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21. 发明申请

US20090008254A1 Microfluidic System and Corresponding Control Method 审中-公开
标题翻译：微流控系统及相应的控制方法
公开(公告)号：US20090008254A1
公开(公告)日：2009-01-08
申请号：US11908605
申请日：2006-03-16
申请人： Torsten Müller , Thomas Schnelle
发明人： Torsten Müller , Thomas Schnelle
IPC分类号： B01D57/02 , C25B11/00
CPC分类号： B03C5/026 , B03C5/005
摘要： The invention relates to a microfluidic system containing a carrier current channel (1) for receiving a carrier current containing particles suspended therein, and at least one electrode arrangement (3) which is arranged in the carrier current channel and used to manipulate the suspended particles (2), the electrode arrangement (3) containing two manipulation electrodes (4, 5). According to the invention, the electrode arrangement (3) contains two centering electrodes (6, 7), in addition to the two manipulation electrodes (4, 5), for centering the particles, the two centering electrodes (6, 7) being arranged in the carrier current channel (1) respectively upstream of one of the two manipulation electrodes (4, 5). The invention also relates to a corresponding control method.
摘要翻译：本发明涉及一种微流体系统，其包含用于接收载流子电流的载流子流道（1），所述载流子流包含悬浮在其中的颗粒;以及至少一个电极装置（3），其布置在所述载流子通道中并用于操纵所述悬浮颗粒 2），电极装置（3）包含两个操纵电极（4,5）。根据本发明，电极装置（3）除了两个操作电极（4,5）之外还包含两个定心电极（6,7），用于使颗粒居中，两个定心电极（6,7）被布置分别位于两个操作电极（4,5）中的一个的上游的载波电流通道（1）中。本发明还涉及相应的控制方法。

22. 发明申请

US20090148937A1 MICRO-FLUIDIC SYSTEM COMPRISING AN EXPANDED CHANNEL 审中-公开
标题翻译：包含扩展通道的微流体系统
公开(公告)号：US20090148937A1
公开(公告)日：2009-06-11
申请号：US11719618
申请日：2005-11-17
申请人： Thomas Schnelle , Torsten Müller , Annette Pfennig
发明人： Thomas Schnelle , Torsten Müller , Annette Pfennig
IPC分类号： C12N5/06 , G01N15/00 , G01N27/26 , B03B5/00
CPC分类号： G01N15/1056 , B01L3/502753 , B01L2200/0647 , B01L2300/0864 , B01L2400/0424 , B03C5/026 , B03C2201/26 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/1236 , G01N2015/149
摘要： The invention relates to a micro-fluidic system including a fluid medium channel that holds a fluid medium containing particles in suspension. According to the invention, the fluid medium channel has an expanded section with an enlarged cross-section along part of its length, in order to reduce the flow speed to allow the analysis of the particles.
摘要翻译：本发明涉及一种微流体系统，其包括流体介质通道，其保持含有悬浮液中的颗粒的流体介质。根据本发明，流体介质通道具有沿其长度的一部分具有放大横截面的膨胀部分，以便减小流速以允许分析颗粒。

23. 发明授权

US07988841B2 Treatment of biological samples using dielectrophoresis 有权
标题翻译：使用介电电泳处理生物样品
公开(公告)号：US07988841B2
公开(公告)日：2011-08-02
申请号：US11531679
申请日：2006-09-13
申请人： Mario Scurati , Torsten Mueller , Thomas Schnelle
发明人： Mario Scurati , Torsten Mueller , Thomas Schnelle
IPC分类号： B03C5/02
CPC分类号： B03C5/026
摘要： A plurality of planar electrodes (5) in a microchannel (4) is used for separation, lysis and PCR in a chip (10). Cells from a sample are brought to the electrodes (5). Depending on sample properties, phase pattern, frequency and voltage of the electrodes and flow velocity are chosen to trap target cells (16) using DEP, whereas the majority of unwanted cells (17) flushes through. After separation the target cell (16) are lysed while still trapped. Lysis is carried out by applying RF pulses and/or thermally so as to change the dielectric properties of the trapped cells. After lysis, the target cells (16) are amplified within the microchannel (4), so as to obtain separation, lysis and PCR on same chip (1).
摘要翻译：微通道（4）中的多个平面电极（5）用于芯片（10）中的分离，裂解和PCR。来自样品的细胞被带到电极（5）。根据样品性质，选择电极的相图，频率和电压以及流速，以使用DEP捕获靶细胞（16），而大多数不需要的细胞（17）冲洗通过。分离后，靶细胞（16）裂解，同时仍被捕获。通过施加RF脉冲和/或热来进行裂解以改变被捕获的细胞的介电性质。裂解后，在微通道（4）内扩增靶细胞（16），以在同一芯片（1）上获得分离，裂解和PCR。

24. 发明申请

US20070221501A1 Method and Device for Collecting Suspended Particles 失效
标题翻译：收集悬浮颗粒的方法和装置
公开(公告)号：US20070221501A1
公开(公告)日：2007-09-27
申请号：US11568895
申请日：2005-05-06
申请人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
发明人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
IPC分类号： B01D57/02
CPC分类号： B03C5/026
摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.
摘要翻译：给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中，，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流（30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环）。还描述了用于收集颗粒的相应装置。

25. 发明申请

US20060243594A1 Impedance measurement in a fluidic microsystem 审中-公开
标题翻译：流体微系统中的阻抗测量
公开(公告)号：US20060243594A1
公开(公告)日：2006-11-02
申请号：US10523175
申请日：2003-07-28
申请人： Thomas Schnelle , Torsten Mueller , Stephen Shirley
发明人： Thomas Schnelle , Torsten Mueller , Stephen Shirley
IPC分类号： B03C5/02
CPC分类号： G01N15/1209 , G01N2015/1236 , G01N2015/1254
摘要： Described are a method and a measuring device for measuring the impedance in a fluidic microsystem comprising a compartment (10) through which a liquid comprising at least one suspended particle (16) flows, and in which at least one impedance detector (40) is arranged, by means of which for detection of the at least one particle at least one impedance value is acquired which is characteristic for the impedance of the compartment, and which in the presence of the at least one particle changes in a predetermined way, wherein focusing of the at least one particle takes place in a predetermined space relative to the impedance detector, wherein focusing involves a movement of the at least one particle relative to the fluid flowing in the compartment as a result of dielectrophoretic forces, which forces are exerted by means of at least two focusing electrodes (30).
摘要翻译：描述了一种用于测量流体微系统中的阻抗的方法和测量装置，其包括隔室（10），包括至少一个悬浮颗粒（16）的液体通过该隔室（10）流过，并且其中布置有至少一个阻抗检测器（40）用于检测至少一个颗粒，获得至少一个阻抗值，该阻抗值是隔室的阻抗的特征，并且在至少一个颗粒的存在下以预定的方式改变，其中聚焦所述至少一个颗粒相对于所述阻抗检测器发生在预定空间中，其中聚焦涉及所述至少一个颗粒相对于由于介电电泳力而在所述隔室中流动的流体的运动，所述力通过至少两个聚焦电极（30）。

26. 发明授权

US07399395B2 Method and device for generating microconvections 失效
标题翻译：用于产生微对流的方法和装置
公开(公告)号：US07399395B2
公开(公告)日：2008-07-15
申请号：US10416054
申请日：2001-11-09
申请人： Thomas Schnelle , Torsten Muller
发明人： Thomas Schnelle , Torsten Muller
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01F3/08 , B01F5/0403 , B01F13/0001 , B01F13/0006 , B01F13/001 , B01F13/0077 , B01F2003/125 , B01L3/50273 , B01L2300/0867 , B01L2400/0415 , B01L2400/0442 , B03C5/028
摘要： The invention relates to a method for generating a convective liquid motion in a fluidic microsystem. According to this method, a liquid in a microsystem is simultaneously exposed to an electrical field and a thermal gradient. The electrical field is generated by means of an electrode arrangement which is subjected to a time-variant voltage. In this way, a time variant electrical field is formed in the liquid volume. The thermal gradient is produced by means of at least one radiation absorber located in the compartment which is exposed to at least one external radiation field.
摘要翻译：本发明涉及在流体微系统中产生对流液体运动的方法。根据该方法，微系统中的液体同时暴露于电场和热梯度。电场通过经历时变电压的电极装置产生。以这种方式，在液体体积中形成时变电场。热梯度是通过位于室内的至少一个辐射吸收器产生的，其暴露于至少一个外部辐射场。

27. 发明申请

US20070119714A1 Methods and devices for analysing a deformable object 审中-公开
标题翻译：用于分析可变形物体的方法和装置
公开(公告)号：US20070119714A1
公开(公告)日：2007-05-31
申请号：US10595771
申请日：2004-11-10
申请人： Thomas Schnelle , Torsten Muller , Andre Homke
发明人： Thomas Schnelle , Torsten Muller , Andre Homke
IPC分类号： B03C5/02
CPC分类号： G01N15/1056 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2400/0415 , B01L2400/0424 , G01N15/1456 , G01N15/1459 , G01N2015/105 , G01N2015/1495 , G01N2015/1497
摘要： Methods are described for analyzing at least one deformable object (O) in a suspension fluid, including the following steps: generation of an electric positioning field and positioning of the object (O) in a potential minimum of the positioning field, generation of an electric deformation field in such a way that a deformation force is exerted on the object (O), and detection of at least one property selected from the group including the dielectric, geometric and optical properties of the object (O), wherein the positioning field is generated in a compartment (12) of a fluidic microsystem (10) and the positioning of the object (O) takes place in a contactless manner in a freely suspended state. Measuring apparatuses for carrying out this method are also described.
摘要翻译：描述了用于分析悬浮液中的至少一个可变形物体（O）的方法，包括以下步骤：产生电定位区域和将物体（O）定位在定位区域的潜在最小值中，产生电变形场，使得变形力施加在物体（O）上，以及检测从包括物体（O）的电介质，几何和光学性质的组中选择的至少一种性质，其中定位场是产生在流体微系统（10）的隔室（12）中，并且物体（O）的定位以无接触的方式在自由悬挂状态下进行。还描述了用于执行该方法的测量装置。

28. 发明申请

US20060152708A1 Multiparametric detection in a fluidic microsystem 审中-公开
标题翻译：流体微系统中的多参数检测
公开(公告)号：US20060152708A1
公开(公告)日：2006-07-13
申请号：US10544423
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.
摘要翻译：公开了一种用于测量移动通过流体微系统的颗粒的性质的方法，所述颗粒悬浮在液体中。根据本发明的方法，首先在第一测试台（11）测量特定颗粒的第一参数。然后在与第一测试站（11）在空间上分离的第二测试站（12）以与第一测量的间隔的间隔测量颗粒的第二参数，并且以相关方式联合评估第一和第二参数，第一和第二参数是测试颗粒的不同性质的特征。评估包括第一和第二参数与预定预期值的比较。根据比较的结果，对测试的颗粒进行另一测量或操作。还公开了被设计用于实施本发明方法的流体微系统。

29. 发明申请

US20060126921A1 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy 有权
标题翻译：用于提供高分辨率显微镜的悬浮微物体三维成像的方法和装置
公开(公告)号：US20060126921A1
公开(公告)日：2006-06-15
申请号：US10532147
申请日：2003-10-24
申请人： Spencer Shorte , Torsten Muller , Thomas Schnelle
发明人： Spencer Shorte , Torsten Muller , Thomas Schnelle
IPC分类号： G06K9/00
CPC分类号： G02B21/22 , G01N2015/144 , G01N2015/1445 , G01N2015/1452 , G02B21/367
摘要： A method for high-resolution image recording of at least one object with a microscope, includes the steps of: (a) positioning the object in a receptacle being arranged in the optical axis of the microscope, (b) generating at least two first data sets per object which represent intermediate images of the object with at least two different orientations relative to the optical axis of the microscope, wherein the different orientations of the object are provided by moving the object relative to the receptacle, and (c) evaluating the data sets for obtaining quantitative three dimensional information.
摘要翻译：一种用显微镜对至少一个物体进行高分辨率图像记录的方法，包括以下步骤：（a）将物体放置在布置在显微镜的光轴上的容器中，（b）产生至少两个第一数据通过相对于显微镜的光轴具有至少两个不同取向来表示对象的每个对象的集合，其中通过相对于插座移动对象来提供对象的不同取向，以及（c）评估数据用于获得定量三维信息。

30. 发明申请

US20060024802A1 Fluidic microsystem comprising field-forming passivation layers provided on microelectrodes 有权
标题翻译：流体微系统包括在微电极上提供的场形成钝化层
公开(公告)号：US20060024802A1
公开(公告)日：2006-02-02
申请号：US10536674
申请日：2003-11-26
申请人： Torsten Muller , Thomas Schnelle
发明人： Torsten Muller , Thomas Schnelle
IPC分类号： C12N13/00 , C12M1/34
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0645 , B01L2300/16 , B01L2400/0415 , B03C5/026
摘要： Described is a fluidic microsystem (100) comprising at least one channel (10) through which a particle suspension can flow; and first and second electrode devices (40, 60) which are arranged on first and second channel walls (21, 31) for generating electrical alternating-voltage fields in the channel (10); wherein the first electrode device (40) for field shaping in the channel comprises at least one first structure element (41, 51); and the second electrode device (60) comprises an area-like electrode layer (61) with a closed second electrode surface which comprises a second passivation layer (70); wherein the effective electrode surface of the first structure element (41, 51), of which element (41, 51) there is at least one, is smaller than the second electrode surface; and the second passivation layer (70) is a closed layer which completely covers the second electrode layer (61).
摘要翻译：描述了流体微系统（100），其包括至少一个通道（10），颗粒悬浮液可以通过该通道流动; 以及布置在第一和第二通道壁（21,31）上的用于在通道（10）中产生电气交变电压场的第一和第二电极装置（40,60）。其中用于所述通道中的场成形的所述第一电极装置（40）包括至少一个第一结构元件（41,51）; 并且第二电极装置（60）包括具有闭合的第二电极表面的区域状电极层（61），其包括第二钝化层（70）; 其中，所述元件（41,51）中至少有一个的所述第一结构元件（41,51）的有效电极表面小于所述第二电极表面; 并且所述第二钝化层（70）是完全覆盖所述第二电极层（61）的封闭层。

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