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21. 发明授权

US4259336A 4-Hydroxy-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H- [1] - 苯并噻吩并[2,3-e] -1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4259336A
公开(公告)日：1981-03-31
申请号：US86743
申请日：1979-10-22
申请人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Walter Haarmann , Gunther Engelhardt , Rainer Zimmermann
发明人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Walter Haarmann , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/54 , A61P9/08 , A61P9/10 , A61P29/00 , C07D333/70 , C07D513/04 , A61K31/38
CPC分类号： C07D513/04 , C07D333/70 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; andR.sub.3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.
摘要翻译：其中R 1是氢，卤素或1至3个碳原子的烷基; R2是氢或1至3个碳原子的烷基; 并且R 3是6至10个碳原子的芳族烃基或2至9个碳原子和1至2个氮原子和/或氧或硫原子的芳族杂环，其中每个所述芳族取代基可以依次被一个或两个1至6个碳原子的烷基，卤素，羟基，三氟甲基，卤代苯基或具有1至3个碳原子的烷氧基; 和与无机或有机碱形成的无毒的，药理学上可接受的盐; 化合物及其盐可用作镇痛药，解热药，抗血栓和消炎药。

22. 发明授权

US4233299A 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4233299A
公开(公告)日：1980-11-11
申请号：US966963
申请日：1978-12-06
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
IPC分类号： A61K31/427 , A61K31/54 , A61K31/5415 , A61P29/00 , C07D275/06 , C07D279/02 , C07D417/12 , C07D513/14 , A61K31/38
CPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/14
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl, ethyl or n-propyl; andY is hydrogen, methyl, methoxy, fluorine or chlorine;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as antiphlogistics.
摘要翻译：其中R 1是氢，甲基或乙基; R2是甲基，乙基或正丙基; Y为氢，甲基，甲氧基，氟或氯; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作消炎剂。

23. 发明授权

US3992535A 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-萘并（{2,1-e {9-1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US3992535A
公开(公告)日：1976-11-16
申请号：US626623
申请日：1975-10-29
申请人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/04 , A61K31/54
CPC分类号： C07D275/06 , C07D279/02
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.
摘要翻译：式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基，噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。

24. 发明授权

US3987197A 3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof 失效
标题翻译： 3-（2'-氟-4-二苯基） - 丁酸及其盐
公开(公告)号：US3987197A
公开(公告)日：1976-10-19
申请号：US577170
申请日：1975-05-14
申请人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Josef Nickl , Gunther Engelhardt
发明人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Josef Nickl , Gunther Engelhardt
IPC分类号： C07C45/46 , C07C57/58 , C07C57/76 , C07C63/333 , C07C245/14 , C07F9/54
CPC分类号： C07C245/14 , C07C255/00 , C07C45/46 , C07C57/58 , C07C57/76 , C07F9/5407
摘要： 3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof formed with inorganic or organic bases; the compound as well as its salts are useful as antiphlogistics and antirheumatics.

25. 发明授权

US5248695A Separation of enantiomers of cimaterol, (-)-cimaterol and the use thereof in animal feeds 失效
标题翻译：西妥替龙，（ - ） - 西咪替尼及其在动物饲料中的用途分离
公开(公告)号：US5248695A
公开(公告)日：1993-09-28
申请号：US693760
申请日：1991-04-30
申请人： Wolfgang Resemann , Adolf Durr , Gunther Engelhardt , John F. Quirke
发明人： Wolfgang Resemann , Adolf Durr , Gunther Engelhardt , John F. Quirke
IPC分类号： C07C255/59 , A23K1/16 , A23K1/18 , A61K31/00 , A61K31/275 , A61K31/277 , A61P3/00 , A61P3/04 , A61P11/00 , A61P11/06 , A61P13/02 , A61P15/00 , A61P21/02 , A61P25/04 , A61P29/00 , A61P37/08 , C07B57/00 , C07C253/34 , C07C255/49
CPC分类号： A61K31/275 , A23K20/111 , A23K50/30 , A61K31/277 , C07C255/59 , Y10S514/826 , Y10S514/888 , Y10S514/909
摘要： The invention relates to the separation of enantiomers, of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.
摘要翻译：本发明涉及西马特罗，（ - ） - 西马特罗的对映异构体的分离，其加成盐及其制备方法及其在药物组合物和动物饲料中的应用。

26. 发明授权

US5068334A Pharmaceutical compositions containing quinolin-2,5-diones, new quinolin-2,5-diones and processes for the preparation thereof 失效
标题翻译：含有喹啉-2,5-二酮的新型喹啉-2,5-二酮的药物组合物及其制备方法
公开(公告)号：US5068334A
公开(公告)日：1991-11-26
申请号：US413369
申请日：1989-09-27
申请人： Erich Muller , Josef Nickl, deceased , Armin Heckel , Gunther Engelhardt
发明人： Erich Muller , Josef Nickl, deceased , Armin Heckel , Gunther Engelhardt
IPC分类号： C07D215/22 , A61K31/47 , A61K31/473 , A61P25/04 , A61P29/00 , C07D215/227 , C07D221/12 , C07D221/16 , C07D405/04
CPC分类号： C07D215/227 , A61K31/47 , C07D221/12 , C07D221/16
摘要： This invention relates to pharmaceutical compositions containing quinolin-2,5-diones of formula ##STR1## wherein A, B, R.sup.1 to R.sup.3 and X are defined hereinbelow, some of which are novel, which compounds have valuable pharmacological properties, particularly analgesic antipyretic and/or antiphlogistic effects, to new intermediates and processes for preparing them.
摘要翻译：本发明涉及含有式（I）的喹啉-2,5-二酮的药物组合物，其中A，B，R 1至R 3和X在下文中定义，其中一些是新的，这些化合物具有有价值的药理学性质，特别是止痛解热和/或消炎作用，用于新中间体及其制备方法。

27. 发明授权

US4995747A Paper stacking apparatus for office machines 失效
标题翻译：办公机械用纸堆叠装置
公开(公告)号：US4995747A
公开(公告)日：1991-02-26
申请号：US230472
申请日：1988-08-09
申请人： Gunther Engelhardt , Gerhard Lohrmann , Thomas Werner
发明人： Gunther Engelhardt , Gerhard Lohrmann , Thomas Werner
IPC分类号： B41J13/00 , B41J13/10 , B65H29/60 , B65H31/06
CPC分类号： B41J13/10 , B41J13/103 , B41J13/106
摘要： A paper stacking apparatus is for an office machine, wherein the office machine has a forward end and a rear end and includes rollers for sequentially supplying sheets of paper upwardly along a generally vertical path. The sheets extend transversely of the office machine. The path is located between the front end and the rear end. The paper stacking apparatus includes a support frame located above the rollers for sequentially supplying said sheets. A paper guide element is mounted within the support frame in alignment with the path. A forward stacker is mounted on the support frame forwardly of the paper guide element. A rear stacker is mounted on the support frame rearwardly of the paper guide element. The paper guide element is selectively movable to a forward position and to a rear position. The paper guide element at the forward position directs the sheets to the forward stacker for forward to rear stacking of the sheets thereon. The paper guide element at the rear position directs the sheets to the rear stacker for rear to forward stacking of the sheets thereon.
摘要翻译：纸张堆叠装置用于办公机器，其中办公机器具有前端和后端，并且包括用于沿着大致垂直的路径向上顺序地供应纸张的辊。纸张横向延伸在办公室机器上。路径位于前端和后端之间。纸张堆垛装置包括位于辊子上方的用于顺序地供应所述片材的支撑框架。纸张引导元件安装在支撑框架内，与路径对齐。向前堆垛机被安装在纸引导元件前方的支撑框架上。后堆垛机安装在纸引导元件后方的支撑框架上。纸张引导元件可选择性地移动到前进位置和后方位置。纸张引导元件在前方位置将纸张引导到向前堆垛机，以便在纸张的前后堆叠。后方的导纸元件将纸张引导到后堆垛机后方，以便将纸张在其上进行堆叠。

28. 发明授权

US4605145A Sheet separating structure 失效
标题翻译：纸张分离结构
公开(公告)号：US4605145A
公开(公告)日：1986-08-12
申请号：US689866
申请日：1985-01-09
申请人： Gunther Engelhardt , Gerhard Lohrmann
发明人： Gunther Engelhardt , Gerhard Lohrmann
IPC分类号： B41J11/26 , B41J11/66 , B41J11/70 , G03B1/30
CPC分类号： B41J11/70
摘要： A structure is disclosed primarily but not exclusively as a supplement to an existing printer or typewriter or the like, which structure includes a clamping shaft, either for clamping endless sheet stock against the traction device for the stock, or against an added on anvil bar or both.
摘要翻译：主要公开了一种结构，但并不排他地作为现有打印机或打字机等的补充，该结构包括夹紧轴，用于将环形片材夹持物抵靠库存的牵引装置，或者相对于添加在砧条上都。

29. 发明授权

US4362738A Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety 失效
标题翻译：含有1-（4-氯苯甲酰基）-5-甲氧基-2-甲基-1H-吲哚-3-乙酰基部分的酯和酰胺
公开(公告)号：US4362738A
公开(公告)日：1982-12-07
申请号：US158587
申请日：1980-06-11
申请人： Johannes Keck , Gerd Kruger , Helmut Pieper , Klaus Noll , Gunther Engelhardt , Norbert Promberger , Rainer Zimmermann
发明人： Johannes Keck , Gerd Kruger , Helmut Pieper , Klaus Noll , Gunther Engelhardt , Norbert Promberger , Rainer Zimmermann
IPC分类号： C07D209/08 , A61K31/495 , A61P29/00 , C07C67/00 , C07C227/00 , C07C227/16 , C07C227/18 , C07C229/54 , C07C237/32 , C07C237/38 , C07C313/00 , C07C323/12 , C07C323/65 , C07D209/28 , C07D213/74 , C07D295/088 , C07D295/155 , C07D401/12 , C07H13/08 , C07D279/18 , A61K27/00
CPC分类号： C07D213/74 , C07D209/28 , C07D295/088 , C07D295/155
摘要： Compounds of the formula ##STR1## wherein each X, which may be identical or different from the other X, is oxygen or imino;R.sub.1 is hydrogen, fluorine, chlorine or bromine;R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms;R.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, are pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-aryl-piperazino or N-(alkyl of 1 to 3 carbon atoms)-piperazino;A is cycloalkylene of 5 to 7 carbon atoms; unsubstituted or substituted alkylene of 2 to 10 carbon atoms, where the substituents are one to two alkyls of 1 to 3 carbon atoms each, one to two carbalkoxys of 2 to 4 carbon atoms each, one to two phenyls, one to four hydroxyls, one halomethyl, one hydroxymethyl, one alkanoyloxy of 1 to 18 carbon atoms, one alkanoyloxymethyl of 1 to 18 carbon atoms in the alkanoyl moiety or one ##STR2## where R.sub.1, R.sub.2 and R.sub.3 have the meanings previously defined; or alkylene of 2 to 10 carbon atoms interrupted by oxygen, sulfur, sulfoxide, sulfonyl, phenyl, cyclohexyl, pyridyl, piperazino or unsubstituted or substituted imino, where the substituent on the imino group is alkyl of 1 to 6 carbon atoms, phenyl or phenylalkyl of 1 to 3 carbon atoms in the alkyl moiety;B is the acyl residue of an antiphlogistic carboxylic acid;and their non-toxic, pharmacologically acceptable acid addition salts. The compounds as well as their salts are useful as anti-inflammatories.
摘要翻译：其中每个X可以相同或不同于另一个X的式“IMAGE”的化合物是氧或亚氨基; R1是氢，氟，氯或溴; R2和R3可以相同或不同，分别为氢; 未取代或单取代的1至6个碳原子的烷基，其中取代基为苯基或每个烷基部分具有1至3个碳原子的二烷基氨基; 吡啶基或5至7个碳原子的环烷基; 吡咯烷基，哌啶子基，六亚甲基亚氨基，吗啉代，N-芳基 - 哌嗪子基或N-（1至3个碳原子的烷基） - 哌嗪基; R 2和R 3彼此连接并连接的氮原子。 A是5至7个碳原子的亚环烷基; 2至10个碳原子的未取代或取代的亚烷基，其中取代基为1至2个碳原子数为1至2个的烷基，每个为2至4个碳原子的1至2个碳烷氧基，1至2个苯基，1至4个羟基，1至2个卤代甲基，一个羟甲基，一个1至18个碳原子的烷酰氧基，一个在烷酰基部分中具有1至18个碳原子的烷酰氧基甲基或一个，其中R1，R2和R3具有以前定义的含义; 或由氧，硫，亚砜，磺酰基，苯基，环己基，吡啶基，哌嗪子基或未取代或取代的亚氨基所取代的2至10个碳原子的亚烷基，其中亚氨基上的取代基是1至6个碳原子的烷基，苯基或苯基烷基在烷基部分中具有1至3个碳原子; B是消炎性羧酸的酰基残基; 及其无毒，药理学上可接受的酸加成盐。化合物及其盐可用作抗炎剂。

30. 发明授权

US4119710A Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts 失效
标题翻译：支气管解痉剂1-（对氨基 - 苯基）-2-氨基 - 乙醇 - （1）和盐
公开(公告)号：US4119710A
公开(公告)日：1978-10-10
申请号：US754981
申请日：1976-12-28
申请人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus-Reinhold Noll , Helmut Pieper
发明人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus-Reinhold Noll , Helmut Pieper
IPC分类号： C07D263/04 , C07D317/58 , A61K31/04 , A61K31/135 , A61K31/275 , A61K31/36
CPC分类号： C07D263/04 , C07D317/58
摘要： Racemic and optically active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, trifluoromethyl, nitro or cyano, andR.sub.3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as .beta..sub.2 -receptor mimetics and .beta..sub.1 -receptor blockers.
摘要翻译：其中R 1为氢，氟，氯，溴，碘或氰基的外消旋和旋光活性化合物，R 2为氟，三氟甲基，硝基或氰基，R 3为3至5个碳原子的烷基，羟基（烷基 3至5个碳原子的环烷基，3至5个碳原子的环烷基，1-（3,4-亚甲二氧基 - 苯基）-2-丙基或1-（对羟基 - 苯基）-2-丙基，和非毒性其药理学可接受的酸添加剂; 这些化合物作为其作为骨质疏松症，骨质疏松症，骨质疏松症和骨质疏松症的抗生素有用的化合物，特别适用于β2受体的MIME和β受体阻断剂。

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