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21. 发明授权

US08409840B2 Recombinant preparation of selected bromelain fractions 失效
$Recombinant preparation of selected bromelain fractions$
标题翻译：选择的菠萝蛋白酶部分的重组制备
公开(公告)号：US08409840B2
公开(公告)日：2013-04-02
申请号：US12678280
申请日：2008-08-08
申请人： Rolf Müller , Nora Luniak , Klaus Eschmann
发明人： Rolf Müller , Nora Luniak , Klaus Eschmann
IPC分类号： C12N9/50 , A61K38/48 , C12N1/19
CPC分类号： C12N9/50 , C12N15/815
摘要： The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.
摘要翻译：本发明一般涉及菠萝蛋白酶，特别涉及这种复合蛋白质混合物中所含的不同活性化合物。本发明提供了在菠萝蛋白酶中发现的重组表达的半胱氨酸蛋白酶。已经发现重组蛋白的表达方法优于菠萝蛋白酶本身的纯化。

22. 发明申请

US20110159537A1 SYNTHETIC PATHWAY ENZYMES FOR THE PRODUCTION OF ARGYRINS 有权
标题翻译：用于生产ARGYRINS的合成途径酶
公开(公告)号：US20110159537A1
公开(公告)日：2011-06-30
申请号：US12999872
申请日：2009-06-15
申请人： Rolf Müller , Silke Wenzel , Ronald Garcia
发明人： Rolf Müller , Silke Wenzel , Ronald Garcia
IPC分类号： C12P21/02 , C12N9/00 , C07H21/04 , C12N1/00
CPC分类号： C12P21/02 , C07K7/56 , C12N9/0069 , C12N9/1007 , C12N9/22 , C12N9/88 , C12N15/52 , C12N15/74 , C12P17/167
摘要： The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins.
摘要翻译：本发明提供了包含在或构成参与Argyrins生产的合成途径酶的氨基酸序列，以及编码参与Argyrins生产的合成途径酶的核酸序列，以及含有编码用于产生Argyrins的合成途径酶的核酸序列，例如用于插入一个或多个这些编码序列，以靶向方式突变这些核酸序列中的一个或多个，在野生型生产者微生物或异源微生物中，用于产生Argyrins。

23. 发明申请

US20100272659A1 RECOMBINANT PREPARATION OF SELECTED BROMELAIN FRACTIONS 失效
标题翻译：选择性BROMELAIN FRACTIONS的重组制备
公开(公告)号：US20100272659A1
公开(公告)日：2010-10-28
申请号：US12678280
申请日：2008-08-08
申请人： Rolf Müller , Nora Luniak , Klaus Eschmann
发明人： Rolf Müller , Nora Luniak , Klaus Eschmann
IPC分类号： C12N9/48 , A61K38/48 , A23C9/12 , A61K8/66 , C12P21/02 , A61Q17/04 , A61P35/04
CPC分类号： C12N9/50 , C12N15/815
摘要： The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.
摘要翻译：本发明一般涉及菠萝蛋白酶，特别涉及这种复合蛋白质混合物中所含的不同活性化合物。本发明提供了在菠萝蛋白酶中发现的重组表达的半胱氨酸蛋白酶。已经发现重组蛋白的表达方法优于菠萝蛋白酶本身的纯化。

24. 发明授权

US06969777B2 Method for the hydroformylation of olefins comprising 2 to 8 carbon atoms 失效
标题翻译：包含2至8个碳原子的烯烃加氢甲酰化的方法
公开(公告)号：US06969777B2
公开(公告)日：2005-11-29
申请号：US10312360
申请日：2001-06-27
申请人： Helmut Walz , Willi Schönmann , Rolf Müller , Roland Krokoszinski
发明人： Helmut Walz , Willi Schönmann , Rolf Müller , Roland Krokoszinski
IPC分类号： C07B61/00 , C07C45/50 , C07C47/02
CPC分类号： C07C45/50 , C07C47/02
摘要： Olefins having from 2 to 8 carbon atoms are hydroformylated in a process in which (i) an olefin-containing feed in which a proportion of a saturated hydrocarbon having from 2 to 8 carbon atoms is present and also carbon monoxide and hydrogen are fed into a reaction zone and reacted in the presence of a hydroformylation catalyst, (ii) a stream consisting essentially of unreacted olefin and saturated hydrocarbon is separated off from the output from the reaction zone, (iii) the stream is separated into an olefin-enriched fraction and an olefin-depleted fraction by rectification, and (iv) at least part of the olefin-enriched fraction is recirculated to the reaction zone.
摘要翻译：具有2至8个碳原子的烯烃在其中（i）含烯烃的进料中存在一部分具有2至8个碳原子的饱和烃以及一氧化碳和氢气进料到反应区并在加氢甲酰化催化剂存在下反应，（ii）基本上由未反应的烯烃和饱和烃组成的物流与反应区的输出分离，（iii）将物流分离成富含烯烃的馏分和通过精馏的烯烃贫化馏分，和（iv）至少部分富烯烃馏分再循环到反应区。

25. 发明授权

US06914162B2 Method for producing hydroformylation products of olefins with 2 to 8 carbon atoms 有权
标题翻译： 2-8个碳原子的烯烃加氢甲酰化产物的制备方法
公开(公告)号：US06914162B2
公开(公告)日：2005-07-05
申请号：US10312365
申请日：2001-06-27
申请人： Wolfgang Richter , Roland Krokoszinski , Rolf Müller , Bernhard Geissler
发明人： Wolfgang Richter , Roland Krokoszinski , Rolf Müller , Bernhard Geissler
IPC分类号： C07B61/00 , C07C45/50 , C07C47/02
CPC分类号： C07C45/50 , C07C45/78 , C07C47/02
摘要： A process for preparing hydroformylation products of olefins having from 2 to 8 carbon atoms comprises a) feeding a hydrocarbon feedstock into a cracking/dehydrogenation zone and subjecting it to thermal and/or catalytic cracking and/or dehydrogenation to give an olefin-containing cracker gas, b) subjecting the cracker gas or fractions thereof to a fractionation to give at least one Ci-olefin-enriched hydrocarbon stream and at least one Ci-olefin-depleted hydrocarbon stream, c) feeding the Ci-olefin-enriched hydrocarbon stream together with carbon monoxide and hydrogen into a hydroformylation zone and reacting it in the presence of a hydroformylation catalyst, d) separating a stream consisting essentially of unreacted Ci-olefin and saturated Ci-hydrocarbon from the output from the hydroformylation zone, e) recirculating at least part of the stream consisting essentially of unreacted Ci-olefin and saturated Ci-hydrocarbon to step b), where i is an integer from to 8. The proposed coupling of the hydroformylation with, for example, a steam cracker allows complete hydroformylation of the olefins produced without olefin losses via the waste gas.
摘要翻译：具有2至8个碳原子的烯烃的加氢甲酰化产物的制备方法包括：a）将烃原料进料到裂化/脱氢区，并进行热和/或催化裂化和/或脱氢，得到含烯烃的裂化气 b）使裂化器气体或其馏分进行分馏以产生至少一种富含C 1 -C 6烃的烃流和至少一种不饱和碳原子的烯烃烃流，c）将富含碳原子的烃流与一氧化碳和氢气一起加入加氢甲酰化区，并在加氢甲酰化催化剂的存在下使其反应，d）将基本上的来自加氢甲酰化区的输出的未反应的C 1 - 烯烃和饱和C 1 -C 4烃，e）使至少部分基本上由未反应的C _{- 烯烃和饱和C 1 - 烃到步骤b），其中i是从8到8的整数。所提出的加氢甲酰化与例如蒸汽裂化器的偶联允许通过废气完全烯烃生成而不产生烯烃。}

26. 发明授权

US06727391B2 Method for processing a liquid hydroformylation discharge 有权
标题翻译：处理液体加氢甲酰化放电的方法
公开(公告)号：US06727391B2
公开(公告)日：2004-04-27
申请号：US10203293
申请日：2002-08-08
申请人： Karl-Heinz Walczuch , Rolf Müller , Roland Krokoszinski , Bernhard Geissler
发明人： Karl-Heinz Walczuch , Rolf Müller , Roland Krokoszinski , Bernhard Geissler
IPC分类号： C07C4550
CPC分类号： C07C45/50 , C07C47/02
摘要： A liquid output from a continuous hydroformylation, which comprises essentially aldehydes, high-boiling by-products, a homogeneously dissolved hydroformylation catalyst, unreacted olefins, low-boiling by-products and dissolved synthesis gas, is worked up by a process in which a) the liquid hydroformylation output is depressurized in a first depressurization stage to a pressure which is from 2 to 20 bar below the reactor pressure, resulting in separation into a liquid phase and a gas phase, and b) the liquid phase obtained in the first depressurization stage is depressurized in a second depressurization stage to a pressure which is lower than the pressure of the first depressurization stage, resulting in separation into a liquid phase comprising essentially high-boiling by-products of the hydroformylation, the homogeneously dissolved hydroformylation catalyst and small amounts of hydroformylation product and unreacted olefin and a gas phase comprising essentially the major part of the hydroformylation product, unreacted olefin and low-boiling by-products.
摘要翻译：来自连续加氢甲酰化的液体产物，其基本上包含醛，高沸点副产物，均匀溶解的加氢甲酰化催化剂，未反应的烯烃，低沸点副产物和溶解的合成气，其中a）在第一减压阶段将液体加氢甲酰化产物减压至低于反应器压力2至20巴的压力，从而分离成液相和气相，和b）将第一减压阶段获得的液相减压在第二减压阶段到低于第一减压阶段的压力的压力，导致分离成包含基本上加氢甲酰化的高沸点副产物的液相，均匀溶解的加氢甲酰化催化剂和少量加氢甲酰化产物和未反应的烯烃和基本上包含水的主要部分的气相罗夫酰化产物，未反应的烯烃和低沸点副产物。

27. 发明授权

US06540048B1 Elevator installation with hoistway doors 失效
标题翻译：电梯安装与井道门
公开(公告)号：US06540048B1
公开(公告)日：2003-04-01
申请号：US09614672
申请日：2000-07-12
申请人： Rolf Müller
发明人： Rolf Müller
IPC分类号： B66B1308
CPC分类号： B66B13/303
摘要： An elevator installation with hoistway doors has door panels that can be laterally displaced beyond the width of the hoistway, and/or they can be at least partially displaced into the hoistway wall resulting in an elevator installation with improved utilization of building space, which also requires less effort to install. The door frame of the hoistway door assembly is transformed into a flat, wide hoistway wall module with integral hoistway doors such that building space hitherto required in the hoistway by the hoistway wall is reduced. The hoistway wall module is either inserted between the landing floors, or else several such hoistway wall modules are fitted together vertically and form a largely freestanding modular hoistway wall which forms between the elevator installation and the building an interface which is either self-supporting or supported individually on each floor.
摘要翻译：具有井道门的电梯安装件具有能够横向移动到井道宽度之外的门板，和/或它们可以至少部分地移动到井道壁中，导致电梯安装改善了建筑空间的利用，这也需要较少的安装工作。井道门组件的门框变换成具有整体式井道门的平坦，宽的井道壁模块，从而减少了通过井道壁在井道中所需的建筑空间。井道壁模块被插入着陆楼层之间，或者几个这样的井道壁模块垂直安装在一起，并形成大体上独立的模块式井道壁，其在电梯安装件和建筑物之间形成一个自支撑或支撑的接口分别在每层楼。

28. 发明授权

US06358732B1 DNA for expression under control of a cell cycle-dependent promoter 失效
标题翻译：用于在细胞周期依赖性启动子控制下表达的DNA
公开(公告)号：US06358732B1
公开(公告)日：2002-03-19
申请号：US08793110
申请日：1997-04-25
申请人： Hans-Harald Sedlacek , Rolf Müller
发明人： Hans-Harald Sedlacek , Rolf Müller
IPC分类号： C12N1585
CPC分类号： A61K48/00 , A61K38/00 , C12N15/85 , C12N2830/15 , C12N2830/30 , C12N2830/85
摘要： A DNA sequence is disclosed for the genetic therapy of diseases of the central nervous system. The essential components for the DNA sequence are the activator sequence, the promoter module, and the active substance coding gene. The activator sequence is specifically activated in activated endothelial or glial cells. Activation is cell cycle-regulated by the promoter module. The active substance represents an inhibitor of the nerve growth factor, a dopanine metabolism enzyme, and/or a nerve cell protection factor. The disclosed DNA sequence is inserted into a viral or non-viral vector, supplemented with a ligand with affinity for the target cells.
摘要翻译：公开了用于中枢神经系统疾病的遗传疗法的DNA序列。 DNA序列的基本组分是激活子序列，启动子模块和活性物质编码基因。激活剂序列在激活的内皮细胞或神经胶质细胞中被特异性激活。激活是由启动子模块细胞周期调控的。活性物质代表神经生长因子的抑制剂，多巴胺代谢酶和/或神经细胞保护因子。将所公开的DNA序列插入补充有对靶细胞具有亲和力的配体的病毒或非病毒载体中。

29. 发明授权

US09580717B2 Heterologous hosts 有权
标题翻译：异种宿主
公开(公告)号：US09580717B2
公开(公告)日：2017-02-28
申请号：US13516758
申请日：2010-12-17
申请人： Youming Zhang , Jun Fu , Xiaoying Bian , Adrian Francis Stewart , Rolf Müller
发明人： Youming Zhang , Jun Fu , Xiaoying Bian , Adrian Francis Stewart , Rolf Müller
IPC分类号： C12N15/74 , C07D245/02 , C07D417/06 , C07D493/04 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/18 , C12N15/70 , A61K35/00 , C12N9/00
CPC分类号： C12N15/70 , A61K35/74 , A61K2035/11 , C07D245/02 , C07D417/06 , C07D493/04 , C07D498/22 , C07G17/00 , C07K5/06139 , C07K7/64 , C12N9/1288 , C12N9/90 , C12N9/93 , C12N15/52 , C12N15/74 , C12P17/10 , C12P17/181 , C12Y207/08007 , Y02P20/52
摘要： This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.
摘要翻译：本发明涉及细菌工程和有用化合物的异源表达。特别地，本发明涉及已被改造用于表达能够进行聚酮化合物或非核糖体肽合成的基因的异源宿主。还公开了治疗癌症的方法。

30. 发明申请

US20130123360A1 METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND ASSOCIATED WITH BACTERIAL INFECTION 审中-公开
标题翻译：与细菌感染相关的化合物鉴定方法和用途
公开(公告)号：US20130123360A1
公开(公告)日：2013-05-16
申请号：US13812794
申请日：2011-07-25
申请人： Rolf Müller , Dominik Pistorius
发明人： Rolf Müller , Dominik Pistorius
IPC分类号： C12Q1/48
CPC分类号： C12Q1/48 , C12Q1/18 , G01N2333/21 , G01N2500/04
摘要： The present invention relates to a method of identifying a compound useful for the treating, reducing or preventing pathogenic infection caused by a microorganism and to the use of the PqsD protein or a functional fragment or variant thereof for the identification of a compound having said effect.
摘要翻译：本发明涉及鉴定可用于治疗，减少或预防由微生物引起的致病性感染的化合物的方法，以及使用PqsD蛋白或其功能片段或变体来鉴定具有所述作用的化合物。

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