会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 21. 发明授权
    • Novel N'-acylated phenyl-hydrazine and hydrozone derivatives
    • 新型N {40-酰基苯基 - 肼和水解产物
    • US3974145A
    • 1976-08-10
    • US439035
    • 1974-02-04
    • Michio KimuraShigeho InabaHisao Yamamoto
    • Michio KimuraShigeho InabaHisao Yamamoto
    • C07D209/60C07D209/70C07D307/54C07D317/66C07D317/68C07D319/18
    • C07D307/54C07D209/60C07D209/70C07D317/66C07D317/68C07D319/18
    • Novel indolylacetic acid derivatives, which have excellent anti-inflammatory, antipyretic and analgesic activities, represented by the formula, ##SPC1##Wherein X.sub.1 and X.sub.2 each is a member selected from the group consisting of oxygen and methylene; A is a member selected from the group consisting of unsubstituted saturated hydrocarbon chain having up to 5 carbon atoms, unsubstituted unsaturated hydrocarbon chain having up to 5 carbon atoms and substituted saturated or substituted ethylenically unsaturated hydrocarbon chain having up to 5 carbon atoms, in which the substituents are selected from the group consisting of halogen or phenyl, the hydrocarbon chain being straight or blanched one; m is 0 or 1; n is 1 or 2; R.sub.1 and R.sub.2 each is a member selected from the group consisting of hydrogen and alkyl having up to 4 carbon atoms; R.sub.3 is a member selected from the group consisting of alkyl having up to 4 carbon atoms, unsubstituted or a lower alkyl-, lower alkoxy-, lower alkylthio-, nitro-, cyano-, methylenedioxy-, ethylenedioxy- or halogen-substituted aryl, each of said alkyl, alkoxy and alkylthio substituents containing up to 4 carbon atoms, or unsubstituted, or halogen-, alkyl- or phenyl-substituted or benzene ring-condensed, saturated or unsaturated mono- or poly-aclicyclic group, or alkyl group substituted by said alicyclic group, or unsubstituted or methyl-, ethyl- or halogen-substituted 5- or 6-membered heterocyclic ring group containing oxygen, sulfur or nitrogen atom; R.sub.4 is a member selected from the group consisting of alkyl having up to 4 carbon atoms or hydrogen, or a group of M (wherein M is a cation).The indolylacetic acid of the formula (I) is prepared by reacting a compound of the formula, ##SPC2##Wherein X.sub.1, X.sub.2 and n are the same as defined above and B is a member selected from the group consisting of ##EQU1## and Z (wherein Z is a nitrogen protecting system comprising at least one readily removable group), with an acid halide represented by the formula,R.sub.3 --(A).sub.m --CO--hal (V)wherein R.sub.3, A and m are the same as defined above and hal is halogen, to obtain N.sup.1 -acylated compound of the formula, ##SPC3##Wherein X.sub.1, X.sub.2, R.sub.3, A, B, m and n are the same as defined above, then reacting the resultant N.sup.1 -acylated compound (II) with an aliphatic acid derivative represented by the formula, ##EQU2## wherein R.sub.1, R.sub.2 and R.sub.4 are the same as defined above.
    • 新型吲哚乙酸衍生物,其具有优异的抗炎,解热和止痛活性,由式WHEREIN X1和X2各自为选自氧和亚甲基的成员; A是选自具有至多5个碳原子的未取代的饱和烃链,具有至多5个碳原子的未取代的不饱和烃链和具有至多5个碳原子的取代的饱和或取代的烯属不饱和烃链的成员,其中 取代基选自卤素或苯基,烃链是直链或漂白的; m为0或1; n为1或2; R1和R2各自是选自氢和具有至多4个碳原子的烷基的成员; R3是选自具有至多4个碳原子的烷基,未取代的或低级烷基,低级烷氧基 - ,低级烷硫基 - ,硝基 - ,氰基 - ,亚甲二氧基 - ,亚乙二氧基或卤素取代的芳基的成员, 所述烷基,烷氧基和烷硫基取代基含有至多4个碳原子,或未取代的或卤素,烷基或苯基取代的或苯环稠合的饱和或不饱和的单 - 或多 - 酰基基团或烷基取代的 或含有氧,硫或氮原子的未取代或甲基,乙基或卤素取代的5元或6元杂环基; R4是选自具有至多4个碳原子的烷基或氢的成员,或一组M(其中M是阳离子)。