Eric A. Eckberg , James N. Humenik , Kathleen A. McGroddy-Goetz , Scott Partington , Christopher F. Perrera , Marco G. Trivella , Timothy M. Wiwel
IPC分类号： C12M1/34
CPC分类号： G01N33/487 , A61B5/685 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L2300/0645 , B01L2300/0887 , B01L2400/0406 , B01L2400/0481 , G01N27/07 , Y10T436/2575
摘要： An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication with the micro-fluidic circuit for determining a property of a fluid contained within the at least one micro-fluidic circuit.
摘要翻译：用于测定流体渗透压的装置，系统和方法。该装置包括至少一个微流体回路和与微流体回路连通的至少一个电路，用于确定包含在至少一个微流体回路内的流体的性质。

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