专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US07094354B2 Method and apparatus for separation of particles in a microfluidic device 有权
标题翻译：用于在微流体装置中分离颗粒的方法和装置
公开(公告)号：US07094354B2
公开(公告)日：2006-08-22
申请号：US10326156
申请日：2002-12-19
申请人： Michael J. Pugia , James A. Profitt , Lloyd Schulman , Gert Blankenstein , Ralf-Peter Peters
发明人： Michael J. Pugia , James A. Profitt , Lloyd Schulman , Gert Blankenstein , Ralf-Peter Peters
IPC分类号： G01N9/30
CPC分类号： B01L3/502753 , B01D21/262 , B01D2221/10 , B01L3/502723 , B01L2200/0668 , B01L2300/0816 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/088 , G01N33/491 , Y10T436/111666
摘要： A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has been transferred into a separation chamber with the application of centrifugal force of less than about five times gravity. With the application of greater force measurement of hematocrit is possible.
摘要翻译：微流体装置提供液体样品中的颗粒的分离，特别是将全血样品分离成其组分用于进一步分析。在血液样品转移到分离室中后，在几分钟内分离成红细胞和血浆，其应用的离心力小于约5倍重力。随着应用更大的力测量血细胞比容是可能的。

22. 发明申请

US20050169778A1 Microstructured arrangement for the bubble-free filling with a liquid of at least one system for draining off liquids, apparatus having such an arrangement and filling method 有权
标题翻译：用于无液泡填充至少一种用于排出液体的系统的液体的微结构布置，具有这种布置的装置和填充方法
公开(公告)号：US20050169778A1
公开(公告)日：2005-08-04
申请号：US11015333
申请日：2004-12-20
申请人： Gert Blankenstein , Ralf-Peter Peters , Claus Marquordt
发明人： Gert Blankenstein , Ralf-Peter Peters , Claus Marquordt
IPC分类号： B01J4/00 , B01L3/00 , B81B1/00 , F04B17/00 , F04B35/04
CPC分类号： B01L3/502723 , B01L3/502746 , B01L2200/0621 , B01L2200/0684 , B01L2300/0864 , B01L2400/0688 , Y10T436/11 , Y10T436/110833 , Y10T436/111666
摘要： The present invention relates to a microstructure arrangement for the bubble-free filling with a liquid of at least one system for draining off liquids. The arrangement has an inlet for the arrangement to be connected to a system for the supply of liquids and at least one outlet for the arrangement to be connected to the at least one liquid-discharging system. The arrangement has a transition region, through which the liquid can be transported from the inlet to the at least one outlet. At a start of the transition region, at least one first microstructure element for producing a point with increased capillary force is provided, in order to achieve gap-free wetting of the areas bounding this point with increased capillary force, in particular side walls, a cover and/or a bottom.
摘要翻译：本发明涉及一种用于无液泡填充至少一种用于排出液体的系统的液体的微结构布置。该装置具有入口，该入口用于将该装置连接到用于供应液体的系统和用于该装置的至少一个出口以连接至该至少一个排液系统。该装置具有过渡区域，液体可以通过该过渡区域从入口运输到至少一个出口。在过渡区域的开始处，提供了用于产生具有增加的毛细管力的点的至少一个第一微结构元件，以便以增加的毛细管力（特别是侧壁）实现与该点相邻的区域的无空隙润湿盖和/或底部。

23. 发明授权

US08084004B2 Microfluidic arrangement for metering of liquids 有权
标题翻译：用于计量液体的微流体装置
公开(公告)号：US08084004B2
公开(公告)日：2011-12-27
申请号：US10762563
申请日：2004-01-23
申请人： Ralf-Peter Peters , Gert Blankenstein , Dirk Osterloh
发明人： Ralf-Peter Peters , Gert Blankenstein , Dirk Osterloh
IPC分类号： G01N1/18
CPC分类号： B01L3/502738 , B01L3/5027 , B01L3/502784 , B01L2200/0605 , B01L2300/0861 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , G01F11/28 , Y10T436/25375 , Y10T436/2575
摘要： The invention relates to a microfluidic arrangement for metering one or more first metered amounts of liquid (A) and for separating the latter from a second amount of liquid (B), having the following features: the arrangement has a first channel and one or more second channels; the first channel has one inlet and one outlet; in the area of the outlet the arrangement has a capillarity, which is greater than or equal to the capillarity in the area of the inlet; the one or more second channels branch off from the first channel at one or more branch points; the one or more second channels have a greater capillarity than the first channel at the branch points; and the one or more second channels have a predetermined volume. In the arrangement as depicted in the invention a liquid is transported in the first channel from the inlet to the outlet. At the branch points one portion of the liquid at a time enters the one or more second channels and fills them completely with the first metered amounts of liquid (A). The portion of the liquid remaining after the last branch point in the first channel emerges as the second amount of liquid via the outlet from the first channel. The amounts of liquid (A) metered in the one or more second channels are separated from the remaining amount of liquid (B) by a gas, which is located in the first channel after filling all one or more second channels.
摘要翻译：本发明涉及一种用于计量一个或多个第一计量的液体（A）并将其与第二量的液体（B）分离的微流体装置，其具有以下特征：该装置具有第一通道和一个或多个第二渠道; 第一个通道有一个入口和一个出口; 在出口的区域中，该布置具有毛细作用，其大于或等于入口区域中的毛细作用; 所述一个或多个第二通道在一个或多个分支点处从所述第一通道分支; 该一个或多个第二通道在分支点具有比第一通道更大的毛细作用; 并且一个或多个第二通道具有预定的体积。在如本发明所述的布置中，液体在第一通道中从入口输送到出口。在分支点处，一次液体的一部分进入一个或多个第二通道并用第一计量的液体（A）完全填充它们。在第一通道中的最后一个分支点之后残留的液体部分作为第二量的液体经由第一通道的出口排出。在一个或多个第二通道中计量的液体（A）的量通过在填充所有一个或多个第二通道之后位于第一通道中的气体与剩余量的液体（B）分离。

24. 发明授权

US07736907B2 Device for collecting blood and separating blood constituents, method for separating blood constituents and use of said device 有权
标题翻译：用于收集血液和分离血液成分的装置，用于分离血液成分的方法和所述装置的使用
公开(公告)号：US07736907B2
公开(公告)日：2010-06-15
申请号：US11569999
申请日：2005-06-03
申请人： Gert Blankenstein , Ralf-Peter Peters
发明人： Gert Blankenstein , Ralf-Peter Peters
IPC分类号： G01N33/50
CPC分类号： B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0621 , B01L2200/0684 , B01L2300/0654 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/084 , B01L2400/086 , B01L2400/088 , Y10T436/25375
摘要： A device and a method for collecting blood and separating blood plasma as a liquid sample using a channel that absorbs the liquid sample by capillary forces. To obtain a uniform filling of the channel with the liquid sample and an effective separation, deaeration takes place in a transverse direction to the main filling direction or to the longitudinal direction of the channel, immediately downstream of a separation device in an inlet region of the channel.
摘要翻译：使用通过毛细管力吸收液体样品的通道来收集血液并分离作为液体样品的血浆的装置和方法。为了获得与液体样品的通道的均匀填充和有效的分离，在主要填充方向或通道的纵向方向的横向方向上进行脱气，紧邻通道的入口区域中的分离装置的下游渠道。

25. 发明授权

US07485118B2 Microstructured arrangement for the bubble-free filling with a liquid of at least one system for draining off liquids, apparatus having such an arrangement and filing method 有权
标题翻译：用于无液泡填充至少一个用于排出液体的系统的液体的微结构布置，具有这种布置的装置和归档方法
公开(公告)号：US07485118B2
公开(公告)日：2009-02-03
申请号：US11015333
申请日：2004-12-20
申请人： Gert Blankenstein , Ralf-Peter Peters , Claus Marquordt
发明人： Gert Blankenstein , Ralf-Peter Peters , Claus Marquordt
IPC分类号： F04B17/00 , F04B35/04
CPC分类号： B01L3/502723 , B01L3/502746 , B01L2200/0621 , B01L2200/0684 , B01L2300/0864 , B01L2400/0688 , Y10T436/11 , Y10T436/110833 , Y10T436/111666
摘要： The present invention relates to a microstructure arrangement for the bubble-free filling with a liquid of at least one system for draining off liquids. The arrangement has an inlet for the arrangement to be connected to a system for the supply of liquids and at least one outlet for the arrangement to be connected to the at least one liquid-discharging system. The arrangement has a transition region, through which the liquid can be transported from the inlet to the at least one outlet. At a start of the transition region, at least one first microstructure element for producing a point with increased capillary force is provided, in order to achieve gap-free wetting of the areas bounding this point with increased capillary force, in particular side walls, a cover and/or a bottom.
摘要翻译：本发明涉及一种用于无液泡填充至少一种用于排出液体的系统的液体的微结构布置。该装置具有入口，该入口用于将该装置连接到用于供应液体的系统和用于该装置的至少一个出口以连接至该至少一个排液系统。该装置具有过渡区域，液体可以通过该过渡区域从入口运输到至少一个出口。在过渡区域的开始处，提供了用于产生具有增加的毛细管力的点的至少一个第一微结构元件，以便以增加的毛细管力（特别是侧壁）实现与该点相邻的区域的无空隙润湿盖和/或底部。

26. 发明申请

US20080257754A1 METHOD AND APPARATUS FOR ENTRY OF SPECIMENS INTO A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于将样本进入微流体装置的方法和装置
公开(公告)号：US20080257754A1
公开(公告)日：2008-10-23
申请号：US12102631
申请日：2008-04-14
申请人： Michael J. Pugia , James A. Profitt , Gert Blankenstein , Ralf-Peter Peters
发明人： Michael J. Pugia , James A. Profitt , Gert Blankenstein , Ralf-Peter Peters
IPC分类号： G01N27/26
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0806 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0478 , B01L2400/0487 , B01L2400/0688 , B01L2400/086
摘要： A microfluidic device for analyzing biological samples is provided with a sample inlet section including an inlet port, a capillary passageway communication with the inlet port and with an inlet chamber. The inlet chamber includes means for uniformly distributing the sample liquid across the inlet chamber and purging the air initially contained therein.
摘要翻译：用于分析生物样品的微流体装置设置有样品入口部分，其包括入口端口，与入口端口的毛细通道连通和入口室。入口室包括用于均匀地分布样品液体穿过入口室并净化最初容纳在其中的空气的装置。

27. 发明申请

US20080000833A1 Microstructured separating device and microfluidic process for separating liquid components from a particle-containing liquid 审中-公开
标题翻译：用于从含颗粒的液体中分离液体组分的微结构分离装置和微流程
公开(公告)号：US20080000833A1
公开(公告)日：2008-01-03
申请号：US11812290
申请日：2007-06-18
申请人： Ralf-Peter Peters , Gert Blankenstein
发明人： Ralf-Peter Peters , Gert Blankenstein
IPC分类号： B01D35/28 , B01D29/88 , C02F1/44
CPC分类号： B01L3/502753 , B01D61/18 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2400/0406 , B01L2400/086 , G01N33/491 , Y10T436/25
摘要： A microstructured separating device, especially for separating liquid components from a particle-containing liquid, comprising the following features: at least one transport channel for transport of the liquid in a given transport direction; at least one separating area at a branch point of the transport channel which is adjoined by a side channel through which a partial flow of the liquid from the transport channel is diverted; a microstructure in the separating area which keeps larger particles of the liquid out of the separating area and which slows down the transport of smaller particles in the separating area.
摘要翻译：一种微结构分离装置，特别用于从含颗粒的液体中分离液体组分，包括以下特征：用于在给定传送方向上输送液体的至少一个输送通道; 在运输通道的分支点处的至少一个分隔区域，其与侧通道邻接，来自输送通道的液体的部分流通过该通道被转向; 在分离区域中的微结构，其将较大的液体颗粒保持在分离区域之外并且减慢了分离区域中较小颗粒的输送。

28. 发明授权

US07134453B2 Microfluidic switch for stopping a liquid flow during a time interval 有权
标题翻译：用于在一段时间间隔内停止液体流动的微流体开关
公开(公告)号：US07134453B2
公开(公告)日：2006-11-14
申请号：US10762564
申请日：2004-01-23
申请人： Ralf Peters , Gert Blankenstein , Holger Bartos , Claus Marquordt
发明人： Ralf Peters , Gert Blankenstein , Holger Bartos , Claus Marquordt
IPC分类号： F15B21/00
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2200/0621 , B01L2300/0883 , B01L2400/0406 , B01L2400/0688 , F16K99/0001 , F16K99/0028 , F16K99/0057 , F16K2099/0084 , Y10T137/2076 , Y10T137/218 , Y10T137/2224
摘要： The invention relates to a microfluidic switch for stopping a liquid flow during a time interval with the following features: the switch has at least one first channel and at least one second channel; the first channel and the second channel have a common end area; the first channel in the end area has a stopping mechanism for stopping of a liquid flow flowing in the first channel; the stopping mechanism can be controlled by means of a liquid flow flowing in the second channel for continuing the liquid flow in the first channel. Transport in the first and the second channel takes place advantageously by the capillarity acting in the channel.
摘要翻译：本发明涉及一种用于在具有以下特征的时间间隔期间停止液体流动的微流体开关：开关具有至少一个第一通道和至少一个第二通道; 第一通道和第二通道具有公共端区域; 端部区域中的第一通道具有用于停止在第一通道中流动的液体流动的停止机构; 可以通过在第二通道中流动的液体流来控制停止机构，以使第一通道中的液体流动继续。在第一和第二通道中的传输有利地通过在通道中起作用的毛细作用而发生。

29. 发明授权

US09216413B2 Plasma separation reservoir 有权
标题翻译：等离子体分离池
公开(公告)号：US09216413B2
公开(公告)日：2015-12-22
申请号：US13381148
申请日：2010-06-08
申请人： Gert Blankenstein , Christian Schoen
发明人： Gert Blankenstein , Christian Schoen
IPC分类号： B01D63/00 , B01D17/00 , B01D29/00 , B01D35/00 , G01N33/50 , G01N33/49 , B01L3/00 , E03B7/07 , G01N33/543 , G01N33/558
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , G01N33/491 , Y10T137/0318 , Y10T137/794
摘要： The invention relates to a microfluidic apparatus for producing a volume flow that is uniform over time in a metering process. In various solution processes or reaction processes it is essential to have a specified given volume flow or mass flow of fluid available to ensure reliable dissolution of the reagent or ensure that the reaction takes place. In microfluidic apparatus in which separation of particles from a fluid, particularly blood, is carried out through a membrane, the volume flow through the membrane decreases continuously. In order to achieve a uniform volume flow during metering, it is envisaged that first of all a reservoir is filled from a first channel, so that the contents of the reservoir can then be fed to the metering process by opening a fluid stop. The emptying of the reservoir takes place with a uniform volume flow of 0.05 microliters per second to 10 microliters per second.
摘要翻译：本发明涉及用于在计量过程中产生随时间均匀的体积流的微流体装置。在各种溶液方法或反应过程中，必须具有指定的给定体积流量或质量流量的流体，以确保试剂的可靠溶解或确保反应发生。在通过膜进行颗粒与流体特别是血液分离的微流体装置中，通过膜的体积流量连续减小。为了在计量期间实现均匀的体积流量，设想首先从第一通道填充储存器，以便随后通过打开流体阻塞将储存器的内容物送入计量过程。储存器的排空以0.05微升/秒至10微升/秒的均匀体积流量进行。

30. 发明申请

US20120118392A1 PLASMA SEPARATION RESERVOIR 有权
标题翻译：等离子体分离储器
公开(公告)号：US20120118392A1
公开(公告)日：2012-05-17
申请号：US13381148
申请日：2010-06-08
申请人： Gert Blankenstein , Christian Schoen
发明人： Gert Blankenstein , Christian Schoen
IPC分类号： E03B7/07 , B01D63/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , G01N33/491 , Y10T137/0318 , Y10T137/794
摘要： The invention relates to a microfluidic apparatus for producing a volume flow that is uniform over time in a metering process. In various solution processes or reaction processes it is essential to have a specified given volume flow or mass flow of fluid available to ensure reliable dissolution of the reagent or ensure that the reaction takes place. In microfluidic apparatus in which separation of particles from a fluid, particularly blood, is carried out through a membrane, the volume flow through the membrane decreases continuously. In order to achieve a uniform volume flow during metering, it is envisaged that first of all a reservoir is filled from a first channel, so that the contents of the reservoir can then be fed to the metering process by opening a fluid stop. The emptying of the reservoir takes place with a uniform volume flow of 0.05 microlitres per second to 10 microlitres per second.
摘要翻译：本发明涉及用于在计量过程中产生随时间均匀的体积流的微流体装置。在各种溶液方法或反应过程中，必须具有指定的给定体积流量或质量流量的流体，以确保试剂的可靠溶解或确保反应发生。在通过膜进行颗粒与流体特别是血液分离的微流体装置中，通过膜的体积流量连续减小。为了在计量期间实现均匀的体积流量，设想首先从第一通道填充储存器，以便随后通过打开流体阻塞将储存器的内容物送入计量过程。储存器的排空以0.05微升/秒至10微升/秒的均匀体积流量进行。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式