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21. 发明授权

US06976965B2 Ultra miniature pressure sensor 失效
标题翻译：超微型压力传感器
公开(公告)号：US06976965B2
公开(公告)日：2005-12-20
申请号：US10247043
申请日：2002-09-19
申请人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
发明人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
IPC分类号： A61B5/0215 , A61F2/958 , A61M25/00 , A61M25/09 , G01L9/00 , A61B5/00
CPC分类号： G01L19/141 , A61B5/0215 , A61B5/6851 , A61B8/06 , A61B8/12 , A61M25/09 , A61M25/10 , A61M2025/0002 , A61M2025/09008 , A61M2025/09083 , G01L9/0054 , G01L19/0084 , G01L19/147 , G01L19/149
摘要： A guide wire having pressure sensing capabilities for measuring the pressure of liquid in a vessel comprising a flexible elongate member and having proximal and distal extremities and having an outside diameter of 0.018″ or less. The distal extremity of said flexible elongate member is adapted to be disposed in the liquid in said vessel. A housing is carried by the flexible elongate member and has a diameter substantially the same as the diameter of the flexible elongate member. The housing has a space therein with a pressure sensor mounted in the space in the housing. The pressure sensor has a diaphragm that is sensitive to changes of pressure in the liquid in the vessel. The diaphragm is rectangular in shape and is bordered by a rim surrounding the well. A backing plate is formed of an insulating material bonded to the crystal and serves to reinforce the rim of the crystal of semiconductor material. The backing plate has a cavity therein underlying the diaphragm and is in substantial registration with the diaphragm. The cavity serves to provide a pressure reference.
摘要翻译：一种导丝，其具有用于测量容器中液体的压力的压力感测能力，该容器包括柔性细长构件并具有近端和远端，外径为0.018“或更小。所述柔性细长构件的远端适于设置在所述容器中的液体中。壳体由柔性细长构件承载并且具有与柔性细长构件的直径基本相同的直径。壳体具有安装在壳体的空间中的压力传感器的空间。压力传感器具有对容器中的液体中的压力变化敏感的隔膜。隔膜是矩形的形状，并且围绕着井的边缘。背板由结合到晶体上的绝缘材料形成，用于加强半导体材料晶体的边缘。背板在其下面具有腔室，并且与隔膜基本上对准。腔用于提供压力参考。

22. 发明授权

US06432068B1 High output therapeutic ultrasound transducer 失效
标题翻译：高输出治疗超声换能器
公开(公告)号：US06432068B1
公开(公告)日：2002-08-13
申请号：US09531027
申请日：2000-03-20
申请人： Paul D. Corl , Joseph Karratt , John McKenzie
发明人： Paul D. Corl , Joseph Karratt , John McKenzie
IPC分类号： A61H100
CPC分类号： A61B17/2202 , A61B2017/22021 , A61B2017/22027
摘要： A therapeutic ultrasound energy delivery system includes a probe having a vibrational transducer. A restraint is disposed about the transducer in order to exert a compressive pre-stress on the transducer. The restraint inhibits tensile failure of the vibrational transducer at high acoustic output.
摘要翻译：治疗性超声能量递送系统包括具有振动换能器的探针。围绕换能器设置约束以便在换能器上施加压缩预应力。约束可以抑制振动传感器在高声输出时的拉伸失效。

23. 发明授权

US6106476A Ultra miniature pressure sensor and guide wire using the same and method 失效
标题翻译：超微型压力传感器和导丝采用相同的方法
公开(公告)号：US6106476A
公开(公告)日：2000-08-22
申请号：US912879
申请日：1997-08-15
申请人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
发明人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
IPC分类号： A61B5/0215 , A61F2/958 , A61M25/00 , A61M25/09 , G01L9/00 , A61B5/00
CPC分类号： G01L19/141 , A61B5/0215 , A61B5/6851 , A61M25/09 , G01L19/0084 , G01L19/147 , G01L19/149 , G01L9/0054 , A61M2025/0002 , A61M2025/09008 , A61M2025/09083 , A61M25/10
摘要： A guide wire having pressure sensing capabilities for measuring the pressure of liquid in a vessel comprising a flexible elongate member and having proximal and distal extremities and having an outside diameter of 0.018" or less. The distal extremity of said flexible elongate member is adapted to be disposed in the liquid in said vessel. A housing is carried by the flexible elongate member and has a diameter substantially the same as the diameter of the flexible elongate member. The housing has a space therein with a pressure sensor mounted in the space in the housing. The pressure sensor has a diaphragm that is sensitive to changes of pressure in the liquid in the vessel. The diaphragm is rectangular in shape and is bordered by a rim surrounding the well. A backing plate is formed of an insulating material bonded to the crystal and serves to reinforce the rim of the crystal of semiconductor material. The backing plate has a cavity therein underlying the diaphragm and is in substantial registration with the diaphragm. The cavity serves to provide a pressure reference.
摘要翻译：一种导丝，其具有用于测量容器中液体的压力的压力感测能力，该容器包括柔性细长构件并具有近端和远端，外径为0.018“或更小。所述柔性细长构件的远端适于设置在所述容器中的液体中。壳体由柔性细长构件承载并且具有与柔性细长构件的直径基本相同的直径。壳体具有安装在壳体的空间中的压力传感器的空间。压力传感器具有对容器中的液体中的压力变化敏感的隔膜。隔膜是矩形的形状，并且围绕着井的边缘。背板由结合到晶体上的绝缘材料形成，用于加强半导体材料晶体的边缘。背板在其下面具有腔室，并且与隔膜基本上对准。腔用于提供压力参考。

24. 发明授权

US5908385A Apparatus for mapping electrical activity in a body and treating tissue 失效
标题翻译：用于绘制身体中的电活动并处理组织的装置
公开(公告)号：US5908385A
公开(公告)日：1999-06-01
申请号：US599223
申请日：1996-02-08
申请人： Victor Chechelski , Jeffrey S. Frisble , Paul D. Corl , John E. Ortiz
发明人： Victor Chechelski , Jeffrey S. Frisble , Paul D. Corl , John E. Ortiz
IPC分类号： A61B5/042 , A61B8/06 , A61B17/00 , A61B18/08 , A61F7/02 , A61F7/12 , A61N1/05 , A61N1/28 , A61N1/40 , A61B5/0408
CPC分类号： A61B8/06 , A61B18/082 , A61B5/0422 , A61B5/6851 , A61B8/12 , A61F7/12 , A61N1/056 , A61N1/40 , A61B2017/00243 , A61B2017/00292 , A61B2562/0209 , A61B2562/043 , A61B8/445 , A61F2007/0285 , A61M25/09033
摘要： A guide wire assembly comprises a tubular body having a distal end and an proximal end. At least a portion of the body comprises a single continuous helical spring to which one or more tubular electrodes are secured. The electrodes are insulated from the spring by means of an insulator. The electrodes can take a variety of forms, including conductive ribbons, longitudinally split conductive tubes, tubular sections, etc. The guide wire assembly may further include a variety of sensors, such as velocity sensors or temperature sensors. In order to allow flowable material to be passed to the distal end of the guide wire, the guide wire can include a catheter tube passable over the tubular body of the guide wire.
摘要翻译：导丝组件包括具有远端和近端的管状体。主体的至少一部分包括固定有一个或多个管状电极的单个连续螺旋弹簧。电极通过绝缘体与弹簧绝缘。电极可以采取各种形式，包括导电带，纵向分开的导电管，管状部分等。导丝组件还可以包括各种传感器，例如速度传感器或温度传感器。为了允许可流动的材料通过导丝的远端，引导线可以包括可导引导丝管状体的导管。

25. 发明授权

US4967753A Apparatus, system and method for measuring spatial average velocity and/or volumetric flow of blood in a vessel 失效
标题翻译：用于测量血管中血液的空间平均速度和/或体积流量的装置，系统和方法
公开(公告)号：US4967753A
公开(公告)日：1990-11-06
申请号：US297111
申请日：1989-01-13
申请人： Wayne C. Haase , Jerome Segal , Paul D. Corl , Jeffrey J. Christian , Ronald G. Williams
发明人： Wayne C. Haase , Jerome Segal , Paul D. Corl , Jeffrey J. Christian , Ronald G. Williams
IPC分类号： A61B8/06 , G01F1/66
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , G01F1/663 , A61M2025/09175
摘要： System for measuring a characteristic of flow of liquid in a vessel of a patient comprising a transducer positioned in a vessel in a patient for supplying ultrasonic energy. The transducer produces a substantially uniform beam which encompasses the vessel. The transducer receives ultrasonic energy back scattered from the red blood cells and provides an electrical output signal. A first moment detector is provided which receives the electrical output from the transducer and provides a first moment signal. Normalization is provided to the output of the first moment detector to provide an electrical output representing a characteristic of the flow of the liquid in the vessel.
摘要翻译：用于测量患者容器中液体流动特性的系统，包括位于病人容器中的换能器，用于提供超声能量。换能器产生包围血管的基本均匀的束。传感器接收从红细胞反向散射的超声能量，并提供电输出信号。提供了第一时刻检测器，其接收来自换能器的电输出并提供第一力矩信号。将标准化提供给第一力矩检测器的输出，以提供表示容器中液体流动的特性的电输出。

26. 发明授权

US4869263A Device and method for measuring volumetric blood flow in a vessel 失效
标题翻译：用于测量血管中体积血流量的装置和方法
公开(公告)号：US4869263A
公开(公告)日：1989-09-26
申请号：US152098
申请日：1988-02-04
申请人： Jerome Segal , Paul D. Corl , Wayne C. Haase
发明人： Jerome Segal , Paul D. Corl , Wayne C. Haase
IPC分类号： A61B8/06 , A61F2/958
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61M25/10
摘要： Device for measuring volumetric blood flow in a vessel comprising a catheter having proximal and distal extremities. A balloon is carried by the distal extremity of the catheter. A balloon inflation lumen is carried by the catheter and is in communication with the balloon. A toroidal ultrasonic transducer is carried by the catheter and is spaced proximally of the balloon. Electrical circuitry is provided for supplying electrical energy to the transducer. The transducer produces a large substantially uniform beam of ultrasonic energy to illuminate a vessel of approximately three centimeters in diameter with the ultrasonic energy.
摘要翻译：用于测量容器中的体积血流的装置，包括具有近端和远端的导管。气囊由导管的远端承载。气囊充气腔由导管携带并与气囊连通。环形超声波换能器由导管承载并且在气囊的近侧间隔开。提供电路用于向换能器提供电能。换能器产生大的基本均匀的超声能量束，以用超声能量照射直径约三厘米的容器。

27. 发明授权

US4407293A Ultrasound imaging apparatus for providing simultaneous B-scan and Doppler data 失效
标题翻译：用于提供同时B扫描和多普勒数据的超声成像装置
公开(公告)号：US4407293A
公开(公告)日：1983-10-04
申请号：US257506
申请日：1981-04-24
申请人： Joe R. Suarez, Jr. , Henry L. Schwartz , Anthony J. Rossetti , Paul D. Corl
发明人： Joe R. Suarez, Jr. , Henry L. Schwartz , Anthony J. Rossetti , Paul D. Corl
IPC分类号： G01N29/06 , A61B8/00 , G01S7/52 , G01S15/89 , G10K11/35 , A61B5/02
CPC分类号： G10K11/355 , G01S15/8979 , G01S7/52073
摘要： An ultrasound imaging apparatus is described. The hand-held device includes a first oscillating transducer for providing a B-scan display and an offset second transducer which is manually positioned for providing Doppler data. The transducer pulses are interlaced and Doppler transmissions are inhibited to permit B-scan transmissions. However, circuits provide a continuous signal representing a Doppler signal when the Doppler transmissions are inhibited.
摘要翻译：描述超声成像装置。手持装置包括用于提供B扫描显示的第一振荡换能器和手动定位以提供多普勒数据的偏移的第二换能器。换能器脉冲是隔行扫描，多普勒传输被禁止允许B扫描传输。然而，当抑制多普勒传输时，电路提供表示多普勒信号的连续信号。

28. 发明申请

US20110251497A1 Ultra Miniature Pressure Sensor 有权
标题翻译：超微型压力传感器
公开(公告)号：US20110251497A1
公开(公告)日：2011-10-13
申请号：US13169174
申请日：2011-06-27
申请人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
发明人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
IPC分类号： A61B5/0215
CPC分类号： G01L19/141 , A61B5/0215 , A61B5/6851 , A61B8/06 , A61B8/12 , A61M25/09 , A61M25/10 , A61M2025/0002 , A61M2025/09008 , A61M2025/09083 , G01L9/0054 , G01L19/0084 , G01L19/147 , G01L19/149
摘要： A method of measuring blood pressure and velocity proximally and distally of a stenosis in a vessel carrying blood includes the steps of providing a guide wire having both a pressure sensor and a velocity sensor disposed on a distal region of the guide wire, introducing the guide wire into the vessel, advancing the guide wire to position the pressure sensor and the velocity sensor proximally and distally of the stenosis, and measuring the blood pressure and velocity proximally and distally of the stenosis with the pressure sensor and the velocity sensor.
摘要翻译：一种在携带血液的容器中向近端和远端测量血压和速度的方法，包括提供具有设置在导丝的远侧区域上的压力传感器和速度传感器两者的导丝的步骤，将引导线进入容器，推进导丝以将压力传感器和速度传感器定位在近端和远端的狭窄处，并用压力传感器和速度传感器测量近端和远端狭窄的血压和速度。

29. 发明授权

US07967762B2 Ultra miniature pressure sensor 有权
标题翻译：超微型压力传感器
公开(公告)号：US07967762B2
公开(公告)日：2011-06-28
申请号：US11650064
申请日：2007-01-04
申请人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
发明人： Paul D. Corl , Robert Z. Obara , John E. Ortiz
IPC分类号： A61B5/02
CPC分类号： G01L19/141 , A61B5/0215 , A61B5/6851 , A61B8/06 , A61B8/12 , A61M25/09 , A61M25/10 , A61M2025/0002 , A61M2025/09008 , A61M2025/09083 , G01L9/0054 , G01L19/0084 , G01L19/147 , G01L19/149
摘要： A method of measuring blood pressure and velocity proximally and distally of a stenosis in a vessel carrying blood includes the steps of providing a guide wire having both a pressure sensor and a velocity sensor disposed on a distal region of the guide wire, introducing the guide wire into the vessel, advancing the guide wire to position the pressure sensor and the velocity sensor proximally and distally of the stenosis, and measuring the blood pressure and velocity proximally and distally of the stenosis with the pressure sensor and the velocity sensor.
摘要翻译：一种在携带血液的容器中向近端和远端测量血压和速度的方法，包括提供具有设置在导丝的远侧区域上的压力传感器和速度传感器两者的导丝的步骤，将引导线进入容器，推进导丝以将压力传感器和速度传感器定位在近端和远端的狭窄处，并用压力传感器和速度传感器测量近端和远端狭窄的血压和速度。

30. 发明申请

US20080139909A1 SENSOR WITH CONDUCTOR AND SEALING GLASS 审中-公开
标题翻译：带导体和密封玻璃的传感器
公开(公告)号：US20080139909A1
公开(公告)日：2008-06-12
申请号：US12027902
申请日：2008-02-07
申请人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
发明人： Paul D. Corl , James D. Mikkelsen , Harry D. Nguyen , Amos Gottlieb , Margaret R. Webber
IPC分类号： A61B5/145
CPC分类号： A61B5/14542 , A61B5/01 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6852 , A61B2562/227
摘要： An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
摘要翻译：一种用于患有携带血液的血管以确定血液特征的患者的装置。该装置包括显示模块和探针，其具有适于插入病人容器中的远端，并具有耦合到显示模块的近端。探头包括远端末端的传感器，用于当探针设置在血液中时向显示模块提供电信号。探针可以具有抗血栓形成表面处理，用于当设置在血液中时抑制血液成分对探针的粘附。

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