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21. 发明申请

US20080249380A1 Protection Mechanism for Spectroscopic Analysis of Biological Tissue 审中-公开
标题翻译：生物组织光谱分析保护机制
公开(公告)号：US20080249380A1
公开(公告)日：2008-10-09
申请号：US11568549
申请日：2005-04-19
申请人： Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen , Marjolein Van Der Voort
发明人： Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen , Marjolein Van Der Voort
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0531 , A61B2090/065
摘要： The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.
摘要翻译：本发明提供了一种用于光谱分析系统的保护机制，其适于确定患者感兴趣体积的生物结构的性质。光谱系统优选利用高功率辐射，并且提供用于防止身体的感光组织的意外暴露的保护机构。本发明提供了多种方法来检测分光系统的测量头是否处于测量位置。测量头的测量位置可以有效地通过使用例如测量头来确定。压力传感器，测量患者皮肤电阻的传感器，或者甚至通过分析提供感兴趣体积的视觉图像的监测光束的强度或空间结构的光学装置来测量。

22. 发明授权

US09901321B2 Monitoring apparatus for monitoring an ablation procedure 有权
公开(公告)号：US09901321B2
公开(公告)日：2018-02-27
申请号：US13142299
申请日：2010-01-08
申请人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
发明人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
IPC分类号： A61B8/08 , A61B8/12 , A61B18/02 , A61B18/14 , A61B18/18 , A61B18/20 , A61B17/00 , A61B18/00 , A61B8/00 , A61B90/00
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/486 , A61B18/02 , A61B18/1442 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00577 , A61B2018/00738 , A61B2090/376 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.

23. 发明申请

US20130083331A1 SYSTEM FOR MONITORING THE POSITION OF A TUBE'S DISTAL END RELATIVE TO A BLOOD VESSEL 有权
标题翻译：用于监测管道与血液管的距离相对位置的系统
公开(公告)号：US20130083331A1
公开(公告)日：2013-04-04
申请号：US13703818
申请日：2011-06-10
申请人： Judith Margreet Rensen , Wouter Harry Jacinth Rensen
发明人： Judith Margreet Rensen , Wouter Harry Jacinth Rensen
IPC分类号： G01B11/14
CPC分类号： G01B11/14 , A61B5/065 , A61B5/15003 , A61B5/150396 , A61B5/150511 , A61B5/150748 , A61B5/153 , A61M5/16836 , A61M2205/3306 , A61M2205/3313
摘要： The invention relates to a system (101) for monitoring a position of a distal end (102) of a tube (104) with respect to a blood vessel (106) of a mamma. The system comprises a source (110) for generating an outgoing beam (112) of electromagnetic radiation having a predefined electromagnetic spectrum. The system furthermore comprises a guideway (114) for guiding the outgoing beam to the distal end, and for guiding an incoming beam (116) of electromagnetic radiation reflected by surroundings of the distal end in response to said outgoing beam to a measurement arrangement (120) which is arranged for measuring a parameter (122) associated with an electromagnetic spectrum of the incoming beam. The system furthermore comprises a comparator arrangement (124) for comparing said parameter with a reference parameter (126) associated with a reference electromagnetic spectrum representing a predefined location of the distal end inside the mammal.
摘要翻译：本发明涉及一种用于监测管（104）的远端（102）相对于母体的血管（106）的位置的系统（101）。该系统包括用于产生具有预定电磁光谱的电磁辐射的输出光束（112）的源（110）。该系统还包括用于将出射光束引导到远端的导轨（114），并且用于响应于所述输出光束将远端周围反射的电磁辐射的入射光束（116）引导到测量装置（120）），其被布置用于测量与入射光束的电磁光谱相关联的参数（122）。该系统还包括比较器装置（124），用于将所述参数与参考参数（126）进行比较，参考参数（126）与表示哺乳动物内的远端的预定位置的参考电磁谱相关联。

24. 发明申请

US20100096551A1 SPECTROSCOPY MEASUREMENTS 审中-公开
标题翻译：光谱测量
公开(公告)号：US20100096551A1
公开(公告)日：2010-04-22
申请号：US12521174
申请日：2007-12-20
申请人： Wouter Harry Jacinth Rensen , Levinus Pieter Bakker
发明人： Wouter Harry Jacinth Rensen , Levinus Pieter Bakker
IPC分类号： G01J5/02 , G01N21/55
CPC分类号： A61B5/14558
摘要： The invention relates to a device and method for the measurement of the concentration of at least one substance in a turbid medium. The device comprises at least one radiation source (12) adapted to illuminate the turbid medium (17) on at least one irradiation area. The device further comprises at least one detector adapted to detect backscattered light from the turbid medium from at least one detection area and to generate detection signals representative of the backscattered light. The device is arranged to generate detection signals with respect to at least two different irradiation-detection distances. The irradiation-detection distances are defined as the respective distances between the irradiation areas and the detection areas. The device also comprises at least one spatial light modulator (2), comprising 17 at least two electrode plates (5, 8) enclosing a liquid (7), the electrode plates supporting a plurality of electrodes (6, 10) arranged to define, with the liquid (7), light transmission patterns depending on the electrical field between the electrodes (6, 10), the irradiation areas and/or the detection areas being defined by said light transmission patterns.
摘要翻译：本发明涉及一种用于测量混浊介质中至少一种物质浓度的装置和方法。该装置包括适于在至少一个照射区域上照射混浊介质（17）的至少一个辐射源（12）。该装置还包括至少一个检测器，适于从至少一个检测区域检测来自混浊介质的反向散射光，并产生表示反向散射光的检测信号。该装置被布置成相对于至少两个不同的照射检测距离产生检测信号。照射检测距离被定义为照射区域和检测区域之间的相应距离。该装置还包括至少一个空间光调制器（2），包括17个至少两个封闭液体（7）的电极板（5,8），所述电极板支撑多个电极（6,10）利用液体（7），根据电极（6,10）之间的电场的透光图案，照射区域和/或检测区域由所述光透射图案限定。

25. 发明申请

US20090015819A1 OPTICAL ANALYSIS SYSTEM, BLOOD ANALYSIS SYSTEM AND METHOD OF DETERMINING AN AMPLITUDE OF A PRINCIPAL COMPONENT 审中-公开
标题翻译：光学分析系统，血液分析系统和确定主成分的幅度的方法
公开(公告)号：US20090015819A1
公开(公告)日：2009-01-15
申请号：US10596563
申请日：2004-12-13
申请人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
发明人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , G01J3/28 , G01N21/274 , G01N21/64 , G01N21/6445 , G01N21/65 , G01N2021/3196 , G01N2021/6417 , G01N2021/655
摘要： The optical analysis system (20) is arranged to determine an amplitude of a principal component of an optical signal. The optical analysis system (20) comprises a multivariate optical element (5, 6) for weighing the optical signal by a spectral weighing function and a detector (7, 8) for detecting the weighed optical signal. The optical signal comprises the principal component and a further component which was not accounted for when designing the spectral weighing function. Therefore, the detected weighed optical signal comprises a part relating to the amplitude of the principal component and a further part relating to a further amplitude of the further component. The optical analysis system (20) further comprises a modulator element (13) for modulating the detected weighed optical signal. The difference between the modulated detected weighed optical signal and the detected weighed optical signal relates to the amplitude of the principal component and thus allows for determining the amplitude of the principal component in an accurate way. The blood analysis system (40) comprises such an optical analysis system (20). The method of determining an amplitude of an principal component makes use of the optical analysis system (20).
摘要翻译：光学分析系统（20）被布置成确定光信号的主分量的幅度。光学分析系统（20）包括用于通过光谱称重功能称量光信号的多元光学元件（5,6）和用于检测加权光信号的检测器（7,8）。光信号包括主分量和另外的分量，在设计光谱称重功能时不考虑。因此，检测到的加权光信号包括与主分量的振幅有关的部分，以及与另一分量的另一幅度相关的另一部分。光学分析系统（20）还包括用于调制检测到的称重光信号的调制器元件（13）。调制检测到的称重光信号与检测到的称重光信号之间的差异与主分量的振幅有关，因此允许以准确的方式确定主分量的振幅。血液分析系统（40）包括这样的光学分析系统（20）。确定主成分的振幅的方法利用光学分析系统（20）。

26. 发明申请

US20080309930A1 Calibration for Spectroscopic Analysis 审中-公开
标题翻译：光谱分析校准
公开(公告)号：US20080309930A1
公开(公告)日：2008-12-18
申请号：US11574159
申请日：2005-08-23
申请人： Wouter Harry Jacinth Rensen
发明人： Wouter Harry Jacinth Rensen
IPC分类号： G01J3/00
CPC分类号： G01J3/36 , G01J3/04 , G01J2003/047 , G01J2003/1278
摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principle component is indicative of the concentration of a particular compound of various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to a wavelength selective weighting. Spectral weighting is preferably performed by means of spatial light manipulation means in combination with a dispersive optical element. The inventive calibration mechanism and method effectively allows for an accurate positioning of the spatial light manipulation means. Calibration is based on a calibration segment on the spatial light manipulation means in combination with a reference light source and a detector.
摘要翻译：本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。主要组分表示受光谱分析的物质的各种化合物的特定化合物的浓度。光信号经受波长选择加权。光谱加权优选地通过与分散光学元件组合的空间光操纵装置来执行。本发明的校准机构和方法有效地允许空间光操纵装置的精确定位。校准基于与参考光源和检测器组合的空间光操纵装置上的校准段。

27. 发明申请

US20080157921A1 Biometrics-Based Identification Method and Apparatus 有权
标题翻译：基于生物识别的识别方法和装置
公开(公告)号：US20080157921A1
公开(公告)日：2008-07-03
申请号：US11577375
申请日：2005-10-20
申请人： Robert Frans Maria Hendriks , Wouter Harry Jacinth Rensen , Antonius Hermanus Maria Akkermans
发明人： Robert Frans Maria Hendriks , Wouter Harry Jacinth Rensen , Antonius Hermanus Maria Akkermans
IPC分类号： G05B19/00 , G06K9/00
CPC分类号： G06K9/0012 , G06K9/00013 , G06K9/00899 , G06K2009/00932
摘要： The invention relates to an identification method carried out as follows. A surface structure and an inner structure of a body member are measured (ST1-ST4, ST7) so as to obtain a surface-structure measurement result (FPM) and an inner-structure measurement result (BVPM), respectively. The surface-structure measurement result (FPM) is compared (ST5) with a surface-structure reference result (FPR) that distinguishes an individual from other individuals. The inner-structure measurement result (BVPM) is compared (ST8) with an inner-structure reference result (BVPR) that is associated with the same individual and that distinguishes the individual from other individuals. The body member may be, for example, a finger. In that case, the surface structure comprises a fingerprint and the inner structure comprises a blood-vessel pattern.
摘要翻译：本发明涉及如下进行的识别方法。测量主体部件的表面结构和内部结构（ST1〜ST4，ST7），以获得表面结构测量结果（FPM）和内部结构测量结果（BVPM）。比较表面结构测量结果（FPM）（ST5）与区分个体与其他个体的表面结构参考结果（FPR）。比较内部结构测量结果（BVPM）（ST8）与与同一个人相关联的内部结构参考结果（BVPR），并将个体与其他个体区分开。身体构件可以是例如手指。在这种情况下，表面结构包括指纹，内部结构包括血管图案。

28. 发明申请

US20080129991A1 Alignment System for Spectroscopic Analysis 失效
标题翻译：光谱分析校准系统
公开(公告)号：US20080129991A1
公开(公告)日：2008-06-05
申请号：US11574161
申请日：2005-08-24
申请人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
发明人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J1/4228 , G01J3/0229 , G01J3/0289
摘要： The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous, tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.
摘要翻译：本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。以这种方式，可以有效地检测光谱系统的横向偏移。通常，多个不同的检测方案是可实现的，允许对分光系统进行自主调谐，并自动消除光谱系统的未对准。

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